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Machine learning prediction model for gray-level co-occurrence matrix features of synchronous liver metastasis in colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1571-1581页

作者： Kai-Feng Yang Sheng-Jie Li Jun Xu yong-bin zheng Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichang Central People’s HospitalYichang 443008Hubei ProvinceChina

BACKGROUND Synchronous liver metastasis(SLM)is a significant contributor to morbidity in colorectal cancer(CRC).There are no effective predictive device integration algorithms to predict adverse SLM events during the diagnosis of *** To explore the risk factors for SLM in CRC and construct a visual prediction model based on gray-level co-occurrence matrix(GLCM)features collected from magnetic resonance imaging(MRI).METHODS Our study retrospectively enrolled 392 patients with CRC from Yichang Central People’s Hospital from January 2015 to May *** were randomly divided into a training and validation group(3:7).The clinical parameters and GLCM features extracted from MRI were included as candidate *** prediction model was constructed using a generalized linear regression model,random forest model(RFM),and artificial neural network *** operating characteristic curves and decision curves were used to evaluate the prediction *** Among the 392 patients,48 had SLM(12.24%).We obtained fourteen GLCM imaging data for variable screening of SLM prediction *** difference,mean sum,sum entropy,sum variance,sum of squares,energy,and difference variance were listed as candidate variables,and the prediction efficiency(area under the curve)of the subsequent RFM in the training set and internal validation set was 0.917[95%confidence interval(95%CI):0.866-0.968]and 0.09(95%CI:0.858-0.960),*** A predictive model combining GLCM image features with machine learning can predict SLM in *** model can assist clinicians in making timely and personalized clinical decisions.

关键词： Colorectal cancer Synchronous liver metastasis Gray-level co-occurrence matrix Machine learning algorithm Prediction model

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Exploring Trade-offs in Thermal Interface Materials:The Impact of Polymer-Filler Interfaces on Thermal Conductivity and Thixotropy

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Chinese Journal of Polymer Science 2024年第7期42卷 916-925,I0006页

作者： bin Zhang zheng-Li Dou yong-zheng Zhang Qiang Fu Kai Wu College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065China

Effective thermal transport across solid-solid interfaces which is essential in thermal interface materials(TIMs),necessitates both optimal thixotropy and high thermal *** role of filler surface modification,a fundamental aspect of TIM fabrication,in the influence of these properties is not fully *** study employs the use of a silane coupling agent(SCA)to modify alumina,integrating experimental approaches with molecular dynamics simulations,to elucidate the interface effects on thixotropy and thermal conductivity in polydimethylsiloxane(PDMS)-based *** findings reveal that the variations of SCAs modify both interface binding energy and transition layer *** interface binding energy restricts macromolecular segmental relaxation near the interface,hindering desirable thixotropy and bond line *** the contrary,the thickness of the transition layer at the interface positively influences thermal conductivity,facilitating the transport of phonons between the polymer and ***,selecting an optimal SCA allows a balance between traditionally conflicting goals of high thermal conductivity and minimal bond line thickness,achieving an impressively low interface thermal resistance of just 2.45-4.29 K·mm^(2)·W^(-1)at275.8 kPa.

关键词： Thermal interface material Surface modification Thermal conductivity Thixotropy Interface thermal resistance

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Comparison of Diver CE and ZEEK manual aspiration catheters for thrombectomy in ST-segment elevation myocardial infarction

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Chinese Medical Journal 2009年第6期122卷 648-654页

作者： ZHAO Han-jun YAN Hong-bing WANG Jian SONG Li LI Qing-xiang LI Shi-ying CHI Yun-peng WU zheng ZHANG Xiao-jiang ZHAO yong zheng bin 28th Division Beijing Anzhen Hospital of Capital Medical University Beijing 100029 China

Background A growing volume of data suggests that simple manual thrombus aspiration followed by direct stenting improves myocardial reperfusion and clinical outcome compared with conventional primary PCI, but there is still limited data comparing the in vivo performance among different devices. This study aimed to compare the efficacy and operability of thrombus aspiration by the Diver CE （Invatec, Brescia, Italy） and ZEEK （Zeon Medical Inc., Tokyo, Japan） aspiration catheters in ST-segment elevation myocardial infarction （STEMI） and their impact on 3-month outcome.Methods From September 2004 to June 2008, 298 consecutive patients with STEMI who received manual thrombus aspiration were involved in a single center retrospective analysis. Of them, 229 and 69 were treated with Diver CE and ZEEK aspiration catheters, respectively. Primary endpoints were myocardial blush grade （MBG）, thrombolysis in myocardial infarction （TIMI） flow grade, ST-segment elevation resolution （STR）, device pushability and trackability as judged by the frequency of usage of dual guide wires and aspiration efficacy as indicated by size distribution of aspirated thrombi. Secondary endpoints were 3-month outcome including left ventricular end diastolic diameter （LVEDD）, left ventricular ejection fraction （LVEF）, as well as cardiac death, target lesion revascularization （TLR）, re-infarction and their combination as major adverse cardiac events （MACE）. Results Baseline characteristics were not different between the two groups expect for a higher frequency of temporary cardiac pacing in the ZEEK group （ZEEK） than in the Diver CE group （Diver CE）（0.44% vs 5.8%, P=0.002）. Visible retrieved thrombi were achieved in 65.9% of the Diver CE and 68.1% of the ZEEK （P=0.74）. Aspirated thrombi were categorized as small thrombi （〈3.5 mm）, moderate thrombi （3.5-7.0 mm） and large thrombi （〉7.0 mm）. Small thrombi were more frequently seen in the Diver CE （61.6% vs 42.6%）, whereas moderate and larger thrombi wer

关键词： primary percutaneous coronary intervention ST-segment elevation myocardial infarction manual thrombus aspiration

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An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

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Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： Ying Li Long-Jie Wang yong-Kang Zhou Jun Liang bin Xiao Ji-Shen zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

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Screening Methods for Waterlogging Tolerance at Maize (Zea mays L.) Seedling Stage

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Agricultural Sciences in China 2010年第3期9卷 362-369页

作者： LIU yong-zhong, TANG bin, zheng yong-lian, MA Ke-jun, XU Shang-zhong and QIU Fa-zhan National Key Laboratory of Crop Genetic Improvement/Huazhong Agricultural University, Wuhan 430070, P.R.China National Key Laboratory of Crop Genetic Improvement/Huazhong Agricultural University Wuhan 430070 P.R.China

Waterlogging strongly affects agronomic performance of maize （Zea mays L.）. In order to investigate the suitable selection criteria of waterflooding tolerant genotypes, and identify the most susceptible stage and the best continuous treatment time to waterlogging, 20 common maize inbred lines were subjected to successive artificial waterflooding at seedling stage, and waterlogging tolerance coefficient （WTC） was used to screen waterflooding tolerant genotypes. In addition, peroxidase （POD） activities and malondialdehyde （MDA） contents were measured for 6 of 20 lines. The results showed that the second leaf stage （V2） was the most susceptible stage, and 6 d after waterflooding was the best continuous treatment time. Dry weight （DW） of both shoots and roots of all lines were significantly reduced at 6 d time-point of waterlogging, compared to control. POD activities and MDA contents were negatively and significantly correlated, and the correlation coefficient was -0.9686 （P 〈 0.0001）. According to the results, WTC of shoot DW can be used for practical screening as a suitable index, which is significantly different from control and waterlogged plants happened 6 d earlier. Furthermore, leaf chlorosis, MDA content and POD activities could also be used as reference index for material screening. The implications of the results for waterlogging-tolerant material screening and waterlogging-tolerant breeding have been discussed in maize.

关键词： maize (Zea mays L.) waterlogging tolerance screening method selection criteria

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Characteristics of proppant transport and placement within rough hydraulic fractures

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Petroleum Exploration and Development 2024年第2期51卷 453-463页

作者： HUANG Hai zheng yong WANG Yi WANG Haizhu NI Jun WANG bin YANG bing ZHANG Wentong School of Petroleum Engineering Xi’an Shiyou UniversityXi’an 710065China Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi’an 710075China Shaanxi Provincial Key Laboratory of Oil and Gas Well and Reservoir Seepage and Rock Mechanics Xi’an 710065China Oil&Gas Field Production Construction Division PetroChina Tarim Oilfield CompanyKorla 841000China National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing 102249China Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi’an 710075China

A three-dimensional reconstruction of rough fracture surfaces of hydraulically fractured rock outcrops is carried out by casting process,a large-scale experimental setup for visualizing rough fractures is built to perform proppant transport *** typical characteristics of proppant transport and placement in rough fractures and its intrinsic mechanisms are investigated,and the influences of fracture inclination,fracture width and fracturing fluid viscosity on proppant transport and placement in rough fractures are *** results show that the rough fractures cause variations in the shape of the flow channel and the fluid flow pattern,resulting in the bridging buildup during proppant transport to form unfilled zone,the emergence of multiple complex flow patterns such as channeling,reverse flow and bypassing of sand-carrying fluid,and the influence on the stability of the sand *** proppant has a higher placement rate in inclined rough fractures,with a maximum increase of 22.16 percentage points in the experiments compared to vertical fractures,but exhibits poor stability of the sand *** fracture width aggravates the bridging of proppant and induces higher pumping *** the viscosity of the fracturing fluid can weaken the proppant bridging phenomenon caused by the rough fractures.

关键词： reservoir fracturing rough fracture proppant transport and placement characteristics bridging buildup

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Optimization-based mode selection scheme for OAM millimeter wave system in the off-axis misalignment case

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Digital Communications and Networks 2024年第1期10卷 101-108页

作者： Haie Dou Lei Wang bin Kang Baoyu zheng Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing210003China School of Internet of Things Nanjing University of Posts and TelecommunicationsNanjing210003China

Millimeter-wave transmission combined with Orbital Angular Momentum(OAM)has the advantage of reducing the loss of beam power and increasing the system ***,to fulfill this advantage,the antennas at the transmitter and receiver must be parallel and coaxial;otherwise,the accuracy of mode detection at the receiver can be seriously *** this paper,we design an OAM millimeter-wave communication system for overcoming the above ***,the first contribution is that the power distribution between different OAM modes and the capacity of the system with different mode sets are analytically derived for performance *** second contribution lies in that a novel mode selection scheme is proposed to reduce the total interference between different *** results show that system performance is less affected by the offset when the mode set with smaller modes or larger intervals is selected.

关键词： Orbital angular momentum Millimeter wave Off-axis misalignment Mode selection Capacity

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Proppant transport in rough fracture networks using supercritical CO_(2)

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Petroleum Science 2024年第3期21卷 1852-1864页

作者： yong zheng Meng-Meng Zhou Ergun Kuru bin Wang Jun Ni bing Yang Ke Hu Hai Huang Hai-Zhu Wang School of Petroleum Engineering Xi'an Shiyou UniversityXian710065ShaanxiChina Shaanxi Key Laboratory of Carbon Dioxide Sequestration and Enhanced Oil Recovery Xi'an710075ShaanxiChina State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing2249China School of Mining and Petroleum Engineering University of AlbertaEdmontonTG2W2AlbertaCanad Shaanxi Yanchang Petroleum(Group)Co. Ltd.Xi'an710075ShaanxiChina

Proppant transport within fractures is one of the most critical tasks in oil,gas and geothermal reservoir stimulation,as it largely determines the ultimate performance of the operating *** transport in rough fracture networks is still a relatively new area of research and the associated transport mechanisms are still *** this study,representative parameters of rough fracture surfaces formed by supercritical CO_(2) fracturing were used to generate a rough fracture network model based on a spectral synthesis *** fluid dynamics(CFD)coupled with the discrete element method(DEM)was used to study proppant transport in this rough fracture *** reveal the turning transport mechanism of proppants into branching fractures at the intersections of rough fracture networks,a comparison was made with the behavior within smooth fracture networks,and the effect of key pumping parameters on the proppant placement in a secondary fracture was *** results show that the transport behavior of proppant in rough fracture networks is very different from that of the one in the smooth fracture *** turning transport mechanisms of proppant into secondary fractures in rough fracture networks are gravity-driven sliding,high velocity fluid suspension,and fracture structure *** the same injection conditions,supercritical CO_(2)with high flow Reynolds number still has a weaker ability to transport proppant into secondary fractures than *** of the supercritical CO_(2)needs to be increased beyond a certain value to have a significant effect on proppant carrying,and under the temperature and pressure conditions of this paper,it needs to be increased more than 20 times(about 0.94 m Pa s).Increasing the injection velocity and decreasing the proppant concentration facilitates the entry of proppant into the branching fractures,which in turn results in a larger stimulated reservoir *** results help to understand the pro

关键词： Reservoir stimulation CCUS Rough fracture network Supercritical CO_(2) Proppanttransport

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Accelerating Asteroidal Period and Pole Inversion from Multiple Lightcurves Using Parallel Differential Evolution and Cellinoid Shape Model

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Research in Astronomy and Astrophysics 2024年第4期24卷 271-286页

作者： yong-Xiong Zhang Wen-Xiu Guo Xiao-Ping Lu Hua zheng Hai-bin Zhao Jun Tian Wei-Lin Wang School of Engineering Guangzhou College of Technology and BusinessGuangzhou 510850China School of Computer Science and Engineering Macao University of Science and TechnologyTaipaMacao 999078China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512099China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Key Laboratory of Planetary Sciences Purple Mountain ObservatoryCASNanjing 210023China

Determining asteroid properties provides valuable physical insights but inverting them from photometric lightcurves remains computationally *** paper presents a new approach that combines a simplified Cellinoid shape model with the Parallel Differential Evolution(PDE)algorithm to accelerate *** PDE algorithm is more efficient than the Differential Evolution algorithm,achieving an extraordinary speedup of 37.983 with 64 workers on multicore *** PDE algorithm accurately derives period and pole values from simulated *** analysis of real asteroid lightcurves validates the method’s reliability:in comparison with results published elsewhere,the PDE algorithm accurately recovers the rotational periods and,given adequate viewing geometries,closely matches the pole *** PDE approach converges to solutions within 20,000 iterations and under one hour,demonstrating its potential for large-scale data *** work provides a promising new tool for unveiling asteroid physical properties by overcoming key computational bottlenecks.

关键词： methods:numerical minor planets asteroids:general techniques:photometric astrom

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Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： zheng-Hua He Jian-Fei Gao Ling-bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

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