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Prostate cancer prediction forest algorithm that takes using the random into account transrectal ultrasound findings, age, and serum levels of prostate-specific antigen

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Asian Journal of Andrology 2017年第5期19卷 586-590页

作者： li-Hong Xiao Pei-Ran Chen zhong-Ping Gou yong-zhong li Mei li liang-Cheng Xiang Ping Feng Institute of Clinical Trials West China Hospital Sichuan University Chengdu China Department of Epidemiology and Biostatistics West China School of Public Health Sichuan University Chengdu China Department of Ultrasound West China Hospital Sichuan University Chengdu China

The aim of this study is to evaluate the ability of the random forest algorithm that combines data on transrectal ultrasound findings, age, and serum levels of prostate-specific antigen to predict prostate carcinoma. Clinico-demographic data were analyzed for 941 patients with prostate diseases treated at our hospital, including age, serum prostate-specific antigen levels, transrectal ultrasound findings, and pathology diagnosis based on ultrasound-guided needle biopsy of the prostate. These data were compared between patients with and without prostate cancer using the Chi-square test, and then entered into the random forest model to predict diagnosis. Patients with and without prostate cancer differed significantly in age and serum prostate-specific antigen levels （P 〈 0.001）, as well as in all transrectal ultrasound characteristics （P 〈 0.05） except uneven echo （P = 0.609）. The random forest model based on age, prostate-specific antigen and ultrasound predicted prostate cancer with an accuracy of 83.10%, sensitivity of 65.64%, and specificity of 93.83%. Positive predictive value was 86.72%, and negative predictive value was 81.64%. By integrating age, prostate-specific antigen levels and transrectal ultrasound findings, the random forest algorithm shows better diagnostic performance for prostate cancer than either diagnostic indicator on its own. This algorithm may help improve diagnosis of the disease by identifying patients at high risk for biopsy.

关键词： diagnosis prostate cancer prostate-specific antigen random forest algorithm transrectal ultrasound characteristics

Diagnostic value of contrast enhanced ultrasound for splenic artery complications following acute pancreatitis

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World Journal of Gastroenterology 2014年第4期20卷 1088-1094页

作者： Di-Ming Cai Shyam Sundar Parajuly Wen-Wu ling yong-zhong li Yan Luo Department of Ultrasound West China Hospital Sichuan University

AIM: To assess the value of contrast-enhanced ultrasound (CEUS) in diagnosing splenic artery complications (SACs) after acute pancreatitis (AP). METHODS: One hundred and eighteen patients with AP were enrolled in the study. All patients were examined by CEUS and contrast-enhanced computed tomography (CECT). CECT was accepted as a gold standard for the diagnosis of SACs in AP. The diagnostic accuracy of splenic CEUS and pancreatic CEUS was compared with that of CECT. Splenic infarction was the diagnostic criterion for splenic artery embolism and local dysperfusion of the splenic parenchyma was the diagnostic criterion for splenic arterial stenosis. The incidence of splenic sub-capsular hemorrhage, splenic artery aneurysms, and splenic rupture was all lower than that of SACs. RESULTS: Nine patients were diagnosed as having SACs after AP by CECT among the 118 patients. The patients with SACs were diagnosed with severe acute pancreatitis (SAP). Among them, 6 lesions were diagnosed as splenic artery embolism, 5 as splenic artery aneurysms, and 1 as splenic arterial stenosis. No lesion was diagnosed by pancreatic CEUS and 5 lesions were diagnosed by splenic CEUS. By splenic CEUS, 4 cases were diagnosed as splenic artery embolism and 1 as splenic arterial stenosis. The accuracy of splenic CEUS in diagnosis of SACs in SAP was 41.7% (5/12), which was higher than that of pancreatic CEUS (0%). CONCLUSION: Splenic CEUS is a supplementary method for pancreatic CEUS in AP patients, which can decrease missed diagnosis of SACs. (C) 2014 Baishideng Publishing Group Co., limited. All rights reserved.

关键词： Acute pancreatitis Severe acute pancreatitis Contrast enhanced ultrasound Splenic artery complications Splenic contrast-enhanced computed tomography

The results of transperineal versus transrectal prostate biopsy： a systematic review and meta-analysis

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Asian Journal of Andrology 2012年第2期14卷 310-315页

作者： Peng-Fei Shen Yu-Chun Zhu Wu-Ran Wei yong-zhong li Jie Yang Yu-Tao li Ding-Ming li Jia Wang Hao Zeng Department of Urology West China HospitalSichuan UniversityChengdu 610041China Department of Ultrasonography West China HospitalSichuan UniversityChengdu 610041China

This systematic review was performed to compare the efficacy and complications of transperineal （TP） vs. transrectal （TR） prostate biopsy. A systematic research of PUBM ED, EMBASE and the Cochrane library was performed to identify all clinical controlled trials on prostate cancer （PCa） detection rate and complications achieved by TP and TR biopsies. Prostate biopsies included sextant, extensive and saturation biopsy procedures. All patients were assigned to a TR group and a TP group. Subgroup analysis was performed according to prostate-specific antigen （PSA） levels and digital rectal examination （DRE） findings. The Cochrane Collaboration＇s RevMan 5.1 software was used for the meta-analysis. A total of seven trials, including three randomized controlled trials （RCTs） and four casecontrol studies （CCS）, met our inclusion criteria. There was no significant difference in the cancer detection rate between the sextant TR and TP groups （risk difference （RD）, -0.02; 95% confidence interval （CI）, -0.08-0.03; P=0.34）. Meta-analysis for RCTs combined with CCS showed that there was no difference in the cancer detection rate between the extensive TR and TP group （RD, -0.01; 95% CI, -0.05-0.04; P=0.81）. There was no significant difference in PCa detection rate between the saturation TR and TP approaches （31.4% vs. 25.7%, respectively;P=0.3）. There were also no significant differences in cancer detection between the TR and TP groups in each subgroup. Although the data on complications were not pooled for the meta-analysis, no significant difference was found when comparing TR and TP studies. TR and TP biopsies were equivalent in terms of efficiency and related complications. TP prostate biopsy should be an available and alternative procedure for use by urologists.

关键词： prostate biopsy prostate cancer transperineal transrectal

Structure of a new sterol from the South China sponge Dysidea fragilis

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Chinese Journal of Chemistry 1993年第6期11卷 560-564页

作者： yong-li zhong Jing-Yu Su Long-Mei Zeng Wei Shen Qi-Wen Wang Department of Chemistry Zhongshan University Guangzhou 510275 State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

A new sterol, 5a-cholesta-8(14),24(25)-diene-3/β, 6a-diol (1) and a known sterol (24Z)- 24-ethyl-cholesta-7(8),24(28)-diene-3β,5a,6β-triol (2) have been isolated from the South China Sea sponge Dysidea fragilis. Th... 详细信息

关键词： Structure of a new sterol from the South China sponge Dysidea fragilis ppm

Two new diterpenoids from the marine Soft coral Clavularia viridis

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Chinese Journal of Chemistry 1992年第2期10卷 155-160页

作者： SU,Jing-Yu zhong,yong-li ZENG,Long-Mei Department of Chemistry,zhongshan University,Guangzhou 510275 Department of Chemistry Zhongshan University Guangzhou 510275

Two new dolabellane diterpenoids named clavudiol B(2)and clavirolide F(5),have been iso- lated from the soft coral Clavularia viridis,collected from Xisha Islands in the South China *** structures have been determined... 详细信息

关键词： Two new diterpenoids from the marine Soft coral Clavularia viridis ppm

ISOLATION AND STRUCTURES OF FOUR CYCLODIPEPTIDES

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Chinese Chemical Letters 1993年第2期4卷 139-140页

作者： Jing Yu SU yong li zhong Long Mei ZENG Wei SHEN Qi Wen WANG Department of Chemistry Zhongshan UniversityGuangzhou510275 State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic ChemistryShanghai 200032

Three novel interesting polychlorinated cyclodipeptides,designated dyssmide A(1),B(2),C(3)and a known compound,2,3-dihydrodyeamide C(4)were isolated from the sponge Dysidea *** structures were elucidated by spectrosco... 详细信息

关键词： CCI IR ISOLATION AND STRUCTURES OF FOUR CYCLODIPEPTIDES

Bilateral testicular Large-cell calcifying Sertoli cell tumor with left epididymal involvement

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Bilateral testicular Large-cell calcifying Sertoli cell tumo...

A NEW NOR-SESQUITERPENOID FROM THE SOFT CORAL PARALEMNaliA THYRSOIDS

中国超声医学工程学会成立30周年暨第十二届全国超声医学学术大会

作者： Meng ZHU Nabin Amatya yong zhong li Department of Diagnostic Ultrasound West China Hospital of Sichuan University Department of Diagnostic Radiology West China Hospital of Sichuan University

Large cell calcifying Sertoli cell tumor(LCCSCT) is an uncommon testicular *** tumor constitutes one of the conditions of Carney’s *** death may occur secondary to cardiac myxoma.1Extra-testicular growths of LCCSCT occur in 75%of the clinically malignant cases but in none of the clinically benign cases.2 We describe the features of bilateral testicular LCCSCT with left epididymal involvement in an adolescent,which has benign *** this diagnosis can be suggested preoperative^,surgical local excision may be the choice.

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Chinese Chemical Letters 1991年第10期2卷 785-786页

作者： Jing Yu SU, yong li zhong, Jian Qing WU, Long Mei ZENG Department of Chemistry, zhongshan University, Guangzhou, 510275

A rare nor-sesquiterpenoid with a γ-spirolactone, pathyiactone A(1), was isolated from the soft coral Paralemnalia thysoides. The structure and absolute stereochemistry of 1 was established by spectral analysis, espe... 详细信息

关键词： NOR A NEW NOR-SESQUITERPENOID FROM THE SOFT CORAL PARALEMNaliA THYRSOIDS NOE

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中国“五化”协同发展的效率测度与时空特征

软科学 2017年第2期31卷 19-23页

作者：杨勇李忠民陕西师范大学国际商学院西安710061 西安工业大学经济管理学院西安710021

利用耦合度方法测度了2001~2013年31个省市自治区的"五化"协同发展指数,并基于VRS的DEA方法测度了各地区"五化"协同发展效率。结果显示,总体上各地区"五化"协同发展指数均呈上升状态,其变异系数有逐渐减小趋势;"五化"协同发展综合效率... 详细信息

利用耦合度方法测度了2001~2013年31个省市自治区的"五化"协同发展指数,并基于VRS的DEA方法测度了各地区"五化"协同发展效率。结果显示,总体上各地区"五化"协同发展指数均呈上升状态,其变异系数有逐渐减小趋势;"五化"协同发展综合效率先升后降,其中东部地区的综合效率水平提高较快,而中西部地区综合效率提升水平较慢。通过四象限法对"五化"协同发展指数与"五化"协同发展效率进行了时空特征分析,并得出结论:具有HH型特征的省区逐渐增多,且主要集中在东部地区,而具有LL型特征的省区主要集中在西部地区且减少较慢,中国"五化"协同发展与协同发展效率还有待进一步提升。

关键词： “五化” 协同发展指数协同发展效率