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Electric Field Evaluation for Slender Conductors Using Collocation Boundary Element Method

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CSEE Journal of Power and Energy Systems 2019年第4期5卷 483-488页

作者： Chijie Zhuang yong Zhang rong Zeng Department of Electrical Engineering Tsinghua UniversityBeijing 100084China Center for Applied Mathematics Tianjin UniversityTianjin 300072China

Evaluation of the electric field at the surface of a conductor,which is well described by the Poisson equation,is of great importance on many occasions in power *** paper proposes a collocation boundary element method where the unknown surface charge density function is assumed to be either azimuth independent or *** formulas,including the quadrature rules and how to accelerate the computation when the target point lies far away from the integral element,are *** examples are shown to confirm the convergence of the method,and manifest the great advantage for the evaluation of the electric field around slender conductors.

关键词： Collocation boundary element method electric field slender conductor

A synergetic formed quantitative model for users' selections in different network service providers

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The Journal of China Universities of Posts and Telecommunications 2014年第6期21卷 61-71页

作者： ZHU Xiao-rong LI Wei WANG yong Wireless Communication Key Lab of Jiangsu Province Nanjing University of Posts and Telecommunications National Mobile Communications Research Laboratory Southeast University Patent Information Service Institution of Jiangsu Province

Multiple heterogeneous wireless techniques, possibly administered by different entities, are coexisted in the rapidly-expanding communications market. In order to understand the complex interactions among different network service providers（NSPs）, it is important to study the factors taken into consideration by users during their selections of the NSPs. The article focuses on interactions between macro-level dynamics of user subscription and the factors causing such dynamics. The key factor was discussed on the interactions between different subpopulations rather than the general factors such as quality of service（Qo S）. Guided by synergetic theory, a general mathematical description model was built. The influence of key factors on users＇ selections was considered and analyzed. Some examples were presented to validate capabilities of the proposed model.

关键词： NSP service selection dynamics synergetic

Immunization of Male Mice with a New Recombinant GnRH Fusion Protein Reduces the Testicular Function

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Agricultural Sciences in China 2009年第3期8卷 380-385页

作者： FANG Fu-gui yang Ya-ping LIU Ya ZHANG Yun-hai TAO yong WANG Suo-lu PU yong ZHANG Xiao-rong Department of Animal Medicine College of Animal Science and Technology Anhui Agricultural University Hefei 230036 P.R.China Department of Animal Science College of Animal Science and Technology Anhui Agricultural University Hefei 230036 P.R.China

The objective of the present study was to evaluate the effect of an immunogenic maltose-binding protein-gonadotropin releasing hormone （GnRH-6-MBP） using genetic engineering. The synthetic mammalian tandem repeated GnRH hexamer gene was inserted into the expression plasmid pMAL-c2x. Recombinant GnRH-6-MBP protein was over- expressed in *** strain BL21. Amylose resin with affinity chromatograph was used to purify target protein. The reactiongenicity of fusion protein was identified by indirect enzyme linked immunosorbent assay （ELISA）, and the antigenicity and biological effects of GnRH-6-MBP were tested in mice. In the experiment, 20 male Kunming white mice of 20 d old were randomly divided into treatment and control group. Ten mice were immunized with 100 μg GnRH-6-MBP administered subcutaneously （s.c.） thrice at 2-week intervals with GnRH-6-MBP. Mice were sacrificed after 3 weeks following the booster injection, the testis was removed, weighed and measured, and the histological structure was observed. The reactiongenicity of fusion protein to GnRH antibody was much higher than the control. Active immunization against GnRH-6-MBP reduced remarkably （P 〈 0.01） the length and weight of the testis, and shortened the girth and width of the testis （P 〈 0.05）, and suppressed testicular spermatogenesis compared to the control mice. These results indicate that the recombinant GnRH-6-MBP acted as a strong immunogen and caused atrophy of the testis.

关键词： GnRH recombinant vaccine maltose-binding protein (MBP) immunocastration

Identification of a germline-expression promoter for genome editing in Bombyx mori

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Insect Science 2019年第6期26卷 991-999页

作者： Jun Xu rong-Mei Chen Shu-Qing Chen Kai Chen Lin-Meng Tang De-Hong yang Xu yang yong Zhang Hong-Sheng Song yong-Ping Huang CAS Key Laboratory of Insect Developmental and Evolutionary Biology CAS Center for Excellence in Molecular Plant Sciences Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences ShanghaiChina College of Life Sciences Shanghai University ShanghaiChina Department of Biology University of NevadaRenoNevadaUSA

Identification of stage- and tissue-specific cis-regulatory elements will enable more precise genomic editing. In previous studies of the silkworm Bombyx mori, we identified and characterized several tissue- and sex-specific cisregulatory elements using transgenic technology, including a female- and fat body-specific promoter, vitellogenin, testis-specific promoters, Radial spoke head 1 (BmRl) and beta-tubulin 4 (Bmp4). Here we report a c/5-regulatory element specific for a somatic and germ cell-expressed promoter, nanos (Bmnos). We investigated activities of three truncated promoter sequences upstream of the transcriptional initiation site sequences of Bmnos in vitro (nos-0.6kb, nos-1 kb and nos-2kb) and in vivo (nos-2kb). In BmN cultured cells, all three lengths drove expression of the gene encoding enhanced green fluorescence protein (EGFP), although nos-2kb had the highest fluorescence activity. In transgenic silkworms, nos-2kb drove EGFP expression at the early embryonic stage, and fluorescence was concentrated in the gonads at later embryonic stages. In addition, this cisregulatory element was not sex differentiated. The fluorescence intensity gradually weakened following the larval developmental stage in the gonads and were broadly expressed in the whole body. The nos-2kb promoter drove the Cas9 system with efficiency comparable to that of the broad-spectrum strong IE1 promoter. These results indicate that Bmnos is an effective endogenous cisregulatory element in the early embryo and in the gonad that can be used in applications involving the clustered, regularly interspaced, short palindromic repeats (CRISPR)/Cas9 system.

关键词： Bombyx mori nanos promoter transgenic CRISPR/Cas9

Advances in coatings on magnesium alloys for cardiovascular stents-A review

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Bioactive Materials 2021年第12期6卷 4729-4757页

作者： Zhao-Qi Zhang yong-Xin yang Jing-An Li rong-Chang Zeng Shao-Kang Guan School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou450001PR China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao266590China

Magnesium(Mg)and its alloys,as potential biodegradable materials,have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and ***,the occurrence of thrombosis,inflammation,and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical *** surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological *** review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade,regarding preparation strategies for metal oxide,metal hydroxide,inorganic nonmetallic,polymer,and their composite coatings;and the performance of these strategies in regulating degradation behavior and *** research direction is also concisely discussed to help guide biological functionalized strategies and inspire further *** is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

关键词： Magnesium alloy Cardiovascular stent Surface modification Rapid endothelialization Functional properties

NURBS curve blending using extension

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第4期10卷 570-576页

作者： yong-jin LIU rong-qi QIU Xiao-hui LIANG Tsinghua National Lab for Information Science and Technology Tsinghua University Beijing 100084 China State Key Lab of Virtual Reality Technology and Systems Beihang University Beijing 100191 China

Curve and surface blending is an important operation in CAD systems, in which a non-uniform rational B-spline （NURBS） has been used as the de facto standard. In local comer blending, two curves intersecting at that comer are first made disjoint, and then the third blending curve is added-in to smoothly join the two curves with G^1- or G^2-continuity. In this paper we present a study to solve the joint problem based on curve extension. The following nice properties of this extension algorithm are exploited in depth：（1） The parameterization of the original shapes does not change; （2） No additional fragments are created. Various examples are presented to demonstrate that our solution is simple and efficient.

关键词： Curve blending Curve fairing Curve extension Non-uniform rational B-spline (NURBS)

Exosomal mi R-182 regulates the effect of RECK on gallbladder cancer

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World Journal of Gastroenterology 2020年第9期26卷 933-946页

作者： Hong Zheng Jin-Jing Wang Li-Jin Zhao Xiao-rong yang yong-Lin Yu Department of Pathology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina

BACKGROUND As the most common biliary malignancy,gallbladder cancer(GC)is an elderlybiased *** extensive studies have elucidated the molecular mechanism of microRNA 182(miR-182)and reversion-inducing-cysteine-rich protein with kazal motifs(RECK)in various cancers,the specific role of exosomal miR-182 and RECK in GC remains poorly *** To explore the relationship between exosomal miR-182/RECK and metastasis of *** Paired GC and adjacent normal tissues were collected from 78 *** polymerase chain reaction was employed to detect miR-182 and exosomal miR-182 expression,and Western blotting was conducted to determine RECK *** addition,the effects of exosomal miR-182/RECK on the biological function of human GC cells were ***,the double luciferase reporter gene assay was applied to validate the targeting relationship between miR-182 and *** Compared with normal gallbladder epithelial cells,miR-182 was highly expressed in GC cells,while RECK had low *** miR-182 could be absorbed and transferred by *** miR-182 inhibited RECK expression and promoted the migration and invasion of GC *** Exosomal miR-182 can significantly promote the migration and invasion of GC cells by inhibiting RECK;thus miR-182 can be used as a therapeutic target for GC.

关键词： Exosome miR-182 RECK Gallbladder cancer Quantitative polymerase chain reaction Therapeutic target

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西安地区犬和猫肿瘤流行现状与防治对策

动物医学进展 2025年第1期46卷 128-134页

作者：白佳秀吕子颖段学鹏韩永荣郭抗抗吕长荣西北农林科技大学动物医学院陕西杨凌712100 海南大学热带农林学院海南海口570228 西北农林科大西安动物医院陕西西安710065

通过对西北农林科大西安动物医院4年7个月共收治的西安地区7399例(犬4813例,猫2586例)犬和猫病例中308例肿瘤的分析,发现犬、猫肿瘤发病率分别为5.96%和0.81%;最常发的肿瘤有乳腺肿瘤、恶性淋巴瘤、脂肪瘤、肥大细胞瘤与肛周腺瘤。犬发... 详细信息

通过对西北农林科大西安动物医院4年7个月共收治的西安地区7399例(犬4813例,猫2586例)犬和猫病例中308例肿瘤的分析,发现犬、猫肿瘤发病率分别为5.96%和0.81%;最常发的肿瘤有乳腺肿瘤、恶性淋巴瘤、脂肪瘤、肥大细胞瘤与肛周腺瘤。犬发病品种以贵宾犬、牧羊犬与金毛犬居多,分别占24.64%、12.56%和11.59%;小型犬发病率最高,占51.57%。老龄犬多发,但9岁以下犬发病率也高达33.45%。发病季节集中在冬春季节。发病部位以乳腺和皮肤最多,分别占29.27%和21.95%。雌性犬、猫发病率分别为58.19%和42.86%,雄性犬、猫发病率分别为41.81%和57.14%;未绝育雌性犬、猫更易发生乳腺肿瘤与泌尿生殖道肿瘤,未去势雄性犬、猫更易发生肛周肿瘤。组织活检与组织病理学结果显示良性肿瘤占58.51%,恶性肿瘤占41.49%。

关键词：肿瘤犬猫流行现状防治对策

Nonlinear stochastic optimal bounded control of hysteretic systems with actuator saturation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第3期9卷 351-357页

作者： rong-hua HUAN Wei-qiu ZHU yong-jun WU Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China College of Information Science and Engineering East China University of Science and Technology Shanghai 200237 China

A modified nonlinear stochastic optimal bounded control strategy for random excited hysteretic systems with actuator saturation is proposed. First, a controlled hysteretic system is converted into an equivalent nonlinear nonhysteretic stochastic system. Then, the partially averaged Itoe stochastic differential equation and dynamical programming equation are established, respectively, by using the stochastic averaging method for quasi non-integrable Hamiltonian systems and stochastic dynamical programming principle, from which the optimal control law consisting of optimal unbounded control and bang-bang control is derived. Finally, the response of optimally controlled system is predicted by solving the Fokker-Planck-Kolmogorov （FPK） equation associated with the fully averaged Itoe equation. Numerical results show that the proposed control strategy has high control effectiveness and efficiency.

关键词： Hysteretic system Stochastic averaging Optimal control Dynamical programming Actuator saturation