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Effect of low intensity pulsed ultrasound on repairing the periodontal bone of Beagle canines

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Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 325-328页

作者： xiao-Qi Gu yong-mei Li Jing Guo Li-Hua Zhang Dong Li xiao-Dong Gai Oral Medical School of North China University Medical School of North China University

Objective:To investigate the repairing effect of low intensity pulsed ultrasound(LIPUS)on the Beagle canines periodontal bone ***:A total of 12 Beagle dogs with periodontal bone defect model were randomly divided into control group,LIPUS group,guided tissue regeneration(GTR)group and LIPUS+GTR group,with three in *** completion of the models,no other proceeding was performed in control group;LIPUS group adopt direct exposure to radiation line LIPUS processing 1 week after modeling;GTR group adopted treatment with GTR,following the CTR standard operation reference;LIPUS+GTR group was treated with LIPUS joint *** change before treatment and histopathological change of periodontal tissue after repair was ***:There was no significant difference in temperature changes of periodontal tissue between groups(P>0.05).The amount and maturity of LIPUS+GTR group were superior to other groups;new cementum,dental periodontal bones of GTR group were superior to the control group but less than LIPUS group;new collagen and maturity of the control group is not high ***:LIPUS can accelerate the calcium salt deposition and new bone maturation,thus it can serve as promoting periodontal tissue repair,and shortening the periodontal tissue repair time.

关键词： LIPUS Periodontal bone defect Repair

New Families of Rational Form Variable Separation Solutions to(2+1)-Dimensional Dispersive Long Wave Equations

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Communications in Theoretical Physics 2009年第5期51卷 789-793页

作者： WEN xiao-yong Department of Mathematics College of Sciences Beijing Information Science and Technology University Beijing 100192China

With the aid of symbolic computation system Maple, some families of new rational variable separation solutions of the （2＋1）-dimensional dispersive long wave equations are constructed by means of a function transformation, improved mapping approach, and variable separation approach, among which there are rational solitary wave solutions, periodic wave solutions and rational wave solutions.

关键词： improved mapping approach variable separation method (2+1)-dimensional dispersive long wave equations symbolic computation

Regulation of influenza virus infection by microRNAs

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Journal of Integrative Agriculture 2019年第7期18卷 1421-1427页

作者： ZOU Zhong GONG Wen-xiao HUANG Kun SUN xiao-mei JIN mei-lin State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070P R.China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070P.R. China Key Laboratory of Development of Veterinary Diagnostic Products Ministry of Agriculture and Rural AffairsWuhan 430070P.R. China

MicroRNAs(miRNAs) are small noncoding RNAs of 18–25 nucleotides(nt) in length that represent key regulators of many normal cellular functions through the inhibition of mRNA translation and mRNA *** date,over 2 500 mature miRNAs have been identified in plants,animals and several types of *** A virus(IAV),which is a negativesense,single-stranded RNA virus,does not encode viral ***,IAV infection can alter the expression of host miRNAs,either in cell culture or in *** turn,host miRNAs regulate IAV life cycle through directly binding to IAV genome or indirectly targeting host factors associated with viral *** this review,we briefly summarized the role and significance of miRNA in relation to IAV *** the role of cellular miRNAs during viral infection may be beneficial to the identification of novel therapeutic strategies to block IAV replication.

关键词： microRNAs influenza A virus pathogenesis therapeutic strategies

Association between serum homocysteine and arterial stiffness in elderly： a community-based study

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Journal of Geriatric Cardiology 2014年第1期11卷 32-38页

作者： Song ZHANG yong-Yi BAI Lei-Ming LUO Wen-Kai xiao Hong-mei WU Ping YE Department of Geriatric Cardiology Chinese PLA General Hospital No.28 Fuxing Road Beijing 100853 China School of Medicine Nankai University N0.94 Weijin Road Tianjin 300071 China

Background Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older popula tions. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons. Methods We related serum levels of homocysteine to two measures of arte- rial stiffness （carotid-femoral pulse wave velocity （PWV） and carotid-radial PWV） in 780 participants （46.3% men, mean age 71.9 years （ranging 65-96 years old）） from two communities of Beijing, China. Arterial stiffness were measured within two days of the time of bio- marker measurement. Results In multiple-adjusted models, homocysteine levels was strongly associated with the carotid-femoral PWV （standardized 13 = 0.13, P 〈 0.001）, even after adjustment for classical risk factors of cardiovascular disease. The association is also stronger when the carotid-femoral PWV is elevated above normal, whereas no significant association with homocysteine was observed for ca-rotid-radial PWV. Conclusions In Chinese elderly persons, serum homocysteine levels are associated with alterations of aortic stiffness.

关键词： The elderly Homocysteine Arterial stiffness Pulse wave velocity

Numerical study on the dynamic fracture of explosively driven cylindrical shells

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Defence Technology（防务技术） 2023年第9期27卷 154-168页

作者： Zhi-yong Yin xiao-wei Chen State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing100081China

Research on the expansion and fracture of explosively driven metal shells has been a key issue in weapon development and structural *** is important to study and predict the failure mode,fracture mechanism,and fragment distribution characteristics of explosively driven metal *** this study,we used the finite element-smoothed particle hydrodynamics(FE-SPH)adaptive method and the fluid-structure interaction method to perform a three-dimensional numerical simulation of the expansion and fracture of a metal cylindrical *** method combined the advantages of the FEM and SPH,avoiding system mass loss,energy loss,and element distortion;in addition,the proposed method had a good simulation effect on the interaction between detonation waves and the cylindrical *** simulated detonation wave propagation,shell damage morphology,and fragment velocity distribution were in good agreement with theoretical and experimental *** divided the fragments into three regions based on their shape *** analyzed the failure mode and formation process of fragments in different *** numerical results reproduced the phenomenon in which cracks initiated from the inner surface and extended to the outer surface of the cylindrical shell along the 45°or 135°shear *** addition,fragments composed of elements are identified,and the mass and characteristic lengths of typical fragments at a stable time are ***,the mass and size distribution characteristics of the fragments were explored,and the variation in the fitting results of the classical distribution function under different explosion pressures was ***,based on mathematical derivation,the distribution formula of fragment velocity was *** improved formula provided higher accuracy and could be used to analyze any metal cylindrical shells with different length-to-diameter ratios.

关键词： Metal cylindrical shell Shear failure Fragment distribution Numerical simulation Fragment velocity

Identification of a Gravitropism-Deficient Mutant in Rice

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Rice science 2017年第2期24卷 109-118页

作者： HE Yan SHI yong-feng ZHANG xiao-bo WANG Hui-mei XU Xia WU Jian-li State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement China National Rice Research InstituteHangzhou 310006China

A gravitropism-deficient mutant M96 was isolated from a mutant bank, generated by ethyl methane sulfonate(EMS) mutagenesis of indica rice accession ZJ100. The mutant was characterized as prostrate growth at the beginning of germination, and the prostrate growth phenotype ran through the whole life duration. Tiller angle and tiller number of M96 increased significantly in comparison with the wild type. Tissue section observation analysis indicated that asymmetric stem growth around the second node occurred in M96. Genetic analysis and gene mapping showed that M96 was controlled by a single recessive nuclear gene, tentatively termed as gravitropism-deficient M96(gd M96), which was mapped to a region of 506 kb flanked by markers RM5960 and In Del8 on the long arm of chromosome 11. Sequencing analysis of the open reading frames in this region revealed a nucleotide substitution from G to T in the third exon of LOC_Os11g29840. Additionally, real-time fluorescence quantitative PCR analysis showed that the expression level of LOC_Os11g29840 in the stems was much higher than in the roots and leaves in M96. Furthermore, the expression level was more than four times in M96 stem than in the wild type stem. Our results suggested that the mutant gene was likely a new allele to the reported gene LAZY1. Isolation of this new allele would facilitate the further characterization of LAZY1.

关键词： plant architecture gravitropism LAZY1 gene mapping mutant

Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway

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Chinese Journal of Natural Medicines 2017年第10期15卷 751-757页

作者： YU Qian ZENG Ke-Wu MA xiao-Li JIANG yong TU Peng-Fei WANG Xue-mei Research Studio of Integration of Traditional and Western Medicine First HospitalPeking UniversityBeijing 100034China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China

The saponin ginsenoside Rk1 is a major compound isolated from *** Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of ***,the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully *** investigated whether ginsenoside Rk1 could suppress the inflammatory response in lipopolysaccharide-stimulated RAW264.7 macrophages and to explore its mechanism of the ***264.7 cells were treated with LPS(1 μg×mL^(–1))in the absence or the presence of Ginsenoside Rk1(10,20,and 40 μmol×L^(–1)).Then the inflammatory factors were tested with Griess reagents,ELISA,and *** proteins were analyzed by Western *** Rk1 inhibited lipopolysaccharide-induced expression of nitric oxide(NO),interleukin(IL)-6,IL-1β,tumor necrosis factor(TNF)-α,and monocyte chemotactic protein(MCP)-*** Rk1 inhibited the lipopolysaccharide-stimulated phosphorylation of NF-κB and janus kinase(Jak)2 and signal transducer and activator of transcription(Stat)3 at Ser727 and *** data suggested that ginsenoside Rk1 could inhibit expression of inflammatory mediators and suppress inflammation further by blocking activation of NF-κB and the Jak2/Stat3 pathway in LPS-stimulated RAW264.7 cells.

关键词： Inflammation RAW264.7 cells Ginsenoside Rkl Jak2/Stat3 NF-xB

Two-Level Linear Clustering Protocol Based on Wireless Sensor Networks

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Journal of Electronic Science and Technology 2016年第3期14卷 257-261页

作者： mei Hu yong-Xi Wang the School of Electronic and Information Engineering Lanzhou Institute of TechnologyLanzhou 730050China

Aiming at the defects of the nodes in the low energy adaptive clustering hierarchy （LEACH） protocol, such as high energy consumption and uneven energy consumption, a two-level linear clustering protocol is built. The protocol improves the way of the nodes distribution at random. The terminal nodes which have not been a two-level cluster head in the cluster can compete with the principle of equivalent possibility, and on the basis of the rest energy of nodes the two-level cluster head is selected at last. The single hop within the cluster and single hop or multiple hops between clusters are used. Simulation experiment results show that the performance of the two-level linear clustering protocol applied to the Hexi corridor agricultural field is superior to that of the LEACH protocol in the survival time of network nodes, the ratio of success, and the remaining energy of network nodes.

关键词： Clustering energy-efficient farmland Hexi corridor low energy adaptive clustering hierarchy (LEACH) linear wireless sensor network (WSN).

Synthesis and Herbicidal Activity of Novel 5-Substituted Benzenesulfonylureas

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Chemical Research in Chinese Universities 2007年第6期23卷 674-678页

作者： WANG mei-yi MU xiao-li GUO Wan-cheng LI yong-hong LI Zheng-ming State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry Nankai University Tianfin 300071 P. R. China

Sulfonylurea herbicides have been widely used because of their low application rates, good crop sdeetivities and low mammalian toxicities. However, some sulfonylureas might persist unfavourably in the environment with residual problems. In order to look for ecologically safer and environmentally benign sulfonylureas, and on keeping the pyrimidine ring being monosubstitated, 15 novd C5-monosubstituted benzenesulfonylurea compounds were synthesized. The structures of all the compounds synthesized were confirmed by demental analysis and ^1H NMR. Preliminary herbicidal activities of these new sulfonylurea compounds were determined by ALS screening （ in vitro） and pot bioassay experiments（ in vivo）. The herbicidal results show that some novel sulfonylureas are comparable to commercial Foramsulfuron and Monosulfuron.

关键词： Sulfonylurea 5-Substituted phenyl ring Herbicidal activity