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Ionizing terahertz waves with 260 MV/cm from scalable optical rectification

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Light(Science & Applications) 2024年第6期13卷 1075-1087页

作者： Hyeongmun Kim Chul Kang Dogeun Jang Yulan Roh Sang hwa lee Joong Wook lee Jae Hee Sung Seong Ku lee Ki-yong Kim Advanced Photonics Research Institute GISTGwangju61005Korea Department of Physics and Optoelectronics Convergence Research Center Chonnam National UniversityGwangju61186Korea Pohang Accelerator Laboratory POSTECHPohang37673Korea Center for Relativistic Laser Science Institute for Basic ScienceGwangju61005Korea Institute for Research in Electronics and Applied Physics Department of PhysicsUniversity of MarylandCollege ParkMaryland20742USA

Terahertz(THz)waves,known as non-ionizing radiation owing to their low photon energies,can actually ionize atoms and molecules when a sufficiently large number of THz photons are concentrated in time and ***,we demonstrate the generation of ionizing,multicycle,15-THz waves emitted from large-area lithium niobate crystals via phase-matched optical rectification of 150-terawatt laser pulses.A complete characterization of the generated THz waves in energy,pulse duration,and focal spot size shows that the field strength can reach up to 260 megavolts per *** particular,a single-shot THz interferometer is employed to measure the THz pulse duration and spectrum with complementary numerical *** intense THz pulses are irradiated onto various solid targets to demonstrate THz-induced tunneling ionization and plasma *** study also discusses the potential of nonperturbative THz-driven ionization in gases,which will open up new opportunities,including nonlinear and relativistic THz physics in plasma.

关键词： optical interferometer matched

Identification and Determination of Phenolic Compounds in Rapeseed Meals (Brassica napus L.)

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Journal of Agricultural Chemistry and Environment 2015年第1期4卷 14-23页

作者： Si-Chang Yang Mariadhas Valan Arasu Jin-Hyuk Chun Young-Seok Jang yong-hwa lee In Ho Kim Ki-Taek lee Soon-Taek Hong Sun-Ju Kim Bio-Environmental and Chemistry Chungnam National University Daejeon Republic of Korea Department of Botany and Microbiology Addiriyah Chair for Environmental Studies College of Science King Saud University Riyadh Saudi Arabia Bio-Energy Crop Center National Institute of Food Science Rural Development Administration Muan-County Republic of Korea Department of Animal Resource & Science Dankook University Cheonan-Si Republic of Korea Food Science and Technology Chungnam National University Daejeon Republic of Korea

This study aimed in the identification and quantification of phenolic compounds in different four varieties of rapeseeds (Brassica napus L.) using LC-MS and HPLC. LC-MS analysis guided to identify 12 phenolic compounds including sinapine, sinapine(4-O-8')guaiacyl, feruloyl choline(4-O-8') guaiacyl, kaempferol-3-O-sinapoyl-sophoroside-7-O-glucoside, kaempferol-3-O-β-sophoroside, cyclic spermidine-alkaloid, feruloyl choline(5-8')guaiacyl, kaempferol-sinapoyl-trihexoside,1,2-di- O-sinapoyl-gentiobiose, 1,2-di-O-sinapoyl-glucose, feruloyl choline(4-O-8')guaiacyl-di-sinapoyl, and sinapine(4-O-8')guaiacyl-di-sinapoyl, respectively. Total phenolic compounds in rapeseed meals were ranged from 38.50 (2012 “Sunmang”) to 63.95 mg/g dry weight (DW) (2014 Jeju local cultivar). Main phenolic compositions were cyclic spermidine-alkaloid, kaempferol, feruloyl choline, and sinapine. Sinapine was predominant compound among all the samples ranged from 29.74 to 52.24 mg/g DW (mean 79% of total phenolic contents). This study provided the information for the variation of phenolic compounds between the varieties of rapeseeds and the cultivation periods. Furthermore, this information can be developed for bio-energy industry as a reducer of the cost of the bio-energy products.

关键词： LC-MS Analysis HPLC Analysis Rapeseed Meal Phenolic Compounds

Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae hwa Kwon Hyung Il Seo Dong Uk Kim Sung yong Han Suk Kim Nam Kyung lee Seung Baek Hong Ji Hyun Ahn Young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

Machine Learning-Assisted Fabrication of PCBM-Perovskite Solar Cells with Nanopatterned TiO2 Layer

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Energy & Environmental Materials 2024年第4期7卷 223-230页

作者： Siti Norhasanah Sanimu hwa-Young Yang Jeevan Kandel Ye-Chong Moon Gangasagar Sharma Gaudel Seung-Ju Yu yong Ju Kim Sejung Kim Bong-Hyun Jun Won-Yeop Rho Graduate School of Integrated Energy-AI Jeonbuk National University School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Department of Herbal Medicine Resources College of Environmental and Bioresource Sciences Jeonbuk National University School of Chemical Engineering Jeonbuk National University Department of Bioscience and Biotechnology Konkuk University School of International Engineering and Science Jeonbuk National University

To unlock the full potential of PSCs,machine learning （ML） was implemented in this research to predict the optimal combination of mesoporous-titanium dioxide （mp-TiO2） and weight percentage （wt%） of phenyl-C61-butyric acid methyl ester （PCBM）,along with the current density(Jsc),open-circuit voltage (Voc),fill factor （ff）,and energy conversion efficiency （ECE）.

关键词： machine learning nanopatterning PCBM perovskite solar cells prediction

Mutation of Oryza sativa CORONATINE INSENSITIVE 1b(OsCOI1b) delays leaf senescence

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Journal of Integrative Plant Biology 2015年第6期57卷 562-576页

作者： Sang-hwa lee Yasuhito Sakuraba Taeyoung lee Kyu-Won Kim Gynheung An Han yong lee Nam-Chon Paek Department of Plant Science Plant Genomics and Breeding InstituteResearch Institute of Agriculture and Life SciencesSeoul National University Interdisciplinary Program in Bioinformatics Seoul National University Department of Plant Molecular Systems Biotechnology Crop Biotech InstituteKyung Hee University Department of Agricultural Biotechnology Seoul National University

Jasmonic acid （JA） functions in plant development, including senescence and immunity. Arabidopsis thaliana CORONATINE INSENSITIVE 1 encodes a JA receptor and functions in the JA‐responsive signaling pathway. The Arabidopsis genome harbors a single COI gene, but the rice （Oryza sativa） genome harbors three COI homologs, OsCOI1a, OsCOI1b, and OsCOI2. Thus, it remains unclear whether each OsCOI has distinct, additive, synergistic, or redundant func-tions in development. Here, we use the oscoi1b‐1 knockout mutants to show that OsCOI1b mainly affects leaf senescence under senescence‐promoting conditions. oscoi1b‐1 mutants stayed green during dark‐induced and natural senescence, with substantial retention of chlorophylls and photosyn-thetic capacity. Furthermore, several senescence‐associated genes were downregulated in oscoi1b‐1 mutants, including homologs of Arabidopsis thaliana ETHYLENE INSENSITIVE 3 and ORESARA 1, important regulators of leaf senescence. These results suggest that crosstalk between JA signaling and ethylene signaling affects leaf senescence. The Arabidopsis coi1‐1 plants containing 35S：OsCOI1a or 35S：OsCOI1b rescued the delayed leaf senescence during dark incubation, sug-gesting that both OsCOI1a and OsCOI1b are required for promoting leaf senescence in rice. oscoi1b‐1 mutants showed significant decreases in spikelet fertility and grain weight, leading to severe reduction of grain yield, indicating that OsCOI1‐mediated JA signaling affects spikelet fertility and grain filling.

关键词： Jasmonic acid leaf senescence OsCOI1b rice stay-green

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Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis

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Cellular & Molecular Immunology 2019年第11期16卷 851-867页

作者： yong-Bae Kim Young-Ho Ahn Ji-Hae Jung Ye-Ji lee Jin-hwa lee Jihee lee Kang Tissue Injury Defense Research Center College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Physiology College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Internal Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea

Apoptotic cell clearance by phagocytes is essential in tissue *** demonstrated that conditioned medium(CM)from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial–mesenchymal transition(EMT),migration,and invasion of cancer *** 344SQ(ApoSQ)cell-induced PPARγactivity in macrophages increased the levels of PTEN,which was secreted in *** PTEN was taken up by recipient lung cancer ***-exposed CM from PTEN knockdown cells failed to enhance PTEN in 344SQ cells,restore cellular polarity,or exert anti-EMT and anti-invasive *** CM that was deficient in PPARγligands,including 15-HETE,lipoxin A4,and 15d-PGJ2,could not reverse the suppression of PPARγactivity or the PTEN increase in 344SQ cells and consequently failed to prevent the EMT ***,a single injection of ApoSQ cells inhibited lung metastasis in syngeneic immunocompetent mice with enhanced PPARγ/PTEN signaling both in tumorassociated macrophages and in tumor ***γantagonist GW9662 reversed the signaling by PPARγ/PTEN;the reduction in EMT-activating transcription factors,such as Snai1 and Zeb1;and the antimetastatic effect of the ApoSQ ***,the injection of apoptotic lung cancer cells may offer a new strategy for the prevention of lung metastasis.

关键词： Apoptotic cell clearance EMT Metastasis Exosomal PTEN PPARγligands

Application of powdered activated carbon coating to fabrics in a hybrid filter to enhance mercury removal

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Journal of Environmental Sciences 2019年第6期31卷 58-65页

作者： Jin-Ho Sung Seung-Ki Back Eun-Song lee Ha-Na Jang yong-Chil Seo Youn-Suk Kang Myong-hwa lee Department of Environmental Engineering Yonsei University J-E Tech Co. Ltd Department of Environmental Engineering Kangwon National University

Elemental mercury(Hg0) is predominant constituent of flue gas emitted from coal-fired power plants. Adsorption has been considered the best available technology for removal of Hg0 from flue gas. However, adsorbent injection increases the amount of ash generated. In the present study, powdered activated carbon(PAC) was coated on polytetrafluoroethylene/glass fiber filters to increase Hg0 removal while concurrently reducing the amount of ash generated. The optimal PAC coating rate was determined in laboratory experiments to ensure better Hg0 removal with low pressure drop. When PAC of particle size less than 45 μm was used, and the areal density was 50 g/m2, the pressure drop remained under 30 Pa while the Hg0 removal efficiency increased to 15.8% from4.3%. The Hg0 removal efficiency also increased with decrease in filtration velocity. The optimal PAC coating rate was applied on a hybrid filter(HF), which was combined with a bag filter and an electrostatic precipitator in a single chamber. Originally designed to remove fine particulates matter, it was retrofitted to the flue gas control device for simultaneous Hg0 removal. By employing the PAC coating, the Hg removal efficiency of the HF increased to 79.79% from 66.35%. Also, a temporary reduction in Hg removal was seen but this was resolved following a cleaning cycle in which the dust layer was removed.

关键词： Mercury Hybrid filter Activated carbon Coating filter Coal-fired power plant

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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

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Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil lee Youngmin hwang Hyeryeon Oh Sunghyun Kim Jin-hwa Kim Jeung-Hoon lee yong Chui Shin Giyoong Tae Won II Choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： hwa-seung YOO,Jang-woo SHIN,Jung-hyo CHO,Chang-gue SON,Yeon-weol lee,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea College of Oriental Medicine Daejeon University Daejeon 301-724 Institute ofTraditional Medicine and Bioscience Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor