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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang yong-Hong tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Direct knitting privileged molecular catalysts into recyclable single-site catalysts with enhanced activity

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Science China Chemistry 2020年第4期63卷 419-420页

作者： yong tang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

An ideal strategy for catalyst immobilization is taking advantage of the widely well studied homogeneous molecular catalysts and transforming them directly into highly efficient and recyclable heterogeneous ***,the obtained heterogeneous catalysts often have inferior activity due to altered chemical environment around active centers and decreased mass/heat transfer[1,2].

关键词： catalysts molecular centers

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Transforming alkanes to alkylsilanes

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Science Bulletin 2016年第12期61卷 914-916页

作者： yong tang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences

Alkanes are the simplest organic molecules that contain only carbon–carbon single bond and carbon–hydrogen *** chemical bonds are very strong,making alkanes the least reactive organic *** the other hand,alkanes are the major components of petroleum and natural *** and renewable biomass are also sources of alkanes,which are produced through gasification of such materials to syngas（a mixture of CO and H2）followed

关键词：烷烃硅烷烷基转化有机分子组成部分碳-碳天然气

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Dark Touristic Perception: Motivation, Experience and Benefits Interpreted from the Visit to Seismic Memorial Sites in Sichuan Province

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Journal of Mountain Science 2014年第5期11卷 1326-1341页

作者： tang yong Department of Tourism Development and Management College of Tourism and Urban-rural Planning Chengdu University of Technology

This study investigates the motivations of Chinese domestic tourists visiting seismic memorial sites after the great Wenchuan earthquake of 2008, and examines their interpretation of experiences and benefits of the visits. Recent research on dark tourism has raised the possibility that people are attracted to death and memorial sites in ways different from other tourist attractions. The study used an empirical research design employing questionnaires to collect data from 255 Chinese domestic visitors at seismic memorial sites in west Sichuan. Analysis revealed that the obligation of commemoration mixed with curiosity represents a different set of travel motivation in dark tourism settings than in other kinds of tourism. In addition, the empirical evidence also suggests an interrelated pattern between motivations, experiences and benefits. This study implies that Chinese domestic tourists were attracted in ways different from other tourist attractions both because they tended to fulfill their obligation of commemoration and were interested in destruction; and visitor experiences played an important mediating role between travel motivations and benefits gained.

关键词： Dark Tourism Travel Motivation Tourist Perception Chinese Domestic Tourists Seismic Memorial sites Wenchuan earthquake Mountains

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Potentials of community-based tourism in transformations towards green economies after the 2008 Wenchuan earthquake in West China

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Journal of Mountain Science 2016年第9期13卷 1688-1700页

作者： tang yong Department of Tourism Management and Development College of Tourism and Urban-rural Planning Chengdu University of Technology

This study investigates the contrasting sceneries of community-based tourism after the 2008 Wenchuan earthquake and focuses on the potentials of tourism in transformations towards green economies. How are tourism and environment linked in a sustainable relationship? And how can potentials of community-based tourism be directed in transformations towards green economies? A qualitative research design is used to examine contrasting sceneries and specific green elements of community-based tourism in a Qiang people's fortress village in Mao County, Sichuan Province, West China and further discuss how tourism can be compatible with human wellbeing through demonstrating a commitment to sustainable development. The study argues that potential economic, social and environmental costs of tourism need to be considered when evaluating the loss of community benefits toward sustainability. The green elements suggest the potential of community-based tourism in transformations towards green economies, involving green agricultural, green building, and green energy, green governance, green service and green consumption. This study will contribute to the debate about the relationship between tourism and environment sustainability in the green economies, as well as the critique of what can be learned for community development from green tourism in mountainous regions after the inevitable natural disasters.

关键词： Green economy Sustainable tourism Green tourism Community tourism Wenchuanearthquake Mountains

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Automatic Voltage Control of Differential Power Grids Based on Transfer Learning and Deep Reinforcement Learning

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 937-948页

作者： Tianjing Wang yong tang Laboratory of Power Grid Safety and Energy Conservation China Electric Power Research InstituteBeijing 100192China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

In terms of model-free voltage control methods,when the device or topology of the system changes,the model’s accuracy often decreases,so an adaptive model is needed to coordinate the changes of *** overcome the defects of a model-free control method,this paper proposes an automatic voltage control(AVC)method for differential power grids based on transfer learning and deep reinforcement ***,when constructing the Markov game of AVC,both the magnitude and number of voltage deviations are taken into account in the ***,an AVC method based on constrained multiagent deep reinforcement learning(DRL)is *** further improve learning efficiency,domain knowledge is used to reduce action ***,distribution adaptation transfer learning is introduced for the AVC transfer circumstance of systems with the same structure but distinct topological relations/parameters,which can perform well without any further training even if the structure ***,for the AVC transfer circumstance of various power grids,parameter-based transfer learning is created,which enhances the target system’s training speed and ***,the method’s efficacy is tested using two IEEE systems and two real-world power grids.

关键词： Deep reinforcement learning differential power grids transfer voltage control

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Polyethylene to gasoline via a self-supplied hydrogen strategy

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Science China Chemistry 2024年第10期67卷 3187-3188页

作者： yong tang State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Polyethylenes(PEs)are one of the most widely used plastics in almost every aspect of modern life and are produced on a huge scale(a market volume of 110.13 million metric tons worldwide in 2022)[1].A large portion of the PEs are used once and discarded as waste,which caused severe problems such as plastic pollution as well as a waste of the fossoil resource.

关键词： pollution plastics strategy

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Extremal P_(8)-Free/P_(9)-Free Planar Graphs

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Journal of the Operations Research Society of China 2023年第3期11卷 451-457页

作者： yong-Xin Lan yong-tang Shi School of Science Hebei University of TechnologyTianjin300401China Center for Combinatorics and LPMC Nankai UniversityTianjin300071China

An H-free graph is a graph not containing the given graph H as a *** is well known that the Turán number ex(n,H)is the maximum number of edges in an H-free graph on n *** on this definition,we define ex_(P)(n,H)to restrict the graph classes to planar graphs,that is,ex_(P)(n,H)=max{|E(G)|:G∈G,where G is a family of all H-free planar graphs on n ***,we have ex_(P)(n,H)=3n−6 if the graph H is not a planar *** study is initiated by Dowden(J Graph Theory 83:213–230,2016),who obtained some results when H is considered as C_(4)or C_(5).In this paper,we determine the values of ex_(P)(n,Pk)with k∈{8,9},where Pk is a path with k vertices.

关键词： Turán number Extremal graph Planar graph

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Characteristics and Formation Mechanism for Stainless Steel Fiber with Periodic Micro-fins

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Chinese Journal of Mechanical Engineering 2016年第3期29卷 564-570页

作者： tang Tao WAN Zhenping LU Longsheng tang yong School of Mechanical and Automotive Engineering South China University of Technology

Metal fibers have been widely used in many industrial applications due to their unique advantages. In certain applications, such as catalyst supports or orthopedic implants, a rough surface or tiny outshoots on the surface of metal fibers to increase surface area are needed. However, it has not been concerned about the surface morphologies of metal fiber in the current research of metal fiber manufacturing. In this paper, a special multi-tooth tool composed of a row of triangular tiny teeth is designed. The entire cutting layer of multi-tooth tool bifurcates into several thin cutting layers due to tiny teeth involved in cutting. As a result, several stainless steel fibers with periodic micro-fins are produced simultaneously. Morphology of periodic micro-fins is found to be diverse and can be classified into three categories： unilateral plane, unilateral tapering and bilateral. There are two forming mechanisms for the micro-fins. One is that periodic burrs remained on the free side of cutting layer of a tiny tooth create micro-fins of stainless steel fiber produced by the next neighboring tiny tooth; the other is that the connections between two fibers stuck together come to be micro-fins if the two fibers are finally detached. Influence of cutting conditions on formation of micro-fins is investigated. Experimental results show that cutting depth has no significant effect on micro-fin formation, high cutting speed is conducive to micro-fin formation, and feed should be between 0.12 mm/r and 0.2 mm/r to reliably obtain stainless steel fiber with micro-fins. This research presents a new pattern of stainless steel fiber characterized by periodic micro-fins formed on the edge of fiber and its manufacturing method.

关键词： stainless steel fiber periodic micro-fins burrs chip morphology

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An experimental determination of W,Nb,and Ta partition coefficients between P-rich peraluminous granitic melt and coexisting aqueous fluid

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Chinese Journal Of Geochemistry 2015年第2期34卷 194-200页

作者： yong tang Hui Zhang Laboratory for High Temperature and High Pressure Study of the Earth's Interior Institute of GeochemistryChinese Academy of Sciences

The partition coefficients of W,Nb,and Ta between the P-rich peraluminous granitic melt and the coexisting aqueous fluid were determined at 800-850 °C and 0.5-1.5 *** experimental results showed that the partition coefficients D_w,D_(Nb) and D_(Ta)(D_i^(v/m) = C_i^V/C_i^m,where C_i^V and C_i^m denote the concentrations of an element,i,in the aqueous fluid and the melt,respectively) were less than *** partition coefficients were affected by pressure,but there was no evidence for the complexation of P2O5 with these elements in the granitic melt or aqueous fluid,except for with W in the *** results showed that W,Nb,and Ta tended to partition into the granitic melt and,in the late period of crystallization of P-rich magma,they formed independent minerals.

关键词：分配系数实验测定水流体过铝质熔体 Nb 共存钽

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