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Synergetic effects of shock waves with polydeoxyribonucleotides on rotator cuff tendon tear in a rabbit model

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BIOCELL 2021年第3期45卷 527-536页

作者： DONG HAN KIM DONG RAK KWON GI-YOUNG PARK yong suk moon Department of Rehabilitation Medicine Catholic University of Daegu School of MedicineDaegu42472South Korea Department of Anatomy Catholic University of Daegu School of MedicineDaegu42472South Korea

This work aimed to investigate the synergetic therapeutic effects of polydeoxyribonucleotides(PDRN)combined with extracorporeal shock waves therapy(ESWT)and the effects of the therapy according to ESWT sequences on a chronic traumatic full-thickness rotator cuff tear(RCT)in rabbit *** this purpose,thirty-two rabbits were randomly allocated into 4 *** excision was made to create a 5-mm sized full-thickness RCT right proximal to the insertion site on the *** 6 weeks,4 different procedures(normal saline,Group 1;PDRN injection,Group 2;PDRN injection before ESWT,Group 3;PDRN injection after ESWT,Group 4)were *** injection and radial type ESWT were each performed 4 times per *** morphology,Immunohistochemistry,and motion analysis were performed at 4 weeks after *** parameters including tear size,Masson’s trichrome(MT)staining,anti-collagen 1 monoclonal antibody immunostaining(COL-1),proliferating cell nuclear antigen(PCNA),vascular endothelial growth factor(VEGF),anti-platelet endothelial cell adhesion molecule-1 polyclonal antibody(PECAM-1),and motion analysis,were significantly greater in Group 2,Group 3,and Group 4 than in Group *** Group 4,all parameters were significantly greater than in Group 2,and parameters including MT staining,COL-1,PCNA,PECAM-1,and fast walking time were significantly greater than Group *** were no significant differences between Group 2 and Group *** study demonstrated that PDRN injection alone and combined with ESWT were more effective than control treatment and applying ESWT before PDRN injection was also shown to yield better outcomes in parameters including angiogenesis,cell proliferation,and fast walking time in a rabbit model with chronic traumatic full-thickness ***,the application of ESWT before PDRN injection could be recommended for optimal outcomes of the conservative treatments when the patients with full-thickness RCT are not suitable in surgical treatment

关键词： Shoulder Rotator cuff Polydeoxyribonucleotides Extracorporeal shock waves

Evaluation of lubrication performance of crank pin bearing in a marine diesel engine

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Friction 2018年第4期6卷 464-471页

作者： suk Man moon yong Joo CHO Tae Wan KIM School of Mechanical Engineering Pusan National University Department of Mechanical Engineering Pukyong National University

In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact.

关键词： crank pin bearing film thickness lubricant film parameter diesel engine

Optimal Cyber Attack Strategy Using Reinforcement Learning Based onCommon Vulnerability Scoring System

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1551-1574页

作者： Bum-Sok Kim Hye-Won suk yong-Hoon Choi Dae-Sung moon Min-suk Kim Department of Electronic Information System Engineering Sangmyung UniversityCheonan31066Republic of Korea Department of Human Intelligence&Robot Engineering Sangmyung UniversityCheonan31066Republic of Korea Intelligent Convergence Research Laboratory Electronics and Telecommunications Research InstituteDaejeon34129Republic of Korea

Currently,cybersecurity threats such as data breaches and phishing have been on the rise due to the many differentattack strategies of cyber attackers,significantly increasing risks to individuals and *** technologies such as intrusion detection have been developed to respond to these cyber ***,advanced integrated cybersecurity that incorporates Artificial Intelligence has been the *** this paper,wepropose a response strategy using a reinforcement-learning-based cyber-attack-defense simulation tool to addresscontinuously evolving cyber ***,we have implemented an effective reinforcement-learning-basedcyber-attack scenario using Cyber Battle Simulation,which is a cyber-attack-defense *** scenarioinvolves important security components such as node value,cost,firewalls,and ***,we applieda new vulnerability assessment method based on the Common Vulnerability Scoring *** approach candesign an optimal attack strategy by considering the importance of attack goals,which helps in developing moreeffective response *** attack strategies are evaluated by comparing their performance using a variety ofReinforcement Learning *** experimental results show that RL models demonstrate improved learningperformance with the proposed attack strategy compared to the original *** particular,the success rateof the Advantage Actor-Critic-based attack strategy improved by 5.04 percentage points,reaching 10.17%,whichrepresents an impressive 98.24%increase over the original ***,the proposed method canenhance security and risk management capabilities in cyber environments,improving the efficiency of securitymanagement and significantly contributing to the development of security systems.

关键词： Reinforcement learning common vulnerability scoring system cyber attack cyber battle simulation

How does ethanol induce apoptotic cell death of SK-N-SH neuroblastoma cells?

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Neural Regeneration Research 2013年第20期8卷 1853-1862页

作者： yong moon yongil Kwon Shun Yu Department of Public Health Administration Namseoul University Division of Gynecologic Oncology Department of Obstetrics and GynecologyKangdong Sacred Heart HospitalHallym University Department of Neurobiology Xuanwu HospitalCapital Medical University

A body of evidence suggests that ethanol can lead to damage of neuronal cells. However, the mechanism underlying the ethanol-induced damage of neuronal cells remains unclear. The role of mitogen-activated protein kinases in ethanol-induced damage was investigated in SK-N-SH neuroblastoma cells. 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide cell viability assay, DNA fragmentation detection, and flow cytometric analysis showed that ethanol induced apoptotic cell death and cell cycle arrest, characterized by increased caspase-3 activity, DNA fragmentation, nuclear disruption, and G1 arrest of cell cycle of the SK-N-SH neuroblastoma cells. In addition, western blot analysis indicated that ethanol induced a lasting increase in c-Jun N-terminal protein kinase activity and a transient increase in p38 kinase activity of the neuroblastoma cells. c-Jun N-terminal protein kinase or p38 kinase inhibitors significantly reduced the ethanol-induced cell death. Ethanol also increased p53 phosphorylation, followed by an increase in p21 tumor suppressor protein and a decrease in phospho-Rb （retinoblastoma） protein, leading to alterations in the expressions and activity of cyclin dependent protein kinases. Our results suggest that ethanol mediates apoptosis of SK-N-SH neuroblastoma cells by activating p53-related cell cycle arrest possibly through activation of the c-Jun N-terminal protein kinase-related cell death pathway.

关键词： neural regeneration ethanol apoptosis nerve cell p53 mitogen-activated protein kinases c-Jun amino-terminal kinases p38K neuroblastoma cell grants-supported paper neuroregeneration

Map-based control method for vehicle stability enhancement

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Journal of Central South University 2015年第1期22卷 114-120页

作者： moon-Young Yoon Seung-Hwan Baek Kwang-suk Boo Heung-Seob Kim Graduate school of Mechanical Engineering Inje University 607 High Safety Vehicle Core Technology Research Center Inje University 607

This work proposes a map-based control method to improve a vehicle's lateral stability, and the performance of the proposed method is compared with that of the conventional model-referenced control method. Model-referenced control uses the sliding mode method to determine the compensated yaw moment; in contrast, the proposed map-based control uses the compensated yaw moment map acquired by vehicle stability analysis. The vehicle stability region is calculated by a topological method based on the trajectory reversal method. A 2-DOF vehicle model and Pacejka's tire model are used to evaluate the proposed map-based control method. The properties of model-referenced control and map-based control are compared under various road conditions and driving inputs. Model-referenced control uses a control input to satisfy the linear reference model, and it generates unnecessary tire lateral forces that may lead to worse performance than an uncontrolled vehicle with step steering input on a road with a low friction coefficient. However, map-based control determines a compensated yaw moment to maintain the vehicle within the stability region,so the typical responses of vehicle enable to converge rapidly. The simulation results with sine and step steering show that map-based control provides better the tracking responsibility and control performance than model-referenced control.

关键词： model-referenced control map-based control vehicle stability yaw moment

Alcoholic liver disease: Treatment

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World Journal of Gastroenterology 2014年第36期20卷 12934-12944页

作者： Ki Tae suk moon Young Kim Soon Koo Baik Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Wonju College of Medicine Wonju Severance Christian Hospital Yonsei University Wonju 220-701 South Korea

The excess consumption of alcohol is associated with alcoholic liver diseases(ALD). ALD is a major healthcare problem, personal and social burden, and significant reason for economic loss worldwide. The ALD spectrum includes alcoholic fatty liver, alcoholic hepatitis, cirrhosis, and the development of hepatocellular carcinoma. The diagnosis of ALD is based on a combination of clinical features, including a history of significant alcohol intake, evidence of liver disease, and laboratory findings. Abstinence is the most important treatment for ALD and the treatment plan varies according to the stage of the disease. Various treatments including abstinence, nutritional therapy, pharmacological therapy, psychotherapy, and surgery are currently available. For severe alcoholic hepatitis, corticosteroid or pentoxifylline are recommended based on the guidelines. In addition, new therapeutic targets are being under investigation.

关键词： Liver disease Alcoholic Treatment

Suggestion of advanced regression model on friction angle of fault gouge in South Korea

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第6期13卷 1368-1379页

作者： Seong-Woo moon Hyun-Seok Yun yong-Seok Seo Department of Earth and Environmental Sciences Chungbuk National University1 Chungdae-roCheongju-siChungcheongbuk-do28644South Korea

Although friction characteristics of fault gouge are important to understand reactivation of fault,behavior of earthquake,and mechanism of slope failure,analysis results of fault gouge have low accuracy mostly than those of soils or rocks due to its high heterogeneity and low ***,to improve the accuracy of analysis results,we conducted simple regression analysis and structural equation model analysis and selected major influential factors of friction characteristics among many factors,and then we deduced advanced regression model with the highest coefficient of determination(R^(2)) via multiple regression *** most coefficients of determination in simple regression analysis are below0.3-0.4,coefficient of determination in multiple regression analysis is remarkably large as 0.657.

关键词： Fault gouge Friction angle Simple regression analysis Structural equation model analysis Multiple regression analysis

Endoscopic treatment of efferent loop syndrome with insertion of double pigtail stent

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World Journal of Gastroenterology 2013年第41期19卷 7209-7212页

作者： Woo yong Lee Jeong Seop moon Department of Surgery Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea

Efferent loop syndrome is a very rare postgastrectomy syndrome that can occur following Billroth-Ⅱor Rouxen-Y *** most common loop syndrome after gastric surgery is afferent loop syndrome;however,efferent loop syndrome has been reported in rare ***,we report a case of efferent loop obstruction that occurred after postoperative adhesiolysis of a small-bowel *** patient had undergone a partial gastrectomy with BillrothⅡanastomosis and gastric ulcer perforation 30 years *** efferent loop obstruction was successfully resolved by the insertion of a double pigtail *** the best of our knowledge,this is the first case in the literature describing the treatment of efferent loop obstruction.

关键词： Efferent loop syndrome Double pigtail stent Postgastrectomy syndrome

Asymptotic Results for Random Processes

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 363-372页

作者： HEE-JIN moon CHANG-HO HAN yong-KAB CHOI Department of Mathematics and RINS Gyeongsang National University Jinju 660-701 South Korea

In this paper we establish asymptotic results and a generalized uniform law of the iterated logarithm （LIL） for the increments of a strictly stationary random process, whose results are proved by separating linearly positive quadrant dependent （LPQD） random process and linearly negative quadrant dependent （LNQD） one, respectively.

关键词： quadrant dependence stationary random process law of the iterated logarithm