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Crustal growth history of the Korean Peninsula: Constraints from detrital zircon ages in modern river sediments

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Geoscience Frontiers 2016年第5期7卷 707-714页

作者： Taejin Choi yong Il lee Yuji Orihashi Department of Energy and Resources Engineering Chosun University School of Earth and Environmental Sciences Seoul National University Earthquake Research Institute The University of Tokyo

U-Pb analyses were carried out on detrital zircon grains from major river-mouth sediments draining South Korea to infer provenance characteristics and the crustal growth history of the southern Korean Peninsula, using a laser ablation inductively coupled plasma mass spectrometer（LA-ICP-MS）. The Korean Peninsula is located in the East Asian continental margin and mainly comprises three Precambrian massifs and two metamorphic belts in between them. We obtained 515 concordant to slightly discordant zircon ages ranging from ca. 3566 to ca. 48 Ma. Regardless of river-mouth location, predominance of Mesozoic（249e79 Ma） and Paleoproterozoic（2491e1691 Ma） ages with subordinate Archean ages indicates that the zircon ages reflect present exposures of plutonic/metamorphic rocks in the drainage basins of the South Korean rivers and the crustal growth of the southern Korean Peninsula was focused in these two periods. Comparison of detrital zircon-age data between the North and South Korean river sediments reveals that the Paleoproterozoic zircon age distributions of both regions are nearly identical,while the Neoproterozoice Paleozoic ages exist and the Mesozoic ages are dominant in southern Korean Peninsula. This result suggests that Precambrian terrains in Korea record the similar pre-Mesozoic magmatic history and that the influence of Mesozoic magmatism was mainly focused in South Korea.

关键词： Detrital zircon U-Pb age dating Crustal growth Korean Peninsula Provenance

Colored ultrathin hybrid photovoltaics with high quantum efficiency

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Light(Science & Applications) 2014年第1期3卷 36-42页

作者： Kyu-Tae lee Jae yong lee Sungyong Seo L Jay Guo Department of Electrical Engineering and Computer Science The University of MichiganAnn ArborMichigan 48109USA

Most current solar panels are fabricated via complex processes using expensive semiconductor materials,and they are rigid and heavy with a dull,black *** a result of their non-aesthetic appearance and weight,they are primarily installed on rooftops to minimize their negative impact on building *** large surfaces and interiors of modern buildings are not efficiently utilized for potential electric power ***,we introduce dual-function solar cells based on ultrathin dopant-free amorphous silicon embedded in an optical cavity that not only efficiently extract the photogenerated carriers but also display distinctive colors with the desired angle-insensitive ***-energy-harvesting colored signage is ***,a cascaded photovoltaics scheme based on tunable spectrum splitting can be employed to increase power efficiency by absorbing a broader band of light *** study pioneers a new approach to architecturally compatible and decorative thin-film photovoltaics.

关键词： color filters nanocavities organic–inorganic nanostructures photovoltaics spectrum splitting

Paclitaxel and curcumin co-bound albumin nanoparticles having antitumor potential to pancreatic cancer

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Asian Journal of Pharmaceutical Sciences 2016年第6期11卷 708-714页

作者： Bomi Kim Changkyu lee Eun seong lee Beom Soo Shin Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do 16419Republic of Korea Division of Biotechnology The Catholic University of Korea43-1 Yeokgok 2-dongWonmi-guBucheon-siGyeonggi-do 14662Republic of Korea College of Pharmacy Catholic University of Daegu330 Geumrak 1-riHayang EupGyeongsan siGyeongbuk 38430Republic of Korea

Albumin nanoparticles are considered to be an effective way to load water-insoluble anticancer drugs and target tumors via the gp60-mediated pathway. Herein, we fabricated an albumin nanoparticle formulation for co-loading paclitaxel(PTX) and curcumin(CCM), both of which have prominent anticancer efficacy, via nanoparticle albumin-bound(NabTM) technology using high-pressure homogenization. The PTX/CCM co-bound albumin nanoparticles(PTX/CCM Alb-NPs) had a slightly greater particle size of ~250 nm than that of plain PTX AlbNPs and CCM Alb-NPs(~234 and ~134 nm, respectively), with spherical surface morphology and stable size maintenance. However, the zeta potential of PTX/CCM Alb-NPs(ca.-30 mV)was not significantly different from that of PTX or CCM Alb-NPs. The loaded PTX and CCM were released gradually from the PTX/CCM Alb-NPs over ~24 h(97.7 ± 1.7% and 76.2 ± 0.5%,respectively). Furthermore, PTX/CCM Alb-NPs appeared to be efficiently internalized into Mia Paca-2 cells and exhibited a 71% increased IC50 versus PTX Alb-NPs in terms of cytotoxicity to Mia Paca-2 cells. These results suggest that PTX/CCM Alb-NPs are a new potential anticancer agent for combination therapy.

关键词： Albumin Nanoparticles Paclitaxel Curcumin NabTM technology Anti-cancer agent

Comparative analysis on homogeneity of Pb and Cd in epoxy molding compounds

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 160-164页

作者： Kyun-Gmee lee yong-Keun SON Jin-Sook lee Tai-Min NOH Hee-Soo lee Department of Chemistry Sungkyunkwan University Department of Chemistry Yonsei University School of Materials Science and Engineering Pusan National University

Reference materials for quantitative determination of regulated heavy metals, such as Pb and Cd in electronic components, were designed and investigated in terms of stability and homogeneity. Reference materials with two concentration levels of heavy metals were prepared by spiking Pb and Cd compounds to epoxy molding compounds made by mixing silica powders and epoxy resin. The concentration changes of the reference materials during stability test for 1 a were not observed. In the homogeneity assessment, the as-prepared reference materials were studied by using three different analytical tools, inductively coupled plasma atomic emission spectrometry (ICP-AES), X-ray fluoroescence spectrometry (XRF) and laser ablation ICP mass. The results show different homogeneities by the characteristics of analytical tools and the materials.

关键词： epoxy molding compound Pb Cd reference materials homogeneity

Conversion of twice-daily to once-daily tacrolimus is safe in stable adult living donor liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 374-379页

作者： seong Hoon Kim Seung Duk lee Young Kyu Kim Sang-Jae Park Center for Liver Cancer National Cancer Center 111 Jungbalsan-ro Ilsandong-gu Goyang-si Gyeonggi-do 410-769 Korea

Once-daily extended-release tacrolimus （Tac-OD） has been introduced as a useful therapeutic option to increase patient adherence to immunosuppressive therapy. This study aimed to evaluate the safety, efficacy and immunosuppressant adherence of conversion from twice-daily tacrolimus （Tac-BID） to Tac-OD in stable adult living donor liver transplant （LDLT） recipients in a single institution. METHODS： Between February and May 2013, Tac-BID was converted to Tac-OD in recipients followed up for at least 12 months after transplantation and without previous rejection episodes. The switching policy was based on a dose ratio of 1：1 with dose adjustment target trough levels at 3-5 ng/mL. Tacro- limus trough levels, laboratory parameters, metabolic disor- ders, and adverse events were assessed. RESULTS： A total of 229 patients were enrolled in the study. The median age at conversion was 53 years （range 31-73）. The median transplant duration was 35.3 months （range 12.0-95.4）. During a median follow-up of 13.5 months after conversion, 9 patients returned to Tac-BID because of adverse events. No acute rejection episodes were observed. Of 214 patients still on Tac-OD at 12 months, 12 （5.6%） received a reduced dose and 95 （44.4%） required an increased dose over baseline. Overall adherence was 82.2% at the end of follow-up. CONCLUSION： The conversion from Tac-BID to Tac-OD with similar target trough levels after conversion is safe and effec- tive for long-term stable LDLT patients.

关键词： liver transplantation living donor immunosuppressive agents tacrolimus

Interventional urethral balloon dilatation before endoscopic visual internal urethrotomy for post-traumatic bulbous urethral stricture:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12787-12792页

作者： Ji yong Ha Mu Sook lee Department of Urology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Department of Radiology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND While several treatment options are available for pediatric urethral strictures,the appropriate treatment must be based on several *** endoscopic visual internal urethrotomy(EVIU)could be a first-line treatment option for short pediatric urethral strictures,it is not feasible if the urethroscope cannot pass through the stricture ***,we present a pediatric case of severe posttraumatic bulbous urethral stricture that was successfully treated by EVIU after securing the urethral route via interventional balloon *** SUMMARY A 12-year-old boy presented at our outpatient clinic with the inability to *** had sustained a straddle injury three months *** post-void residual urine volume was 644 mL,and retrograde urethrography confirmed severe stricture of the bulbous *** was planned;however,the first attempt to treat the stricture failed because the urethroscope could not pass through the stricture *** urethral route was subsequently secured via balloon dilatation of the stricture,which was performed in collaboration with specialists from the department of interventional *** urethroscope was then able to pass,and the repeat EVIU was *** Interventional urethral balloon dilatation before EVIU may help secure the urethral route in the treatment of pediatric urethral strictures.

关键词： Urethral stricture Endoscopic visual internal urethrotomy Urethroplasty Urethral balloon dilatation Interventional radiology Case report

Recommendation application for video head impulse test based on fuzzy logic control

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Journal of Central South University 2016年第5期23卷 1208-1214页

作者： NGUYEN Thi Anh Dao KIM Dae Young lee Sang Min KIM Kyu Sung seong Ro lee KWON Jang Woo Department of Computer and Information Engineering Inha University Department of Otorhinolaryngology Inha University Hospital Department of Electronic Engineering Inha University Department of Information and Electronics Engineering Mokpo National University

Vestibulo-ocular reflex(VOR) is an important biological reflex that controls eye movement to ensure clear vision while the head is in ***,VOR measurement is commonly done with a video head impulse test based on a velocity gain algorithm or a position gain algorithm,in which velocity gain is a VOR calculation on head and eye velocity,whereas position gain is calculated from head and eye *** aim of this work is first to compare the two algorithms' performance and to detect covert catch-up saccade,then to propose a stand-alone recommendation application for the patient's *** the first experiment,for ipsilesional and contralesional sides,the calculated position gain(0.94±0.17) is higher than velocity gain(0.84±0.19).Moreover,gain asymmetry of both lesion and intact sides using velocity gain is mostly higher than that from using position gain(four out of five subjects).Consequently,for subjects who have unilateral vestibular neuritis diagnosed from clinical symptoms and a vestibular function test,vestibular weakness is depicted by velocity gain much better than by position *** catch-up saccade and position gain then are used as inputs for recommendation applications.

关键词： vestibulo-ocular response video head impulse velocity gain position gain desaccade

A case of intussuscepted Meckel’s diverticulum

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World Journal of Gastroenterology 2009年第40期15卷 5109-5111页

作者： Tae Hee lee Jin-Oh Kim Jae Joon Kim seong Sook Hong So Young Jin Hyun Gun Kim Joo Young Cho Joon seong lee Institute for Digestive Research SoonChunHyang College of Medicine Department of Surgery SoonChunHyang College of Medicine Department of Radiology SoonChunHyang College of Medicine Department of Pathology SoonChunHyang College of Medicine

We report colonoscopic features of an intussuscepted Meckel's diverticulum, presenting with hematochezia. A 35-year-old woman presented to the emergency room with acute onset, transient, sharp, severe epi-gastric pain that began 6 h earlier. Colonoscopy re-vealed a reddish, soft, fi st-sized polypoid lesion in the terminal ileum. The lesion was misinterpreted as a hematoma by an inexperienced endoscopist. The pa-tient began to complain of intermittent, severe peri-umbilical pain following the colonoscopic examination. Subsequent computed tomography showed an enteric intussusception. An exploratory laparotomy revealed an intussuscepted Meckel's diverticulum, with trans-mural infarction. Colonoscopy was of little use in as-sessing the intussusception. However, colonoscopic examination may be performed initially, especially in an intussuscepted Meckel's diverticulum present-ing with hematochezia. Endoscopists should note the endoscopic features of an intussuscepted Meckel's diverticulum.

关键词： Colonoscopy Intussusception Meckel's diverticulum

Guardian of the rice:Unveiling OsSSP1 for broad-spectrum disease resistance

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Molecular Plant 2024年第7期17卷 996-998页

作者： You-Jin Lim yong-Hwan lee Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea interdisciplinary Program in Agricultural Genomics Center for Fungal Genetic ResourcesPlant Immunity Research Centerand Center for Plant Microbiome ResearchSeoul National UniversitySeoul 08826Republic of Korea

Plants are continuously exposed to numerous biotic stresses throughout their *** arms race-driven coevolution with pathogens,plants have developed sophisticated immune systems,including pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI)and effector-triggered immunity(ETI).PTI is initiated by the binding of danger signals to extracellular membrane-localized receptors calledpattern recognition receptors(PRRs).PTI triggers responses,including reactive oxygen species(ROS)bursts and the expression of defenseassociated ***,pathogens adapted to PTl secrete virulence proteins,effectors,to aid colonization,and ETl is then triggered by the recognition of these effectors by resistance proteins with a nucleotide-binding domain leucinerich repeat receptor(NLR).To circumvent this immune response,pathogens secrete various effectors into the host intracellular region and induce effector-triggered susceptibility(Zhou and Zhang.,2020).Currently,research on plant immunity has been primarily focused on plasma membrane and cytoplasmlocalized proteins,including oligomeric NLRs,resistosomes,and the secretion mechanisms of cytoplasmic effectors.

关键词： immunity resistance Guard