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Association between cytochrome CYP17A1, CYP3A4, and CYP3A43 polymorphisms and prostate cancer risk and aggressiveness in a Korean study population

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Asian Journal of Andrology 2015年第2期17卷 285-291,I0010页

作者： Jun Hyun Han yong seong lee Hae Jong Kim Shin Young lee Soon Chul Myung Department of Urology Hallym University Dongtan Sacred Heart Hospital Hwaseong-si 445-170 Korea Department of Urology Hallym University Kangnam Sacred Heart Hospital Seoul 150-950 Korea Advanced Urogenital Disease Research Center Chung-Ang University College of Medicine Seoul 156-756 Korea Research Institute for Translational System Biomics Chung-Ang University College of Medicine Seoul 156-756 Korea Department of Urology Seoul Medical Center Seoul 131-865 Korea Department of Urology Chung-Ang University Hospital Seou1156-756 Korea.

In this study, we evaluated genetic variants of the androgen metabolism genes CYP17A1, CYP3A4, and CYP3A43 to determine whether they play a role in the development of prostate cancer （PCa） in Korean men. The study population included 240 pathologically diagnosed cases of PCa and 223 age-matched controls. Among the 789 singie-nucleotide polymorphism （SNP） database variants detected, 129 were reported in two Asian groups （Han Chinese and Japanese） in the HapMap database. Only 21 polymorphisms of CYP17A1, CYP3A4, and CYP3A43 were selected based on linkage disequilibrium in Asians （d = 1）, locations （SNPs in exons were preferred）, and amino acid changes and were assessed. In addition, we performed haplotype analysis for the 21 SNPs in CYP17A1, CYP3A4, and CYP3A43 genes. To determine the association between genotype and haplotype distributions of patients and controls, logistic analyses were carried out, controlling for age. Twelve sequence variants and five major haplotypes were identified in CYP17A1. Five sequence variants and two major haplotypes were identified in CYP3A4. Four sequence variants and four major haplotypes were observed in CYP3A43. CYP17A1 haplotype-2 （Ht-2）（odds ratio [OR], 1.51; 95% confidence interval [Cl], 1.04-2,18） was associated with PCa susceptibility. CYP3A4 Ht-2 （OR. 1.87; 95% CI. 1.02-3.43） was associated with PCa metastatic potential according to tumor stage, rs17115149 （OR： 1.96; 95% Ch 1.04-3.68） and CYP17A1 Ht-4 （OR： 2.01; 95% Ch 1.07-4.11） showed a significant association with histologic aggressiveness according to Gleason score. Genetic variants of CYP17A1 and CYP3A4 may play a role in the development of PCa in Korean men.

关键词： androgens CYP17A1 CYP3A4 CYP3A43 genetics prostatic neoplasms

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Increased type III interferons and NK cell functions in SARS-CoV-2-infected children

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Signal Transduction and Targeted Therapy 2023年第3期8卷 888-890页

作者： seong Dong Jeong Hoyoung lee Ju Young Chang seong yong lee Ji Eun Choi Eunmi Yang Hye Won Jeong Jae-Phil Choi Mi Seon Han Eui-Cheol Shin The Center for Viral Immunology Korea Virus Research InstituteInstitute for Basic Science(IBS)Daejeon 34126Republic of Korea Department of Pediatrics Seoul Metropolitan Government-Seoul National University Boramae Medical Center and Seoul National University of College of MedicineSeoul 07061Republic of Korea Division of infectious diseases Seoul Medical CenterSeoul 02053Republic of Korea Department of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Republic of Korea Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is more likely to progress to severe disease in the elderly,and the rates of hospitalization for coronavirus disease 2019(COVID-19)increase with age.1,2 Herein,we comprehensively compared adaptive and innate immune responses between children and adults infected with SARS-CoV-2.

关键词： infected acute respiratory

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Relationship between insulin resistance, obesity and serum prostate-specific antigen levels in healthy men

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Asian Journal of Andrology 2010年第3期12卷 400-404,I0011页

作者： June Hyun Han yong Taec lee Kyung Won Kwak Seung Hyun Ahn In Ho Chang Soon Chul Myung Seung Young Oh yong-seong lee Wonyong Kim Young-Woo Jin Tae-In Choi Sook Hee Sung Department of Urology KEPCO Medical Foundation Hanil General Hospital Seou1132-703 Korea Department of Urology Chung-Ang University Hospital Seoul 140-757 Korea Department of Urology Hyundae General Hospital Namyangju 472-865 Korea Department of Urology Hallym University Hangang Sacred Heart Hospital Seoul 150-719 Korea Department of Microbiology College of Medicine Chung-Ang University Seoul 156- 756 Korea Radiation Health Research Institute Korea Hydro ＆ Nuclear Power Co. LTD Seoul 132-703 Korea

The purpose of this study was to determine the relationship between insulin resistance, obesity and serum prostate-specific antigen （PSA） levels in healthy men with serum PSA level below 4 ng mL-1. The men included in the study cohort were 11 827 healthy male employees of the Korea Hydro and Nuclear Power Co., LTD who had undergone medical checkups including fasting glucose, fasting insulin and serum PSA between January 2003 and December 2008. Insulin resistance was calculated by homeostasis model assessment （HOMA [fasting glucose × fasting insulin]/22.5） and quantitative insulin sensitivity check index （QUICK/; 1/[log （fasting insulin）＋ log （fasting glucose）]）. Age-adjusted body mass index （BMI） was significantly increased according to increasing quartile of insulin resistance as determined by HOMA and QUICKI, respectively, in analysis of variance （ANOVA） test and Duncan＇s multiple comparison test （P 〈 0.001）, but age-adjusted serum PSA concentration was significantly decreased according to increasing quartile of insulin resistance as determined by HOMA and QUICK/（P 〈 0.001）. Age, BMI, insulin resistance by HOMA or QUICK/were significantly independent variables to serum PSA level in a multivariate linear regression analysis （P 〈 0.001）. Insulin resistance was a significant independent variable to serum PSA level along with BMI. Insulin resistance and BMI were negatively correlated with serum PSA level in healthy men. Insulin resistance was positively correlated with BMI.

关键词： body mass index insulin resistance metabolic syndrome X obesity prostate-specific antigen

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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun lee yong Nam Ahn seongjoon So Chanwoo Park Jong-seong Bae Taehyun Park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Artificial layer Dielectric constant Zn metal anode Zinc aqueous battery

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Robot-Assisted Laparoscopic Adrenalectomy:15 cases

Robot-Assisted Laparoscopic Adrenalectomy:15 cases

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第十七届全国泌尿外科学术会议

作者： Young Goo lee Dae Sung Kim yong seong lee Nak Kyu Choi Dep.of Urology.Hallym University SeoulKorea

Introduction Robot-assisted laparoscopic adrenalectomy(RLA) has become an accepted surgical procedure for resection of benign adrenal lesions *** reviewed our experience and report our results.

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Direct dynamic-simulation approach to trajectory optimization

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Chinese Journal of Aeronautics 2021年第10期34卷 6-19页

作者： Sung Wook HUR seong Han lee yong Hyeon NAM Chang-Joo KIM Department of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea

This paper proposes a new direct method for an efficient trajectory optimization using the point that the dynamics of a deterministic system are uniquely determined by initial states and controls imposed over the time horizon of *** effectively implement this concept,the Hermite spline is adopted to interpolate the continuous controls and the system dynamics are integrated with corresponding control parameters in *** a result,the optimal control problem can be transcribed into a nonlinear programming problem which has no dynamic equality constraints and no intermediate states in its design *** addition,the paper proposes an efficient recursive Jacobian estimation technique and introduces a Jacobian transformation matrix to straightforwardly handle the general state *** properties of the present method are thoroughly investigated through its applications to the trajectory optimization for a soft lunar landing from a parking orbit,including the detailed analyses for the de-orbiting *** computed results are compared with those using the pseudo-spectral method to demonstrate an extreme outperformance of the proposed method in the aerospace applications over the traditional direct method.

关键词： Trajectory optimization Direct method Hermite spline interpolation Pseudo-spectral integrator Soft lunar landing

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Electrochemical characteristics of Al-Mg and Al-Mg-Si alloy in sea water

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中国有色金属学会会刊：英文版 2012年第S3期22卷 881-886页

作者： seong-jong KIM Seung-jun lee Jae-yong JEONG Kyu-hwan KIM Division of Marine Engineering Mokpo Maritime University

Among Al alloys,particularly 5000 series Al Mg and 6000 series Al Mg Si often used as marine materials have excellent corrosion resistance,low melting point,and thereby showing recycling availability when compared to other *** experiments were conducted to select the most suitable material for marine *** electrochemical experiments were conducted in natural *** corrosion test was performed in many methods such as anodic/cathodic polarization and Tafel analysis using multi-channel potentio/galvanostat WMPG *** results,anodic and cathodic polarization behaviors indicate the characteristics of passive state and concentration polarization by reduction reaction in dissolved oxygen,which shows excellent electrochemical *** analysis results show no significant difference but 5052-O alloy of various alloy materials indicates the lowest corrosion current ***,5052-O Al alloy presents most anti-corrosion material in marine environment.

关键词： Al alloy ship electrochemical characteristics corrosion

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Hepatectomy vs radiofrequency ablation for colorectal liver metastasis:A propensity score analysis

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World Journal of Gastroenterology 2015年第11期21卷 3300-3307页

作者： Huisong lee Jin Seok Heo yong Beom Cho seong Hyeon Yun Hee Cheol Kim Woo yong lee seong Ho Choi Dong Wook Choi Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To compare outcomes from radiofrequency ablation(RFA) and hepatectomy for treatment of colorectal liver metastasis(CRLM).METHODS:From January 2000 to December 2009,408 patients underwent curative intent treatment for *** excluded patients using the criteria:size of CRLM > 3 cm,number of CRLM ≥ 5,percutaneous RFA,follow-up period 2 cm) CRLM(P = 0.034).However,survival curves were similar for single or small(≤ 2 cm) CRLM(P = 0.714,P = 0.740).CONCLUSION:Hepatectomy is better than RFA for the treatment of ***,RFA might be suitable for selected patients with single,small(≤ 2 cm) CRLM.

关键词： Colorectal neoplasm Metastasis Catheter ablation H

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Effect of the semen extract of Cuscuta chinensis on inflammatory responses in LPS-stimulated BV-2 microglia

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Chinese Journal of Natural Medicines 2014年第8期12卷 573-581页

作者： Seok yong Kang Hyo Won Jung Mi-Young lee Hye Won lee seong Wook Chae yong-Ki Park Department of Herbology College of Korean Medicine Dongguk University 707 Sekjang-Dong Gyeongju Gyeongsangbuk- Do 780-714 Republic of Korea Korean Medicine R&D Center Dongguk University 707 Sekjang-Dong Gyeongju Gyeongsangbuk-Do 780-714 Republic of Korea Korea Institute of Oriental Medicine 1672 Yuseongdae-ro Yuseong-gu Daejeon 305-811 Republic of Korea

AIM: To investigate the anti-inflammatory activities of the semen extract of Cuscuta chinensis Lam.(Cuscutae Semen; CS) on the production of inflammatory mediators, nitric oxide(NO), prostaglandin 2(PGE2), and proinflammatory cytokines in lipopolysaccharide(LPS)-stimulated BV-2 microglia. METHOD: BV-2 cells were treated with CS extract for 30 min, and then stimulated with LPS or without for 24 h. The levels of NO, PGE2 and proinflammatory cytokines were measured by Griess assay and ELISA. The expression of inducible nitric oxide synthase(iNOS), and cyclooxygenase(COX)-2 mRNA and protein was determined by RT-PCR and Western blot, respectively. The phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2), Jun N-terminal kinase(JNK), and p38 mitogen-activated protein kinase(MAPK), and the nuclear expression of nuclear factor(NF)-κB p65 were investigated by Western blot analysis. RESULTS: CS extract significantly decreased the production of NO and PGE2 by suppressing the expression of iNOS and COX-2 in activated microglia. CS extract decreased the production of TNF-α, IL-1β, and IL-6 by down-regulating their transcription levels. In addition, CS extract suppressed the phosphorylation of ERK1/2, JNK, and p38 MAPK, and the nuclear translocation of NF-κB p65 in activated microglia. CONCLUSION: These results indicate that CS extract is capable of suppressing the inflammatory response by microglia activation, suggesting that CS extract has potential in the treatment of brain inflammation.

关键词： Cuscuta chinensis Cuscutae Semen Microglia Inflammation NF-κB pathway

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Patterning of Metal Halide Perovskite Thin Films and Functional Layers for Optoelectronic Applications

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Nano-Micro Letters 2023年第10期15卷 494-513页

作者： Jin‑Wook lee seong Min Kang Department of Nano Engineering and Department of Nano Science and Technology SKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea

In recent years,metal halide perovskites have received significant attention as materials for next-generation optoelectronic devices owing to their excellent optoelectronic *** unprecedented rapid evolution in the device performance has been achieved by gaining an advanced understanding of the composition,crystal growth,and defect engineering of *** device performances approach their theoretical limits,effective optical management becomes essential for achieving higher *** this review,we discuss the status and perspectives of nano to micron-scale patterning methods for the optical management of perovskite optoelectronic *** initially discuss the importance of effective light harvesting and light outcoupling via optical ***,the recent progress in various patterning/texturing techniques applied to perovskite optoelectronic devices is summarized by categorizing them into top-down and bottom-up ***,we discuss the perspectives of advanced patterning/texturing technologies for the development and commercialization of perovskite optoelectronic devices.

关键词： Perovskites Optoelectronics Light outcoupling Light harvesting Patterning

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