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Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： yong rao Rui Su Chenyan Wu Xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

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Geochemical characteristics and origins of natural gases in the eastern Cote d’Ivoire Basin,West Africa

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Acta Oceanologica Sinica 2024年第8期43卷 26-36页

作者： Li Li Quan Li Tao Cheng Songling Yang yong rao Xinyu Liu Wenjing Ding CNOOC International Ltd. Beijing 100028China School of Natural Sciences Macquarie UniversitySydneyNSW2109Australia CNOOC Research Institute Beijing 100028China

The gas sources in the eastern Cote d’Ivoire Basin(Tano Basin)are seldom reported and remain controversial due to multiple sets of potential source rocks and poorly documented geochemical characteristics of natural *** marine source rock potential from the Upper Albian to Turonian as well as the molecular composition and the stable carbon isotope composition of natural gases in the eastern Cote d’Ivoire Basin were studied in detail to investigate the origins of natural *** total organic carbon(TOC),hydrogen index(HI),and generation potential(S_(1)+S_(2))of source rocks indicate that both sapropelic source rocks and humic source rocks developed during the late Albian,whereas sapropelic source rocks developed during the Cenomanian and the *** normal order ofδ^(13)CH_(4)<δ^(13)C_(2)H6<δ^(13)C_(3)H_(8)(δ^(13)C_(1)<δ^(13)C_(2)<δ^(13)C_(3)),the relationship between C_(2)/C_(3)molar ratio andδ^(13)C_(2)-δ^(13)C_(3),and the plot ofδ^(13)C_(1)versus C_(1)/(C_(2)+C_(3))collectively show that the natural gases are thermogenic due to the primary cracking of kerogen,including the typical oil-associated gases from Well D-1,the mixed oil-associated gases and coal-derived gases from Well G-1 and Well *** on the plot ofδ^(13)C_(1)versusδ^(13)C_(2)and the established relationship betweenδ^(13)C_(1)and equivalent vitrinite reflectance(Ro),we proposed that the natural gases are in a mature stage(Ro generally varies from 1.0%to 1.3%).Combined with results of basin modelling and oil-to-source correlation,the transitional to marine source rocks during the late Albian were thought to have made a great contribution to the natural *** study will make a better understanding on petroleum system in the eastern Cote d’Ivoire Basin.

关键词： marine source rocks potential molecular composition stable carbon isotopes Upper Albian Tano Basin

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Geochemical characteristics and origins of natural gases in the eastern Cote d'Ivoire Basin,West Africa

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Acta Oceanologica Sinica 2024年第08期 26-36页

作者： Li Li Quan Li Tao Cheng Songling Yang yong rao Xinyu Liu Wenjing Ding CNOOC International Ltd. School of Natural Sciences Macquarie University CNOOC Research Institute

The gas sources in the eastern Cote d'Ivoire Basin（Tano Basin） are seldom reported and remain controversial due to multiple sets of potential source rocks and poorly documented geochemical characteristics of natural *** marine source rock potential from the Upper Albian to Turonian as well as the molecular composition and the stable carbon isotope composition of natural gases in the eastern Cote d'Ivoire Basin were studied in detail to investigate the origins of natural gases. The total organic carbon（TOC）, hydrogen index（HI）, and generation potential（S1+ S2） of source rocks indicate that both sapropelic source rocks and humic source rocks developed during the late Albian, whereas sapropelic source rocks developed during the Cenomanian and the Turonian. The normal order of δ13CH4< δ13C2H6< δ13C3H8(δ13C1< δ13C2< δ13C3), the relationship between C2/C3molar ratio and δ13C2-δ13C3, and the plot of δ13C1versus C1/（C2+C3） collectively show that the natural gases are thermogenic due to the primary cracking of kerogen, including the typical oil-associated gases from Well D-1, the mixed oil-associated gases and coal-derived gases from Well G-1 and Well L-1. Based on the plot of δ13C1versus δ13C2and the established relationship between δ13C1and equivalent vitrinite reflectance（Ro）, we proposed that the natural gases are in a mature stage（Ro generally varies from 1.0% to 1.3%）. Combined with results of basin modelling and oil-to-source correlation, the transitional to marine source rocks during the late Albian were thought to have made a great contribution to the natural gases. Our study will make a better understanding on petroleum system in the eastern Cote d'Ivoire Basin.

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亚紫裸伞的生物学特性及驯化栽培

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生物技术通报 2024年第4期40卷 264-270页

作者：饶永斌张君丽三明市农业农村局三明365000 西藏自治区农牧科学院蔬菜研究所拉萨850000

【目的】为实现西藏野生真菌资源的高效开发与利用,促进食药用真菌产业的发展。【方法】对采自西藏自治区林芝市波密县易贡乡的一株野生真菌进行分离纯化,依据形态学特征和ITS序列进行菌种鉴定,并对该菌株进行了生物学特性探究和驯化栽... 详细信息

【目的】为实现西藏野生真菌资源的高效开发与利用,促进食药用真菌产业的发展。【方法】对采自西藏自治区林芝市波密县易贡乡的一株野生真菌进行分离纯化,依据形态学特征和ITS序列进行菌种鉴定,并对该菌株进行了生物学特性探究和驯化栽培试验。【结果】结合形态学特征和ITS系统发育树结果将该菌株鉴定为亚紫裸伞Gymnopilus subpurpuratus;生物学特性分析表明,亚紫裸伞菌丝生长最佳碳源为葡萄糖,最佳氮源为酵母粉,最适pH为6.0,最适温度为30℃;驯化结果表明,亚紫裸伞在以木屑为主要栽培料的培养基中的满袋时间为39 d,原基形成时间为18 d,出原基后经8 d达到采收期,单朵鲜重45.99 g。【结论】成功以木屑为主要栽培料获得亚紫裸伞的人工驯化子实体,增加了药用菌的人工驯化新种类。

关键词：亚紫裸伞鉴定生物学特性驯化栽培

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数学学科核心素养导向下的教育数学实证研究

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数学教育学报 2024年第1期33卷 21-27页

作者：谭琳张永胜陈如仙徐章韬饶永生广州大学计算科技研究院广东广州510006 广州城市职业学院信息工程学院广东广州510405 邛崃市教研培训中心四川成都611530 华中师范大学数学与统计学学院湖北武汉430070

教育数学实验是中国教育改革的重要组成部分,学生的数学学科核心素养发展状况是其改革实验效果的重要衡量指标之一.研究选取初中数学核心素养评价框架,对邛崃市教育数学实验进行评价研究,分析该实验对学生数学核心素养发展的影响.基于... 详细信息

教育数学实验是中国教育改革的重要组成部分,学生的数学学科核心素养发展状况是其改革实验效果的重要衡量指标之一.研究选取初中数学核心素养评价框架,对邛崃市教育数学实验进行评价研究,分析该实验对学生数学核心素养发展的影响.基于所选框架对该市2017级初三第二次诊断试卷考查的数学核心素养进行分类.根据学生核心素养的得分,对比分析该市3672名初三学生与93名教育数学实验班学生数学核心素养的发展状况.研究发现:该市初三学生的整体数学核心素养发展不平衡,特别是在数学建模、逻辑推理素养上不合格比例较高;教育数学体系下的实验组核心素养发展情况普遍优于该市整体水平,且其发展更为均衡.结论说明教育数学可促进学生数学核心素养的普遍均衡发展,实验风险可控,适合大规模普及.

关键词：数学学科核心素养教育数学教学改革评价研究

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大型走滑转换带对油气分布差异性控制作用: 以西非科特迪瓦盆地为例

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地质科技通报 2024年第3期43卷 108-119页

作者：饶勇程涛赵红岩李全吕彩丽刘正中国海洋石油国际有限公司北京100028

科特迪瓦盆地位于西非赤道段,发育大型走滑转换带,为典型的转换型被动陆缘盆地,是当前油气勘探热点区域,勘探潜力巨大,但油气平面分布、纵向富集均存在较大的差异性。基于前人研究,利用井、震资料并结合近年来新发现油气藏数据,重点从... 详细信息

科特迪瓦盆地位于西非赤道段,发育大型走滑转换带,为典型的转换型被动陆缘盆地,是当前油气勘探热点区域,勘探潜力巨大,但油气平面分布、纵向富集均存在较大的差异性。基于前人研究,利用井、震资料并结合近年来新发现油气藏数据,重点从构造和沉积2个方面阐述了走滑转换带对油气分布差异性的控制作用。研究表明,盆地经历了陆内裂谷、洋陆转换和被动陆缘3个主要的构造-沉积演化阶段,形成了总体上“西窄东宽”的斧型构造格局特征,西部为陡窄转换边缘,东部为宽缓离散边缘,中部为过渡边缘,宏观上控制了油气“西少东多”的分布规律。走滑转换作用应力主要响应区为中部过渡边缘,中部隆起马尾带发育大量的构造圈闭,具有南北双向供烃特征,控制了北部凸起阿尔比构造油气藏的形成与分布。走滑转换作用形成的古地貌对转换早期上阿尔比-森诺曼和转换晚期土伦阶储层的空间展布特征均有重要的控制作用,内斜坡洼陷(盆地)往往是最为有利的富砂处,同时也是最有利的地层-岩性圈闭发育区,油气分布与沉积体系展布具有较好的一致性,即转换控储,分布控藏。

关键词：科特迪瓦盆地转换型被动陆缘盆地走滑转换带转换边缘离散边缘过渡边缘

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Deep Fault Diagnosis for Rotating Machinery with Scarce Labeled Samples

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Chinese Journal of Electronics 2020年第4期29卷 693-704页

作者： ZHANG Jing TIAN Jing WEN Tao YANG Xiaohui rao yong XU Xiaobin School of Automation Hangzhou Dianzi University School of Electronic and Information Engineering Beijing Jiaotong University School of Mathematics and Statistics Henan University Hofon Automation Co. Ltd

Early and accurately detecting faults is crucial for the modern manufacturing *** proposed a novel Deep fault diagnosis(DFD) method for rotating machinery with scarce labeled samples.A spectrogram of the raw vibration signal is calculated by applying a Short-time Fourier transform(STFT).Several candidate Support vector machine(SVM) models are trained with different combinations of features in the feature pool with scarce labeled *** evaluating the pretrained SVM models on the validation set, the most discriminative features and best-performed SVM models can be selected, which are used to make predictions on the unlabeled *** predicted labels reserve the expert knowledge originally carried by the SVM *** are combined together with the scarce fine labeled samples to form an Augmented training set(ATS).Finally,a novel 2D deep Convolutional neural network(CNN)model is trained on the ATS to learn more discriminative features and a better *** results on two fault diagnosis datasets demonstrate the effectiveness of the proposed DFD.

关键词： Fault diagnosis Deep CNN Spectrograms Knowledge-transferring

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Method for Processing Graph Degeneracy in Dynamic Geometry Based on Domain Design

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Journal of Computer Science & Technology 2021年第4期36卷 910-921页

作者： Hao Guan yong-Sheng rao Jing-Zhong Zhang Sheng Cao Xiao-Lin Qin Institute of Computing Science and Technology Guangzhou UniversityGuangzhou 510006China Chengdu Institute of Computer Applications Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Engineering University of Electronic Science and Technology of China Chengdu 61173China

A dynamic geometry system,as an important application in the field of geometric constraint solving,is widely used in elementary mathematics education;moreover,the dynamic geometry system is also a fundamental environment for automated theorem proving in *** a geometric constraint solving process,a situation involving a critical point is often encountered,and geometric element degeneracy may occur at this ***,the degeneracy situation must be substantively focused on during the learning and exploration ***,many degeneracy situations cannot be completely presented even by the well-known dynamic geometry *** this paper,the mechanisms causing the degeneracy of a geometric element are analyzed,and relevant definitions and formalized descriptions for the problem are provided according to the relevant modern Euclidean geometry *** solve the problem,the data structure is optimized,and a domain model design for the geometric element and the constraint relationships thereof in the dynamic geometry system are formed;furthermore,an update algorithm for the element is proposed based on the novel domain *** addition,instances show that the proposed domain model and the update algorithm can effectively cope with the geometric element degeneracy situations in the geometric constraint solving process,thereby achieving unification of the dynamic geometry drawing and the geometric intuition of the user.

关键词： dynamic geometry critical point degeneracy domain model

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控释尿素和有机物料添加提高黄壤冬油菜产量及养分吸收利用

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中国土壤与肥料 2024年第1期 113-121页

作者：魏全全张萌芶久兰饶勇顾小凤柳玲玲肖华贵贵州省农业科学院土壤肥料研究所贵州贵阳550006 贵州省农业科学院油料研究所贵州贵阳550006

利用田间试验探讨控释尿素和不同有机物料添加对黄壤冬油菜产量、养分吸收及利用的影响,为贵州黄壤地力改善以及冬油菜丰产提质提供科学依据。于2018—2022年连续4年在贵州省贵阳市开展控释尿素和不同有机物料添加长期定位试验,以冬油... 详细信息

利用田间试验探讨控释尿素和不同有机物料添加对黄壤冬油菜产量、养分吸收及利用的影响,为贵州黄壤地力改善以及冬油菜丰产提质提供科学依据。于2018—2022年连续4年在贵州省贵阳市开展控释尿素和不同有机物料添加长期定位试验,以冬油菜为试验材料,分别设置不施氮肥(U0)、控释尿素(CRU180)、普通尿素(U180)以及在普通尿素施用下配施3种有机物料[秸秆(U180+S)、生物炭(U180+B)和商品有机肥(U180+O),均为3000 kg/hm^(2)],在冬油菜收获后,分别测定不同处理冬油菜产量、产量构成因子、生物量、养分吸收和利用。结果表明,与U0处理相比,CRU180和U180处理冬油菜产量分别提高732.5和588.8 kg/hm^(2),配施有机物料后,U180+S、U180+B和U180+O处理冬油菜产量较U180处理分别增加516.9、662.6和622.0 kg/hm^(2),其中以U180+B处理冬油菜产量最高,为2646.8 kg/hm^(2)。与U0处理相比,CRU180和U180处理冬油菜地上部生物量显著增加;与U180处理相比,配施有机物料显著提高冬油菜地上部生物量,4年均以U180+B处理最优,但与U180+S和U180+O处理差异不显著。冬油菜氮磷钾累积量均以U180+B处理最大,4年平均值分别为164.7、31.9和139.1 kg/hm^(2)。CRU180处理氮素农学效率(AEN)、偏生产力(PEPN)和吸收利用效率(REN)高于U180处理;配施有机物料后,U180+S、U180+B和U180+O处理冬油菜AEN、PEPN和REN较U180处理均呈现增加的趋势,其中以U180+B处理最高,分别为6.95 kg/kg、14.70 kg/kg和38.43%,高于其他处理。U180+S处理冬油菜经济效益为7109.9元/hm^(2),高于其他处理。综上所述,控释尿素和有机物料(秸秆、生物炭和商品有机肥)添加均能提高冬油菜产量和养分吸收及利用,且以配施生物炭冬油菜产量最高,但配施秸秆冬油菜经济效益最优,建议在贵州黄壤区冬油菜生长季,正常肥料施用量情况下,可施用控释尿素替代常规尿素,且适当增施外源有机物料以保证冬油菜的产量和养分吸收利用效率。

关键词：控释尿素有机物料黄壤冬油菜产量养分吸收利用

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Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA

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Chinese Journal of Natural Medicines 2019年第9期17卷 663-671页

作者： XU Yao-Hao LI Wei rao yong HUANG Zhi-Shu YIN Sheng Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical Sciences Sun Yat-sen University

Bioassay-guided fractionation of an ethanolic extract of Ochrosia borbonica led to the isolation of two known pyridocarbazole alkaloids,ellipticine(1)and 9-methoxyellipticine(2),and six known monoterpenoid indole alkaloids(3-8).Lipid-lowering assay in 3 T3-L1 cell model revealed that 1 and 2 could significantly inhibit the lipid droplet formation(EC50(28)0.41 and 0.92μmol·L^–1,respectively)and lower triglyceride levels by 50%-60%at the concentration of 1μmol·L^–1,being more potent than the positive drug luteolin(EC50(28)2.63μmol·L–^1).A mechanistic study indicated that 1 and 2 could intercalate into supercoiled DNA,which consequently inhibited the mitotic clonal expansion of 3 T3-L1 cells at the early differentiation phase,leading to the retardance of following adipogenesis and *** findings suggest that 1 and 2 may serve as promising leads for further d evelopment of anti-obesity drugs.

关键词： Ochrosia borbonica Pyridocarbazole alkaloids Lipid-lowering agents

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