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DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2774-2790页

作者： Mingjing Yan Junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing Tang Xiyue Zhang yong man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen The Key Laboratory of Geriatrics Beijing Institute of GeriatricsInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing Hospital/National Center of Gerontology of National Health CommissionBeijing 100730China Peking University Fifth School of Clinical Medicine Beijing 100730China Department of Laboratory Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Cardiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Graduate School of Peking Union Medical College Beijing 100730China Department of Health Care Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Department of Pathology and Pathophysiology and Department of Cardiology at Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310058China Department of Cardiovascular Surgery Peking University Shenzhen HospitalShenzhen 518036China Experimental Technology Center for Life Sciences at Beijing Normal University Beijing 100875China

DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor *** DDX17 is abundantly expressed in the myocardium,its role in heart is not fully *** generated cardiomyocyte-specific Ddx17-knockout mice(Ddx17-cKO),cardiomyocyte-specific Ddx17 transgenic mice(Ddx17-Tg),and various models of cardiomyocyte injury and heart failure(HF).DDX17 is downregulated in the myocardium of mouse models of heart failure and cardiomyocyte ***-specific knockout of Ddx17 promotes autophagic flux blockage and cardiomyocyte apoptosis,leading to progressive cardiac dysfunction,maladaptive remodeling and progression to heart *** of DDX17 expression in cardiomyocytes protects cardiac function under pathological *** studies showed that DDX17 can bind to the transcriptional repressor B-cell lymphoma 6(BCL6)and inhibit the expression of dynamin-related protein 1(DRP1).When DDX17 expression is reduced,transcriptional repression of BCL6 is attenuated,leading to increased DRP1 expression and mitochondrial fission,which in turn leads to impaired mitochondrial homeostasis and heart *** also investigated the correlation of DDX17 expression with cardiac function and DRP1 expression in myocardial biopsy samples from patients with heart *** findings suggest that DDX17 protects cardiac function by promoting mitochondrial homeostasis through the BCL6-DRP1 pathway in heart failure.

关键词： DDX17 homeostasis cardiac

Expert Consensus on the Treat-to-Target Strategy for Psoriasis With Biological Agents in China(Simplified Edition)

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International Journal of Dermatology and Venereology 2024年第2期7卷 61-69页

作者： Ai-Jun Chen Da-Xing Cai Xiang Chen yong Cui Yan Ding Heng Gu Xing-Hua Gao Chao Ji Xiao-Jing Kang Ye-Hong Kuang Cheng-Zhi Lyu Min Li Wei Li Xia Li Yu-Zhen Li Xiao-yong man Jian-Jun Qiao Juan Su Liang-Dan Sun Yu-Ling Shi Juan Tao Jian-Xin Xia Rong Xiao Bin Yang Wu Zhu Xue-Jun Zhang Committee on Psoriasis Dermatology and Venereology Branch of the Chinese Medical Association Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250100China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology China-Japan Friendship HospitalBeijing 100192China Department of Dermatology Hainan Provincial Hospital of Skin DiseaseHaikouHainan 570311China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uyghur Autonomous Region 830001China Department of Dermatology Dalian Dermatosis HospitalDalianLiaoning 116021China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhouJiangsu 215127China Department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610044China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200093China Department of Dermatology The Union Hospital of Tongji Medical CollegeHuazhong University of Science and Te

Psoriasis is a chronic,recurrent,inflammatory systemic disease that is not only characterized by skin manifestations but may also be accompanied by various comorbidities,imposing a heavy burden on patients’physical and mental health and affecting their quality of *** the continuous approval of various biological agents for clinical use has provided more effective treatment options to patients with psoriasis,no consensus on the evaluation of comprehensive treatment goals has yet been *** treat-to-target(T2T)strategy requires consideration of multiple dimensions of treatment outcomes,the development of long-term management goals,and regular assessments of treatment conditions,which are often used in the management of chronic ***,based on the latest consensuses and guidelines,research data,and clinical experience as well as the combination of survey results and expert group discussions,the present consensus focuses on 4 dimensions of short-and long-term integrated management goals for biological agents:alleviating skin lesions,improving quality of life,screening and managing psoriasis comorbidities,and ensuring drug *** implementation methods,evaluation time,treatment monitoring,and program adjustments are also herein described to achieve comprehensive management of psoriasis to the maximum *** consensus provides a reference for clinical practice.

关键词： psoriasis biological agents treat-to-target comorbidity consensus

北部湾盆地油气成藏规律与勘探新领域、新类型、资源潜力

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石油学报 2024年第1期45卷 202-225页

作者：邓勇胡德胜朱继田刘国昌陈奎童传新张道军徐新德满勇游君君满晓吴云鹏周刚张建新油气资源与工程全国重点实验室中国石油大学(北京)北京102249 中海石油(中国)有限公司湛江分公司广东湛江524057

北部湾盆地是南海西部海域重要的原油勘探区和产区,具备多凹陷含油、多层系成藏、多种油气成藏模式等优势成藏条件,近年来在页岩油、潜山、岩性、深层油气、后备凹陷/洼陷等新领域、新类型油气勘探中取得了突破。为了落实北部湾盆地重... 详细信息

北部湾盆地是南海西部海域重要的原油勘探区和产区,具备多凹陷含油、多层系成藏、多种油气成藏模式等优势成藏条件,近年来在页岩油、潜山、岩性、深层油气、后备凹陷/洼陷等新领域、新类型油气勘探中取得了突破。为了落实北部湾盆地重要生烃凹陷的区域成藏规律,指导后续常规油气精细勘探开发及新领域、新类型油气勘探,对区域石油地质条件开展了研究,总结了成藏规律。研究结果表明,多期构造运动控制了北部湾盆地的构造演化和物质充填;古近系始新统流沙港组二段油页岩和半深湖亚相泥岩为盆地最重要的烃源岩,此外,在流沙港组三段、流沙港组一段、涠洲组二段也发育多套烃源岩;发育潜山储层和碎屑岩储层,形成了多源、多储、多盖的格局;凹陷区原生近源成藏、凹中断裂带/断隆带/陡坡带垂向成藏、斜坡区过路成藏、凸起/隆起区汇流成藏等多种成藏模式控制了北部湾盆地的多凹陷成藏;油气在多凹多带有序分布,油气的差异聚集控制了内气外油、深气浅油的油气分布特征,不同区带内的油气藏类型差异显著。在区域石油地质条件与成藏规律的指导下,从资源潜力、成藏条件、勘探开发程度综合分析,页岩油、潜山、岩性圈闭、深层油气、后备凹陷/洼陷是北部湾盆地未来勘探开发的重要领域。

关键词：北部湾盆地新领域新类型成藏条件资源潜力

The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis

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Asian Journal of Andrology 2022年第3期24卷 238-242页

作者： yong-Hong man Isabella Warmbrunn Ling Zhang Zhi-Bing Zhang Department of Occupational and Environmental Medicine School of Public HealthWuhan University of Science and TechnologyWuhan 430065China Center of Scientific Research and Experiment Nanyang Medical CollegeNanyang 473006China Department of Physiology Wayne State University School of MedicineDetroitMI 48201USA Department of Obstetrics and Gynecology Wayne State University School of MedicineDetroitMI 48201USA

Cilium,an organelle with a unique proteome and organization,protruding from the cell surface,generally serves as a force generator and signaling *** ciliogenesis,ciliary proteins are synthesized in cytoplasm and transported into cilia by intraflagellar transport(IFT)particles,where the inner counterparts undergo reverse *** homeostasis of IFT plays a key role in cilial structure assembly and signaling *** progress has been made on the mechanisms and functions of IFT;however,recent studies have revealed the involvement of IFT particle subunits in organogenesis and *** this review,we discuss new concepts concerning the molecular functions of IFT protein IFT25 and how its interactions with other IFT particle subunits are involved in mammalian development and fertility.

关键词： IFT25 cilium hedgehog signaling intraflagellar transport spermatogenesis

基于熵权AHP-FGCM的飞行进近着陆操纵绩效评估方法

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数学的实践与认识 2024年第7期54卷 228-236页

作者：陈农田陈凯韩亦杨满永政李俊辉中国民用航空飞行学院航空工程学院四川广汉618307

为客观量化评估飞行进近着陆操纵绩效,提出基于熵权层次模糊灰色聚类(AHP-FGCM)的飞行进近着陆操纵绩效综合评估方法.针对进近着陆阶段飞行操纵存在高风险因素耦合致险特征,结合进近着陆飞机俯仰、横侧及偏航飞行主操纵表征,通过采集与... 详细信息

为客观量化评估飞行进近着陆操纵绩效,提出基于熵权层次模糊灰色聚类(AHP-FGCM)的飞行进近着陆操纵绩效综合评估方法.针对进近着陆阶段飞行操纵存在高风险因素耦合致险特征,结合进近着陆飞机俯仰、横侧及偏航飞行主操纵表征,通过采集与分析某飞行训练单位真实飞机进近着陆飞行数据,依据飞行绩效监控咨询通告(AC),采用Delphi法确定升降速率、俯仰姿态、横侧加速度等7项指标作为进近着陆操纵绩效评估指标,利用熵权层次法确定组合权重,运用模糊灰色聚类对进近着陆飞行操纵绩效进行综合评估.实例评估结果与实际操纵绩效水平相吻合,证明了该方法客观有效性.

关键词：进近着陆熵权层次法模糊灰色聚类绩效评估飞行安全

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甘肃省安西县三峰山金矿地质特征与矿床成因浅析

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世界有色金属 2024年第6期 110-112页

作者：钱林武魏永满石为江甘肃省有色金属地质勘查局兰州矿产勘查院甘肃兰州730046

文章详细探讨和分析甘肃省安西县三峰山金矿地质特征,阐述了金矿矿体产状、形态及规模和控矿因素等。

关键词：三峰山地质特征矿床成因找矿标志

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Ten-year Time-trend Analysis of Dyslipidemia Among Adults in Wuhan

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Current Medical Science 2022年第5期42卷 1099-1105页

作者： man ZHANG Zheng-ce WAN yong-man LV Yuan-cheng HUANG Liu HU Hui XU Xiao-mei LEI Health management Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Dyslipidemia is associated with an increased risk of cardiovascular disease,the major cause of death in an aging *** study aimed to estimate the prevalence of dyslipidemia for the past decade among adults in Wuhan,*** We performed a serial cross-sectional study that recruited 705219 adults from the Health management Center of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology from 2010 to *** diagnosis of dyslipidemia was based on the 2016 Chinese Guidelines for the management of Dyslipidemia in *** effects and random effects models were applied to adjust the confounding variables(gender and age).Results The overall prevalence of dyslipidemia was 33.1%(46.2%in men and 14.7%in women)in *** prevalence of dyslipidemia was significantly increased over 10 years[from 28.6%(95%CI:28.2%–29.1%)in 2010 to 32.8%(95%CI:32.6%–33.1%)in 2019;.P<0.001],especially for hypo-high-density lipoprotein cholesterolemia[from 18.4%(95%CI:18.0%–18.8%)in 2010 to 24.5%(95%CI:24.3%–24.7%)in 2019;P<0.001].In 2019,the prevalence of dyslipidemia was higher in participants with comorbidities,including overweight/obesity,hypertension,diabetes,hyperuricemia,or chronic kidney disease,and dyslipidemia was the most significant among participants aged 30–39 *** This study demonstrated that dyslipidemia is on the rise in men,and more emphasis should be provided for the screening of dyslipidemia in young males for the primary prevention of cardiovascular and renal diseases.

关键词： dyslipidemia prevalence man cardiovascular disease

基于学生需求的高职教学设计与实践——以汽车空调系统教学内容为例

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广东水利电力职业技术学院学报 2024年第1期22卷 59-64页

作者：管卫华林用满杨旭志简浩钧广东农工商职业技术学院广州510640

为落实精准化教学,必须在充分把握学生学情与发展需求的基础上进行个性化教学设计。对此,以广东农工商职业技术学院2021届汽车营销与服务专业学生为例,以毕业生和用人单位需求为前提,根据学生知识技能基础、学习能力、兴趣爱好等学情进... 详细信息

为落实精准化教学,必须在充分把握学生学情与发展需求的基础上进行个性化教学设计。对此,以广东农工商职业技术学院2021届汽车营销与服务专业学生为例,以毕业生和用人单位需求为前提,根据学生知识技能基础、学习能力、兴趣爱好等学情进行教学设计,并在采用灵活多样教学方式的同时融入思政元素。不仅有效达成教学目标,全面提升学生职业素养;而且高效突破学习重难点,岗课赛证互融互通,激发学生学习动力,实施成效显著。

关键词：高职教学设计学生需求学情汽车空调系统

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棒柄杯伞的化学成分及其抗肿瘤活性研究

中国中药杂志 2024年第11期49卷 2947-2952页

作者：雷启军吕杰马国需孙照翠许旭东魏华石磊岭逯永满新疆大学新疆乌鲁木齐830046 新疆维吾尔自治区中药民族药研究所新疆乌鲁木齐830002 中国医学科学院北京协和医学院药用植物研究所北京100193 吉首大学湖南吉首416000

对棒柄杯伞进行化学成分研究,采用硅胶、ODS、Sephadex LH-20柱色谱和半制备液相等多种色谱学技术对棒柄杯伞乙醇提取物进行分离纯化,通过^(1)H-NMR、^(13)C-NMR以及质谱等多种波谱学方法共鉴定出6个化合物,分别为clavilactone L(1)、cl... 详细信息

对棒柄杯伞进行化学成分研究,采用硅胶、ODS、Sephadex LH-20柱色谱和半制备液相等多种色谱学技术对棒柄杯伞乙醇提取物进行分离纯化,通过^(1)H-NMR、^(13)C-NMR以及质谱等多种波谱学方法共鉴定出6个化合物,分别为clavilactone L(1)、clavilactone A (2)、clavilactone B (3)、clavilactone E (4)、clavilactone H (5)和clavilactone I (6)。其中,化合物1是1个新的苯并十元碳环混源萜。通过MTT法测定了化合物1~6的抗肿瘤活性,结果表明化合物1~6对人胃癌细胞(MGC-803)、人非小细胞肺癌细胞(A549)、宫颈癌细胞(HeLa)具有不同程度的增殖抑制作用。其中化合物1对人胃癌细胞MGC-803具有较显著的抑制活性,IC_(50)为11.76μmol·L^(-1)。

关键词：棒柄杯伞化学成分混源萜 clavilactone L 抗肿瘤活性

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