检索结果-南通市图书馆

Effects of traditional Chinese medicine on intestinal mucosal permeability in early phase of severe acute pancreatitis

引用

Chinese Medical Journal 2010年第12期123卷 1537-1542页

作者： CHEN Hong LI Fei JIA Jian-guo diao yong-peng LI Zong-xin SUN Jia-bang Department of General Surgery Xuan Wu Hospital of Capital Medical University Beijing 100053 China Department of Traditional Chinese Medicine Xuan Wu Hospital of Capital Medical University Beijing 100053 China

Background Traditional Chinese medicine has been used widely for many years in China to treat acute pancreatitis. We have investigated the effects of Dachengqi decoction on intestinal mucosal permeability and outcome in patients with severe acute pancreatitis （SAP）. Methods Forty patients with sustained SAP that required admission to the surgical intensive care unit were enrolled prospectively in the study. All of these patients were divided randomly into the Dachengqi decoction group （n=-20） and control group （n=-20） on admission. Intestinal permeability was assessed by measuring absorption of two metabolically inert markers, lactulose （L） and mannitol （M）, which were administered orally. Serum concentrations of endotoxin （lipopolysaccharide, LPS） and the ratio of lactulose to mannitol in urine （L/M） were detected in all patients. Results Compared with those in the control group, urinary L/M ratio decreased significantly in the Dachengqi decoction group on the 7th day after admission （P=0.001）. Also, serum concentrations of LPS were reduced on the 5th and 7th day after admission （P=-0.006, P=0.008, respectively）. Incidence of multiple organ dysfunction syndrome （MODS） and pancreatic infection was significantly lower in the Dachengqi decoction group compared with those in the control group （P=-0.038, P=-0.025, respectively）. Conclusion Dachengqi decoction may promote the recovery of intestinal mucosal permeability and decrease the incidence of MODS and pancreatic infection in patients with SAP.

关键词： medicine, Chinese traditional Dachengqi decoction pancreatitis, acute necrotizing bacterial translocation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

金融危机下我国体育用品企业的发展现状及机遇

引用

成都体育学院学报 2009年第10期35卷 20-22页

作者：刁永辉西南财经大学体育部四川成都610074

采用文献资料法和逻辑分析法,首先分析了我国体育用品企业在金融危机下外贸出口需求下降、国内消费需求降低和承担OEM业务面临的挑战及发展现状,然后分析了金融危机给体育用品企业带来的发展机遇。

关键词：金融危机体育用品企业发展现状机遇

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnostic performance comparisons of two commonly used multi-biomarker-based scores for detection of hepatocellular carcinoma in non-alcoholic fatty liver disease

引用

iLIVER 2024年第2期3卷 3-10页

作者： Wei Ouyang Ming-Da Wang Ming-Cheng Guan yong-Kang diao Li-Yang Sun Nan-Ya Wang Feng Shen Hong Zhu Tian Yang Hubei Cancer Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430070China Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200438China Department of Medical Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Cancer Center First Hospital of Jilin UniversityChangchun 130015China Department of Graduate Bengbu Medical CollegeBengbu 233099China

Background and aims:The ASAP and GALAD scores are widely used diagnostic models for detecting hepatocellular carcinoma(HCC),incorporating factors such as sex,age,alpha-fetoprotein(AFP),protein induced by vitamin K absence or antagonist-Ⅱ(PIVKA-Ⅱ),and lens culinaris agglutinin-reactive fraction of AFP(AFP-L3%).This study compares the diagnostic efficacy of the ASAP and GALAD scores in the early detection of HCC in patients with non-alcoholic fatty liver disease(NAFLD).Methods:NAFLD patients with and without HCC were recruited from 12 Chinese tertiary *** levels of AFP,PIVKA-II,and AFP-L3%were *** diagnostic accuracy of individual biomarkers,the ASAP score,and the GALAD score in detecting NAFLD-HCC at various stages was evaluated using receiver operating characteristic(ROC)curves and area under the curve(AUC)***:In a cohort of 147 NAFLD-HCC cases and 460 NAFLD controls,both the ASAP and GALAD scores outperformed individual biomarkers in detecting *** ASAP score demonstrated a high AUC of 0.910(sensitivity:80.3%,specificity:92.8%)for identifying NAFLD-HCC at all stages,surpassing AFP(AUC:0.716,P<0.001),PIVKA-II(AUC:0.849,P<0.001),AFP-L3%(AUC:0.663,P<0.001),and the GALAD score(AUC:0.882,P?0.014).Comparable results were observed for early-stage NAFLD-HCC and for detecting HCC in NAFLD patients with or without ***:The ASAP score,which excludes the AFP-L3%indicator,demonstrated superior performance in differentiating NAFLD-HCC compared to the GALAD score,suggesting its potential for early screening of HCC in NAFLD patients.

关键词： Hepatocellular carcinoma Nonalcoholic fatty liver disease Alpha-fetoprotein Lens culinaris agglutinin-reactive alpha-fetoprotein Protein induced by vitamin K absence or antagonist-Ⅱ ASAP score GALAD score Early diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重组腺相关病毒载体诱导的天然免疫反应及机制

引用

微生物学报 2012年第5期52卷 550-557页

作者：刁勇许瑞安分子药物教育部工程研究中心华侨大学分子药物学研究所泉州362021

重组腺相关病毒(rAAV)已成为基因治疗领域应用最广泛的载体之一。临床前研究显示其具有很高的安全性,但人体免疫毒性仍是制约其临床疗效的关键,因此有关rAAV免疫机制的研究成为近期热点。尽管天然免疫在获得性免疫反应中发挥重要作用,但... 详细信息

重组腺相关病毒(rAAV)已成为基因治疗领域应用最广泛的载体之一。临床前研究显示其具有很高的安全性,但人体免疫毒性仍是制约其临床疗效的关键,因此有关rAAV免疫机制的研究成为近期热点。尽管天然免疫在获得性免疫反应中发挥重要作用,但与rAAV有关的天然免疫研究过去一直未被重视。直到最近,才确认有至少3种人体细胞(树突状细胞、巨噬细胞和内皮细胞)参与了rAAV的天然免疫,作用机制为可识别载体基因组的TLR9或病毒衣壳TLR2所介导,NF-κB或干扰素调节因子(IRFs)信号通路被激活,导致各种炎性因子及I型干扰素的大量表达。自身互补型rAAV诱导的TLR9依赖性天然免疫较单链rAAV更为强烈。本文重点对近期发现的激活天然免疫反应的宿主与rAAV的相互作用、涉及的信号通路、天然免疫对获得性免疫以及转基因表达的影响进行综述。

关键词：重组腺相关病毒基因治疗免疫信号通路

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of HbA1c on short-term blood pressure variability in type 2 diabetic patients with diabetic nephropathy

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 1033-1040页

作者： Fang LIU Min WU Yan-huan FENG Hui ZHONG Tian-lei CUI You-qun HUANG Ya-ping LIANG yong-shu diao Li ZANG Ling LI Jing ZANG Hong-yu QIU Song-min HUANG Ping FU Division of Nephrology West China Hospital of Sichuan University

The aim of this study was to understand the characteristics of blood pressure （BP） variability in subjects with diabetic nephropathy （DN）, and identify the probable predictors affecting BP variability. Fifty-one chronic kidney disease （CKD）-hypertensive patients without diabetes （NDN group） and sixty type 2 diabetic patients with overt DN （DN group） were enrolled in this study. The values of short-term BP variability were obtained from 24 h ambulatory BP monitoring （ABPM）. Variance analysis or nonparametric analysis revealed that 24-h systolic BP variability and night- time systolic BP variability of the DN group were significantly higher than those of the NDN group [（12.23±3.66） vs. （10.74±3.83） mmHg, P〈0.05; （11.23±4.82） vs. （9.48±3.69） mmHg, P〈0.05]. Then the patients of the DN group were divided into two groups according to glycated hemoglobin （HbAlc） level： Group A （HbA1c〈7%） and Group B （HbA1c〉7%）, and the t-test showed that patients in Group B had larger 24-h diastolic, daytime diastolic, and nighttime systolic/diastolic BP variability compared with Group A. In the DN group, partial correlation analysis revealed that HbAlc exhibited a strong association with 24-h diastolic, daytime diastolic, nighttime systolic and diastolic BP vari- ability （P〈0.001, P〈0.001, P〈0.05, and P〈0.001, respectively）. Taken together, larger short-term BP variability was detected in hypertensive type 2 diabetic patients with overt nephropathy and renal insufficiency. It may imply that the optimal BP variability level could benefit from a better glycaemic control.

关键词： Short-term blood pressure variability Diabetic nephropathy Glycated hemoglobin (HbAlc) Hypertension Glycaemic control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

雷贝拉唑钠的合成

引用

中国医药工业杂志 2010年第1期41卷 9-10页

作者：邱飞刁勇华侨大学分子药物学研究所福建泉州362021 分子药物教育部工程研究中心福建泉州362021

雷贝拉唑钠（rabeprazole sodium，1），化学名为2-[[[4-（3-甲氧基丙氧基）-3-甲基-2-吡啶基]-甲基]亚磺酰基]-1H-苯并咪唑钠盐，由日本卫材开发，1998年首次在日本上市，临床用于治疗十二指肠溃疡与胃溃疡、反流性食管炎等消化系统疾... 详细信息

雷贝拉唑钠（rabeprazole sodium，1），化学名为2-[[[4-（3-甲氧基丙氧基）-3-甲基-2-吡啶基]-甲基]亚磺酰基]-1H-苯并咪唑钠盐，由日本卫材开发，1998年首次在日本上市，临床用于治疗十二指肠溃疡与胃溃疡、反流性食管炎等消化系统疾病。本品起效快、抑酸效果好，可24h持续抑酸、缓解症状。

关键词：钠盐合成十二指肠溃疡消化系统疾病苯并咪唑甲氧基磺酰基吡啶基

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surgical treatment of multivessel lesions in Takayasu arteritis

引用

Chinese Medical Journal 2013年第24期126卷 4804-4805页

作者： diao yong-peng LIU Chang-wei SONG Xiao-jun CHEN Yue-xin GUO Li-long LIAN Li-shan LI yong-jun Department of Vascular Surgery Peking Union Medical CollegeHospital Peking Union Medical College Chinese Academy ofMedical Science Beijing 100730 China

Takayasu arteritis （TA） is a chronic progressive nonspecific vasculitis that involves the aorta and itsmain branches, resulting in luminal stenosis in the large vessels. Steroid therapy is the foundation for TA treatment and the guarantee of surgery. When a patient presents with uncontrolled symptoms, surgical treatment is the only measure that may be adopted to prevent greater risk to life. However, surgical repair for extensive arteriopathy requires an ingenious design to avoid morbidity in response to the complexity of the pathophysiology of TA. A 41-year-old woman presented with pulselessness, recurrent dizziness, and visual disturbance for the past 23 years. The patient had been diagnosed with TA 13 years ago and had received steroid therapy. However, the symptoms of dizziness and visual disturbance had increased in intensity and duration over the last 2 years. Upon admission, physical examination revealed that pulse in both arms were absent. Her blood pressure was 98/63 mmHg （1 mmHg=0.133 kPa） in the left arm,

关键词： Takayasu arteritis surgical procedures, vascular grafting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacy of exercises in improving the quality of life for chronic kidney disease patients without dialysis

引用

Chinese Medical Journal 2020年第14期133卷 1738-1740页

作者： Deng-Yan Ma Chong-Cheng Chen yong-Shu diao Kun Yang Yi Li Steve Salerno Ping Fu Department of Nephrology/West China School of Nursing West China HospitalSichuan UniversityChengduSichuan 610041China Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Biostatistics University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic kidney disease(CKD)is rapidly becoming a major public disease burden,affecting approximately 11%to 13%of the general population.[1]Its related treatments severely influence the physical,psychological,and social well-being of patients by restricting their daily *** has been shown that exercise may have multiple benefits for patients with CKD in terms of improving their physical activity,enhancing cardio-respiratory function,and promoting quality of life(QoL).

关键词： patients dialysis kidney

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

N-(Z)-9-十八烯基-2-丙磺酰胺对2型糖尿病小鼠胰岛素抵抗的影响及其机制

引用

药学学报 2017年第12期52卷 1871-1876页

作者：任桐林辰曦刁勇华侨大学生物医学学院福建泉州362021 厦门大学附属中山医院福建厦门361102

探索新化合物N-(Z)-9-十八烯基-2-丙磺酰胺(N15)对2型糖尿病(T2DM)胰岛素抵抗小鼠的影响并探讨其可能作用机制。采用链脲佐菌素(STZ)连续小剂量腹腔注射诱导T2DM小鼠模型,N15(50、100和200mg·kg^(-1)·d^(-1))和吡格列酮(6 mg·kg^(-1)... 详细信息

探索新化合物N-(Z)-9-十八烯基-2-丙磺酰胺(N15)对2型糖尿病(T2DM)胰岛素抵抗小鼠的影响并探讨其可能作用机制。采用链脲佐菌素(STZ)连续小剂量腹腔注射诱导T2DM小鼠模型,N15(50、100和200mg·kg^(-1)·d^(-1))和吡格列酮(6 mg·kg^(-1)·d^(-1))连续灌胃给药6周,期间分别对小鼠空腹血糖(FBG)、胰岛素(FIns)和胰岛素抵抗指数(HOMA-IR)进行测定比较;并于末次给药后测定各组小鼠葡萄糖耐量(OGTT)和胰岛素耐量(IPITT);通过Western blot对能量代谢关键蛋白Akt、AMPK和Glut4加以分析。结果表明,N15可显著降低模型小鼠FBG、Fins和HOMA-IR水平(P0.05)。上述结果表明,新型化合物N15具有改善2型糖尿病胰岛素抵抗的功效,其机制可能与增加肝内胰岛素受体调节及促使磷脂酰肌醇3磷酸磷酸化相关。

关键词： N-(Z)-9-十八烯基-2-丙磺酰胺糖尿病胰岛素抵抗蛋白激酶B 葡萄糖转运蛋白4

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Salvianolic acid B increases recombinant adeno-associated virus transduction through redirecting trafficking pathways and stabilizing perinuclear accumulations

引用

中国药理学与毒理学杂志 2018年第4期32卷 274-274页

作者： Jing CAI Xue MI Shi-jie CAI yong diao School of Medicine Huaqiao University Quanzhou China School of Biomedical Science Huaqiao University Quanzhou China Molecular Oncology Laboratories Department of Oncology Weather all Institute of Molecular Medicine University of Oxford Jo

OBJECTIVE To screen small molecule compounds from traditional Chinese medicine that can enhance recombinant adeno-associated virus(rAAV) *** Recombinant adeno-associated virus(rAAV) has been established as a powerful tool for in vivo gene transfer and achieved much promise in gene therapy ***,widespread clinical use has been limited by transduction *** the current study,we screened a panel of small molecule compound from traditional Chinese medicine focused on AAV intracellular trafficking process and found salvianolic acid B can significantly enhance rAAV2 *** Salvianolic acid B caused a *** increase in rAAV2 transduction regardless of vector dose,genome architecture,and over a broad range of cell line from various cell type and species(HEK293,HeLa,HepG2,Huh-7,CHO-K1,LO-2).Salvianolic acid B treatment redirected rAAV2 particles toward large vesicles positive for late endosomal(Rab7) and lysosomal(LAMP1) ***,salvianolic acid B acted to increase accumulation of viral particles at the perinuclear *** In summary,our results suggest that *** acid B redirects rAAV2 toward more productive trafficking pathways and stabilizes perinuclear accumulations of vectors,facilitating productive nuclear trafficking.

关键词：重组腺病毒中药治疗方法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：