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Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

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Neural Regeneration Research 2023年第7期18卷 1553-1562页

作者： Jin-Yun Zhao Xiao-Long Sheng Cheng-Jun Li Tian Qin Run-Dong He Guo-Yu Dai yong cao Hong-Bin Lu Chun-Yue Duan Jian-Zhong Hu Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Hunan Engineering Research Center of Sports and Health ChangshaHunan ProvinceChina Department of Sports Medicine Research Centre of Sports MedicineXiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Treatment with metformin can lead to the recovery of pleiotropic biological activities after spinal cord injury.However,its effect on spinal cord injury in aged mice remains unclear.Considering the essential role of angiogenesis during the regeneration process,we hypothesized that metformin activates the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway in endothelial cells,thereby promoting microvascular regeneration in aged mice after spinal cord injury.In this study,we established young and aged mouse models of contusive spinal cord injury using a modified Allen method.We found that aging hindered the recovery of neurological function and the formation of blood vessels in the spinal cord.Treatment with metformin promoted spinal cord microvascular endothelial cell migration and blood vessel formation in vitro.Furthermore,intraperitoneal injection of metformin in an in vivo model promoted endothelial cell proliferation and increased the density of new blood vessels in the spinal cord,thereby improving neurological function.The role of metformin was reversed by compound C,an adenosine monophosphate-activated protein kinase inhibitor,both in vivo and in vitro,suggesting that the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway likely regulates metformin-mediated angiogenesis after spinal cord injury.These findings suggest that metformin promotes vascular regeneration in the injured spinal cord by activating the adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway,thereby improving the neurological function of aged mice after spinal cord injury.

关键词： adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway angiogenesis aged mice compound C metformin spinal cord injury

A cache-friendly sampling strategy for texture-based volume rendering on GPU

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Visual Informatics 2017年第2期1卷 92-105页

作者： Junpeng Wang Fei Yang yong cao The Ohio State University ColumbusOH 43210USA NVIDIA Semiconductor Technology(Shanghai)Co. Ltd.ShanghaiChina The Boeing Company North CharlestonSC 29418USA

The texture-based volume rendering is a memory-intensive algorithm.Its performance relies heavily on the performance of the texture cache.However,most existing texture-based volume rendering methods blindly map computational resources to texture memory and result in incoherent memory access patterns,causing low cache hit rates in certain cases.The distance between samples taken by threads of an atomic scheduling unit(e.g.a warp of 32 threads in CUDA)of the GPU is a crucial factor that affects the texture cache performance.Based on this fact,we present a new sampling strategy,called Warp Marching,for the ray-casting algorithm of texture-based volume rendering.The effects of different sample organizations and different thread-pixel mappings in the ray-casting algorithm are thoroughly analyzed.Also,a pipeline manner color blending approach is introduced and the power of warp-level GPU operations is leveraged to improve the efficiency of parallel executions on the GPU.In addition,the rendering performance of the Warp Marching is view-independent,and it outperforms existing empty space skipping techniques in scenarios that need to render large dynamic volumes in a low resolution image.Through a series of micro-benchmarking and real-life data experiments,we rigorously analyze our sampling strategies and demonstrate significant performance enhancements over existing sampling methods.

关键词： Warp marching Texture cache hit rate GPU Volume rendering

Towards a bright future： polymer solar cells with power conversion efficiencies over 10%

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Science China Chemistry 2017年第5期60卷 571-582页

作者： Zhicheng Hu Lei Ying Fei Huang yong cao State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of Technology

Remarkable progress Indeed,in high-performance power polymer solar cells demonstrates their great potential for practical groups,applications which in the near future.the conversion efficiencies over 10%have been and reported device by many research are achieved review,through rational optimization recent of light-harvesting of materials,interfaces solar processing technologies.In this mini we summarized molecular the progress highly efficient polymer cells,with specifically concern on successful strategies and of rational design of electron-donating and electron-accepting materials,elaborative interfacial engineering,reasonable device architectures.

关键词： polymer solar cells donor/acceptor design interface engineering device engineering

“十四五”时期药品安全监管相关政策分析与比较

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中国新药杂志 2024年第7期33卷 644-650页

作者：唐湘燕曹永芳何辉国家药品监督管理局药品审评中心北京100061

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《... 详细信息

人民健康是民族昌盛和国家强盛的重要标志。为保障人民健康、促进医药产业走高质量发展道路,我国先后发布了“十四五”时期的规划、纲要,针对国家药品安全、医药工业、中医药发展、市场监管等方面提出一系列重要政策和措施。本文围绕《“十四五”国家药品安全及促进高质量发展规划》,系统梳理相关国家部委针对“十四五”所发布有关药品安全监管的相关内容,并对其进行分析和比较,以期更好地理解国家层面对药品安全监管政策的整体规划和制定脉络。

关键词：药品安全 “十四五”规划高质量发展监管现代化

Special issue on recent progress in organic electronics and photonics

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Science China Chemistry 2017年第4期60卷 431-432页

作者： Fei Huang yong cao Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510641 China

Organic electronic and photonic devices have received tremendous attention from both academia and industry because of their great promise for practical use as organic light-emitting diodes(OLEDs),organic solar cells(OSCs),organic field-effect transistors(OFETs),and chemical and biological sensors.During the past decade,remarkable pro-

关键词：电子学有机发光二极管光子学有机太阳能电池场效应晶体管有机电子器件功率转换效率生物传感器

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血管内皮细胞体细胞突变与脑血管畸形

首都医科大学学报 2024年第3期45卷 379-384页

作者：赵绍智曹勇首都医科大学附属北京天坛医院神经外科北京100070

脑血管畸形(cerebral vascular malformations,CVMs)是指脑血管在胚胎时期因各种内、外界因素的影响,导致基因、细胞因子和蛋白等发生改变而引起的脑局部血管数量和结构的非肿瘤性发育异常所导致的疾病。血管内皮细胞基因突变作为关键... 详细信息

脑血管畸形(cerebral vascular malformations,CVMs)是指脑血管在胚胎时期因各种内、外界因素的影响,导致基因、细胞因子和蛋白等发生改变而引起的脑局部血管数量和结构的非肿瘤性发育异常所导致的疾病。血管内皮细胞基因突变作为关键始动因素之一,在CVMs的发生发展中起到了重要作用。了解CVMs中存在的内皮细胞突变对于预防其发生发展,开发靶向药物及指导临床治疗具有重要意义。本文将针对血管内皮细胞体细胞突变在CVMs中的发现、临床相关性及潜在的治疗意义进行综述。

关键词：脑血管畸形内皮细胞体细胞突变靶向治疗

Microstructures and Properties of Biomedical Mg-Zn-Sn-Zr Rolled Alloys

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 766-773页

作者：周生刚 ZHANG Daxin XU Yang DUAN Jihao LI Tao LIU Junfeng WANG Peng 曹勇 Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The as-cast Mg-2.0Zn-1.5Sn-xZr(x=0,0.4,0.6,0.8,1.0 wt%)alloy was rolled with the pressure less than 5%each time.The microstructure,mechanical properties,corrosion properties and biocompatibility of the alloy were investigated.The microstructure of the alloy was observed and analyzed by scanning electron microscope,and the tensile test was carried out by universal tensile machine.The corrosion resistance of the alloy in Hank's solution was studied by hydrogen evolution experiment and electrochemical test,and the biocompatibility of the alloy was tested by L929 cells.The results show that Mg-2Zn-1.5Sn-xZr alloy has excellent mechanical properties.The elongation of Mg-2Zn-1.5Sn-xZr alloy decreases with the increase of Zr content,but the tensile strength first increases and then decreases with the increase of Zr concentration.When the Zr content is 0.8 wt%,the maximum tensile strength of the alloy is 235 MPa.The results of hydrogen evolution experiment and electrochemical analysis show that the corrosion resistance of the alloy is the best when the Zr content is 0.8 wt%,and all the five alloys have high biocompatibility.In conclusion,the rolled alloy has good properties and has broad application prospects in the field of biomaterials.

关键词： magnesium alloy corrosion performance mechanical properties biocompatibility

Exploiting quasi-one-dimensional confinement for proficient hydrogen production from formic acid at room temperature

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Journal of Energy Chemistry 2020年第10期29卷 205-213页

作者： Tao Jiang Peng Lu Meng-Jiao Xu Jian-Dong Lin yong-Mei Liu yong cao He-yong He Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Department of ChemistryFudan UniversityShanghai 200433China

We describe herein that the quasi-one-dimensional confinement effect of functionalized nanoporous supports is particularly advantageous for boosting formic acid(FA)dehydrogenation efficiency over palladium nanoparticles(NPs).Benefiting from their unique structural merits that lead to significant lowering of the entropic barrier for FA activation,the Pd NPs interiorly located on the amino-modified MCM-41 offer the promise of more than an order of magnitude speedup of the initial activity in H2 production from FA over their exterior analogs.Under mild and additive-free conditions,ultrafine Pd NPs confined in aminomodified MCM-41 channels exhibit an initial turnover frequency as high as 46,677 h-1 and a turnover number up to 1,060,000 at 60℃.In conjunction with the enhancement and robust performance for efficient regeneration of FA via CO2 hydrogenation,the presented approach greatly contributes to the development of FA-based hydrogen storage and related technologies as viable means of enabling sustainable future energy prospects.

关键词： Confinement effect Formic acid Heterogeneous catalysis Hydrogen storage

基于WRF-LES模式的大气边界层近地风场精细化模拟研究

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上海交通大学学报 2024年第2期58卷 220-231页

作者：刘达琳陶韬曹勇周岱韩兆龙上海交通大学船舶海洋与建筑工程学院上海200240 安徽工程大学建筑工程学院安徽芜湖241060

台风等极端气象灾害对工程结构安全造成严重威胁,研究近地面大气边界层精细化模拟对于土木工程具有重要应用价值.数值天气预报系统(WRF)中的大涡模拟(LES)模块具有参数方案多、精度高等优点,适用于近地面风场精细化模拟,但数值天气预报... 详细信息

台风等极端气象灾害对工程结构安全造成严重威胁,研究近地面大气边界层精细化模拟对于土木工程具有重要应用价值.数值天气预报系统(WRF)中的大涡模拟(LES)模块具有参数方案多、精度高等优点,适用于近地面风场精细化模拟,但数值天气预报-大涡模拟(WRF-LES)精细化模拟效果与参数设置密切相关.寻求适用于精细化模拟近地面风场的参数设置,选用WRF-LES模式中的几种次网格模型和空间差分格式,采用较细密的网格分辨率,进行理想大气边界层模拟.对比平均风速剖面、湍流强度剖面和功率谱等风场特性,讨论关键参数对近地面风场模拟精度的影响,确定合适的参数设置.研究表明:对次网格模型,非线性回波散射和各向异性(NBA1)模型可有效改善近地面风场模拟精度;对网格方案,在计算域底部不均匀加密垂直网格可更好地描述近地面风场空间分布特征,有效减小计算资源;对空间差分格式,偶数阶差分相较奇数阶差分格式可捕获更小尺度湍流结构.所提出的WRF-LES模式参数方案,可为精细化模拟近地面风场和台风边界层提供技术参考.

关键词：次网格模型网格分辨率空间差分格式数值天气预报-大涡模拟