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Literature-based analysis on relationship of symptoms,drugs and therapies in treatment of intestinal diseases

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Journal of Traditional Chinese Medicine 2014年第1期34卷 106-114页

作者： Luan Gao jian Wang yong deng Fenggang Li Sihua Gao Traditional Chinese Medicine Clinical College of Anhui Traditional Chinese Medicine University Department of Automation and Systems Technology of Aalto University Management College of Hefei Industrial University Basic Medicine College of BeijingTraditional Chinese Medicine University

OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal *** also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid ***:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal ***:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the *** these agents,Kuxingren(Semen Armeniacae Amarum)was used most *** Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red *** Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key ***:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,a

关键词： Lung being connected with large intes-tine Intestinal diseases Information storage and re-trieval Data mining

Extended state observer-based control with an adjustable parameter for a large ground-based telescope

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Research in Astronomy and Astrophysics 2021年第12期21卷 509-518页

作者： Xiao-Xia Yang yong-Ting deng Bin Zhang jian-Li Wang Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

The high-precision requirements will always be constrained due to the complicated operating conditions of the ground-based telescope. Owing to various internal and external disturbances, it is necessary to study a control method, which should have a good ability on disturbance rejection and a good adaptability on system parameter variation. The traditional proportional-integral(PI) controller has the advantage of simple and easy adjustment, but it cannot deal with the disturbances well in different situations. This paper proposes a simplified active disturbance rejection control law, whose debugging is as simple as the PI controller, and with better disturbance rejection ability and parameter adaptability. It adopts a simplified second-order extended state observer(ESO) with an adjustable parameter to accommodate the significant variation of the inertia during the different design stages of the telescope. The gain parameter of the ESO can be adjusted online with a recursive least square estimating method once the system parameter has changed significantly. Thus, the ESO can estimate the total disturbances timely and the controller will compensate them accordingly. With the adjustable parameter of the ESO, the controller can always achieve better performance in different applications of the telescope. The simulation and experimental verification of the control law was conducted on a 1.2-meter ground based telescope. The results verify the necessity of adjusting the parameter of the ESO, and demonstrate better disturbance rejection ability in a large range of speed variations during the design stages of the telescope.

关键词： extended state observer large ground based telescope recursive least square disturbance rejection

Smelting practice of scrap addition in blast furnace and theoretical analysis of cost saving

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Journal of Iron and Steel Research International 2020年第9期27卷 1005-1010页

作者： yong deng jian-liang Zhang Ran Liu Ke-xin Jiao Bing-ji Yan Institute for Metallurgical Engineering and Technology North China University of Science and TechnologyTangshan 063210HebeiChina College of Metallurgy and Energy Ministry of Education Key Laboratory of Modern Metallurgy TechnologyNorth China University of Science and TechnologyTangshan 063210HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Iron and Steel Soochow UniversitySuzhou 215137JiangsuChina

The recycling of scrap has attracted more attention in recent years,and scrap can be used as iron-bearing material to smelt hot *** smelting practice of blast furnace(BF)with scrap addition in China was investigated,with the types of scrap being small pieces of scrap,such as crushed materials,light and thin materials,and small compacts which were easy to be added into *** higher productivity of BFs with scrap addition was observed compared with that of BFs without scrap addition at the same volume,and the positive correlation between production increase rate and addition amount of scrap was *** reducing agent rate of most BFs with scrap addition was lower than the average reducing agent rate at the same volume,while the gas utilization of BFs with scrap addition would not be reduced *** theoretical analysis of cost saving was carried out as well,and the results indicated that the cost could be saved by scrap *** melting and carburizing were the two main processes of scrap in BF,in which three steps were involved in the melting process of *** amount of carburization depended on the carbon content of hot metal in hearth and the original carbon content in *** calculation showed that the coke rate could be reduced by 27 kg with 100 kg scrap addition per ton of hot metal,and the saving cost was decided by the amount of scrap and the actual situation of BF.

关键词： Blast furnace Scrap addition Smelting practice Cost saving

CaO_(2)预处理耦合ZVI强化含油餐厨垃圾厌氧消化

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中国给水排水 2024年第1期40卷 90-96页

作者：程晓格王琬邓冠勇苏涵钰钱佳鑫王建树贵州大学化学与化工学院贵州贵阳550025

餐厨垃圾中油脂降解困难,易导致厌氧消化失败。为促进含油餐厨垃圾的厌氧消化过程,采用过氧化钙(CaO_(2))预处理和添加零价铁(ZVI)耦合策略,并优化投加量。结果表明,CaO_(2)预处理最优投加量为0.05 g/gVS,最佳预处理时间为24 h。预处理... 详细信息

餐厨垃圾中油脂降解困难,易导致厌氧消化失败。为促进含油餐厨垃圾的厌氧消化过程,采用过氧化钙(CaO_(2))预处理和添加零价铁(ZVI)耦合策略,并优化投加量。结果表明,CaO_(2)预处理最优投加量为0.05 g/gVS,最佳预处理时间为24 h。预处理后油脂降解率提高了300.06%,溶解性蛋白质和多糖的浓度分别提高了2.87和1.95倍。添加3 g/L的ZVI使累积产气量达368.92 mL/gVS,较空白组提高了95.92%,辅酶F420和电子传递体系(ETS)活性分别提高了46.93%和105.13%。CaO_(2)预处理促进了有机质的降解,ZVI提高了系统稳定性和相关酶活性。CaO_(2)预处理和添加ZVI耦合策略可有效提高含油餐厨垃圾的厌氧消化产气性能。

关键词：餐厨垃圾油脂过氧化钙(CaO_(2)) 零价铁(ZVI) 厌氧消化

应用决策树和logistic回归模型分析胃肠道穿孔修补术后手术部位感染的影响因素

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中国感染控制杂志 2024年第7期23卷 826-832页

作者：胡登敏胥润李建艾余绵阳市第三人民医院(四川省精神卫生中心)普通外科四川绵阳621000 绵阳市第三人民医院(四川省精神卫生中心)肾病内科四川绵阳621000

目的应用决策树和logistic回归模型分析胃肠道穿孔修补术后并发手术部位感染(SSI)的影响因素。方法选取2018年1月—2023年1月于绵阳市某医院进行胃肠道穿孔修补术的患者为研究对象,收集患者临床资料,根据术后是否发生SSI将患者分为SSI(+... 详细信息

目的应用决策树和logistic回归模型分析胃肠道穿孔修补术后并发手术部位感染(SSI)的影响因素。方法选取2018年1月—2023年1月于绵阳市某医院进行胃肠道穿孔修补术的患者为研究对象,收集患者临床资料,根据术后是否发生SSI将患者分为SSI(+)组(n=41)和SSI(-)组(n=322)。使用单因素和多因素logistic回归分析胃肠道穿孔修补术后并发SSI的影响因素,并建立相关决策树预测模型。结果363例胃肠道穿孔修补术患者术后发生SSI 41例,发病率为11.29%。单因素分析结果显示,两组患者身体质量指数(BMI)、清蛋白水平、术前应用抗菌药物、术前腹痛时间和手术时间比较,差异均有统计学意义(均P<0.05)。多因素logistic回归分析显示,BMI较高(OR=2.059,95%CI:1.103~3.842)、清蛋白水平<35 g/L(OR=2.761,95%CI:1.312~5.811)、术前腹痛时间≥24 h(OR=3.589,95%CI:1.659~7.763)和手术时间≥2 h(OR=3.314,95%CI:1.477~7.435)是胃肠道穿孔修补术后患者并发SSI的独立危险因素(P<0.05),术前应用抗菌药物是其保护因素(OR=0.338,95%CI:0.166~0.690,P<0.05)。基于上述因素建立预测胃肠道穿孔修补术后患者并发SSI风险的决策树模型。模型验证结果显示,受试者工作特征曲线下面积(AUC)为0.811(95%CI:0.794~0.825)。结论胃肠道穿孔修补术后患者并发SSI的危险因素包括BMI较高、清蛋白水平<35 g/L、术前腹痛时间≥24 h和手术时间≥2 h,保护因素为术前应用抗菌药物,基于影响因素构建的决策树模型对胃肠道穿孔修补术后患者并发SSI风险具有良好的预测能力。

关键词：胃肠道穿孔修补术手术部位感染危险因素 logistic回归决策树

Nonlinear perturbation developments in flow around a vibrating cylinder

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Journal of Hydrodynamics 2021年第6期33卷 1129-1138页

作者： jian deng Xuerui Mao State Key Laboratory of Fluid Power and Mechatronic Systems Department of MechanicsZhejiang UniversityHangzhou 310027China Faculty of Engineering University of NottinghamNottinghamUK

We investigate the flow around a circular cylinder vibrating with a prescribed magnitude and frequency at Reynolds number *** Navier-stokes equations and the adjoint equations are solved to search for the 3-D nonlinear optimal initial perturbation,which is amplified by the attached shear via the Orr mechanism and then activates wake *** energy growth and the spanwise distributions of the nonlinear optimal perturbation vary significantly with the initial phase to introduce the *** the initial perturbation energy increases,linear amplification,nonlinear saturation and nonlinear growth are sequently *** last one is owing to the generation of a spanwise homogeneous mode,which modifies the pressure distributions on the cylinder surface and induces an extra lift ***,at all the initial phases,this force is opposite to the acceleration of the cylinder,illustrating the potential to reduce the magnitude of vibration.

关键词： Vortex induced vibration nonlinear optimal perturbation Orr mechanism

基于ChineseBERT的中文知识图谱问答方法

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科学技术与工程 2024年第23期24卷 9947-9956页

作者：邓健志方雨桐杨燕桂林理工大学地球科学学院桂林541004 桂林理工大学广西嵌入式技术与智能系统重点实验室桂林541004 桂林理工大学物理与电子信息工程学院桂林541004

为了解决中文文字字形繁杂和语义信息复杂导致问答性能不佳的问题,提出了一种名为ChineseBERT-KBQA的方法,利用中文预训练语言模型ChineseBERT作为文本的语义嵌入层且融合了字形和拼音信息,从而提升传统语义解析方法在实体提及识别和关... 详细信息

为了解决中文文字字形繁杂和语义信息复杂导致问答性能不佳的问题,提出了一种名为ChineseBERT-KBQA的方法,利用中文预训练语言模型ChineseBERT作为文本的语义嵌入层且融合了字形和拼音信息,从而提升传统语义解析方法在实体提及识别和关系预测子任务上的性能。具体而言,提出的两个模型分别是基于ChineseBERT-CRF的实体提及识别模型和基于ChineseBERT-TextCNN-Softmax的关系预测模型,这两个模型综合提高了对中文文本的语义理解能力。最后,再结合子任务间的相关信息,进行最终的答案预测,并且使用教育问答数据集MOOC Q&A和开放域问答数据集NLPCC2018进行实验,实验结果表明该方法在中文知识图谱问答中的有效性和准确性。

关键词：知识图谱 BERT 智能问答深度学习预训练语言模型

胫骨近端双平面截骨结合关节镜技术治疗合并内侧半月板损伤的膝关节内翻性骨性关节炎

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中国内镜杂志 2020年第4期26卷 35-39页

作者：李晨肖雷李俊肖嘉堃邹凌峰邓雪强易轩邓斌斌邓建勇郝亮南昌大学第二附属医院骨科江西南昌330006

目的探讨胫骨近端双平面截骨结合关节镜技术治疗膝关节内翻性骨性关节炎(OA)的初步临床效果。方法纳入2016年11月-2018年9月30例进行内侧胫骨近端撑开截骨结合关节镜治疗的膝关节内翻畸形OA患者,并采用美国膝关节协会评分(KSS)、疼痛视... 详细信息

目的探讨胫骨近端双平面截骨结合关节镜技术治疗膝关节内翻性骨性关节炎(OA)的初步临床效果。方法纳入2016年11月-2018年9月30例进行内侧胫骨近端撑开截骨结合关节镜治疗的膝关节内翻畸形OA患者,并采用美国膝关节协会评分(KSS)、疼痛视觉模拟评分(VAS)和股胫角(FTA)等指标对疗效进行评估与分析。结果27例患者获得随访,随访时间12~34个月,平均随访时间20.6个月,X线片复查示所有患者的膝内翻畸形得到纠正,截骨均愈合,愈合时间3~8个月,平均3.5个月。所有患者切口均Ⅰ期愈合,无伤口感染。末次随访术后KSS评分(88.42±3.27)分、FTA(176.88±3.36)°和VAS评分(1.48±0.89)分与术前比较,差异均有统计学意义(P<0.05)。结论胫骨近端双平面截骨结合关节镜技术能有效纠正力线,缓解关节疼痛,改善关节功能。

关键词：膝关节骨性关节炎胫骨近端双平面截骨术关节镜技术

基于网络药理学和转录组学及实验验证探究菲牛蛭冻干粉抗高尿酸血症的作用机制

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中国现代应用药学 2024年第12期41卷 1671-1681页

作者：董云怡刘艺柯邓晓琳梁健广西大学医学院南宁530004

目的基于网络药理学和转录组学的方法,结合动物实验验证,探究菲牛蛭冻干粉(Poecilobdella manillensis lyophilizedpowder,以下简称SZ)抗高尿酸血症(hyperuricemia, HUA)的多靶点作用机制。方法利用Symmap、SwissTargetPrediction、Pharmmapper数据库,获得SZ潜在活性成分以及对应的靶点;通过Gene Cards和OMIM数据库获得HUA相关靶点;取交集映射得到SZ和HUA的共同靶点,利用Cytoscape 3.9.0软件构建药物成分-疾病靶点相互作用网络,结合STRING数据库构建蛋白相互作用网络并筛选核心靶点;使用DAVID数据库对交集靶点进行GO生物功能注释和KEGG通路富集分析。采用氧嗪酸钾联合高嘌呤饮食构建HUA小鼠模型,通过生化指标检测、ELISA法探究SZ对HUA小鼠的影响,qRT-PCR法验证RNA-Seq及网络药理学富集分析结果。结果网络药理学分析表明SZ中有11种主要生物活性物质,72种潜在靶点参与治疗HUA,涉及多种生物过程和不同的信号通路。实验表明,SZ通过抑制黄嘌呤氧化酶活性,显著降低了HUA小鼠的血清尿酸、肌酐和尿素氮水平。SZ还降低了URAT1水平,同时提高了ABCG2的水平。RNA测序分析发现,模型组与治疗组、对照组与模型组和对照组与治疗组分别有112、536和107个差异表达基因。qRT-PCR结果表明,SZ下调了Th17细胞分化相关的基因以及IL-17和PI3K/Akt信号通路上基因mRNA的表达。结论 SZ具有降尿酸作用,其作用机制可能是抑制肝脏黄嘌呤氧化酶活性,下调URAT1水平,上调ABCG2水平,影响Th17细胞的分化,进而影响IL-17信号通路,从而减轻炎症反应。

关键词：高尿酸血症水蛭网络药理学 RNA-seq