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Glucagon-like peptide 1 receptor activation:anti-inflammatory effects in the brain

Neural Regeneration Research 2024年第8期19卷 1671-1677页

作者： yolanda Diz-Chaves Zainab Maastor Carlos Spuch José Antonio Lamas Lucas C.González-Matías Federico Mallo Biomedical Research Centre(CINBIO) Laboratory of EndocrinologyUniversity of VigoGalicia Sur Health Research InstituteVigoSpain Translational Neuroscience Research Group Galicia Sur Health Research InstituteCIBERSAMHospitalÁlvaro CunqueiroSala InvestigaciónEstrada Clara CampoamorVigoSpain Biomedical Research Centre(CINBIO) Laboratory of NeuroscienceUniversity of VigoGalicia Sur Health Research InstituteVigoSpain

The glucagon-like peptide 1 is a pleiotropic hormone that has potent insulinotropic effects and is key in treating metabolic diseases such as diabetes and ***-like peptide 1 exerts its effects by activating a membrane receptor identified in many tissues,including diffe rent brain ***-like peptide 1 activates several signaling pathways related to neuroprotection,like the support of cell growth/survival,enhancement promotion of synapse formation,autophagy,and inhibition of the secretion of proinflammatory cytokines,microglial activation,and apoptosis during neural *** glial cells,including astrocytes and microglia,maintain metabolic homeostasis and defe nse against pathogens in the central nervous *** brain insult,microglia are the first cells to respond,followed by reactive *** activated cells produce proinflammato ry mediators like cytokines or chemokines to react to the ***,under these circumstances,mic roglia can become chro nically inflammatory by losing their homeostatic molecular signature and,consequently,their functions during many *** processes promote the development of neurological disorders and influence their pathological evolution:like the formation of protein aggregates,the accumulation of abnormally modified cellular constituents,the formation and release by injured neurons or synapses of molecules that can dampen neural function,and,of critical impo rtance,the dysregulation of inflammato ry control *** glucagonlike peptide 1 receptor agonist emerges as a critical tool in treating brain-related inflammatory pathologies,restoring brain cell homeostasis under inflammatory conditions,modulating mic roglia activity,and decreasing the inflammato ry *** review summarizes recent advances linked to the anti-inflammato ry prope rties of glucagon-like peptide 1 receptor activation in the brain related to multiple sclerosis,Alzheimer’s disease,Parkins

关键词： astrocytes brain glucagon-like peptide 1 receptor inflammation microglia

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Free

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小学生时代（大嘴英语） 2023年第6期 22-23页

作者： yolanda Z 不详

和小伙伴约着玩,记得提前询问一下“档期”。如果对方说“I am free.”,就表示他这段时间“没有安排”,可以赴约!

关键词：小伙伴 Free free

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Fall

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小学生时代（大嘴英语） 2022年第10期 26-28页

作者： yolanda Z 不详

这边在说自己“跌倒”,那边却谈起了“秋天”,这是怎么一回事?fall一词让松鼠们摸不着头脑,却难不倒M豆,接下来就为你揭晓它的多重“身份”!

关键词： Fall fall 松鼠

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CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture

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World Journal of Stem Cells 2015年第2期7卷 470-476页

作者： María álvarez-Viejo yolanda Menéndez-Menéndez Jesús Otero-Hernández Unidad de Trasplantes Terapia Celulary Medicina RegenerativaAvenida de Roma s/nHospital Universitario Central de Asturias

Mesenchymal stem cells, due to their characteristics are ideal candidates for cellular therapy. Currently, in culture these cells are defined by their adherence to plastic, specific surface antigen expression and multipotent differentiation potential. However, the in vivo identification of mesenchymal stem cells, before culture, is not so well established. Pre-culture identification markers would ensure higher purity than that obtained with selection based on adherence to plastic. Up until now, CD271 has been described as the most specific marker for the characterization andpurification of human bone marrow mesenchymal stem cells. This marker has been shown to be specifically expressed by these cells. Thus, CD271 has been proposed as a versatile marker to selectively isolated and expand multipotent mesenchymal stem cells with both immunosuppressive and lymphohematopoietic engraftment-promoting properties. This review focuses on this marker, specifically on identification of mesenchymal stem cells from different tissues. Literature revision suggests that CD271 should not be defined as a universal marker to identify mesenchymal stem cells before culture from different sources. In the case of bone marrow or adipose tissue, CD271 could be considered a quite suitable marker; however this marker seems to be inadequate for the isolation of mesenchymal stem cells from other tissues such as umbilical cord blood or wharton's jelly among others.

关键词： Mesenchymal stem cells CD271 Lowaffinitynerve growth factor receptor p75 Bone marrow

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Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives

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Neural Regeneration Research 2021年第12期16卷 2425-2426页

作者： Gustavo de Bem Silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila Paulo Cesar Lock Silveira Laboratory of Experimental Pathophysiology Graduate Program in Health SciencesUniversidade do Extremo Sul CatarinenseCriciúmaSCBrazil Programa de Pós Graduação em Farmacologia UFSCFlorianópolisSCBrazil

Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to disability due to gradual neuronal death in both the central nervous system and the peripheral nervous *** many of these diseases have unknown causes,sometimes these are due to medical conditions such as alcoholism,a tumor,or a stroke,or other causes which may include genetic mutations,toxins,chemicals,and viruses.

关键词： diseases degenerative treatment

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How to Say Yes

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小学生时代（大嘴英语） 2019年第11期 26-29页

作者： yolanda Z 不详

在M豆很小的时候,遇到请求或建议只会说yes,no或OK。在学习英语的过程中,M豆渐渐发现,原来表示yes还有那么多种说法。今天M豆就和大家分享一下如何作出肯定的回应。

关键词： How 学习英语 yes 分享

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The detrimental effects of lipopolysaccharideinduced neuroinflammation on adult hippocampal neurogenesis depend on the duration of the pro-inflammatory response

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Neural Regeneration Research 2019年第5期14卷 817-825页

作者： Martha Pérez-Domínguez Evangelina ávila-Mu?oz Eduardo Domínguez-Rivas Angélica Zepeda Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones Biomédicas.Universidad Nacional Autónoma de MéxicoCDMX

Adult hippocampal neurogenesis is a finely tuned process regulated by extrinsic factors. Neuroinflammation is a hallmark of several pathological conditions underlying dysregulation of neurogenesis. In animal models, lipopolysaccharide(LPS)-induced neuroinflammation leads to a neurogenic decrease mainly associated to the early inflammatory response. However, it is not well understood how the neuroinflammatory response progresses over time and if neurogenesis continues to be diminished during the late neuroinflammatory response. Moreover, it is unknown if repeated intermittent administration of LPS along time induces a greater reduction in neurogenesis. We administered one single intraperitoneal injection of LPS or saline or four repeated injections(one per week) of LPS or saline to young-adult mice. A cohort of new cells was labeled with three 5-bromo-2-deoxyuridine injections(one per day) 4 days after the last LPS injection. We evaluated systemic and neuroinflammation-associated parameters and compared the effects of the late neuroinflammatory response on neurogenesis induced by each protocol. Our results show that 1) a single LPS injection leads to a late pro-inflammatory response characterized by microglial activation, moderate astrocytic reaction and increased interleukin-6 levels. This response correlates in time with decreased neurogenesis and 2) a repeated intermittent injection of LPS does not elicit a late pro-inflammatory response although activated microglia persists. The latter profile is not accompanied by a continued longterm hippocampal neurogenic decrease. Hereby, we provide evidence that the neuroinflammatory response is a dynamic process that progresses in a milieu-dependent manner and does not necessarily lead to a neurogenic decrease, highlighting the complex interaction between the immune system and neurogenesis.

关键词： dentate gyrus subgranular zone inflammation microglia astrocytes IL-6 cytokines cell proliferation neural progenitor cells immature neurons long-term short-term adult hippocampal neurogenesis

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New

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小学生时代（大嘴英语） 2023年第1期 16-17页

作者： yolanda Z 不详

A new year is coming.新年到,万象更新,让我们了解new多一点。和好久不见的朋友如何“破冰”?无论是打电话还是发信息,都可以大大方方地说:"What's new?"new和字母s“联手”,就是"新闻"。Listening to the news every day is a good ha... 详细信息

A new year is coming.新年到,万象更新,让我们了解new多一点。和好久不见的朋友如何“破冰”?无论是打电话还是发信息,都可以大大方方地说:"What's new?"new和字母s“联手”,就是"新闻"。Listening to the news every day is a good habit.

关键词： habit coming every

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You Look Angry

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小学生时代（大嘴英语） 2020年第6期 40-44页

作者： yolanda Z 不详

谁都有不顺心的时候,比如M豆,他觉得今天糟透了。一整天遇到了不少倒霉事儿,这让他有时“有些恼了”,有时“挺生气的”,有时“非常愤怒”……这些不同程度的生气,除了I'm angry,还有哪些表达方式呢?

关键词： Angry Look You

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How to Say "Be Strong"

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小学生时代（大嘴英语） 2020年第4期 24-27页

作者： Peter yolanda Z 不详

冬去春来,万物复苏。在2020这个春天,我们都曾有过紧张,有过担忧,甚至还有悲伤。但是,不管怎样,我们都要“挺住”“加油”……这一期,我们就来学一学“怎样鼓励他人,怎样给自己打气、加油”!

关键词： How 鼓励加油

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