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Effects of Nonpharmacological Therapies for Diseases of the Elderly

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Psychology Research 2014年第5期4卷 389-396页

作者： Yoshihisa Koike yoko yamanishi Yoshio Kano Prefectural University of Hiroshima Mihara Japan Kibi International University Takahashi Japan

Distance dependence of atomic-resolution near-field imaging on α-Al2O3 （0001） surface with respect to surface photovoltage of silicon probe tip

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Nano Research 2016年第2期9卷 530-536页

作者： Junsuke yamanishi Takashi Tokuyama Yoshitaka Naitoh Yan Jun Li Yasuhiro Sugawara Department of Applied Physics Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka 565-0871 Japan

Recently, we achieved atomic-resolution optical imaging with near-field scanning optical microscopy using photon-induced force detection. In this technique, the surface photovoltage of the silicon-tip apex induced by the optical near field on the surface is measured as the electrostatic force. We demonstrated atomicresolution imaging of the near field on the α-Al2O3 （0001） surface of a prism. We investigated the spatial distribution of the near field by scanning at different tip-sample distances and found that the atomic corrugation of the near-field signal was observed at greater distances than that of the atomic force microscopy signal. As the tip-sample distance increased, the normalized signal-to-noise ratio of the near field is in a gradual decline almost twice that of the frequency shift （Δf）.

关键词： near-field scanning optical microscopy near field surface photovoltage ci-Al2O3 (0001) force detection

Low-intensity walking as mild medication for pressure control in prehypertensive and hypertensive subjects:how far shall we wander?

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Acta Pharmacologica Sinica 2019年第8期40卷 1119-1126页

作者： Qin Lu Sheng-ming Wang Yi-xiao Liu Hong Chen Rui Zhang Wen-hui Zhang Yuan-yuan Zou Jia-wei Zhou Xin-yi Guo Ying Zhang Teng-Li Huang Yu-hang Liu Si-qi Zhang Kyosuke yamanishi Hiromichi yamanishi Hideaki Higashino Haruki Okamura Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine Hirakata Ryoikuen

Successful prevention and treatment of hypertension depend on the appropriate combination of antihypertensive drug therapy and nondrug lifestyle *** most hypertension guidelines recommend moderate-to high-intensity exercise,we decided to explore a mild yet effective type of exercise to add to hypertension management,especially in populations with complications or *** comparing the short-term cardiovascular effects of low-speed walking versus high-speed walking for 3 kilometers(km)(3 km/h versus 6 km/h)in young,healthy volunteers,we delivered low-speed walking(low-intensity walking,2.5 metabolic equivalents of task,METs)as exercise therapy in 42 prehypertensive and 43 hypertensive *** found that one session of 3 km low-intensity walking exerted a transient pressure-lowering effect as well as a mild negative chronotropic effect on heart rate in both the prehypertensive and hypertensive subjects;these short-term benefits on blood pressure and heart rate were accompanied by a brief increase in urine β-endorphin *** we prescribed regular low-intensity walking with a target exercise dose(exercise volume)of 500-1000 METs-min/week(50-60 min/day and 5-7 times/week)in hypertensive subjects in addition to their daily *** low-intensity walking also showed mild but significant blood pressure-lowering and heart rate-reducing effects in 7 hypertensive subjects within two *** is hypothesized that regular low-intensity exercise of the necessary dose could be taken as a pragmatic and supplementary medication for hypertension management.

关键词： hypertension prehypertension exercise medication low-intensity walking metabolic equivalent of task blood pressure heart rate urine β-endorphin

The effect of edaravone to leukocyte rolling and adhesion molecule expression in microvessels

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Health 2013年第3期5卷 402-408页

作者： Kumi Sakamoto Tsutomu Yamashita Hiroshi yamanishi Junichiro Yamamoto Laboratory of Medical Technology Faculty of Nutrition Kobe Gakuin University Kobe Japan Laboratory of Physiology Faculty of Nutrition Kobe Gakuin University Kobe Japan

Background: Recently, it has become apparent that reactive oxygen species (ROS) play a critical role in the initiation of atherosclerosis. In this study, the effect of radical scavenger edaravone to the leukocyte rolling and to the expression of adhesion molecules on microvascular endothelium was investigated. Methods: DSS induced rat colitis model was used as an inflammation model. Edaravone (10.5 mg/kg, Mitsubishi Tanabe Pharma Corporation, Japan) was used to examine the action of ROS. Images of leukocyte rolling in mesenteric microvessels were investigated in a fluorescence bio-imaging model. Each cross section from the target blood vessel (aotic root, aorta, superior mesenteric artery) were examined by immune-peroxidase staining with anti-P-selectin, E-selectin, ICAM-1 antibody using the streptavidin/biotinylated horseradish peroxidase method. Results: 1) Leukocyte rolling in mesenteric microvessels was significantly increased in colitis. The number of rolling leukocyte was significantly decreased in edaravone group than placebo group (501.3 ± 39.2 vs 252.2 ± 37.2 count/100 μm/10 min). 2) The expression of P-selectin in endothelial cell was significantly increased in colitis. However, this expression was decreased in edaravone group. 3) The expression of E-selectin was not induced to intact aortic root and aorta. In the superior mesenteric artery, the expression was induced by inflammation, and it was attenuated by edaravone. 4) There was little expression of ICAM-1 in both intact aortic root and aortas. While, in the superior mesenteric artery, the expression was confirmed only in placebo group in colitis, and it was attenuated in edaravone group. Conclusions: It was suggested that administration of edaravone led to improving a haemostasis of microcirculation based on down-regulation of adhesion molecules. These results support the evidence that ROS plays a critical role in micro- vascular dysfunction.

关键词： Edaravone Radical Scavenger Atherosclerosis P-Selectin E-Selectin ICAM-1

Measurement of Bubble Behavior and Impact on Solid Wall Induced by Fiber-Holmium:YAG Laser

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Journal of Flow Control, Measurement & Visualization 2015年第4期3卷 135-143页

作者： Yasuhiro Sugimoto Yoshiaki yamanishi Keiichi Sato Manabu Moriyama Department of Mechanical Engineering Kanazawa Institute of Technology Ishikawa Japan Himi Municipal Hospital Kanazawa Medical University Toyama Japan

The holmium:YAG (Ho:YAG) laser is effectively used for transurethral ureterolithotripsy. The laser is applied through an optical fiber in a ureter. A bubble is formed by a laser irradiated from the fiber tip and a calculus is crushed by the impact of the bubble collapse. In this study, we observed the characteristic behavior of a bubble induced by a Ho:YAG laser near a wall surface, using a high-speed video camera. Furthermore, we measured the forces of a bubble collapse using an impulsive force sensor. As a result, we showed characteristic bubble collapse behavior and impulsive force distribution for various fiber placement conditions.

关键词： Laser-Induced Cavitation Bubble Bubble Collapse Shock Waves Transurethral Ureterolithotripsy

Chiral Polyamides Having L-Glutamyl Residue as a Component

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Open Journal of Polymer Chemistry 2012年第4期2卷 125-131页

作者： Yoshimi Ikeuchi Masakazu Yoshikawa Hidekazu Yoshida Hiroki yamanishi Shinichi Sakurai Department of Biomolecular Engineering Kyoto Institute of Technology Matsugasaki Kyoto Japan Department of Macromolecular Science and Engineering Kyoto Institute of Technology Matsugasaki Kyoto Japan

Polyamides with chiral environment were obtained from aromatic diamine, 1,3-phenylenediamine (1,3-PDA) or 1,4- phenylenediamine (1,4-PDA), and N-α-benzoyl-L-glutamic acid (Benzoyl-L-Glu). The optical rotation ([α]D) for 1,3- PDA-Benzoyl-L-Glu was determined to be 3.7 deg cm2 g–1, while that for 1,4-PDA-Benzoyl-L-Glu to be 9.7 deg cm2 g–1. 1,3-PDA-Benzoyl-L-Glu showed adsorption selectivity toward D-Glu and its adsorption selectivity was determined to be 1.68. Contrary to this, 1,4-PDA-Benzoyl-L-Glu showed adsorption selectivity toward L-Glu and the adsorption selectivity toward L-Glu was determined to be 1.33. From those results, those two types of chiral polyamide are expected to applicable to chiral separation or chiral recognition.

关键词： Adsorption Selectivity Chiral Polyamide Glutamyl Residue Polyamide Surface Plasmon Resonance (SPR) Spectroscopy

Negative Photoimaging Is Useful For the Dermoscopic Examination of Fibroepithelioma of Pinkus

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Negative Photoimaging Is Useful For the Dermoscopic Examinat...

The 10th China-Japan Joint Meeting of Dermatology 20th Anniversary

作者： Masaaki Yamamoto Tatsuya Tsuda Takaaki Ito Kiyofumi yamanishi Department of Dermatology Hyogo College of MedicineJapan

＜正＞Introduction:Fibroepithelioma of pinkus（FP） is an uncommon variant of basal cell carcinoma（BCC）, which often appears as a well-bordered,non-pigmented flat *** dermoscopy of BCC typically reveals large blue-g...

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人类疱疹病毒6型

微生物学免疫学进展 1993年第2期21卷 65-67页

作者： yamanishi K 秦思栋

人类疱疹病毒6型(HHV-6)最先是从淋巴细胞增生性疾病患者中分离出来的一种新的疱疹病毒。其抗原性和遗传学特性与疱疹病毒1型,疱疹病毒2型,巨细胞病毒(CMV),水痘一带状疱疹病毒(VZV)及EBV均不相同。后来发现HHV-6是幼儿急疹(ES)的病原... 详细信息

人类疱疹病毒6型(HHV-6)最先是从淋巴细胞增生性疾病患者中分离出来的一种新的疱疹病毒。其抗原性和遗传学特性与疱疹病毒1型,疱疹病毒2型,巨细胞病毒(CMV),水痘一带状疱疹病毒(VZV)及EBV均不相同。后来发现HHV-6是幼儿急疹(ES)的病原体。本文就HHV-6的血清流行病学,从ES患儿中的分离检测,与HHV— 6感染有关的疾病及其病毒学特性等综述如下。

关键词：人类疱疹病毒疱疹病毒 6型

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日本学生使用汉语程度副词偏误调查分析

日本学生使用汉语程度副词偏误调查分析

作者：山西里佳（Rika yamanishi）苏州大学

学位级别：硕士

本文首先考察了日语中和汉语中的程度副词,然后比较日本学生学习汉语中使用程度副词的情况。本文的通过调查HSK动态作文语料库,CCL语料库,并按HSK大纲制成问卷调查,以问卷的形式对日本学生进行调查,得到第一手的资料,分析产生偏误的原... 详细信息

本文首先考察了日语中和汉语中的程度副词,然后比较日本学生学习汉语中使用程度副词的情况。本文的通过调查HSK动态作文语料库,CCL语料库,并按HSK大纲制成问卷调查,以问卷的形式对日本学生进行调查,得到第一手的资料,分析产生偏误的原因,提出相应的教学策略。很多日本学生学习程度副词时,把汉语程度副词直接翻译成日语解决。比如说,“很”和“非常”的日语翻译是一样的,所以很多日本学生认为这两个副词是同一个意思。同时,调查中我们发现了很多学汉语的日本学生不重视程度副词的学习。在教学方面,应该注重比较日语和汉语中程度副词的共同点和差异点,加深对程度副词的理解。

关键词：日语程度副词汉语程度副词偏误