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Efficacy of omarigliptin,once-weekly dipeptidyl peptidase-4 inhibitor,in patients with type 2 diabetes

World Journal of Diabetes 2021年第12期12卷 2087-2095页

作者： Eiji Kawasaki Yuko Nakano Takahiro Fukuyama Aira Uchida yoko sagara Hidekazu Tamai Masayuki Tojikubo Yuji Hiromatsu Nobuhiko Koga Department of Diabetes and Endocrinology Shin-Koga HospitalKurume 830-8577Japan

BACKGROUND Omarigliptin is one of several once-weekly dipeptidyl peptidase-4 inhibitors(DPP-4is).Despite the high frequency of switching from various daily DPP-4is to omarigliptin in actual clinical practice,data regarding its efficacy in patients with type 2 diabetes(T2D)after switching are *** To analyze the efficacy of omarigliptin in Japanese patients with T2D who had previously received treatment with other glucose-lowering *** Forty-nine T2D patients treated for the first time with omarigliptin were recruited retrospectively and divided into four groups defined as either add-on or switched from daily DPP-4is:switched from linagliptin,switched from sitagliptin,and switched from *** a 3-mo follow-up,the clinical parameters among these groups were assessed and compared,with the impact of the switch on glycemic variability as measured by continuous glucose monitoring also being evaluated in the switched *** Hemoglobin A1c levels saw a significant decrease of-0.32%±0.41%in the add-on group(P=0.002).However,the other groups’variables depended on the preswitch daily DPP-4i:switched from linagliptin,-0.05%±0.22%;switched from sitagliptin,-0.17%±0.33%;and switched from vildagliptin,0.45%±0.42%,which saw significant worsening(P=0.0007).Multivariate logistic regression analysis revealed that switching from vildagliptin to omarigliptin was independently associated with worsening glycemic control(P=0.0013).The mean and standard deviation of sensor glucose value,the mean amplitude of glycemic excursions,and the mean of daily difference significantly improved when switching the patient from either linagliptin or sitagliptin to ***,in patients switched from vildagliptin,not only did the glucose variability indices see no improvements,the mean of daily difference even underwent significant *** Administering omarigliptin as add-on therapy or switching to it from sitagliptin and linagliptin,but not v

关键词： Omarigliptin Once-weekly dipeptidyl peptidase-4 inhibitor Real-world practice Retrospective study Type 2 diabetes

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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai Takahiro Fukuyama yoko sagara Ryutaro Hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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Scale Effects on Magnet Systems of Heliotron-Type Reactors

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Plasma Science and Technology 2005年第1期7卷 2626-2628页

作者： S.Imagawa A.sagara National Institute for Fusion Science 322-6 Oroshi-cho Toki 509-5292 JapanNational Institute for Fusion Science 322-6 Oroshi-cho Toki 509-5292 Japan

For power plants heliotron-type reactors have attractive advantages, such asno current-disruptions, no current-drive, and wide space between helical coils for the maintenanceof in-vessel components. However, one disadvantage is that a major radius has to be large enough toobtain large Q-value or to produce sufficient space for blankets. Although the larger radius isconsidered to increase the construction cost, the influence has not been understood clearly, *** effects on superconducting magnet systems have been estimated under the conditions of aconstant energy confinement time and similar geometrical parameters. Since the necessary magneticfield with a larger radius becomes lower, the increase rate of the weight of the coil support to themajor radius is less than the square root. The necessary major radius will be determined mainly bythe blanket space. The appropriate major radius will be around 13 m for a reactor similar to theLarge Helical Device (LHD).

关键词： helical reactor superconducting magnet blanket

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Efficacy of cytapheresis in patients with ulcerative colitis showing insufficient or lost response to biologic therapy

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World Journal of Gastroenterology 2022年第34期28卷 4959-4972页

作者： Masahiro Iizuka Takeshi Etou Shiho sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

For the optimal management of refractory ulcerative colitis(UC),secondary loss of response(LOR)and primary non-response to biologics is a critical *** article aimed to summarize the current literature on the use of cytapheresis(CAP)in patients with UC showing a poor response or LOR to biologics and discuss its advantages and ***,we summarized the efficacy of CAP in patients with UC showing insufficient response to thiopurines or immunomodulators(IM).Eight studies evaluated the efficacy of CAP in patients with UC with inadequate responses to thiopurines or *** were no significant differences in the rate of remission and steroid-free remission between patients exposed or not exposed to thiopurines or *** studies evaluated the efficacy of CAP in patients with UC showing an insufficient response to biologic *** remission rates of biologics exposed or unexposed patients were 29.4%and 44.2%,*** studies evaluated the efficacy of CAP in combination with biologics in patients with inflammatory bowel disease showing a poor response or LOR to *** rates of remission/response and steroid-free remission in patients with UC ranged 32%-69%(mean:48.0%,median:42.9%)and 9%-75%(mean:40.7%,median:38%),*** had the same effectiveness for remission induction with or without prior failure on thiopurines or IM but showed little benefit in patients with UC refractory to *** heterogeneity existed in the efficacy of the combination therapy with CAP and biologics,these combination therapies induced clinical remission/response and steroid-free remission in more than 40%of patients with UC refractory to biologics on *** the excellent safety profile of CAP,this combination therapy can be an alternative therapeutic strategy for UC refractory to *** prospective studies are needed to understand the efficacy of combination therapy with CAP and biologics.

关键词： Ulcerative colitis Inflammatory bowel disease Cytapheresis Granulocyte and monocyte adsorptive apheresis Anti-tumor necrosis factor-αantibody Combination therapy

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Acute respiratory distress syndrome associated with severe ulcerative colitis

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World Journal of Gastroenterology 2010年第19期16卷 2440-2442页

作者： Shiho sagara Yasuo Horie Yumiko Anezaki Hideaki Miyazawa Masahiro Iizuka Health Care Center Akita Red Cross Hospital Akita 010-0001 Japan Department of Internal Medicine Akita University School of Medicine Akita 010-8543 Japan Department of Surgery Akita University School of Medicine Akita 010-8543 Japan

Various extraintestinal manifestations including pulmonary abnormalities have been reported in patients with ulcerative colitis. Acute respiratory distress syndrome (ARDS) is a serious and fatal pulmonary manifestation. We have experienced a 67-year-old male patient with ARDS associated with a severe type of ulcerative colitis (UC). Severe dyspnea symptoms occurred during the treatment of UC in a previous hospital and the patient was transferred to our hospital on June 27, 2007. Both blood and sputa cultures for bacteria and fungi were negative. Cytomega-lovirus antigenemia was also not detected. From the clinical and radiological [Chest X-ray, computed tomography (CT)] findings, the patient was diagnosed with ARDS on the basis of the def inition of ARDS developed by the European-American Consensus Conference on ARDS. Both colonic inflammations and ARDS symptoms of the patient were resistant to any medical treatment includingcorticosteroids and antibiotics. However, ARDS symptoms were dramatically improved after surgical colectomy. We believe that severe colonic inflammation from UC was closely associated with the onset of ARDS of the patient. Our case report suggests that a severe type of ulcerative colitis might be taken into consideration as one of the predisposing factors of ARDS.

关键词： Acute respiratory distress syndrome Ulcerative colitis Inflammatory bowel disease Extra-intestinal manifestation

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Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis

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World Journal of Gastroenterology 2021年第12期27卷 1194-1212页

作者： Masahiro Iizuka Takeshi Etou Yosuke Shimodaira Takashi Hatakeyama Shiho sagara Akita Health Care Center Akita Red Cross HospitalAkita 010-0001Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan Department of Gastroenterology and Neurology Akita University Graduate School of MedicineAkita 010-8543Japan akashi Hatakeyama Department of NephrologyAkita Red Cross HospitalAkita 010-1495Japan

BACKGROUND It is a crucial issue for patients with refractory ulcerative colitis(UC),including steroid-dependent and steroid-refractory patients,to achieve and maintain steroid-free ***,clinical studies focused on the achievement of steroid-free remission in refractory UC patients are ***(CAP)is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse *** study comprised UC patients treated with CAP and suggested the efficacy of CAP for refractory UC *** To clarify the efficacy of CAP in achieving steroid-free remission in refractory UC *** We retrospectively reviewed the collected data from 55 patients with refractory UC treated with *** analyzed the following points:(1)Efficacy of the first course of CAP;(2)Efficacy of the second,third,and fourth courses of CAP in patients who experienced relapses during the observation period;(3)Efficacy of CAP in colonic mucosa;and(4)Long-term efficacy of *** efficacy was evaluated using Lichtiger’s clinical activity index or Sutherland index(disease activity index).Mucosal healing was evaluated using Mayo endoscopic *** primary and secondary endpoints were the rate of achievement of steroidfree remission and the rate of sustained steroid-free remission,*** analysis was performed using the paired t-test and chi-squared *** The rates of clinical remission,steroid-free remission,and poor effectiveness after CAP were 69.1%,45.5%,and 30.9%,*** were no significant differences in rate of steroid-free remission between patients with steroiddependent and steroid-refractory *** mean disease activity index and Lichtiger’s clinical activity index scores were significantly decreased after CAP(P<0.0001).The rates of steroid-free remission after the second,third,and fourth courses of CAP in patients who achieved steroid-free remission after the first course of CAP were 8

关键词： Ulcerative colitis Cytapheresis Steroid-dependent Steroid-refractory Steroid-free remission Inflammatory bowel disease

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Modeling of Reinforced Concrete Beams Damaged by Cyclic Loading

Modeling of Reinforced Concrete Beams Damaged by Cyclic Load...

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作者： sagara AMAKAYE MAXIME（马新明）西安建筑科技大学

学位级别：硕士

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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi Ohmura Kazuki Komatsu Kosuke sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

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A case of follicular cystitis treated successfully with diethylcarbamazine

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Asian Journal of Urology 2021年第2期8卷 235-237页

作者： Maduwe Gedara sagara Ruwan Kumara Prasanga Thiranagama Cherine Sosai Anuruddha Abeygunasekera Department of Urology Colombo South Teaching HospitalDehiwalaSri Lanka Department of Pathology Colombo South Teaching HospitalDehiwalaSri Lanka

Follicular cystitis is a non-specific inflammatory condition of the bladder where the aetiology is *** extent of the disease can be mild or proliferative and ***,steroids,therapies used for interstitial cystitis,palliative cystectomy and radiotherapy have been reported as successful treatment *** report a case of follicular cystitis that responded to a course of oral diethyl carbamazine.

关键词： Chronic cystitis Pyuria Bladder pathology Urosepsis

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Dusty Sheaths in Magnetized Plasmas

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Plasma Science and Technology 2004年第4期6卷 2377-2382页

作者： Yu.I.Chutov O.Yu.Kravchenko S.Masuzaki A.sagara R.D.Smirnov Yu.Tomita Taras Shevchenko Kiev University KievUkraineTaras Shevchenko Kiev UniversityKievUkraineNational Institute for Fusion ScienceJapanNational Institute for Fusion ScienceJapanThe Graduate University for Advanced StudiesJapanNational Institute for Fusion ScienceJapan

Parameters of self-consistent magnetized dusty sheaths are investigated usingcomputer simulations of a temporal evolution of one-dimensional slab plasma with dust *** evolution is caused by a collection of electrons and ions by both a wall (electrode) and dustparticles, which are initially immersed into plasma and distributed in front of the *** results show the existence of oscillations of a self-consistent potential in magnetizeddusty sheaths including boundary potentials. Dust particles weaken magnetized sheaths and createadditional sheaths close to a boundary of dust particles. The magnetic field does not influence onthe dust particle charge.

关键词： dusty sheaths magnetized plasmas computer simulations

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