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Peritoneal bleeding due to percutaneous transhepatic gallbladder drainage:An autopsy report

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World Journal of Hepatology 2012年第10期4卷 288-290页

作者： yoko ihama Maki Fukazawa Kenji Ninomiya Takumi Nagai Chiaki Fuke Tetsuji Miyazaki Department of Forensic Medicine Graduate School of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

A 77-year-old man underwent percutaneous transhepatic gallbladder drainage(PTGBD) for acute cholecystitis as a preoperative procedure;however,he suddenly suffered cardiopulmonary arrest 4 h after the PTGBD and *** were three centesis scars for the PTGBD,and only one pathway from the most dorsal centesis scar reached the ***,the PTGBD pathway crossed and injured the intrahepatic arterial wall,and hepatic parenchymal bleeding extended along the PTGBD pathway to the inferior surface of the *** flowed to the peritoneal cavity through a small gap between the liver and ***,the PTGBD caused lethal *** the percutaneous transhepatic cholangio drainage/PTGBD pathway runs close to vessels near the liver surface,it might be necessary to deal with the possibility of rapid and lethal peritoneal bleeding.

关键词： Percutaneous transhepatic gallbladder drainage Percutaneous transhepatic cholangio drainage Lethal complication Autopsy

Endoscopic and histopathological study on the duodenum of Strongyloides stercoralis hyperinfection

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World Journal of Gastroenterology 2008年第11期14卷 1768-1773页

作者： Kazuto Kishimoto Akira Hokama Tetsuo Hirata Yasushi ihama Manabu Nakamoto Nagisa Kinjo Fukunori Kinjo Jiro Fujita Department of Endoscopy Ryukyu University HospitalOkinawa 903-0215Japan Department of Medicine and Therapeutics(First Department of Internal Medicine) Control and Prevention of Infectious DiseaseFaculty of Medicine University of the RyukyusOkinawa 903-0215Japan

AIM:To investigate endoscopic and histopathological findings in the duodenum of patients with Strongyloides stercoralis(***)hyperinfection. METHODS:Over a period of 23 years(1984-2006),we investigated 25 patients *** hyperinfection who had had an esophagogastroduodenoscopy before undergoing treatment for *** clinical and endoscopic findings were analyzed retrospectively. RESULTS:Twenty-four(96%)of the patients investigated were under immunocompromised condition which was mainly due to a human T lymphotropic virus type 1(HTLV-1)*** abnormal endoscopic findings,mainly edematous mucosa,white villi and erythematous mucosa,were observed in 23(92%) *** degree of duodenitis including villous atrophy/destruction and inflammatory cell infiltration corresponded to the severity of the endoscopic findings. The histopathologic yield for identifying larvae was 71.4% by duodenal *** endoscopic findings of duodenitis were more severe in patients whose biopsies were positive for larvae than those whose biopsies were negative(Endoscopic severity score:4.86±2.47vs 2.71 ±1.38,P<0.05). CONCLUSION:Our study clearly demonstrates that,in addition to stool analysis,endoscopic observation and biopsies are very *** also emphasize that *** and HTLV-1 infections should be ruled out before immunosuppressive therapy is administered in endemic regions.

关键词： Strongyloides stercoralis Strongyloidiasis Hyperinfection Endoscopy Histopathology Duodenum

A case of congenital aneurysm of the ulnar artery of the palm

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Plastic and Aesthetic Research 2020年第1期7卷 17-23页

作者： yoko Kishi Department of Pediatric Surgery Dokkyo Medical University Saitama Medical CenterSaitama 343-8555Japan.

Congenital aneurysms of the palm are uncommon in the pediatric population compared to aneurysms in adults.A seven-month-old boy presented with a true aneurysm of the ulnar artery with reconstruction with surgical excision and end-to-end microvasculer anastomosis using a superficial vein of the dorsal *** our knowledge,there have been only 15 reports of congenital aneurysms of the palm.

关键词： Congenital aneurysm of the palm ulnar artery microvascular reconstruction

Improvement of aerodynamic stability of suspension bridges with H-shaped simplified stiffening girder

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Frontiers of Structural and Civil Engineering 2016年第1期10卷 93-102页

作者： Hiroshi KATSUCHI Hitoshi YAMADA Mayuko NISHIO yoko OKAZAKI Department of Civil Engineering Yokohama National University Yokohama 240-8501 Japan

Wind-tunnel study on the improvement of aerodynamic stability of simplified suspension-bridge girder structures was conducted with using a 1/40-scaled section model. Objective of the study is the development of an economically superior suspension bridge with 500-1,000 m center span length. The wind-tunnel test showed that an edge-girder type cross section exhibited large amplitude torsional vortex-induced vibration as well as torsional flutter at a low wind speed. Accordingly, aerodynamic countermeasures of open grating deck and triangular fating, and structural countermeasures of center stay, diagonal bracing and mass increase were tried to improve the aerodynamic stability. Finally, feasibility of the best combination to a full-scale bridge was examined by structural analysis.

关键词： suspension bridge aerodynamics simplified girder wind-tunnel test

Carbonation of low heat portland cement paste precured in water for different time

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Journal of University of Science and Technology Beijing 2007年第2期14卷 178-184页

作者： Deping Chen Etsuo Sakai Masaki Daimon yoko Ohba Civil and Environmental Engineering School University of Science and Technology Beijing Beijing 100083 China Graduate School of Science and Engineering Tokyo Institute of Technology Tokyo 152-8552 Japan

The carbonation technique was applied to accelerate the hydration of low heat portland cement （LHC）. Before carbonation, the demoulded pastes were precured in water for 0, 2, 7, and 21 d, respectively. The results show that precuring time in water strongly influences the carbonation process. The phenolphthalein test indicates that the paste precured in water for a shorter time is more quickly carbonated than that for a longer time. The content of calcium hydroxide increases with increasing the precuring time in water, whereas, the amount of absorbed carbon dioxide changes contrarily. Scanning electron microscope （SEM） observation shows that portlandite always fills up big air bubbles in the paste during precuring in water, and the mercury intrusion porosimetry （MIP） results show that there are less large capillary pores in the paste precured in water for a longer time. It is found that the paste without precuring in water has more carbon dioxide absorption during curing in carbon dioxide atmosphere, and its total pore volume decreases remarkably with an increase in the carbonation time than that precured in water. X-ray diffraction （XRD） and Brunauer-Emmett-Teller （BET） surface area analyses indicate that the carbonate products are vaterite and calcite; CxSHy formed from carbonation has low BET surface area in comparison with that of C-S-H formed from curing in water.

关键词： carbonation carbon dioxide absorption vaterite BET surface area pore size distribution

WORK/LIFE COMMUNITY BY TELEWORK—POSSIBILITIES AND ISSUES IN THE CASE OF LOMA LINDA

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Journal of Green Building 2008年第2期3卷 128-139页

作者： yoko Kawai Penguin Environmental Design L.L.C.in HamdenConnecticut

This paper suggests telework, and work/life community created by it, as potential design tools for the sustainability oflocal communities, and investigates their possibility and issues through a case study of Loma Linda Connected CommunityProgram (LLCCP).A new work/life style enabled by information communication technology (ICT), often called telework, is expandingin the U.S. The environmental impact which this gives on community scale has been neglected. Yet, since teleworkcan give the area economic advancement without huge development, make mixed-use zoning plausible, and grantssense of community, it could bring physical, economic and social sustainability to local ***, as an example of emerging municipal ICT deployment programs, was examined on two levels;i.e. levelof urban policy and of urban design. It was revealed that LLCCP, as an urban policy, has a good potential to createICT-served work/life community, thus to contribute to the smart growth of the city. It does so by promoting new businessesyet small/home ones only, and developing new neighborhoods yet ICT-served work/life communities only. Itslink to regional plans and to the building code which ensures the connectivity in entire city elevate its *** paper also pointed out that city’s urban design strategies are not yet supporting LLCCP toward its goal. Itlacks coordination with teleworkers’ life style, and with spatial system for the entire city. A current design proposaloverlooks teleworkers’ driving habits and their specifi c needs to the types of retails/business-services, for example. Theresult implies that the use of telework in creating sustainable community may have started to be recognized on urbanpolicy level, but that urban/architectural design for it is still behind to be developed.

关键词： sustainability telework information communication technology urban policy urban design

Mobilization and Acquisition of Sparingly Soluble P-Sources by Brassica Cultivars under P-Starved Environment I. Differential Growth Response,P-Efficiency Characteristics and P-Remobilization

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Journal of Integrative Plant Biology 2009年第11期51卷 1008-1023页

作者： Muhammad Shahbaz Akhtar yoko Oki Tadashi Adachi Department of Environmental Management Engineering Faculty of Environmental Science and TechnologyThe Graduate School of Environmental ScienceOkayama University

Phosphorus （P） starvation is highly notorious for limiting plant growth around the globe. To combat P-starvation, plants constantly sense the changes in their environment, and elicit an elegant myriad of plastic responses and rescue strategies to enhance P-solublization and acquisition from bound soil P-forms. Relative growth responses, P-solublization and P- acquisition ability of 14 diverse Brassica cultivars grown with sparingly soluble P-sources （Rock-P （RP） and Ca3（PO4）2 （TCP）） were evaluated in a solution culture experiment. Cultivars showed considerable genetic diversity in terms of biomass accumulation, concentration and contents of P and Ca in shoots and roots, P-stress factor （PSF） and P use efficiency. Cultivars showed variable P-stress tolerance, and cultivars depicting low PSF and high P-efficiency values were better adaptable to P-starvation. In experiment 2, after initial feeding on optimum nutrition for 12 d after transplanting （DAT）, class-I （low P-tolerant （Oscar and Con-II）） and class-II （low P-sensitive （Gold Rush and RL-18）） cultivars were exposed to P-free environment for 25 d. All of the cultivars remobilized P from above ground parts to their roots during growth in P-free environment, the magnitude of which was variable in tested cultivars. P-concentrations （[P]s） at 37 DAT were higher in developing compared with developed leaves. Translocation of absorbed P from metabolically inactive to active sites in P- stressed plants may have helped class-I cultivars to establish a better rooting system, which provided a basis for enhanced P-utilization efficiency （PUE） and tolerance against P-stress. By supplying TCP and RP spatially separated from other nutrients in split root study, class-I cultivars were still able to mobilize RP and TCP more efficiently compared with class-II cultivars. To compare the growth behavior under P-stress, cultivars were grown in pots for 41 d after sowing, using a soil low in P （NaHCO3-extractable P = 3.97 mg/kg, Mehlich

关键词： Brassica Ca3(PO4)2 P-remobilization P-stress P-use efficiency P-stress factor rock phosphate.

Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

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World Journal of Gastroenterology 2011年第4期17卷 409-418页

作者： Toshiyuki Ishiwata yoko Matsuda Zenya Naito Department of Pathology Integrative Oncological Pathology Nippon Medical School

Nestin is a class Ⅵ intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues. Under pathological conditions, nestin is expressed in repair processes in the CNS, muscle, liver, and infarcted myocardium. Furthermore, increased nestin expression has been reported in various tumor cells, including CNS tumors, gastrointestinal stromal tumors, pancreatic cancer, prostate cancer, breast cancer, malignant melanoma, dermatofibrosarcoma protuberances, and thyroid tumors. Nestin is reported to correlate with aggressive growth, metastasis, and poor prognosis in some tumors; however, the roles of nestin in cancer cells have not been well characterized. Furthermore, nestin is more specifically expressed in proliferating small-sized tumor vessels in glioblastoma and gastric, colorectal, and prostate cancers than are other tumor vessel markers. These findings indicate that nestin may be a marker for newly synthesized tumor vessels and a therapeutic target for tumor angiogenesis. It has received a lot of attention recently as a cancer stem cell marker in various cancer cells including brain tumors, malignant rhabdoid tumors, and uterine, cervical, prostate, bladder, head and neck, ovarian, testicular, and pancreatic cancers. The purpose of this review is to clarify the roles of nestin in cancer cells and in tumor angiogenesis, and to examine the association between nestin and cancer stem cells. Nestin has the potential to serve as a molecular target for cancers with nestin-positive cancer cells and nestin-positive tumor vasculature.

关键词： Cancer growth Intermediate filament protein Cancer invasion Tumor migration Nestin Stem cell marker Tumor angiogenesis

Nestin:A novel angiogenesis marker and possible target for tumor angiogenesis

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World Journal of Gastroenterology 2013年第1期19卷 42-48页

作者： yoko Matsuda Masahito Hagio Toshiyuki Ishiwata Departments of Pathology and Integrative Oncological Pathology Nippon Medical SchoolTokyo 113-8602Japan

Abnormal vasculature,termed tumor vessels,is a hallmark of solid *** degree of angiogenesis is associated with tumor aggressiveness and clinical ***,exact quantification of tumor vessels is useful to evaluate ***,selective detection of newly formed tumor vessels within cancer tissues using specific markers raises the possibility of molecular targeted therapy via the inhibition of tumor ***,an intermediate filament protein,is reportedly expressed in repair processes,various neoplasms,and proliferating vascular endothelial *** expression is detected in endothelial cells of embryonic capillaries,capillaries of the corpus luteum,which replenishes itself by angiogenesis,and proliferating endothelial progenitor cells,but not in mature endothelial ***,expression of nestin is relatively limited to proliferating vascular endothelial cells and endothelial progenitor *** expression is also reported in blood vessels within glioblastoma,prostate cancer,colorectal cancer,and pancreatic cancer,and its expression is more specific for newly formed blood vessels than other endothelial cell ***-positive blood vessels form smaller vessels with high proliferation activity in *** of nestin in vascular endothelial cells suppresses endothelial cell growth and tumor formation ability of pancreatic cancers in *** nestin to more accurately evaluate microvessel density in cancer specimens may be a novel prognostic ***,nestin-targeted therapy may suppress tumor proliferation via inhibition of angiogenesis in numerous malignancies,including pancreatic *** this review article,we focus on nestin as a novel angiogenesis marker and possible therapeutic target via inhibition of tumor angiogenesis.

关键词： Nestin Angiogenesis Molecular targeting therapy Gastrointestinal cancer Pancreatic cancer Microvessel density CD34 CD31 Factor VIII