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A multiwavelength view of a classical T Tauri star CV Cha

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Research in Astronomy and Astrophysics 2019年第1期19卷 75-86页

作者： Jeewan chandra Pandey Subhajeet Karmakar Arti Joshi Saurabh sharma Shashi Bhushan Pandey Anil Kumar Pandey Aryabhatta Research Institute of Observational Sciences (ARIES)

Using long-term optical, ultraviolet(UV) and X-ray data, we present a study of a classical T Tauri star CV Cha. The V-band light curve obtained from the All Sky Automated Survey(ASAS) shows short as well as long-term variability. The short-term variability could be due to rotational modulation of CV Cha. We derive the rotational period of 3.714 ± 0.001 d for CV Cha. UV light curves obtained from Swift also show the variations. X-ray light curves from XMM-Newton and Swift do not show any significant short as well as long-term variability. However, the light curve from chandra appears to be variable, which could be due to the emergence of flaring activities. X-ray spectra from all observations are explained well by the single temperature plasma of 0.95 keV with X-ray luminosity of 1030.4erg s-1in the 0.5–7.5 keV energy band. It appears that variability in optical and UV bands could be due to the presence of both hot and cool spots on the surface, while X-ray emission is dominated by magnetic processes.

关键词： stars:activity stars:individual(CV Cha) stars:pre-main sequence stars:variable:T Tauri X-ray:stars

Synthesis of Fluorite-Type Nanopowders by Citrate-Nitrate Auto-Combustion Process: A Systematic Approach

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Materials Sciences and Applications 2012年第2期3卷 110-115页

作者： Mridula Biswas Prasanta Kumar Ojha Chadalapaka Durga Prasad Nitin Madhusudan Gokhale Suresh chandra sharma 不详

Citrate-nitrate autocombustion process is a promising synthesis route in the field of nanomaterials. This route involves many controlling parameters which ultimately affect properties of the products. In the present research work, the effect of concentration of fuel to that of metal nitrates has been studied in a systematic manner. The nature of exothermic reaction was analyzed with DSC-TGA and the powder properties were characterized by XRD, TEM and BET measurement. The properties of the powders have been explained with respect to fuel content, vigorousness of the exothermic reaction, combustion temperature and duration. The most vigorous reaction was found to occur for the composition with FER of 0.50 with the production of the smallest crystallite size of 9 nm.

关键词： Combustion Synthesis DSC-TGA XRD TEM

<i>Gsta</i>4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity

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Open Journal of Apoptosis 2013年第1期2卷 1-11页

作者： Kevin E. McElhanon Chhanda Bose Rajendra sharma Liping Wu yogesh C. Awasthi Sharda P. Singh Central Arkansas Veterans Healthcare System Little Rock USA Department of Molecular Biology and Immunology University of North Texas Health Science Center Fort Worth USA Department of Pharmacology and Toxicology University of Arkansas for Medical Sciences Little Rock USA

The alpha class glutathione s-transferase (GST) isozyme GSTA4-4 (EC2.***.1.18) exhibits high catalytic efficiency towards 4-hydroxynon-2-enal (4-HNE), a major end product of oxidative stress induced lipid peroxidation. Exposure of cells and tissues to heat, radiation, and chemicals has been shown to induce oxidative stress resulting in elevated concentrations of 4-HNE that can be detrimental to cell survival. Alternatively, at physiological levels 4-HNE acts as a signaling molecule conveying the occurrence of oxidative events initiating the activation of adaptive pathways. To examine the impact of oxidative/electrophilic stress in a model with impaired 4-HNE metabolizing capability, we disrupted the Gsta4 gene that encodes GSTA4-4 inmice. The effect of electrophile and oxidants on embryonic fibroblasts (MEF) isolated from wild type (WT) and Gsta4 null mice were examined. Results indicate that in the absence of GSTA4-4, oxidant-induced toxicity is potentiated and correlates with elevated accumulation of 4-HNE adducts and DNA damage. Treatment of Gsta4 null MEF with 1,1,4-tris(acetyloxy)-2(E)-nonene [4-HNE(Ac)3], a pro-drug form of 4-HNE, resulted in the activation and phosphorylation of the c-jun-N-terminal kinase (JNK), extracellular-signal-regulated kinases (ERK 1/2) and p38 mitogen activated protein kinases (p38 MAPK) accompanied by enhanced cleavage of caspase-3. Interestingly, when recombinant mammalian or invertebrate GSTs were delivered to Gsta4 null MEF, activation of stress-related kinases in 4-HNE(Ac)3 treated Gsta4 null MEF were inversely correlated with the catalytic efficiency of delivered GSTs towards 4-HNE. Our data suggest that GSTA4-4 plays a major role in protecting cells from the toxic effects of oxidant chemicals by attenuating the accumulation of 4-HNE.

关键词： Glutathione Transferase Protein Adducts Lipid Peroxidation Oxidants Stress Kinases

Chemotherapy induced Takotsubo cardiomyopathy

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World Journal of Clinical Cases 2014年第10期2卷 565-568页

作者： Sunny Goel Abhishek sharma Aakash Garg Abhinav chandra Vijay Shetty Department of Medicine Maimonides Medical Center Department of Internal Medicine James J. Peters VA Medical Center Mount Sinai School of Medicine Bronx NY 10468 United States

Chemotherapy has been linked with Takotsubo cardiomyopathy. Most of the literature on chemotherapy associated Takotsubo cardiomyopathy is on the drug 5-fluorouracil. In this report, we describe the case of a 55-year-old Asian male who developed Takotsubo cardiomyopathy while receiving dual chemotherapy with cytarabine and daunorubicin for acute myeloid leukemia. To our knowledge, it is the first case of Takotsubo cardiomyopathy associated with daunorubicin and/or cytarabine.

关键词： Takotsubo cardiomyopathy Chemotherapy Cytarabine Daunorubicin

Equivalent Electrical ＆ Mechanical Networks of Human Body

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Equivalent Electrical ＆ Mechanical Networks of Human Body

Study of anisotropic variation of cosmic rays intensity with solar activity

2011 International Conference on Management and Service Science（ICMSS 2011）

作者： Varun Gupta Gavendra Singh Akash Gupta Shobhit sharma Ramesh chandra Dept.of Instrumentation & Control Engg Dr.B.R.Ambedkar NIT Jalandhar

Using the model,we explain a basic principle of electric-field communication that uses the human *** it is well known that electricity easily passes through the human *** this we have given equivalent mechanical ＆ electrical networks （Models） of human *** this purpose we have used Force current （F-I） analogy ＆ Force Voltage （F-V） *** this paper we examine the physical justification for these analogies to improve mutual understanding.A simple way to relate analogies to common physical intuition is *** ’mass-inductor’ （F-V） analogy reflects a real-world distinction between equilibrium energy-storage phenomena and steady-state energy-storage *** comparison between these two *** conclude that electrical network theory （from which the force-current analogy is derived） is an inappropriate basis for a general representation of physical system.

关键词： Physical systems Force current (F-I) analogy Force Voltage (F-V) analogy electric-field communication

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Natural Science 2011年第2期3卷 101-103页

作者： chandra Mani Tiwari Devendra sharma Lalji Tiwari Ajay Kumar Saxena Dadan Prasad Tiwari 不详

The annual average values of amplitudes and phases of first two harmonics of cosmic ray anisotropy have been derived by using the harmonic analysis technique for the period 1989 to 2004, which covers mostly the major period of solar cycles 22 and 23. In this paper we have taken the pressure corrected hourly data for Kiel neutron monitor station (cut off rigidity ≈ 2.29 GV) to derive the harmonic component of cosmic ray daily variation and compared with the data of Halekala neutron monitor (cut off rigidity ≈ 13.2 GV) for the period 1991 to 2004. From the analysis it has been concluded that the diurnal amplitude and phase of daily variation of cosmic rays have been found to be correlated with solar activity. However, the semi-diurnal amplitude and phase are inversely correlated with solar activity for both the stations.

关键词： Cosmic Ray Anisotropic Variation Solar Parameter

Efficacy of Whole Blood Reconstituted (WBR) in Exchange Transfusion (ET) in Hemolytic Disease of New Born (HDN) —A Study of 110 Cases

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Open Journal of Blood Diseases 2013年第1期3卷 15-20页

作者： Dharmesh chandra sharma Sunita Rai Sudha Iyengar Bharat Jain Satya Sao Ajay Gaur Rahul Sapra Department of Pathology Gajra Raja Medical College Gwalior India Emergency Blood Bank Gwalior India Kilkari Nursing Home Gwalior India

Aim: This study was aimed to review and establish the practice of exchange transfusion (ET) with whole blood reconstituted (WBR) in hemolytic disease of newborn (HDN). Objectives: To observe fall in indirect serum bilirubin, correction of anemia and comparison with related studies. Background: Hemolytic disease of the Newborn is characterized by presence of IgG antibodies in maternal circulation, which causes hemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by macrophages in the fetal spleen with consequent hyperbilirubinemia. Exchange transfusion with or without phototherapy is the method of choice for treating the newborn with on going hemolysis Methods/Materials: Sample size consisted of 110 neonates in whom 119 exchange transfusions were carried out with WBR. WBR was prepared by suspending O Rhesus-D (RhD) positive/negative cells (compatible with neonate’s/ mother’s serum) in AB plasma. Double volume exchange transfusion(s) were carried out through umbilical vein by push-pull technique. Results: Out of 110 cases, 61 (55.5%) were of RhD HDN whereas ABO and other group HDN cases were 30 (27.3%) and 19 (17.3%) respectively. An average post-ET fall in indirect serum bilirubin by 54.6% and correction of anemia by3.7 gm/dl were reported in the study. Conclusion: An average post-ET fall in indirect serum bilirubin and correction of anemia was found to be more significant when compared to other studies. Hence we recommend exchange transfusion in HDN with WBR to obtain reasonable fall in indirect serum bilirubin and high average rate of correction of anemia.

关键词： Whole Blood Reconstituted (WBR) Hemolytic Disease of Newborn (HDN) Exchange Transfusion (ET) Hyperbilirubinemia Anemia Correction

Omics Studies and Systems Biology Perspective towards Abiotic Stress Response in Plants

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American Journal of Plant Sciences 2020年第12期11卷 2172-2194页

作者： Jyoti Prakash Sahoo Laxmipreeya Behera Siddhartha Shankar sharma Jannila Praveena Suman Kumari Nayak Kailash chandra Samal Department of Agricultural Biotechnology Odisha University of Agriculture and Technology Bhubaneswar India Department of Genetics and Plant Breeding Uttar Banga Krishi Viswavidyalaya Cooch Behar India Department of Fruit Science and Horticulture Technology Odisha University of Agriculture and Technology Bhubaneswar India Department of Plant Physiology Odisha University of Agriculture and Technology Bhubaneswar India

Plant abiotic stress responses are vital yield-restricting aspect in agriculture. Recent technology in plant biology allows research of such stress responses at a molecular scale in plants. Network analysis provides in-depth knowledge regarding omics information visualisation as it reduces the intrinsic intricacy of such data. The use of integrated functional genomics helps to understand the relationship between the genomic profile and the phenotypic profile in different environmental conditions of an organism. Plants’ responses to abiotic stress are often considered as a complex process. Systems biology approaches allow visualising and understanding how plant life works to overcome abiotic stress. The combination of integrated functional genomics along with bioinformatics will put a hand in additional in-depth research knowledge on stress tolerance to plants by exploiting available genetic information and continuously improving techniques and strategies. Most of the omics technologies are high throughput with very rapid data generation rates and humongous outputs. These technologies have made noticeable contributions to the modern-day improvements in our knowledge of plant biology. So, in this review, omics studies and the system biology approach towards abiotic stress tolerance in plants are highlighted.

关键词： Genomics Proteomics Transcriptomics System Biology Abiotic Stress Plants

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开展机构协作发展远程教育

中国远程教育 2004年第4S期 29-32页

作者： chandra B.sharma Sohanvir S.Chaudhary 肖俊洪汕头广播电视大学

本文原文发表于“学习联邦”(CommonwealthofLearning)网站《知识系列》(KnowledgeSeries)栏目(2003年)。学习联邦是英联邦各成员国的政府首脑倡议成立的政府间组织,其宗旨是鼓励开发和共享开放学习和远程教育的知识、资源和技术。目前... 详细信息

本文原文发表于“学习联邦”(CommonwealthofLearning)网站《知识系列》(KnowledgeSeries)栏目(2003年)。学习联邦是英联邦各成员国的政府首脑倡议成立的政府间组织,其宗旨是鼓励开发和共享开放学习和远程教育的知识、资源和技术。目前我国远程教育机构也正在开展各种形式的协作,既有电大之间的协作,也有电大与其他教育机构的协作,还有国际间的协作,但毕竟一切刚刚起步许多地方有待于进一步完善。因此,我们认为这篇经验之谈的文章所提出的一些原则、建议、指南等对我们有一定指导意义和借鉴价值。现将其译成中文,以飨读者,并向印度甘地国立开放大学sharma高级讲师和Chaudhary教授以及学习联邦组织致谢!

关键词：机构协作远程教育资源共享教育政策评估标准