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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 673-679页

作者： Sumitra Chanda yogesh Baravalia Mital Kaneria Phytochemical Pharmacological and Microbiological LaboratoryDepartment of BiosciencesSaurashtra UniversityRajkot-360 005GujaratIndia

Objective:To explore antiulcer and antimicrobial properties of methanolic extract of Polyalthia longifolia ***:Gastroprotective potential of Polyalthia longifolia was studied on ethanol and ethanol/HCl induced ulcers at 2 different doses(270 and 540 mg/kg/body weight). Antimicrobial efficacy of Polyalthia longifolia(25 mg/mL) was also studied against six gram positive,seven gram negative bacteria and five fungi by agar well diffusion *** inhibitory concentration was determined by agar well diffusion method in two fold serial dilution, in the range of 97-25 000μg/***:The reduction of ulcer index in Polyalthia longifolia treated animals was found to be statistically significant with respect to control *** Polyalthia longifolia exhibited ulcer protection activity in dose dependent manner and was also better than the *** antimicrobial activity,gram positive bacteria were more susceptible to Polyalthia longifolia than gram negative bacteria and fungal ***:Results obtained confirm the antiulcer and antimicrobial potential of the Polyalthia longifolia.

关键词： Polyalthia longifolia Antimicrobial activity Antiulcer activity Ulcer index Methanol extract

Formononetin alleviates diabetic cardiomyopathy by inhibiting oxidative stress and upregulating SIRT1 in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第6期10卷 254-262页

作者： Manisha J.Oza yogesh A.Kulkarni Shobhaben Pratapbhai Patel School of Pharmacy&Technology Management SVKM's NMIMSV.L.Mehta RoadVile Parle(W)Mumbai 400056India SVKM's Dr.Bhanuben Nanavati College of Pharmacy Vile Parle(W)Mumbai 400056India

Objective:To evaluate the effect of formononetin on type 2 diabetic ***:Diabetes was induced by feeding high-fat diet for 2 weeks and administration of 35 mg/kg of streptozotocin in *** was administered at 10,20 and 40 mg/kg for 16 weeks once a *** glucose,lipid parameters,and cardiac markers in blood samples were *** weight and relative heart weight were *** parameters,oxidative stress parameters and silence information regulator 1(SIRT1)expression in cardiac tissue were *** changes in cardiac tissue were also ***:Formononetin significantly reduced the levels of glucose,triglycerides,cholesterol,low density lipoprotein,creatine kinaseMB,lactate dehydrogenase and aspartate *** addition,formononetin significantly improved hemodynamic parameters,alleviated oxidative stress and increased SIRT1 ***:The study indicates that formononetin can improve hyperglycemia and hyperlipemia,reduce oxidative stress and increase SIRT1 *** can be a potential therapeutic agent for diabetic cardiomyopathy.

关键词： Cardiomyopathy Formononetin Type 2 diabetes SIRT1 Creatinine kinase Cardiac hypertrophy

Approach to a patient with cardiac amyloidosis

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Journal of Geriatric Cardiology 2019年第7期16卷 567-574页

作者： Christopher Strouse Alexandros Briasoulis Rafael Fonseca yogesh Jethava Department of Internal Medicine Division of HematologyOncologyand Blood and Marrow TransplantationUniversity of IowaIowa CityIAUSA Cardiomyopathy Section Cardiology DivisionUniversity of IowaIowa CityIowaUSA Bone Marrow Transplant Program Mayo ClinicPhoenixArizonaUSA

1 Introduction Cardiac amyloid(CA)is characterized by inexorably progressive heart failure making early diagnosis and treatment *** article will review the pathophysiology,clinical presentation,diagnosis,prognostication and treatment of patients with CA.2 Pathophysiology CA is the result of extracellular deposition of a misfolded protein into cardiac tissue,forming insoluble aggregations of rigid,nonbranching 10 nm wide *** causes impaired cardiac function by disrupting cardiac architecture,direct myotoxicity and ischemic injury secondary to infiltration of intramyocardial vessels.

关键词： Cardiac amyloidosis Heart failure The elderly

Resonant magnetoelastic microstructures for wireless actuation of liquid flow on 3D surfaces and use in glaucoma drainage implants

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Microsystems & Nanoengineering 2015年第1期1卷 26-34页

作者： Venkatram Pepakayala Joshua Stein yogesh Gianchandani Center for Wireless Integrated MicroSensing and Systems(WIMS2) Department of Electrical Engineering and Computer ScienceUniversity of MichiganAnn ArborMIUSA Department of Ophthalmology and Visual Sciences University of MichiganAnn ArborMIUSA

Magnetoelastic resonators made from metal alloy foils are widely used for miniature wireless anti-theft tags and have also been explored for use in various sensing *** annealing within three-dimensional(3D)molds,these foils can be formed into curved ***,magnetoelastic materials present an opportunity for the development of a new class of wireless,actuators that have small form factors and low surface profiles and that can conform to curved *** paper describes passive,wireless,resonant magnetoelastic actuators intended for the generation of fluid flow on the surfaces of implantable Ahmed glaucoma drainage *** actuators are remotely excited to resonance using a magnetic field generated by external *** fluid flow is intended to limit cellular adhesion to the surface of the implant,as this adhesion can ultimately lead to implant encapsulation and *** actuators are micromachined from planar 29-μm-thick foils of Metglas 2826MB(Fe_(40)Ni_(38)Mo_(4)B_(18)),an amorphous magnetoelastic alloy,using photochemical *** 10.3×5.6 mm^(2),the planar structures are annealed in 3D molds to conform to the surface of the drainage device,which has an aspherical *** actuator designs are described,with varying shapes and resonant mode *** resonant frequencies for the different designs vary from 520 Hz to 4.7 *** velocities of up to 266μm s^(−1) are recorded at a wireless activation range of 25–30 mm,with peak actuator vibration amplitudes of 1.5μ*** actuators such as those described here have the potential to greatly enhance the effectiveness of glaucoma drainage devices at lowering eye pressure and may also be useful in other areas of medicine.

关键词： actuator fibrosis glaucoma magnetostriction Metglas

Population I Cepheids and understanding star formation history of the Small Magellanic Cloud

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Research in Astronomy and Astrophysics 2016年第4期16卷 71-78页

作者： yogesh Chandra Joshi Auro Prasad Mohanty Santosh Joshi Aryabhatta Research Institute of Observational Sciences Manora PeakNainital 263002India National Institute of Technology Rourkela 769008India

In this paper, we study the age and spatial distributions of Cepheids in the Small Magellanic Cloud （SMC） as a function of their ages using data from the OGLE III photometric catalogue. A period - age relation derived for Classical Cepheids in the Large Magellanic Cloud （LMC） has been used to find the ages of Cepheids. The age distribution of the SMC Classical Cepheids is found to have a peak at log（Age）： 8.40 ± 0.10 which suggests that a major star formation event might have occurred in the SMC about 250 4- 50 Myr ago. It is believed that this star forming burst had been triggered by close interactions of the SMC with the LMC and/or the Milky Way. A comparison of the observed spatial distributions of the Cepheids and open star clusters has also been carried out to study the star formation scenario in the SMC.

关键词： stars: Cepheids -- star type: Pop I (classical) -- galaxies: SMC -- methods: statistical

Numerical Investigation of Sound Generation due to Laminar Flow Past Elliptic Cylinders

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Numerical Mathematics(Theory,Methods and Applications) 2020年第1期13卷 27-62页

作者： Bikash Mahato Naveen Ganta yogesh G.Bhumkar Scientific Computing Laboratory School of Mechanical SciencesIndian Institute of Technology BhubaneswarOdishaIndia

Numerical investigation of sound generation due to unsteady laminar flow past elliptic cylinders has been carried out using direct numerical simulation(DNS)approach at a free-stream Mach number of *** of aspect ratio(0.6≤AR≤1.0)and Reynolds number(100≤Re≤160)on the characteris-tics of radiated sound fields are ***-dimensional compressible fluid flow equations are solved on a refined grid using high resolution dispersion relation pre-serving(DRP)*** present DNS data,equivalent noise sources as given by various acoustic analogies are *** and frequencies associated with these noise sources are further related to characteristics of disturbance pressure *** pressure fields are intensified with increase in Reynolds number and aspect ***,radiated sound power increases with increase in Reynolds number and aspect *** various cases studied here,minimum and max-imum values of radiated sound power are found at Re=120&AR=0.6 and Re=160&AR=1.0,*** patterns show that the generated sound fields are dominated by the lift dipole for all ***,proper orthogonal decomposition(POD)technique has been implemented for decomposing distur-bance pressure *** POD modes associated with the lift and the drag dipoles have been *** analyses also clearly display that the radiated sound fields are dominated by the lift dipole ***,acoustic and hydrodynamic modes obtained using Doak’s decomposition method have confirmed the patterns of radiated sound field intensities.

关键词： Computational aeroacoustics acoustic analogies aeolian tones proper orthogonal decomposition Doak’s decomposition

Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 342-346页

作者： yogesh Baravalia yogeshkumar Vaghasiya Sumitra Chanda Phytochemical Pharmacological and Microbiological LaboratoryDepartment of BiosciencesSaurashtra UniversityRajkot-360 005GujaratIndia

Objective:To evaluate the protective effect of Woodfordia fruticosa Kurz flowers against experimentally induced liver toxicity in ***:Two different doses of methanol extract of Woodfordia fruticosa(WFM) were evaluated for the hepatoprotective activity against diclofenac sodium induced hepatotoxicity in *** biochemical parameters like alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total protein(TP),albumin(ALB),blood urea nitrogen(BUN) from serum;total protein(TP),glutathione (GSH) levels,catalase(CAT) and glutathione peroxidase(GPx) activities from liver were studied; histopathologic changes of liver were also ***:WFM effectively reduced the elevated levels of serum ALT,AST,ALP and BUN,enhanced the reduced TP,ALB and hepatic GSH,CAT,GPx *** histopathological analysis suggested that WFM decreased the degree of liver fibrosis induced by ***:This study demonstrates the hepatoprotective activity of WFM and thus scientifically support the use of this plant in traditional medicine for the treatment of liver disorders.

关键词： Woodfordia fruticosa Diclofenac Hepatoprotective Biochemical analysis Histopathology

Anthropogenic disturbances and status of forest and wildlife in the dry deciduous forests of Chhattisgarh state in India

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Journal of Forestry Research 2012年第1期23卷 45-52页

作者： Chandra Prakash Kala yogesh Dubey Ecosystem & Environment Management Indian Institute of Forest Management P.B. No. 357 Nehru Nagar Bhopal - 462 003 Madhya Pradesh INDIA

The advent of modem forces and the changes in socio- economic patterns of forest dwellers have increased the pressures on the forests. In order to mitigate such pressures and also to protect the forests and wildlife the model of protected areas networks has shifted and en- hanced such pressures in the unprotected natural forests due to several reasons. Being a low profile category of protected status and continuous human settlements, the present study highlights the case of dry deciduous forests of Sarguja district of Chhattisgarh state of India. The major objec- tives of this study were to quantify the status of forests and wildlife and also to determine the extent of anthropogenic disturbances faced by the dry deciduous forests of central India. Transect and silent drive count methods were used for sampling wildlife and quadrat method was used for sampling vegetation. Besides, the local uses of various forest pro- duces were also studied in view of understanding the people dependency on forests. The forest vegetation, in the study area, was pre-dominated by Shorea robusta, which had Madhuca indica, Diospyrus melanoxylon and Buchnania lanzan as the major companion species. The forest had either the high girth class mature tree species or the saplings. The low vegeta- tion cover and density were due to the high anthropogenic pressures mainly in the form of heavy livestock grazing and collection of etlmo- botanically important species. The study though reveals that the area is not rich in wildlife and the forest is fragmented, the area still supports some important species, which include many rare and endangered plants and animals. The findings of this study have been discussed in view of the management and conservation of the forest and wildlife in the dry deciduous forests.

关键词： dry deciduous forest central India wildlife anthropogenicdisturbances biodiversity conservation

Estimating an Exponential Scale Parameter Under Double Censoring

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Communications in Mathematics and Statistics 2019年第3期7卷 309-328页

作者： yogesh Mani Tripathi Constantinos Petropoulos Farha Sultana Department of Mathematics Indian Institute of Technology PatnaBihta 801106India Department of Mathematics University of Patras26504 RioGreece

We consider estimation of the scale parameter of a two-parameter exponential distribution on the basis of doubly censored *** of estimators,improving upon the minimum risk equivariant estimator,are derived under an arbitrary strictly convex loss *** existing dominating procedures are shown to belong to the proposed classes of estimators.

关键词： Brewster-Zidek estimator Censored samples Equivariant estimator Inadmissibility Stein-type estimator

Inhibition of hepatic tumor cell proliferation in vitro and tumor growth in vivo by taltobulin,a synthetic analogue of the tripeptide hemiasterlin

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World Journal of Gastroenterology 2006年第42期12卷 6771-6778页

作者： yogesh K Vashist Celine Tiffon Christoforos Stoupis Claudio A Redaelli Department of General Visceral and Thoracic Surgery University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Visceral and Transplantation Surgery University Clinic Bern Switzerland Department of Clinical Research University of Bern Switzerland Institute of Clinical Radiology University of Bern Switzerland Gastrozentrum Hirslanden-Viszeralchirurgie Hirslanden Klinik Zurich Switzerland Department of Visceral and Transplantation Surgery and Department of Clinical Research University of Bern Switzerland

AIM： To investigate the inhibitory effects of taltobulin （HTI-286）, a synthetic analogue of natural hemiasterlin derived from marine sponges, on hepatic tumor growth in vitro and in vivo. METHODS： The potential anti-proliferative effects of HTI-286 on different hepatic tumor cell lines in vitro and in vivo were examined. RESULTS： HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines （mean IC50 = 2 nmol/L ±1 nmol/L） in vitro. Interestingly, no decrease in viable primary human hepatocytes （PHH） was detected under HTI-286 exposure. Moreover, intravenous administration of HTI-286 significantly inhibited tumor growth in vivo （rat allograft model）. CONCLUSION： HFI-286 might be considered a potent promising drug in treatment of liver malignancies. HTI-286 is currently undergoing clinical evaluation in cancer patients.

关键词： Hepatocellular carcinoma Antimicrotubuleagent HTI-286