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World Journal of Gastroenterology 2006年第42期12卷 6771-6778页

作者： yogesh K Vashist Celine Tiffon Christoforos Stoupis Claudio A Redaelli Department of General Visceral and Thoracic Surgery University Medical Center Hamburg-Eppendorf Hamburg Germany Department of Visceral and Transplantation Surgery University Clinic Bern Switzerland Department of Clinical Research University of Bern Switzerland Institute of Clinical Radiology University of Bern Switzerland Gastrozentrum Hirslanden-Viszeralchirurgie Hirslanden Klinik Zurich Switzerland Department of Visceral and Transplantation Surgery and Department of Clinical Research University of Bern Switzerland

AIM： To investigate the inhibitory effects of taltobulin （HTI-286）, a synthetic analogue of natural hemiasterlin derived from marine sponges, on hepatic tumor growth in vitro and in vivo. METHODS： The potential anti-proliferative effects of HTI-286 on different hepatic tumor cell lines in vitro and in vivo were examined. RESULTS： HTI-286 significantly inhibited proliferation of all three hepatic tumor cell lines （mean IC50 = 2 nmol/L ±1 nmol/L） in vitro. Interestingly, no decrease in viable primary human hepatocytes （PHH） was detected under HTI-286 exposure. Moreover, intravenous administration of HTI-286 significantly inhibited tumor growth in vivo （rat allograft model）. CONCLUSION： HFI-286 might be considered a potent promising drug in treatment of liver malignancies. HTI-286 is currently undergoing clinical evaluation in cancer patients.

关键词： Hepatocellular carcinoma Antimicrotubuleagent HTI-286

Dynamic threshold voltage operation in Si and SiGe source junctionless tunnel field effect transistor

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Journal of Semiconductors 2014年第11期35卷 32-39页

作者： Shibir Basak Pranav Kumar Asthana yogesh Goswami Bahniman Ghosh Department of Electrical Engineering Indian Institute of Technology Kanpur Microelectronics Research Center 10100Burnet RoadBldg.160University of Texas at Austin

We propose a dynamic threshold voltage j unctionless tunnel FET （DT-JLTFET） in wnlcn me mresnolu voltage can be dynamically adjusted, resulting in higher ON-current. Through 2D numerical simulations, it is presented that the threshold voltage in the DT-JLTFET can be adjusted by applying a voltage to the adjust gate. The impact of the threshold voltage shift on the overall performance of the device is also studied. A comparison is made between the dynamic threshold voltage characteristics of a silicon JLTFET and a Sio.7Geo.3 source JLTFET.

关键词： SiGe tunnel field effect transistor ON-current

Chemical Protein Synthesis by Native Chemical Ligation and Variations Thereof

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Chinese Journal of Chemistry 2019年第11期37卷 1181-1193页

作者： Siyao Wang yogesh Abaso Thopate Qingqing Zhou Ping Wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

For a long time,the total synthesis of proteins was considered as a "mission impossible" because of the tedious and complex synthetic steps and demanding purification ***,with the development of modern synthetic methodologies,many protein syntheses have now been *** importantly,through chemical synthesis,desired modifications can be installed to target proteins precisely,which is a major advantage over trad卜tional bio-synthesis *** review summarizes the techniques developed for protein assembly,including native chemical ligation,5e-mediated ligation,and a range of other ligation methods. .

关键词： processes. methods. synthesis

Evaluation of Postharvest Senescence of Broccoli via Hyperspectral Imaging

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Plant Phenomics 2022年第1期4卷 298-309页

作者： Xiaolei Guo yogesh K.Ahlawat Tie Liu Alina Zare University of Florida Department of Electrical and Computer EngineeringGainesvilleFloridaUSA University of Florida Horticultural Sciences DepartmentGainesvilleFloridaUSA

Fresh fruit and vegetables are invaluable for human health;however,their quality often deteriorates before reaching consumers due to ongoing biochemical processes and compositional *** currently lack any objective indices which indicate the freshness of fruit or vegetables resulting in limited capacity to improve product quality eventually leading to food loss and waste.

关键词： eventually indices vegetables

Gastroenteric tube feeding: Techniques, problems and solutions

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World Journal of Gastroenterology 2014年第26期20卷 8505-8524页

作者： Irina Blumenstein yogesh M Shastri Jürgen Stein Department of Gastroenterology and Clinical Nutrition Johann Wolfgang Goethe University Clinic Gastroenterology and Clinical Nutrition Hospital Sachsenhausen Crohn Colitis Clinical Research Center RheinMain

Gastroenteric tube feeding plays a major role in the management of patients with poor voluntary intake,chronic neurological or mechanical dysphagia or gut dysfunction,and patients who are critically ***,despite the benefits and widespread use of enteral tube feeding,some patients experience *** review aims to discuss and compare current knowledge regarding the clinical application of enteral tube feeding,together with associated complications and special *** conducted an extensive literature search on PubMed,Embase and Medline using index terms relating to enteral access,enteral feeding/nutrition,tube feeding,percutaneous endoscopic gastrostomy/jejunostomy,endoscopic nasoenteric tube,nasogastric tube,and refeeding *** literature showed common routes of enteral access to include nasoenteral tube,gastrostomy and jejunostomy,while complications fall into four major categories:mechanical,e.g.,tube blockage or removal;gastrointestinal,e.g.,diarrhea;infectious e.g.,aspiration pneumonia,tube site infection;and metabolic,e.g.,refeeding syndrome,*** the type and frequency of complications arising from tube feeding vary considerably according to the chosen access route,gastrointestinal complications are without doubt the most *** associated with enteral tube feeding can be reduced by careful observance of guidelines,including those related to food composition,administration rate,portion size,food temperature and patient supervision.

关键词： Enteral tube feeding Percutaneous endoscopic gastrostomy Refeeding syndrome Enteral nutrition Buried bumper syndrome Nasoenteral tubes Colocutaneous fistulae

Fecal tumor M2 pyruvate kinase is not a specific biomarker for colorectal cancer screening

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World Journal of Gastroenterology 2007年第19期13卷 2768-2769页

作者： yogesh M Shastri Jürgen M Stein Department of Medicine I-ZAFES Division of Gastroenterology and Clinical Nutrition Johann Wolfgang Goethe-University Hospital Frankfurt am Main Germany

TO THE EDITORWe read with great interest and a bit of surprise the article by Tonus et al. We would share herein our comments about it. The specificity of the fecal tumor M2 pyruvate kinase 0VI2-PK） reported by Tonus et al for diagnosing colorectal cancer （CRC） is 93%. This is considerably higher than in any of the previously published studies. In our work, the maximum specificity of fecal M2- PK is 78% （Table 1）. There is a vast difference of 15% between the previous studies and the current study of Tonus et al, which is difficult to explain. We are skeptical about such a high specificity reported by the authors.

关键词： Gastroenterology

Genetic grey wolf optimization and C-mixture for collaborative data publishing

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第6期9卷 188-210页

作者： yogesh R.Kulkarni T.Senthil Murugan Vel Tech University Avadi Chennai 600062Tamil NaduIndia Department of Computer Science and Engineering Vel Tech University Chennai 600062 Tamil NaduIndia

Data publishing is an area of interest in present day technology that has gained huge attention of researchers and *** concept of data publishing faces a lot of security issues,indicating that when any trusted organization provides data to a third party,personal information need not be ***,to maintain the privacy of the data,this paper proposes an algorithm for privacy preserved collaborative data publishing using the Genetic Grey Wolf Optimizer(Genetic GWO)algorithm for which a C-mixture parameter is *** C-mixture parameter enhances the privacy of the data if the data does not satisfy the privacy constraints,such as the k-anonymity,l-diversity and the m-privacy.A minimum fitness value is maintained that depends on the minimum value of the generalized information loss and the minimum value of the average equivalence class *** minimum value of the fitness ensures the maximum utility and the maximum *** was carried out using the adult dataset,and the proposed Genetic GWO outperformed the existing methods in terms of the generalized information loss and the average equivalence class metric and achieved minimum values at a rate of 0.402 and 0.9,respectively.

关键词： k-Anonymity l-diversity m-privacy C-mixture Genetic GWO.

Role of endoscopy in surgical management of cholesteatoma:A systematic review

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Journal of Otology 2020年第4期15卷 166-170页

作者： Bhavika Verma yogesh G.Dabholkar Department of ENT School of MedicineD.Y.Patil UniversityNavi MumbaiIndia

Endoscopes are increasingly being used in cholesteatoma surgeries either as an adjunct to microscopes or sometimes *** role at present is more as adjunct to microscope which still remains the work-horse for ***,as endoscopy and endoscopic instruments are increasingly getting refined,role of endoscopy in management of cholesteatoma is continuously being appraised with progressively newer *** review aims to assess outcomes of several studies in which endoscopic techniques were used in cholesteatoma surgery and recognize common *** extensive review of literature on this theme was *** studies comprising of 1685 patients treated endoscopically either exclusively or in combination with microscope were ***-operatively,in 267(15.82%)cases,residual cholesteatoma was identified by endoscope in hidden areas after completion of surgery with *** follow-up,recidivism was identified in 108 cases(6.4%)in second look *** sites of recurrence were hidden areas like sinus *** review while acknowledging the value of microscope,highlights the merit of endoscope usage in cholesteatoma surgery and its role in reducing recurrence.

关键词： Endoscopic ear surgery Systematic review Adjunctive endoscopy Cholesteatoma Mastoidectomy Recurrence

Assessment of a fuzzy logic based MRAS observer used in a photovoltaic array supplied AC drive

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Frontiers in Energy 2014年第1期8卷 81-89页

作者： Bhavnesh KUMAR yogesh K CHAUHAN Vivek SHRIVASTAVA School of Engineering Gautam Buddha University Greater Noida201310 India Electrical Engineering Department National Institute of Technology Delhi Delhi 110077 India

In this paper a fuzzy logic （FL） based model reference adaptive system （MRAS） speed observer for high performance AC drives is proposed. The error vector computation is made based on the rotor-flux derived from the reference and the adaptive model of the induction motor. The error signal is processed in the proposed fuzzy logic controller （FLC） for speed adaptation. The drive employs an indirect vector control scheme for achieving a good closed loop speed control. For powering the drive system, a standalone photovoltaic （PV） energy source is used. To extract the maximum power from the PV source, a constant voltage controller （CVC） is also proposed. The complete drive system is modeled in MATLAB/Simulink and the performance is analyzed for different operating conditions.

关键词： induction motor drive fuzzy logic (FL)control model reference adaptive system (MILAS) photo-voltaic (PV) array vector control

Artificial neural network (ANNs) and mathematical modelling of hydration of green chickpea

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Information Processing in Agriculture 2021年第1期8卷 75-86页

作者： yogesh Kumar Lochan Singh Vijay Singh Sharanagat Ayon Tarafdar Department of Food Engineering National Institute of Food Technology Entrepreneurship and ManagementHaryanaIndia Department of Agriculture and Environmental Sciences National Institute of Food Technology Entrepreneurship and ManagementHaryanaIndia

The present study was aimed to model the hydration characteristics of green chickpea(GC)using mathematical modelling and examine predictive ability of artificial neural network(ANN)*** of GC was performed at different temperatures 25,35,45,55 and 65℃.Different mathematical models were tested for the hydration at different *** ANN modelling,the hydration time and hydration temperature were used as input variables and moisture ratio,moisture content and hydration ratio were taken as output *** model best described the hydration behavior at 25℃;while hydration at high-temperature was better described by Page model and Ibarz et *** optimum temperature obtained for hydration was 35℃.Effective mass diffusion coefficient(D_(e))increased from 1.5510^(-11)-1.7910^(-9) m^(2)/s with the increase in the hydration *** low activation energy(39.66 kJ/moL)shows the low-temperature sensitiveness of *** temperature hydration(25℃)required higher time(>200 min)to achieve the equilibrium moisture content(EMC),however high temperature hydration(35–65℃)reduced the EMC time(150 min).ANN was used to predict the hydration behavior and K fold cross validation was performed to check the over fitting of ANN *** show that the LOGSIGMOID transfer function showed better performance when used at the hidden layer input node in conjunction to both PURELIN and *** was found suitable for moisture ratio(MR)and hydration ratio(HR)prediction,as opposed to PURELIN for moisture content(MC)*** model prediction was obtained when the number of neurons in the hidden layer for MC,MR and HR was 12,8 and 15,*** and ANN modelling results are useful to improve/predict the MC,MR and HR during hydration process of GC at different temperature and other similar process.

关键词： Green chickpea Water absorption Hydration temperature ANN modeling