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The incidence of sporadic viral hepatitis in North India:a preliminary study

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Hepatobiliary & Pancreatic Diseases International 2007年第6期6卷 596-599页

作者： Subrat kumar Radha kanta Ratho yogesh kumar Chawla Anuradha Chakraborti Department of Virology Department of Hepatology Department of Experimental Medicine and Biotechnology

BACkGROUND: Viral hepatitis is one of the major causes of mortality and morbidity in developing countries. Hepatitis E virus (HEV) among the major etiological agents is responsible for both sporadic and epidemic outbreaks. The epidemic outbreak is water-borne whereas the sporadic outbreak is possibly through contact. Various diagnostic tools at times fail to pinpoint the cause of viral hepatitis. This study was carried out to evaluate the utility of ELISA and nRT-PCR (nested reverse transcriptase polymerase chain reaction) for the diagnosis of sporadic and acute viral hepatitis (AVH) caused by HEV in an endemic situation in North India. METHODS: Serum samples were collected from all the affected and suspected persons and subjected to serological detection of HAV IgM, HBsAg, HCV antibody and HEV IgM. The samples that were positive for HEV IgM were further processed for the detection of HEV RNA by nRT-PCR. RESULTS: A total of 843 samples were collected from 685 patients with AVH, 70 patients with fulminant hepatic failure (FHF), 53 patients with chronic liver disease (CLD), 11 patients with antituberculosis therapy (ATT)-induced jaundice, and 24 pregnant women. The percentage of positivity for anti-HEV IgM was 58.3% in the pregnant women, 41.4% in the paients with FHF, 38.6% in the patients with AVH, 9.4% in the patients with CLD and 18.2% in the patients with ATT induced jaundice. 9.4% of HBsAg carriers were positive for anti-HEV IgM. Males outnumbered females (62.8% vs. 37.1%). Furthermore, the rates of fulminant and acute outbreaks of hepatitis with HEV RNA positivity were 41.4% and 9.4%, respectively. CONCLUSION: Serological and molecular analysis should be combined for the diagnosis of viral infections, especially in endemic areas.

关键词： viral hepatitis fulminant liver failure pregnancy

Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations

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World Journal of Gastroenterology 2005年第3期11卷 393-395页

作者： Ajay Duseja Reena Das Mohit Nanda Ashim Das Gurjeewan Garewal yogesh Chawla Department of Hepatology Department of Hematology Department of Histopathology

AIM: The pathogenesis of occurrence of liver inflammation and fibrosis in patients with nonalcoholic steatohepatitis (NASH) is not completely understood. Other than insulin resistance, iron abnormalities have been thought to be one of the triggering factors. Therefore, our aim was to study the role of iron abnormalities and HFE gene mutations in patients with NASH. METHODS: Thirty-one patients of NASH diagnosed on the basis of clinical examination biochemistry, ultrasonography and liver biopsy (n = 14) were included in the study. Serum iron parameters (n = 23) (iron, ferritin, total iron-binding capacity and transferrin saturation), Perls' iron staining on liver biopsies (n = 14) and HFE gene mutations (C282Y and H63D) (n = 16) were studied in these patients. The association between iron staining, necroinflammatory activity and fibrosis stage on liver biopsies was also determined. RESULTS: Elevated serum iron, ferritin and transferrin saturation above 55% were observed in 4.3% of patients. On histology, 71% of the patients had negative iron staining, 21.4% had 1+ staining, 7.2% had 2+ staining and none had 3+ or 4+ staining. There was no association between the degree of iron staining and necroinflammatory activity (P=0.55) and fibrosis stage (P= 0.09) on histology. None of the patients had C282Y HFE gene mutation and four patients (25%) were found to be heterozygotes for H63D gene mutation. CONCLUSION: Our study does not favor iron overload and HFE gene mutations as major factors in the pathogenesis of NASH in Asian Indians.

关键词： Nonalcoholic steatohepatitis Iron overload HFE gene Mutation

Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospitalbased observational study

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Asian Journal of Andrology 2023年第2期25卷 240-244页

作者： Tribhuwan kumar kamlesh Jha Md Zabihullah kumari Neelu yogesh kumar kumar Siddharth Department of Physiology All India Institute of Medical SciencesPatna 801507BiharIndia Akshat Spandan Clinic Patna 801507BiharIndia

The effects of the coronavirus disease 2019(COVID-19)pandemic on male fertility have received considerable attention because human testes contain high levels of angiotensin-converting enzyme-2 receptors,through which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)can *** studies showed decreases in semen quality during and after recovery from ***,no semen quality studies have examined the effects of widespread subclinical and mild disease,as well as changes in lifestyle,psychosocial behavior,intake of dietary supplements,and *** cross-sectional study compared semen quality parameters in male partners of infertile couples between men who underwent semen analysis before the COVID-19 pandemic(prepandemic group)and men who underwent semen analysis during the pandemic period(pandemic group);the analysis sought to clarify the overall effects of the *** participants in the pandemic group had experienced clinically overt *** the 239 participants,mean body weight(P=0.001),mean body mass index(P<0.001),median sperm concentration(P=0.014),total sperm count(P=0.006),and total percentages of motile(P=0.013)and abnormal cells(P<0.001)were significantly greater in the pandemic group(n=137)than those in the prepandemic group(n=102).Among abnormal cells,the percentages of cells with excess residual cytoplasm(P<0.001),head defects(P<0.001),and tail defects(P=0.015)were significantly greater in the pandemic group than those in the prepandemic *** the exception of morphology,the overall semenogram results were better in the pandemic group than those in the prepandemic group.

关键词： coronavirus disease 2019 pandemic male infertility SARS-CoV-2 semen analysis

Towards a systematic understanding of blockchain governance in proposal voting: A dash case study

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Blockchain(Research and Applications) 2022年第3期3卷 89-99页

作者： Lawrence Mosley Hieu Pham Xiaoshi Guo yogesh Bansal Eric Hare Nadia Antony Omni Analytics Group AmesIA50014USA College of Business The University of Alabama in HuntsvilleHuntsvilleAL35899USA Department of Industrial and Manufacturing Systems Engineering Iowa State UniversityAmesIA50014USA Omni Analytics Innovative Technologies Initiative AmesIA50014USA

The transparent and immutable nature of blockchain provides incentives for organizations wishing to create and implement an open,decentralized governance *** members exercise their voting rights,a fault-tolerant record accumulates on the blockchain that can be analyzed to diagnose and intercept potential threats to the governing *** date,there has not been a systematic study of on-chain governance with respect to *** this paper,we provide an analysis of blockchain governance through a case study of the first cryptocurrency to adopt on-chain voting,*** analysis introduces the key characteristics of blockchain governance,steps through a data-driven exploration of Dash's on-chain voting system,and highlights exploitable attack vectors and vulnerabilities for the subversion of Dash's on-chain voting system via a novel network analysis *** then conclude with guidelines for other organizations looking to implement similar blockchain governance solutions while maintaining integrity in their operations.

关键词： Decentralized governance Blockchain Voting systems Data mining Network analysis

Finite Element Analysis (FEA) and Thermal Gradient of a Solid Rectangular Fin with Embossing’s for Aerospace Applications

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Advances in Aerospace Science and Technology 2018年第3期3卷 49-60页

作者： Joel Hemanth k. B. yogesh Presidency University Bangalore India JSS Academy of Technical Education Bangalore India

Fins are the extended surfaces through which heat transfer takes place by conduction and convection to keep the base surface cool. Fins of various configurations are presently used ranging from automobile engines to cooling of chip in a computer. Fins used presently are solid with different shapes but in the present research such solid fins are compared with solid fins having maximum of 10 numbers of embossing’s that further increases the surface area for maximum heat transfer. Importance in this research is given to variation of temperature along the length of the fins which in turn gives rate of heat transfer. Thus this research is under taken to increase the efficiency of fins (by extracting heat from the base surface) which is highly demanded today for air cooled engines, compressors, refrigerators etc. In the present research, SOLID70 element and SURF152 elements are used for FE analysis. Methodology involves 3D rectangular fin modelling and meshing, creation of surf elements for the modeling, applying the boundary conditions and source temperature, applying the material property (aluminum) to obtain the steady state thermal contours. FEA results are finally compared with analytic and experimental values for validity. In the present research, a solid rectangular aluminum fin and the same rectangular fin with 2, 4, 8 and 10 embossing’s were compared through finite element analysis for its temperature distribution along the length. FEA analysis of the present research showed that fins having embossing’s were more efficient compared to that a simple solid fin. Hence it is concluded from the present research that embossing’s at preferred locations further increases the rate of heat transfer. From the present analysis it is concluded that the mathematical and FEA for a solid rectangular fin without embossing’s are converging within ±1.2°C and rectangular fin with 10 embossing’s is converging within ±1.4°C and hence the validity.

关键词： Fin FEA Temperature Embossing and Surface

Nanoscale Ⅲ-Ⅴ on Si-based junctionless tunnel transistor for EHF band applications

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Journal of Semiconductors 2017年第5期38卷 42-48页

作者： yogesh Goswami Pranav Asthana Bahniman Ghosh Department of Electrical Engineering Indian Institute of Technology Kanpur Microelectronics Research Center University of Texas at Austin

A single gate Ⅲ-Ⅴ junctionless tunnel field effect transistor（SG-JLTFET） has been reported which shows excellent dc characteristics at low power supply *** device has a thin uniformly n-type doped channel of GaSb *** antimonide which is grown epitaxially over silicon *** DC performance parameters such as I（on）,I（on）/I（off）,average and point subthreshold slope as well as device parameters for analog applications *** gm,transconductance generation efficiency gm/ID,various capacitances and the unity gain frequency fT are studied using a device *** with examining its endurance to short channel effects,the performances are also compared with a Silicon Dual Gate Junctionless Tunnel FET（DG-JLTFET）.The DC and small signal analog performance reflects that GaSb SG-JLTFET has immense purview for extreme high-frequency and low-power applications.

关键词： single gate junctionless tunnel field effect transistor (SG JL-TFET) gallium antimonide band-to-band tunnelling sub-threshold slope (SS)

The use of hydrogel-delivered extracellular vesicles in recovery of motor function in stroke:a testable experimental hypothesis for clinical translation including behavioral and neuroimaging assessment approaches

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Neural Regeneration Research 2021年第4期16卷 605-613页

作者： Magdalini Tsintou kyriakos Dalamagkas Tara LMoore yogesh Rathi Marek kubicki Douglas LRosene Nikos Makris Departments of Psychiatry and Neurology Services Center for Neural Systems InvestigationsCenter for Morphometric AnalysisAthinoula A.Martinos Center for Biomedical ImagingMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Psychiatry Psychiatry Neuroimaging LaboratoryBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA University College of London Division of Surgery&Interventional Science Center for Nanotechnology&Regenerative MedicineUniversity College LondonLondonUK Department of Physical Medicine and Rehabilitation The University of Texas Health Science Center at HoustonHoustonTXUSA The Institute for Rehabilitation and Research Memorial Hermann Research Center The Institute for Rehabilitation and Research Memorial Hermann HospitalHoustonTXUSA Department of Anatomy&Neurobiology Boston University School of MedicineBostonMAUSA

Neural tissue engineering,nanotechnology and neuroregeneration are diverse biomedical disciplines that have been working together in recent decades to solve the complex problems linked to central nervous system(CNS)*** is known that the CNS demonstrates a very limited regenerative capacity because of a microenvironment that impedes effective regenerative processes,making development of CNS therapeutics *** the high prevalence of CNS conditions such as stroke that damage the brain and place a severe burden on afflicted individuals and on society,it is of utmost significance to explore the optimum methodologies for finding treatments that could be applied to humans for restoration of function to pre-injury *** vesicles(EVs),also known as exosomes,when derived from mesenchymal stem cells,are one of the most promising approaches that have been attempted thus far,as EVs deliver factors that stimulate recovery by acting at the nanoscale level on intercellular communication while avoiding the risks linked to stem cell *** the same time,advances in tissue engineering and regenerative medicine have offered the potential of using hydrogels as bio-scaffolds in order to provide the stroma required for neural repair to occur,as well as the release of biomolecules facilitating or inducing the reparative *** review introduces a novel experimental hypothesis regarding the benefits that could be offered if EVs were to be combined with biocompatible injectable *** rationale behind this hypothesis is presented,analyzing how a hydrogel might prolong the retention of EVs and maximize the localized benefit to the *** sustained delivery of EVs would be coupled with essential guidance cues and structural support from the hydrogel until neural tissue remodeling and regeneration ***,the importance of including nonhuman primate models in the clinical translation pipeline,as well as the added benefit of m

关键词： cortical injury exosomes extracellular vesicles hydrogels neural tissue engineering neural tissue repair neuroregeneration non-human primates stroke

Structural,magnetic and dielectric properties of nano-crystalline Ni-doped BiFeO_(3) ceramics formulated by self-propagating high-temperature synthesis

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Journal of Advanced Ceramics 2013年第2期2卷 135-140页

作者： yogesh A.CHAUDHARI Chandrashekhar M.MAHAJAN Prashant P.JAGTAP Subhash T.BENDRE Department of Physics School of Physical SciencesNorth Maharashtra UniversityJalgaon 425001India Department of Engineering Sciences and Humanities(DESH) SRTTC-FOEKamshetPune 410405India Department of Engineering Sciences and Humanities(DESH) Vishwakarma Institute of Technology(VIT)Pune 411037India

Ni-doped BiFeO_(3) powders with the composition BiFe_(1-x)Ni_(x)O_(3)(x=0.05,0.1 and 0.15)were prepared by a self-propagating high-temperature synthesis(SHS),using metal nitrates as oxidizers and glycine as *** X-ray diffraction(XRD)patterns depict that Ni-doped BiFeO_(3) ceramics crystallize in a rhombhohedral *** scanning electron micrographs of Ni-doped BiFeO_(3) ceramics show a dense morphology with interconnected *** is found that,the room-temperature magnetization measurements in Ni-incorporated BiFeO_(3) ceramics give rise to nonzero *** magnetization of Ni-doped BiFeO_(3) ceramics is significantly enhanced when Ni doping concentration reaches to x=0.1 at 5 *** variations of dielectric constant with temperature in BiFe_(0.95)Ni_(0.05)O_(3),BiFe_(0.9)Ni_(0.1)O_(3) and BiFe_(0.85)Ni_(0.15)O_(3) samples exhibit clear dielectric anomalies approximately around 450℃,425℃and 410℃respectively,which correspond to antiferromagnetic to paramagnetic phase transition of the parent compound BiFeO_(3).

关键词： Ni-doped BiFeO_(3) self-propagating high-temperature synthesis(SHS) X-ray diffraction(XRD) magnetic properties dielectric properties

Novel Z-Scheme ZnIn_(2)S_(4)-based photocatalysts for solar-driven environmental and energy applications: Progress and perspectives

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Journal of Materials Science & Technology 2021年第28期87卷 234-257页

作者： yogesh kumar Rohit kumar Pankaj Raizada Aftab Aslam Parwaz khan Quyet Van Le Pardeep Singh Van-Huy Nguyen School of Advanced Chemical Sciences Shoolini UniversitySolanHP173229India Department of Chemistry Government Degree CollegeSolanHP173212India Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah21589Saudi Arabia Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam Department for Management of Science and Technology Development Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Applied Sciences Ton Duc Thang UniversityHo Chi Minh CityVietnam

Benefiting from strong redox ability,improved charge transport,and enhanced charge separation,Zscheme heterostructures of ZnIn_(2)S_(4) based photocatalysts have received considerable interest to tackle energy needs and environmental *** present review highlights the properties of ZnIn_(2)S_(4),which make it a promising photocatalyst,and a suitable combination with oxidation photocatalyst to form Zscheme,leading to improve their photocatalytic properties *** the central part of this review,various types of Z-scheme heterojunction developed recently based on ZnIn_(2)S_(4) and their application in pollutant degradation,water splitting,CO_(2) reduction,and toxic metals *** analytical techniques to detect or trap the active radical and study the charge separation and lifetime of charge carriers in these Z-schemes are *** review offers its readers a broad optical window for the structural architecture of ZnIn_(2)S_(4)-based Z-schemes,photocatalytic activity,stability,and their technological ***,we discuss the challenges and opportunities for further development on Z-Scheme ZnIn_(2)S_(4)-based photocatalysts toward energy and environmental applications based on the recent progress.

关键词： ZnIn_(2)S_(4) Z-scheme photocatalyst Charge transfer mechanism Pollutant degradation Environmental remediation