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t.e Genome of Cucurbit. argyrosperma (Silver- Seed Gourd) Reveals Fast.r Rat.s of Prot.in- Coding Gene and Long Noncoding RNA t.rnover and Neofunct.onalizat.on wit.in Cucurbit.

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Molecular Plant 2019年第4期12卷 506-520页

作者： Josue Barrera-Red on do Enrique Ibarra-Laclet.e Alejandra Vazquez-Lobo yocelyn t. gutierrez-guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Mont.s-Hernandez Rafael Lira-Saade Luis E. Eguiart. Depart.ment. de Ecologia Evolut.va Instituto de Ecologia Universidad Nacional Aut6noma de Mexico Circuito Exterior s/n Anexo al Jardin Bot合nico 04510 Ciudad de Mexico Mexico Depart.ment. de Est.dios Moleculares Avanzados Instituto de Ecologia A.C. Carretera Antigua a Coatepec No. 351 Col. El Haya. C.P. Xalapa Veracruz 91070 Mexico Cent.o de Invest.gaciones en Biodiversidad y Conservacion Universidad Autdnoma del Estado de Morelos Av. Universidad 1001 Col. Chamilpa Cuernavaca Morelos 62209 Mexico Campo Experiment.l Bajio Instituto Nacional de In vestigaciones Forestales Agricolas y Pecuarias (INIFAP) Km 6.5 Carretera Celaya-San Miguel de Allen de Celaya Guanajuato 38110 Mexico UBIPRO Facultad de Estudios Superiores Iztacala Universidad Nacional Autdnoma de Mexico Av. de los Barrios #1 Col. Los Reyes Iztacala Tlanepantla Edo. de Mex 54090 Mexico

Whole-genome duplicat.ons are an import.nt.source of evolut.onary novelt.es t.at.change t.e mode and t.mpo at.which genet.c element. evolve wit.in a genome. t.e Cucurbit. genus experienced a wholegenome duplicat.on around 30 million years ago, alt.ough t.e evolut.onary dynamics of t.e coding and noncoding genes in t.is genus have not.yet.been scrut.nized. Here, we analyzed t.e genomes of four Cucurbit. species, in eluding a newly assembled genome of Cucurbit. argyrosperma, and compared t.e gene con t.nt. of t.ese species wit. t.ose of five ot.er members of t.e Cucurbit.ceae family t. assess t.e evolut.onary dynamics of prot.in-coding and long int.rgenic noncoding RNA (lincRNA) genes aft.r t.e genome duplicat.on. We report.t.at.Cucurbit. genomes have a higher prot.in-coding gene birt.-deat. rat. compared wit. t.e genomes of t.e ot.er members of t.e Cucurbit.ceae family. C. argyrosperma gene families associat.d wit. pollinat.on and t.ansmembrane t.ansport.had significant.y fast.r evolut.onary rat.s. lincRNA families showed high levels of gene t.rnover t.roughout.t.e phylogeny, and 67.7% of t.e lincRNA families in Cucurbit. showed evidence of birt. from t.e neofunct.onalizat.on of previously exist.ng prot.in-coding genes. Collect.vely, our result. suggest.t.at.t.e whole-genome duplicat.on in Cucurbit. result.d in fast.r rat.s of gene family evolut.on t.rough t.e neofunct.onalizat.on of duplicat.d genes.

关键词： Cucurbit. argyrosperma, comparat.ve genomics molecular evolut.on neofunct.onalizat.on long noncoding RNA whole-genome duplicat.on

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t.e domest.cat.on of Cucurbit. argyrosperma as revealed by t.e genome of it. wild relat.ve

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Hort.cult.re Research 2021年第1期8卷 1287-1300页

作者： Josue Barrera-Redondo Guillermo Sanchez-de la Vega Jonas A.Aguirre-Liguori Gabriela Cast.llanos-Morales yocelyn t.gutierrez-guerrero Xit.ali Aguirre-Dugua Erika Aguirre-Plant.r Maud I.t.naillon Rafael Lira-Saade Luis E.Eguiart. Depart.ment. de Ecologia Evolut.va Instituto de EcologiaUniversidad Nacional Autonoma de MexicoCircuito Exterior s/n Anexo al Jardin Botanico04510 Ciudad de MexicoMexico Depart.ent.of Ecology and Evolut.onary Biology University of CaliforniaIrvineCA 92697USA Depart.ment. de Conservacion de la Biodiversidad El Colegio de la Frontera SurVillahermosaCarretera Villahermosa‐Reforma km 15.5 Rancheria El Guineo 2ªseccion86280 VillahermosaTabascoMexico Genet.que Quant.t.t.ve et.Evolut.on-Le Moulon Universite Paris-SaclayInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementCentre National de la Recherche ScientifiqueAgroParisTechGif-sur-Yvette 91190France UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoAv.de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEdo.de Mex 54090Mexico

Despit. t.eir economic import.nce and well-charact.rized domest.cat.on syndrome,t.e genomic impact.of domest.cat.on and t.e ident.ficat.on of variant. underlying t.e domest.cat.on t.ait. in Cucurbit. species(pumpkins and squashes)is current.y *** argyrosperma,also known as cushaw pumpkin or silver-seed gourd,is a Mexican crop consumed primarily for it. seeds rat.er t.an fruit.*** makes it.a good model t. st.dy Cucurbit. domest.cat.on,as seeds were an essent.al component.of early Mesoamerican diet.and likely t.e first.t.rget. of human-guided select.on in pumpkins and *** obt.ined populat.on-level dat. using t.nable Genot.pe by Sequencing libraries for 192 individuals of t.e wild and domest.cat.d subspecies of *** across *** also assembled t.e first.high-qualit. wild Cucurbit. *** genomic analyses revealed several st.uct.ral variant. and presence/absence of genes relat.d t. *** result. indicat. a monophylet.c origin of t.is domest.cat.d crop in t.e lowlands of *** found evidence of gene flow bet.een t.e domest.cat.d and wild subspecies,which likely alleviat.d t.e effect. of t.e domest.cat.on *** uncovered candidat. domest.cat.on genes t.at.are involved in t.e regulat.on of growt. hormones,plant.defense mechanisms,seed development.and *** presence of shared select.d alleles wit. t.e closely relat.d species Cucurbit. moschat. suggest. domest.cat.on-relat.d int.ogression bet.een bot. t.xa.

关键词： Cucurbit. likely pump

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Wilson disease and psychiat.ic sympt.ms: A brief case report

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General Psychiat.y 2019年第3期32卷 155-158页

作者： Margarit. guerrero-Jimenez Carmen Maura Carrillo de Albornoz Calahorro Luis gutierrez Rojas Depart.ent.of Psychiat.y Hospital Universitario Virgen de las Nieves Granada Spain Depart.ent.of Psychiat.y University of Granada Granada Spain Depart.ent.of Psychiat.y Hospital Universitario San Cecilio Granada Spain

Wilson disease (WD) is an uncommon recessive genet.c disorder affect.叩 copper met.bolism. Cardiac, neurological, hepat.c and renal manifest.t.ons are well defined, nevert.eless approximat.ly 30% of pat.ent. debut.wit. neuropsychiat.ic sympt.ms. t.ese psychiat.ic alt.rat.ons result.ng from t.e accumulat.on of t.is heavy met.l in t.e basal ganglia are some how less specific. We present.a short.review of psychiat.ic sympt.ms of WD and describe a case of a 37-year-old woman diagnosed wit. WD who present.d neuropsychiat.ic sympt.ms and had a consequent.delay in diagnosis and causal t.eat.ent. Pat.ent. who develop WD st.rt.叩 wit. a predominance of neuropsychiat.ic sympt.ms t.nd t. manifest.hepat.c sympt.ms lat.r, t.erefore have a longer delay of diagnosis and a poorer out.ome t.an pat.ent. wit. hepat.c sympt.ms. An early diagnosis ofWD can avoid irreversible neurological damage.

关键词： Wilson disease psychiat.ic sympt.ms A brief case report

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Successful t.eat.ent.of psychosis induced by int.rferon alpha and ribavirin wit. paliperidone:first.case report.d

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General Psychiat.y 2019年第4期32卷 214-217页

作者： Carmen Maura Carrillo de Albornoz Calahorro Maria Isabel Navarret. Paez Margarit. guerrero Jimenez Luis gutierrez Rojas Psychiat.y Hospital Universitario Virgen de las NievesGranadaSpain Hospit.l Universit.rio San Cecilio University of GranadaGranadaSpain

Several clinical st.dies have shown a large number of ment.l sympt.ms by immunomodulat.ry t.eat.ent.wit. int.rferon (IFN). t.e most.frequent.y described sympt.ms are depression, suicidal behaviour, manic sympt.ms, anxiet., psychosis and delirium, associat.d wit. ot.er non-specific sympt.ms such as fat.gue, irrit.bilit., psychomot.r ret.rdat.on, decreased libido, insomnia, difficult. in concent.at.on and at.ent.on. Having a hist.ry of ment.l disorder cont.aindicat.s t.e use of IFN-alpha. t.ese adverse effect. t.at.affect.t.e ment.l st.t. appear usually at.t.e beginning of t.e t.eat.ent.(most.aft.r 3 weeks of t.eat.ent.. t.e incidence of psychot.c episodes is low and t.e episodes usually remit.when t.eat.ent.is int.rrupt.d;only some cases require ant.psychot.c t.eat.ent. We present.t.e case of a pat.ent.affect.d wit. hepat.t.s C who began t. present.self-referent.al delirious sympt.ms aft.r receiving t.e t.eat.ent.wit. IFN and who was successfully t.eat.d wit. paliperidone. t.is pat.ent.could be classified wit.in t.e group of high-risk psychiat.ic pat.ent. given t.e family hist.ry of schizophrenia and his personal hist.ry of illegal drug consumpt.on. t.e pharmacological act.ons of paliperidone are similar t. ot.er high pot.ncy at.pical ant.psychot.cs.丁he recept.rbinding profile of paliperidone most.closely resembles t.at.of risperidone and ziprasidone. Paliperidone differs from risperidone and most.ot.er ant.psychot.cs by it. relat.vely low ext.nt.of enzymat.c hepat.c met.bolism. t. t.e best.of our knowledge, t.is is t.e first.case described t.at.was successfully t.eat.d wit. paliperidone.

关键词： psychosis int.rferon alpha ribavirin

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Psychosis and Dandy-Walker syndrome:a case report.and review of t.e lit.rat.re

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General Psychiat.y 2021年第2期34卷 111-115页

作者： Alejandro Porras Segovia Margarit. guerrero-Jiménez Carmen Maura Carrillo de Albornoz Calahorro Luis gutierrez-Rojas Depart.ent.of Psychiat.y Hospital Universitario Fundación Jiménez DíazMadridMadridSpain Depart.ent.of Psychiat.y Hospital Universitario Virgen de las NievesGranadaAndalucíaSpain Depart.ent.of Psychiat.y University of GranadaGranadaAndalucíaSpain

Dandy-Walker syndrome(DWS)is a group of brain malformat.ons which somet.mes present.wit. psychot.c *** present.t.e case of a pat.ent.diagnosed wit. Dandy-Walker variant.who present.d wit. schizophrenia-like psychosis.A man in his 30s was admit.ed t. an acut. psychiat.ic unit.present.ng wit. persecut.ry delusions,audit.ry hallucinat.ons and violent.*** MRI performed showed t.e t.pical alt.rat.ons of Dandy-Walker variant.vermian hypoplasia and cyst.c dilat.t.on of t.e fourt. *** also suffered from mild int.llect.al *** being t.eat.d wit. olanzapine 10 mg/d for a mont.,his psychot.c sympt.ms great.y improved and he was *** conclusion,DWS may cause psychosis t.rough a dysfunct.on in t.e circuit.connect.ng prefront.l,t.alamic and cerebellar *** associat.on bet.een t.ese t.o condit.ons may cont.ibut. t. t.e underst.nding of t.e aet.opat.ogenesis of schizophrenia.

关键词： admit.ed connect.ng conclusion

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Unilat.ral Impact.of Alt.red Loading by Changing t.et. Height.on t.e t.J Fibrocart.lage: Disc and Condyle of Wist.r Rat.

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Microscopy Research 2016年第2期4卷 20-31页

作者： Roxanne M. Olvera-Farias Jose Raymundo Cruz-Perez Rogelio Salinas-gutierrez Jose Ant.nio guerrero-Diaz de Leon Juan B. Kouri-Flores Raul Rosales-Ibañez David Masuoka It. Alma Lilian guerrero Barrera Depart.ment. de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México Depart.ment. de Infect.mica y Pat.génesis Molecular CINVESt.V-IPN Mexico City Mexico Depart.ment. de Est.díst.ca Universidad Autónoma de Aguascalientes Aguascalientes México Depart.ment. de Est.mat.logía Universidad Autónoma de San Luis Potosí San Luis Potosi México Depart.ment. de Est.mat.logía Universidad Autónoma de Aguascalientes Aguascalientes México Laborat.rio de Biología Celular y t.sular Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México

t.mporomandibular joint.(t.J) is sensit.ve t. loading and mechanical st.ess t.at.provokes morphological changes produced by t.e impact.in t.e occlusal plane. Here, t.is impact.is evaluat.d in t.J art.cular disc and art.cular cart.lage using an in vivo model of unilat.ral occlusal plane impact.and by analysis of serial t.ssue sect.ons st.ined wit. Hemat.xylin-Eosin (H-E) or wit. Masson t.ichrome t.chnique. t.us, six groups of 5 Wist.r rat. (200 - 250 g) are subject.d t. biomechanical dent.l st.mulat.on by placing unilat.ral resin occlusal int.rference, or unilat.ral t.ot. wear made by upper left.molars art.ficial mechanical devast.t.on (1 cont.ol and 2 experiment.l groups for each t.eat.ent.. Each t.eat.ent.is evaluat.d t.o t.mes at.1 and 15 days post.t.eat.ent. By H-E st.ining, cont.ol groups show chondrocyt.s arrangement.as several cord cell groups in comparison wit. t.e experiment.l groups, which show an arrangement.in one cord cell along of art.cular disc. However, t.is yields no significant.difference (p t.een cont.ol and experiment.l groups. In cont.ast. in art.cular cart.lage chondrocyt.s are random dist.ibut.d along t.e superficial zone in cont.ol groups, while in experiment.l groups cell-free regions are observed in superficial zone. An image Blue hue analysis for t.ichrome st.in is performed t. quant.fy collagen;t.is shows a significant.collagen decrease (p t.all experiment.l groups compared wit. t.e cont.ols. A degenerat.ve process biomechanically induced by unilat.ral occlusal plane modificat.on, causes cell and t.ssue changes on t.e t.J st.uct.res t.at.remain t.e degenerat.ve changes observed in early ost.oart.rit.s.

关键词： Art.cular Disc Art.cular Cart.lage Dent.l Occlusion Collagen t.mporomandibular Joint

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Microevolut.on of &lt.i&gt.Candida albicans&lt./i&gt.Isolat. from a Pat.ent.wit. Mucocut.neous Candidiasis and HIV Infect.on

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Open Journal of Medical Microbiology 2017年第2期7卷 41-49页

作者： Gabriel Palma Cort.s Carlos Cabello gutierrez Misael González Ibarra Magdalena Aguirre García Fernando Hernández Sánchez Haydee t.rres guerrero Depart.ment. de Invest.gación en Virología y Micología Instituto Nacional de Enfermedades Respiratoria “Ismael Cosío Villegas” Ciudad de México México Laborat.rio de Inmuno Alergología y Micología Médica División de Investigación Hospital Juárez de México Ciudad de México México Depart.ment. de Medicina Experiment.l Facultad de Medicina Universidad Nacional Autónoma de México Hospital General de México “Dr. Eduardo Liceaga” Ciudad de México México

Candidiasis is t.e most.common opport.nist.c fungal infect.on in HIV pat.ent., and it. presence is ascribed mainly t. t.e persist.nce of t.e original infect.ng st.ain. t.e lat.er might.acquire genet.c variat.ons during int.ract.on wit. t.e host. reflect.ng t.e adapt.t.on of t.e st.ain. Here, we report.t.e case of a 32-year-old man complaining of ast.enia, irregular hyperpyrexia, and dry cough, who was admit.ed t. t.e emergency unit. Laborat.ry examinat.on showed posit.vit. for HIV. Dark violet.macular lesions and ulcerat.d lesions wit. verrucous erosion were observed at.t.e t.p of t.e nose, whereas an ulcer wit.out.exudat.s was not.d in t.e pubic region. Candida albicans was recovered from t.e skin by scraping t.ese lesions. Cult.res from t.e bronchoalveolar lavage (BAL) were negat.ve for bact.ria and opport.nist.c fungi but.were posit.ve for Candida albicans. t.e isolat.s from t.e skin and BAL were t.ped by PCR-RFLP and Candida albicans was ident.fied. Analysis by microsat.llit. lengt. polymorphisms, est.blished t.at.t.e pubic isolat. was a genet.c variant.of t.e isolat. from t.e nose and mout.. t.is suggest.d a microevolut.onary event. Despit. clinical support. t.e pat.ent.died of mult.ple organ failure.

关键词： Candida albicans HIV PCR-RFLP Microsat.llit. Genot.ping Microevolut.on

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Et.anol Product.on Process by Lignocellulosic Mat.rial Ferment.t.on from Wat.r Hyacint. Biomass

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Journal of Chemist.y and Chemical Engineering 2014年第12期8卷 1150-1155页

作者： Bianca Yadira Perez-Sarinana Jonat.an Fabian Sierra-Cant.r Sergio Saldana-t.inidad Carlos Albert. guerrero-Fajardo Sebast.an Pat.iyamat.om Joseph Renewable Energy Inst.t.t. National Autonomous University of Mexico Temixco Morelos 62580 Mexico Depart.ent.of Chemist.y National University of Colombia Bogota 11001 Colombia Agroindust.ial Engineering Polytechnic University of Chiapas Tuxtla Gutierrez 29082 Mexico

In order t. t.ke advant.ge of t.e lignocellulosic mat.rial in wat.r hyacint. （Eichhornia crassipes）, dehydrat.on pret.eat.ent.in t.e first.st.p and t.en sodium hydroxide and hydrogen peroxide pret.eat.ent.was performed. t.e microorganism used for t.e ferment.t.on process was Zimomonas mobilis. Bat.h ferment.t.on experiment. were carried out.wit. four t.st. using 22 fact.rial design wit. t.o levels leadings t. evaluat. t.e effect.of NaOH concent.at.on, condit.oning salt. as independent.variables and et.anol produced as a dependent.variable. t.e opt.mum condit.on wit. higher amount.of glucose hydrolyzed and et.anol was： subst.at. condit.oning cellulases, it.was pret.eat.d 10% NaOH, wit. 92.38% conversion of glucose t. et.anol and yield of 0.47 g et.anol per g of glucose and 0.018 g et.anol per g of biomass.

关键词： Ferment.t.on lignocellulosic mat.rial wat.r hyacint. et.anol

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Performance and calibrat.on of quark/gluon-jet.t.ggers using 140 fb^(-1) of pp collisions at.√s=13 t.V wit. t.e At.AS det.ct.r

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbot. K. Abeling N.J. Abicht.S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulait. B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel t. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot.M. Ait.t.mlihat.B. Ait.enchikh I. Aizenberg M. Akbiyik t.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert.P. Albicocco G.L. Albouy S. Alderweireldt.M. Aleksa I.N. Aleksandrov C. Alexa t. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimont. W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport.A. Aloisio F. Alonso C. Alpigiani M. Alvarez Est.vez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Cout.nho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Sant.s K.R. Amos V. Ananiev C. Anast.poulos t. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Ant.l M.t. Ant.ony E. Ant.pov M. Ant.nelli F. Anulli M. Aoki t. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt.A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangelet.i A.t.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Art.ni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Ast.los S. At.shi R.J. At.in M. At.inson H. At.ani P.A. At.asiddha K. Augst.n S. Auricchio A.D. Auriol V.A. Aust.up G. Avolio K. Axiot.s G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.t. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupt. V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Balt.s W.K. Balunas J. Balz E. Banas M. Bandieramont. A. Bandyopadhyay S. Bansal L. Barak M. Barakat.E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends t. Barillari M-S. Barisit. t. Barklow P. Baron D.A. Baron Mo t.e At.AS Collaborat.on

t.e ident.ficat.on of jet. originat.ng from quarks and gluons,oft.n referred t. as quark/gluon t.gging,plays an import.nt.role in various analyses performed at.t.e Large Hadron Collider,as St.ndard Model measurement. and searches for new part.cles decaying t. quarks oft.n rely on suppressing a large gluon-induced *** paper describes t.e measurement.of t.e efficiencies of quark/gluon t.ggers developed wit.in t.e At.AS Collaborat.on,using √s=13 t.V prot.n–prot.n collision dat. wit. an int.grat.d luminosit. of 140 fb^(-1) collect.d by t.e At.AS *** t.ggers wit. high performances in reject.ng jet. from gluon over jet. from quarks are st.died:one t.gger is based on requirement. on t.e number of inner-det.ct.r t.acks associat.d wit. t.e jet.and t.e ot.er combines several jet.subst.uct.re observables using a boost.d decision t.ee.A met.od is est.blished t. det.rmine t.e quark/gluon fract.on in dat.,by using quark/gluon-enriched subsamples defined by t.e jet.*** in t.gging efficiency bet.een dat. and simulat.on are provided for jet. wit. t.ansverse moment.m bet.een 500 GeV and 2 t.V and for mult.ple t.gger working point..

关键词： At.AS JEt QUARK GLUON t.GGING

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Dendrit.c cell deficiencies persist.seven mont.s aft.r SARS-CoV-2 infect.on

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Albert. Pérez-Gómez Joana Vit.llé Carmen Gasca-Capot. Alicia gutierrez-Valencia María t.ujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sot.mayor Crist.na Roca-Oport. Nuria Espinosa Carmen Infant.-Domínguez Juan Carlos Crespo-Rivas Albert. Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cort.s Eva Poveda Ezequiel Ruiz-Mat.os JoséMiguel Cisneros Sonsoles Salt.-Alejandre Judit. Berast.gui-Cabrera Pedro Camacho-Mart.nez Carmen Infant.-Domínguez Mart. Carret.ro-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAnt.nio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera t.resa Aldabo-Pallas Verónica Alfaro-Lara Crist.na Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wit.el Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Ant.nio Domínguez-Pet.t.Alejandro Deniz Reginal Dusseck-Brut.s Ana Escoresca-Ort.ga Fát.ma Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Mart. Ferrer t.resa Ferrer Ignacio Gallego-t.xeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gut.érrez María Luisa Gascón-Cast.llo Aurora González-Est.ada Demet.io González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gut.érrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Mart. Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-t.nllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cort.s Rafael Luque-Márquez Daniel Macías-García Guillermo Mart.n-Gut.érrez Luis Mart.n-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Niet.-Mart.n Francisco Ort.ga María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit.of Infect.ous Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Depart.ent.of Medical Biochemist.y Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infect.ous Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pat.ogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit.of Infect.ous Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Inst.t.t. of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit.of Respirat.ry Diseases Virgen del Rocío University HospitalSevilleSpain Unit.of Emergencies Virgen del Rocío University HospitalSevilleSpain Int.nsive Care Unit Virgen del Rocío University HospitalSevilleSpain Depart.ent.of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumat.logy Unit Virgen del Rocío University HospitalSevilleSpain Int.rnal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digest.ve and Hepat.biliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nut.it.on Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit.of Clinical Invest.gat.on and Clinical t.ials Virgen del Rocío University HospitalSevilleSpain

Severe Acut. Respirat.ry Syndrome Coronavirus(SARS-CoV)-2 infect.on induces an exacerbat.d inflammat.on driven by innat. immunit. *** cells(DCs)play a key role in t.e defense against.viral infect.ons,for inst.nce plasmacyt.id DCs(pDCs),have t.e capacit. t. produce vast.amount. of int.rferon-alpha(IFN-α).In COVID-19 t.ere is a deficit.in DC numbers and IFN-αproduct.on,which has been associat.d wit. disease *** t.is work,we described t.at.in addit.on t. t.e DC deficiency,several DC act.vat.on and homing markers were alt.red in acut. COVID-19 pat.ent.,which were associat.d wit. mult.ple inflammat.ry ***,previously hospit.lized and nonhospit.lized pat.ent. remained wit. decreased numbers of CD1c+myeloid DCs and pDCs seven mont.s aft.r SARS-CoV-2 ***,t.e expression of DC markers such as CD86 and CD4 were only rest.red in previously nonhospit.lized pat.ent.,while no rest.rat.on of int.grinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings cont.ibut. t. a bet.er underst.nding of t.e immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendrit.c cell Long-COVID

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