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Disruption of the gatekeeper p53 tumor suppressor is involved in various virus-associated tumorigeneses,with aberrant ubiquitination as the major cause of abnormal p53 accumulation in virus-associated *** previously showed that p53 is accumulated and phosphorylated by Epstein-Barr virus(EBV) latent membrane protein 1(LMPl) in nasopharyngeal carcinoma(NPC) which is constantly associated with EBV in our ***,we further identified that LMPl upregulated p53 expression via two-distinct ubiquitin ***1 promoted p53 stability and accumulation by suppressing the E3 ligase MDM2-mediated K48 ubiquitination,associated with p53 Ser20 phosphorylation,but increased the total level of p53 *** also induced p53 UbK63-linked ubiquitination by interacting with tumor necrosis factor receptor-associated factor 2(TRAF2), resulting in p53 accumulation without its proteasomal ***, LMPl rescued p53-UbK63 ubiquitination-mediated regulation of cell apoptosis and cell cycle ***,these results demonstrate that the regulation of p53 accumulation/stability and functions via different ubiquitin-modifications mediated by viral protein LMPl,which has broad implications to the pathogenesis of multiple EBV-associated tumors.

关键词： apoptosis Viral oncoprotein LMPl disrupts p53-induced cell cycle arrest and apoptosis through modulating K63-linked ubiquitination of p53 EBV cycle

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Words apart:Standardizing forestry terms and definitions across European biodiversity studies

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Forest Ecosystems 2023年第4期10卷 459-471页

作者： Giovanni Trentanovi Thomas Campagnaro Tommaso Sitzia Francesco Chianucci Giorgio Vacchiano Christian Ammer MichałCiach Thomas ANagel Miren del Río Yoan Paillet Silvana Munzi Kris Vandekerkhove Andrés Bravo-Oviedo Andrea Cutini Ettore D'Andrea Pallieter De Smedt Inken Doerfler Dimitris Fotakis Jacob Heilmann-Clausen Jeňýk Hofmeister Jan Hošek Philippe Janssen Sebastian Kepfer-Rojas Nathalie Korboulewsky Bence Kovács Daniel Kozák Thibault Lachat Anders Mårell Radim Matula Martin Mikoláš Björn Nordén PéterÓdor x Marko Perović Elisabeth Pötzelsberger Peter Schall Miroslav Svoboda Flóra Tinya Mariana Ujházyová Sabina Burrascano Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via Madonna Del Piano 1950019Sesto FiorentinoFIItaly Department of Land EnvironmentAgriculture and ForestryUniversitàdegli Studi di PadovaViale Dell’Università1635020LegnaroPDItaly National Biodiversity Future Center Piazza Marina 6190133PalermoItaly CREA Research Centre for Forestry and Wood Viale S.Margherita 8052100ArezzoItaly Department of Agricultural and Environmental Sciences(DISAA) University of MilanVia Celoria 220133MilanItaly Silviculture and Forest Ecology of the Temperate Zones University of GöttingenGermany Department of Forest Biodiversity Faculty of ForestryUniversity of Agricultureal.29 Listopada 4631-425KrakówPoland Department of Forestry and Renewable Forest Resources Biotechnical FacultyUniversity of LjubljanaVecna pot 831000LjubljanaSlovenia Instituto de Ciencias Forestales(ICIFOR-INIA) CSICCtra.de la Coruña Km 7.528040MadridSpain University Grenoble Alpes LessemINRAE2 Rue de la Papeterie38402 Saint-Martin-d'HèresFrance Centro Interuniversitário de História Das Ciências e da Tecnologia Faculdade de CiênciasUniversidade de LisboaPortugal Centre for Ecology Evolution and Environmental ChangesFaculdade de Ciências&CHANGE-Global Change and Sustainability InstituteUniversidade de LisboaPortugal Research Institute for Nature and Forest(INBO) Havenlaan 88 Bus 731000BrusselBelgium Department of Biogeography and Global Change National Museum of Natural Sciences-CSICC/Serrano 115bis28006MadridSpain Research Institute on Terrestrial Ecosystems-National Research Council(IRET-CNR) Via G.Marconi N.205010PoranoTRItaly Forest&Nature Lab Department of EnvironmentGhent UniversityGeraardsbergsesteenweg 2679090GontrodeBelgium Institute of Biology and Environmental Science Vegetation Science&Nature ConservationUniversity of OldenburgAmmerländer Heerstraße 114-11826129OldenburgGermany Forest Research Institute Hellenic Agricultural Organization DimitraVassilikaThessal

Forest biodiversity studies conducted across Europe use a multitude of forestry terms,often *** hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly *** attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity *** work aims to establish common standards for silvicultural and vegetation definitions,creating a shared conceptual framework for a consistent study on the effects of forest management on *** have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity *** quantitative data on forest biomass and dominant tree species are frequently included,information on silvicultural activities and vegetation composition is often lacking,shallow,or based on broad and heterogeneous *** discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process,and ultimately propose a common *** will enhance the comparability of forest biodiversity studies in Europe,and puts the basis for effective implementation and monitoring of sustainable forest management *** standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions.

关键词： Forest management Multi-taxon Terminology Silviculture Data harmonization

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