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微小RNA-148a-3p靶向核心1β13-半乳糖基转移酶1增强肺腺癌细胞的放疗敏感性的研究

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实用临床医药杂志 2024年第6期28卷 1-8页

作者：申霖任粤邓一洲殷旭东陈勇扬州大学附属医院肿瘤科江苏扬州225000

目的探讨微小RNA-148a-3p(miR-148a-3p)在肺腺癌中的表达及临床意义,分析miR-148a-3p靶向蛋白核心1β13-半乳糖基转移酶1(C1GALT1)对肺腺癌细胞放疗敏感性的影响及机制。方法选取肺腺癌组织芯片中76例患者肿瘤组织及肺腺癌A549细胞株为... 详细信息

目的探讨微小RNA-148a-3p(miR-148a-3p)在肺腺癌中的表达及临床意义,分析miR-148a-3p靶向蛋白核心1β13-半乳糖基转移酶1(C1GALT1)对肺腺癌细胞放疗敏感性的影响及机制。方法选取肺腺癌组织芯片中76例患者肿瘤组织及肺腺癌A549细胞株为研究对象。对组织芯片分别进行miR-148a-3p原位杂交(ISH)染色和C1GALT1免疫组织化学染色,分析76例肺腺癌患者肿瘤组织中miR-148a-3p的表达与临床病理、预后及C1GALT1表达的关系。采用细胞转染技术对A549细胞进行miR-148a-3p过表达质粒的转染;转染细胞接受2 Gy放疗后采用克隆形成实验检测细胞的放疗敏感性;采用蛋白质印迹法检测细胞C1GALT1蛋白表达水平;采用双荧光素酶报告基因实验验证miR-148a-3p与C1GALT1的靶向调控关系;采用共转染技术分析miR-148a-3p调控A549细胞放疗敏感性的机制。结果76例肺腺癌组织中低表达miR-148a-3p与患者淋巴结转移显著相关(P=0.012);miR-148a-3p高表达者预后显著优于miR-148a-3p低表达者(P=0.005);肺腺癌组织中miR-148a-3p与C1GALT1的表达呈显著负相关(P=0.023)。多因素分析显示,miR-148a-3p低表达、T分期及淋巴结转移是预后的独立危险因素。克隆形成实验显示,过表达miR-148a-3p组克隆形成数显著低于对照组(P<0.001);Western Blot结果显示,miR-148a-3p过表达可以显著下调细胞中C1GALT1蛋白水平(P<0.001)。双荧光素酶报告基因实验显示miR-148a-3p通过结合C1GALT1的3′UTR来调控C1GALT1的表达。功能拯救试验显示C1GALT1能够部分抵消miR-148a-3p的放疗增敏效应。结论肺腺癌中miR-148a-3p低表达与淋巴结转移、C1GALT1高表达及预后不良显著相关,miR-148a-3p通过负调控C1GALT1的表达增强肺腺癌细胞的放疗敏感性。

关键词：微小RNA-148a-3p 核心1β13-半乳糖基转移酶1 肺腺癌放疗敏感性预后

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论抗战时期中国共产党的科技发展观

生产力研究 2009年第4期 19-20,27页

作者：邓怡舟湖南科技学院湖南永州425100

中国共产党历来尊重人才,重视科技的发展。抗战时期,中国共产党树立正确的科技发展观,领导了陕甘宁边区和其他抗日根据地的科技实践,开创了自己的科教事业,为抗战胜利和根据地经济文化建设做出了巨大贡献。文章回顾历史,阐述抗战时期党... 详细信息

中国共产党历来尊重人才,重视科技的发展。抗战时期,中国共产党树立正确的科技发展观,领导了陕甘宁边区和其他抗日根据地的科技实践,开创了自己的科教事业,为抗战胜利和根据地经济文化建设做出了巨大贡献。文章回顾历史,阐述抗战时期党的科技发展观的主要内容,以期对今天科学发展观的落实、和谐社会的构建提供历史经验。

关键词：抗战时期中国共产党科技发展观

培育大学生社会主义核心价值体系:高校思想政治理论课的当务之急和重中之重

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河南广播电视大学学报 2013年第1期26卷 50-52页

作者：邓怡舟湖南科技学院思想政治理论课教学部湖南永州425100

社会主义核心价值体系的提出,为高校思想政治教育指明了新的方向和任务。作为大学生思想政治教育主渠道和主阵地的思政课,应承担培育大学生社会主义核心价值体系这一政治使命和历史重任。本文在分析大学生理想信念和价值观所存在问题及... 详细信息

社会主义核心价值体系的提出,为高校思想政治教育指明了新的方向和任务。作为大学生思想政治教育主渠道和主阵地的思政课,应承担培育大学生社会主义核心价值体系这一政治使命和历史重任。本文在分析大学生理想信念和价值观所存在问题及其产生原因的基础上,重点论述以培育大学生社会主义核心价值体系作为解决这一问题的当务之急和重中之重。

关键词：高校思政课社会主义核心价值体系大学生精神世界

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开展创业教育应注重培育大学生的民族精神

经济师 2006年第3期 83-85页

作者：邓怡舟湖南科技学院两课部湖南永州425006

创业教育是大学生综合素质不可缺少的一个重要方面,民族精神是一个民族赖以生存和发展的精神支柱。文章在分析创业教育和中华民族精神的基本内涵的基础上,深入论述创业教育中培育民族精神的必要性,并为高校开展创业教育中培育民族精神... 详细信息

创业教育是大学生综合素质不可缺少的一个重要方面,民族精神是一个民族赖以生存和发展的精神支柱。文章在分析创业教育和中华民族精神的基本内涵的基础上,深入论述创业教育中培育民族精神的必要性,并为高校开展创业教育中培育民族精神提供了可供参考的思路和方法。

关键词：创业教育民族精神必要性思路和方法

大革命时期农民运动失败原因的多维思考——以湖南农民运动的起落为例

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内蒙古农业大学学报（社会科学版） 2010年第6期12卷 331-333页

作者：邓怡舟湖南科技学院思想政治理论课教学部湖南永州425100

关于大革命时期的农民运动的起落及其原因,学界多有论著论述。但迄今为止,仍鲜有专文对其失败的原因作一综论。本文在前辈和同仁论题的基础上,以最为典型的湖南农运的起落为例,对大革命这段史实作一简单梳理,撰写成文,以期对提高我党在... 详细信息

关于大革命时期的农民运动的起落及其原因,学界多有论著论述。但迄今为止,仍鲜有专文对其失败的原因作一综论。本文在前辈和同仁论题的基础上,以最为典型的湖南农运的起落为例,对大革命这段史实作一简单梳理,撰写成文,以期对提高我党在新时期复杂环境下的应变和决策能力有所裨益。

关键词：大革命湖南:农民运动失败原因

Introducing B–N unit boosts photocatalytic H_(2)O_(2) production on metal-free g-C_(3)N_(4)nanosheets

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Nano Research 2023年第2期16卷 2177-2184页

作者： Weikang Wang Wei Zhang Yueji Cai Qing Wang Juan deng Jingsheng Chen Zhifeng Jiang yizhou Zhang Chao Yu School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China Institute for Energy Research Jiangsu UniversityZhenjiang 212013China School of Chemistry and Materials Science Institute of Advanced Materials and Flexible Electronics(IAMFE) Nanjing University of Information Science and TechnologyNanjing 210044China

Metal-free catalyst for photocatalytic production of H_(2)O_(2)is highly desirable with the long-term vision of artificial photosynthesis of solar *** particular,the specific chemical bonds for selective H_(2)O_(2)photosynthesis via 2e–oxygen reduction reactions(ORR)remain to be explored for understanding the forming mechanism of active ***,we report a facile doping method to introduce boron-nitrogen(B–N)bonds into the structure of graphitic carbon nitride(g-C_(3)N_(4))nanosheets(denoted as BCNNS)to provide significant photocatalytic activity,selectivity and *** theoretical calculation and experimental results reveal that the electron-deficient B–N units serving as electron acceptors improve photogenerated charge separation and *** units are also proved to be superior active sites for selective O_(2)adsorption and activation,reducing the energy barrier for*OOH formation,and thereby enabling an efficient 2e–ORR pathway to H_(2)O_(2).Consequently,with only bare loss of activity during repeated cycles,the optimal H2O2 production rate by BCNNS photocatalysts reaches 1.16 mmol·L^(–1)·h^(–1)under 365 nm-monochrome light emitting diode(LED365nm)irradiation,increasing nearly 2–5 times as against the state-of-art metal-free *** work gives the first example of applying B–N bonds to enhance the photocatalytic H_(2)O_(2)production as well as unveiling the underlying reaction pathway for efficient solar-energy transformations.

关键词： graphitic carbon nitride(g-C_(3)N_(4))nanosheets metal-free photocatalyst B–N bonds oxygen reduction reaction H2O2 production

少数民族传统文化传承创新与社会主义核心价值观培育互动探论

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惠州学院学报 2019年第5期39卷 11-16页

作者：郭开虎潘剑锋邓怡舟湖南科技学院马克思主义学院

少数民族传统文化与社会主义核心价值观文化基因的同根性与价值理念的一致性,为传承创新少数民族传统文化与培育社会主义核心价值观两个过程的互动提供了可能性。为此,一方面,应通过少数民族优秀传统文化的传承弘扬,增强民族成员对本民... 详细信息

少数民族传统文化与社会主义核心价值观文化基因的同根性与价值理念的一致性,为传承创新少数民族传统文化与培育社会主义核心价值观两个过程的互动提供了可能性。为此,一方面,应通过少数民族优秀传统文化的传承弘扬,增强民族成员对本民族文化精神价值理念的了解、认同,巩固社会主义核心价值观的认同基础,激发少数民族传统文化的"创新"精神,为社会主义核心价值观在民族地区的内化生长提供动力;另一方面,应坚持用社会主义核心价值观引领少数民族传统文化的传承创新,为其续存发展提供价值标准和方向导向。

关键词：少数民族传统文化社会主义核心价值观互动

Novel gold nanoparticles targeting somatostatin receptor subtype two with near-infrared light for neuroendocrine tumour therapy

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Nano Research 2022年第10期15卷 9149-9159页

作者： Qichen Chen Zilin Li Jiangyuan Yu Qing Xie Haizhen Lu Yiqiao deng Jinghua Chen Wenjia Zhu Li Huo yizhou Zhang Wei Song Jianqiang Lan Jianqiang Cai Zhen Huang Zixi Wang Hong Zhao Department of Hepatobiliary Surgery State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Gene Editing Screening and R&D of Digestive System Tumor Drugs Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Department of Nuclear Medicine Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing 100142China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17Panjiayuan NanliBeijing 100021China Nuclear Medicine Department State Key Laboratory of Complex Severe and Rare DiseasesCenter for Rare Diseases ResearchBeijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear MedicinePeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Guangdong Research Center of Organoid Engineering and Technology Accurate International Biotechnology Co.Ltd.Guangzhou 510650China

Neuroendocrine tumours(NETs)are rare cancers with positive somatostatin receptor 2(SSTR2)expression,and treatment strategies for NETs are not ***-mediated therapy targeting SSTR2 in NETs is very *** study firstly combined mesoporous silica-coated gold nanorods(AuNRs@mSiO_(2))and targeting-SSTR2 dodecane tetraacetic acidtyrosine3-octreotate(DOTA-TATE)into AuNRs@mSiO_(2)@DOTA-TATE to investigate NETs inhibition under near-infrared ***@mSiO_(2)@DOTA-TATE showed good photothermal conversion *** vitro,under light irradiation,the cell viability significantly decreased with increasing AuNR@mSiO_(2)@DOTA-TATE concentration;in two successfully established neuroendocrine tumour organoids with SSTR2 expression,AuNRs@mSiO_(2)@DOTA-TATE with light inhibited tumours significantly better than AuNRs@mSiO_(2) with *** vivo,the SSTR2-targeting ability and biodistribution of AuNRs@mSiO_(2)@DOTA-TATE were confirmed with AuNRs@mSiO_(2)@64Cu-DOTA-TATE under micro-positron emission tomography/computed tomography(micro-PET/CT);in the AuNRs@mSiO_(2)@DOTA-TATE with laser group,the tumour surface temperature increased rapidly,with tumour volumes similar to those in the octreotide group and significantly lower than those in other *** was no significant difference in mice body weight between the AuNRs@mSiO_(2)@DOTA-TATE with laser group and other *** significant inflammatory lesions or cell necrosis was found in the main *** summary,we presented a feasible strategy to construct AuNRs@mSiO_(2)@DOTA-TATE with good photothermal conversion efficiency,targetingSSTR2 ability,significant antitumour effects,and good biocompatibility,warranting further explorations of AuNRs@mSiO_(2)@DOTA-TATE for NETs therapy applications.

关键词： neuroendocrine tumours somatostatin receptor 2 nanoparticles photothermal therapy

Polluted lake restoration to promote sustainability in the Yangtze River Basin,China

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National Science Review 2022年第1期9卷 12-14页

作者： Boqiang Qin Yunlin Zhang Jianming deng Guangwei Zhu Jianguo Liu David P.Hamilton Hans W.Paerl Justin D.Brookes Tingfeng Wu Kai Peng yizhou Yao Kan Ding Xiaoyan Ji State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences School of Geography and Ocean Science Nanjing University Nanjing Zhongke Deep Insight Institute Co.Ltd. Center for Systems Integration and Sustainability Department of Fisheries and Wildlife Michigan State University Australian Rivers Institute Griffith University Institute of Marine Sciences University of North Carolina at Chapel Hill College of the Environment Hohai University Water Research Centre School of Biological Science University of Adelaide China National Environmental Monitoring Centre (CNEMC)

China has sought to address water pollution in the last decade by introducing a wide range of laws and regulations(Table S1), which led to nationwide water quality improvement [1]. However, recent quantitative assessment of progress toward Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for water pollution and biodiversity have not been met [2]. Specifically,

关键词： PHOSPHORUS RATIOS NITROGEN