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Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging

Protein & Cell 2023年第4期14卷 279-293页

作者： yiyuan zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi zhang Shuai Ma Jing Qu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 10o101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Aging Translational Medicine Center Xuanwu HospitalCapital Medical UniversityBeijing 100053China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China

Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged ***,the cell type-specific changes underlying cardiac aging are far from being ***,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with *** found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional *** transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac ***,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived ***,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases.

关键词： single-nucleus RNA-sequencing primate aging FOxP1 cardiomyocyte

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Visualization Analysis of Research on Student Classroom Engagement by Knowledge Mapping

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教育研究前沿（中英文版） 2021年第3期11卷 6-14页

作者： Pengbin Gao yiyuan zhang Yan Xiang Yiduo Song School of Economics and Management Harbin Institute of Technology at WeihaiShandong Weihai 264209China

The aim of the paper is to identify and explore leading development situation within the research field related to student classroom *** knowledge mapping tools,this paper conducted the visualization analysis on internationalliteraturein relation to student classroom engagementfrom the Web of Science *** combination of the statistical data and visualizationmapping,this paper studied on the research relationship networks and status for the co-authors'countries/institutions,co-citation documents/journalsand co-occurring keywordsbased on the sample *** results indicate that the number ofpublished papershasincreased obviously and expanded graduallysince *** countries and institutions of researches were the UnitedStates,Australia,United Kingdom,Canada and China in order,and these countries had intense *** theoretical basis of the research come from education and teaching,*** hotspots of researches fromthe global literature coveredvarious fields including achievement,motivation,behavior,education,*** a result of the multidisciplinary integration,many relevant internationalresearch constantly expanded the research scopes,which promoted the combination and development of theories.

关键词： Student Classroom Engagement Knowledge Mapping Visualization Analysis Co-authorship Analysis Co-citation Analysis Keywords Co-occurrence Analysis

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风火调峰权交易促进风电再次接纳研究

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电力自动化设备 2017年第11期37卷 14-21页

作者：江岳文张艺渊福州大学电气工程与自动化学院福建福州350116

系统调峰能力不足导致负荷低谷时期风电场大量弃风,成为制约风电接纳水平的主要原因之一,调峰权交易可以激励火电机组发挥调峰潜力,为风电提供消纳空间。将风电引入调峰权交易模型中,提出风电参与调峰权交易的市场模式,分析火电机组调... 详细信息

系统调峰能力不足导致负荷低谷时期风电场大量弃风,成为制约风电接纳水平的主要原因之一,调峰权交易可以激励火电机组发挥调峰潜力,为风电提供消纳空间。将风电引入调峰权交易模型中,提出风电参与调峰权交易的市场模式,分析火电机组调峰权交易成本和风电场调峰权交易效益,建立以社会效益最大和风电再次接纳量最大为多目标的调峰权交易模型,并采用多目标粒子群优化算法对模型进行求解。IEEE 14节点测试系统的仿真结果验证了所提模型的有效性。

关键词：风电再次接纳社会效益风火调峰权交易多目标粒子群优化算法风电模型

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A Mehrotra-Type Predictor-Corrector Algorithm for P*（κ） Linear Complementarity Problems

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Journal of Mathematical Research with Applications 2012年第3期32卷 297-312页

作者： Weihua LI,Mingwang zhang,yiyuan ZHOU College of Science,China Three Gorges University,Hubei 443002,P.R.China College of Science China Three Gorges University Hubei 443002

Mehrotra-type predictor-corrector algorithm,as one of most efficient interior point methods,has become the backbones of most optimization *** et *** a cut strategy based algorithm for linear optimization that enjoyed polynomial complexity and maintained its efficiency in *** extend their algorithm to P（κ）linear complementarity *** way of choosing corrector direction for our algorithm is different from theirs. The new algorithm has been proved to have an ο(（1+4κ）(17+19κ) √（1+2κn）log[（x）s/ε] worst case iteration complexity *** numerical experiment verifies the feasibility of the new algorithm.

关键词： P_*(κ)linear complementarity problems Mehrotra-type predictor-corrector algo- rithm polynomial iteration complexity interior point method.

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Bioinspired micro/nanostructured surfaces prepared by femtosecond laser direct writing for multi-functional applications

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International Journal of Extreme Manufacturing 2020年第3期2卷 42-62页

作者： yiyuan zhang Yunlong Jiao Chuanzong Li Chao Chen Jiawen Li Yanlei Hu Dong Wu Jiaru Chu Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes CAS Key Laboratory of Mechanical Behavior and Design of MaterialsDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230026People's Republic of China Institute of Tribology Hefei University of TechnologyHefei 230009People's Republic of China School of Instrument Science and Opto-Eelectronics Engineering Hefei University of TechnologyHefei 230009People's Republic of China

manufacturing of biomimetic micro/nanostructures due to its specific advantages including high precision,simplicity,and compatibility for diverse materials in comparison with other methods(*** etching,sol-gel process,chemical vapor deposition,template method,and self-assembly).These biomimetic micro/nanostructured surfaces are of significant interest for academic and industrial research due to their wide range of potential applications,including self-cleaning surfaces,oil-water separation,and fog *** review presents the inherent relationship between natural organisms,fabrication methods,micro/nanostructures and their potential ***,we throw a list of current fabrication strategies so as to highlight the advantages of FLDW in manufacturing bioinspired microstructured ***,we summarize a variety of typical bioinspired designs(*** leaf,pitcher plant,rice leaf,butterfly wings,etc)for diverse multifunctional micro/nanostructures through extreme femtosecond laser processing *** on the principle of interfacial chemistry and geometrical optics,we discuss the potential applications of these functional micro/nanostructures and assess the underlying challenges and opportunities in the extreme fabrication of bioinspired micro/nanostructures by *** review concludes with a follow up and an outlook of femtosecond laser processing in biomimetic domains.

关键词： femtosecond laser direct writing multiscale micro/nanostructures extreme fabrication bioinspired applications

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Clinical effects of phototherapy combined with albumin administration on hyperbilirubinemia in newborns

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中西医结合护理（中英文） 2018年第3期4卷 1-3页

作者： GAO Yan LI Shenmei XU Yunyun LIU Qiuju zhang yiyuan Department of Neonatology Affiliated Hospital of Guilin Medical University

Objective To investigate the effects of phototherapy combined with albumin administration on hyperbilirubinemia in newborns. Methods Totally 64 newborns with neonatal hyperbilirubinemia were randomly divided into the control group and the study group,with 32 cases in each group. The newborns in control group received phototherapy and routine care,while those in study group were administrated with intravenous injection of albumin in addition to phototherapy and routine care. The concentration of total serum bilirubin,newborns' body weight and amount of milk intake were measured before and after phototherapy. Results There was a significant difference in the milk intake between two groups after phototherapy( P 0. 05). Conclusion Combined application of phothotherapy and albumin administration on neonatal hyperbilirubinemia could promote the newborns' appetite and improve the recovery of the neonates,but the effect on reducing blood bilirubin level and weight gain needs further study.

关键词： neonatal hyperbilirubinemia albumin phototherapy weight gain

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面向感知微系统的系统级设计方法

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清华大学学报（自然科学版） 2019年第3期59卷 236-242页

作者：张益源赵嘉昊尤政清华大学精密仪器系精密测试技术及仪器国家重点实验室北京100084 清华大学北京市未来芯片技术高精尖创新中心北京100084

作为传感器系统的典型代表与技术发展趋势,感知微系统具有尺寸小、功能多与自供电等优势。然而当前的设计方法无法平衡其实用性能与约束性能之间的矛盾,使得其进一步发展陷入瓶颈。该文基于多学科设计优化思想提出一种针对感知微系统的... 详细信息

作为传感器系统的典型代表与技术发展趋势,感知微系统具有尺寸小、功能多与自供电等优势。然而当前的设计方法无法平衡其实用性能与约束性能之间的矛盾,使得其进一步发展陷入瓶颈。该文基于多学科设计优化思想提出一种针对感知微系统的系统级设计方法。该方法根据设计目标与各性能边界条件进行学科划分,在子系统分析器内进行参数分析后代入系统级优化器完成目标优化,最终实现感知微系统的优化设计。以重型车辆检测微系统为例,选取不同的设计目标进行系统级优化,并通过叠层集成的方式研制了验证样机。样机的性能测试结果与设计值相符,且满足优化设计目标的需求。该方法可行性和准确性表明,其能够在设计阶段平衡感知微系统的实用性能与约束性能,实现系统的最优化设计。

关键词：感知微系统多学科设计优化系统级设计方法

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基于高斯马尔科夫随机场的区域产量保险定价

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统计与决策 2019年第16期35卷 34-39页

作者：张译元中国人民大学统计学院哈尔滨师范大学数学科学学院

文章基于农作物产量具有较强的时空分布特征,在产量分布的参数中引入时空固定效应和空间随机效应构建嵌入式时空模型。趋势拟合和分布拟合同时进行,避免了传统两步法中建模误差的叠加;高斯马尔科夫随机场的引入改进了模型的预测效果;对... 详细信息

文章基于农作物产量具有较强的时空分布特征,在产量分布的参数中引入时空固定效应和空间随机效应构建嵌入式时空模型。趋势拟合和分布拟合同时进行,避免了传统两步法中建模误差的叠加;高斯马尔科夫随机场的引入改进了模型的预测效果;对多个地区的产量分布同步进行拟合,增大了样本量,参数估计更稳健。对一组实际数据的分析结果表明,基于逻辑斯特分布的嵌入式时空模型预测能力最强,能够有效提高农作物区域产量保险定价的准确性。

关键词：区域产量保险逻辑斯特分布高斯马尔科夫随机场时空模型

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The effects of icariine concentration on osteoclasts bone resorption induced by titanium particles in vitro

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Regenerative Biomaterials 2015年第3期2卷 197-202页

作者： yiyuan zhang Yu Lin Lili Xiao Eryou Feng Wulian Wang Liqiong Lin Joint Surgery Department the Second Hospital of Fuzhou Affiliated to Xiamen UniversityFuzhou 350007China

In artificial joint replacement,osteoclast bone resorption induced by wear debris of the implant is a main reason for aseptic *** extend the life of the prosthesis,detailed mechanisms of aseptic loosening and the ways to prevent it should be *** aim of this study was to investigate the in vitro effect of icariine on the bone resorption of osteoclasts induced by titanium *** colony stimulating factor(M-CSF)and receptor activator of NF-kB ligand(RANKL)were used to generate osteoclasts from RAW264.7 *** proliferation of RAW264.7 precursors in the presence of different doses of icariine was evaluated by MTT *** cells were treated with titanium particles,titanium particles with icariine and culture medium only(control),*** 48 h after treatment,the expression level of receptor activator of NF-kB(RANK)was detected by ELISA,and messenger RNA(mRNA)levels of tartrate-resistant acid phosphatase(TRAP),matrix metalloproteinase 9(MMP-9),carbonic anhydrase II(CAII)and Cathepsin K(CtsK)were determined by real-time polymerase chain *** blot was applied to analyze the expression levels of TRAP,RANK and *** addition,bone chips were cultured in the above conditions,and Toluidine blue staining was then employed to calculate the number and area of resorption pits in the bone *** treatment with icariine,expression level of RANK was significantly decreased in the RAW264.7 cell that induced by titanium particle and its cultural medium,mRNA and protein levels of TRAP,CAII,MMP-9 and CtsK were reduced as *** addition,the numbers of bone resorption pits and areas on bone slices were both reduced by icariine *** could inhibit bone resorption of osteoclast induced by titanium particle,and it might be used as a promising drug for treating of aseptic loosening.

关键词： icariine titanium particle osteoclast bone resorption aseptic loosening

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企业人力资源管理的发展趋势

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职业时空 2005年第2期1卷 58-59页

作者：张议元陈滨河北职业技术学院

随着知识经济时代的来临,人类进入了一个以知识为主宰的全新经济时代.企业间的竞争由产品经营竞争到资本经营的竞争,逐渐发展到智力资本经营的竞争.人力资源的价值成为衡量企业整体竞争力的标志.企业只有取得了优于竞争对手的人力资源,... 详细信息

随着知识经济时代的来临,人类进入了一个以知识为主宰的全新经济时代.企业间的竞争由产品经营竞争到资本经营的竞争,逐渐发展到智力资本经营的竞争.人力资源的价值成为衡量企业整体竞争力的标志.企业只有取得了优于竞争对手的人力资源,并充分发挥他们的智力能量,才能在竞争中取胜并保持其优势,因此企业人力资源管理日益成为企业提高效率、保证自身竞争优势的强有力的武器.21世纪的人力资源管理既有着工业文明时代的深刻烙印,又反映着知识经济时代游戏规则的基本要求,从而呈现出新的发展趋势.

关键词：企业人力资源管理发展趋势知识经济

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