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Nanolubricant additives: A review

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Friction 2021年第5期9卷 891-917页

作者： Jun ZHAO yiyao huang Yongyong HE Yijun SHI College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Division of Machine Elements LuleåUniversity of TechnologyLuleå97187Sweden

Using nanoadditives in lubricants is one of the most effective ways to control friction and wear,which is of great significance for energy conservation,emission reduction,and environmental *** the scientific and technological development,great advances have been made in nanolubricant additives in the scientific research and industrial *** review summarizes the categories of nanolubricant additives and illustrates the tribological properties of these *** on the component elements of nanomaterials,nanolubricant additives can be divided into three types:nanometal-based,nanocarbon-based,and nanocomposite-based *** dispersion stabilities of additives in lubricants are also discussed in the review *** affecting factors and effective dispersion methods have been investigated in ***,the review summarizes the lubrication mechanisms of nanolubricant additives including tribofilm formation,micro-bearing effect,self-repair performance,and synergistic *** addition,the challenges and prospects of nanolubricant additives are proposed,which guides the design and synthesis of novel additives with significant lubrication and antiwear properties in the future.

关键词： nanolubricant additive dispersion stability tribological properties lubrication mechanism

Improvement of the lubrication properties of grease with Mn_(3)O_(4)/graphene (Mn_(3)O_(4)#G) nanocomposite additive

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Friction 2021年第6期9卷 1361-1377页

作者： Bao JIN Guangyan CHEN Jun ZHAO Yongyong HE yiyao huang Jianbin LUO State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100029China

Although grease can effectively lubricate machines,lubrication failure may occur under high speed and heavy load *** this study,Mn_(3)O_(4)/graphene nanocomposites(Mn_(3)O_(4)#G)were synthetized using a hydrothermal method as lubricant *** lubrication properties of compound grease with Mn_(3)O_(4)#G nanocomposite additive under heavy contact loads of 600–900 N(3.95–4.59 GPa)were ***,the nanocomposites were dispersed into L-XBCEA 0 lithium grease via successive electromagnetic stirring,ultrasound vibration,and three-roll *** grease with additives of commercial graphene(Com#G)was also investigated for *** test results revealed that the trace amounts of Mn_(3)O_(4)#G(as low as 0.02 wt%)could reduce the coefficient of friction(COF)of grease *** the concentration of Mn_(3)O_(4)#G was 0.1 wt%,the COF and wear depth were 43.5%and 86.1%,lower than those of pure graphene,*** addition,under the effect of friction,the microstructure of graphene in Mn_(3)O_(4)#G nanocomposites tends to be ordered and ***,most of the Mn_(3)O_(4) transformed into Mn_(2)O_(3) owing to the high temperature generated from *** the Ar gas cluster ion beam sputtering method,the thickness of the tribofilm was estimated to be 25–34 ***,the improvement of the lubrication properties was attributed to the synergistic effect of the adsorbed tribofilm,i.e.,the graphene island effect and the filling effect of Mn_(3)O_(4)#G.

关键词： friction nanocomposite additive graphene synergistic lubrication

Biomimetic“Gemini nanoimmunoregulators”orchestrated for boosted photoimmunotherapy by spatiotemporally modulating PD-L1 and tumor-associated macrophages

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1345-1361页

作者： Honglin huang Ningxi Li Xiaodan Wei Qingzhi Li Junhan Guo Geng Yang Hong Yang Lulu Cai yiyao Liu Chunhui Wu Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Provincial People’s Hospitaland School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China

A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer ***,a new type of spatiotemporal biomimetic“Gemini nanoimmunoregulators”was engineered to activate robust systemic photoimmunotherapy by integrating the triple-punch of amplified immunogenic cell death(ICD),tumor-associated macrophages(TAMs)phenotype reprogramming and programmed cell death ligand 1(PD-L1)***“Gemini nanoimmunoregulators”PM@RM-T7 and PR@RM-M2 were constructed by taking the biocompatible mesoporous polydopamine(mPDA)as nanovectors to deliver metformin(Met)and toll-like receptor 7/8 agonist resiquimod(R848)to cancer cells and TAMs by specific biorecognition via wrapping of red blood cell membrane(RM)inlaid with T7or M2 ***/Met@RM-T7(abbreviated as PM@RM-T7)was constructed to elicit an amplified in situ ICD effect through the targeted PTT and effectively stimulated the anticancer ***,PD-L1 on the remaining cancer cells was degraded by the burst metformin to prevent immune ***,mPDA/R848@RM-M2(abbreviated as PR@RM-M2)specifically recognized TAMs and reset the phenotype from M2 to M1 state,thus disrupting the immunosuppressive microenvironment and further boosting the function of cytotoxic T *** pair of sister nanoimmunoregulators cooperatively orchestrated the comprehensive anticancer activity,which remarkably inhibited the growth of primary and distant 4T1 tumors and prevented malignant *** study highlights the spatiotemporal cooperative modalities using multiple nanomedicines and provides a new paradigm for efficient cancer immunotherapy against metastatic-prone tumors.

关键词： Biomimetic immunoregulator Spatiotemporal delivery Targeted photothermal therapy Amplified immunogenic cell death Immunosuppressive tumor microenvironment PD-L1 degradation TAMs phenotype reversion Metastasis inhibition

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重视外泌体的实验诊断价值

中华检验医学杂志 2015年第11期38卷 724-726页

作者：黄依瑶郑磊南方医科大学南方医院检验科广州510515

Exosomes是可由体内多种活细胞分泌的纳米级双层膜结构小囊泡，可运载核酸、蛋白质和脂质等生物信息物质。Exosomes可保护易在循环系统中失活或降解的信息物质（如miRNA），将它们安全转移至特异性的靶细胞中参与信号调节，在细胞间信... 详细信息

Exosomes是可由体内多种活细胞分泌的纳米级双层膜结构小囊泡，可运载核酸、蛋白质和脂质等生物信息物质。Exosomes可保护易在循环系统中失活或降解的信息物质（如miRNA），将它们安全转移至特异性的靶细胞中参与信号调节，在细胞间信息传递中发挥重要的作用。Exosomes广泛存在于人类血液、尿液、胸腹腔积液等多种体液样本中，并可提供丰富、稳定、灵敏且特异的生物信息，是应用价值很高的液体活检标本。

关键词：外泌体蛋白质类微RNAs 生物学标记

Biallelic variants in RBM42 cause a multisystem disorder with neurological,facial,cardiac,and musculoskeletal involvement

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Protein & Cell 2024年第1期15卷 52-68页

作者： yiyao Chen Bingxin Yang Xiaoyu Merlin Zhang Songchang Chen Minhui Wang Liya Hu Nina Pan Shuyuan Li Weihui Shi Zhenhua Yang Li Wang Yajing Tan Jian Wang Yanlin Wang Qinghe Xing Zhonghua Ma Jinsong Li He-Feng huang Jinglan Zhang Chenming Xu Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China bstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China Intermational Peace Matermity and Child Health Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases Shanghai 200030China State Key Laboratory of Cell Biology Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China State Key Laboratory of Rice Biology the Key Laboratory of Molecular Biology of Crop Pathogens and InsectsInstitute of BiotechnologyZhejiang UniversityHangzhou 310058China Verna and Marrs McLean Department of Biochemistry and Molecular Biology Baylor College of MedicineHoustonTX 77030USA Children's hospital of Fudan University Shanghai 201102China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024ZhejiangChina Research Units of Embryo Original Diseases Chinese Academy of Medical Sciences(No.2019RU056)Shanghai 200011China

Here,we report a previously unrecognized syndromic neurodevelopmental disorder associated with biallelic loss-of-function variants in the RBM42 *** patient is a 2-year-old female with severe central nervous system(CNs)abnormalities,hypotonia,hearing loss,congenital heart defects,and dysmorphic facial *** whole-exome sequencing(WEs)reveals that the patient has two compound heterozygous variants,c.304C>T(p.R102*)and c.1312G>A(p.A438T),in the RBM42 gene which encodes an integral component of splicing complex in the RNA-binding motif protein *** p.A438T variant is in the RRM domain which impairs RBM42 pro-tein stability in ***,p.A438T disrupts the interaction of RBM42 with hnRNP K,which is the causa-tive gene for Au-Kline syndrome with overlapping disease characteristics seen in the index *** human R102*or A438T mutant protein failed to fully rescue the growth defects of RBM42 ortholog knockout△FgRbp1 in Fusarium while it was rescued by the wild-type(WT)human RBM42.A mouse model carying Rbm42 compound heterozygous variants,c.280C>T(p.Q94*)and c.1306_1308delinsACA(p.A436T),demonstrated gross fetal develop-mental defects and most of the double mutant animals died by ***-seq data confirmed that Rbm42 was involved in neurological and myocardial functions with an essential role in alternative splicing(As).Overall,we present clinical,genetic,and functional data to demonstrate that defects in RBM42 constitute the underlying etiology of a new neurodevelopmental disease which links the dysregulation of global AS to abnormal embryonic development.

关键词： RBM42 gene RNA-binding protein neurodevelopmental disorder Au-Kline syndrome alternative splicing

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血清中外泌体及外泌体RNA提取方法的比较

中华检验医学杂志 2016年第6期39卷 427-432页

作者：黄依瑶唐月汀覃思华徐咏安泰学郑磊南方医科大学南方医院检验科广东省重大疾病临床快速诊断生物传感工程技术研究中心广州510515

目的评价超高速离心法、ExoQuick与TEI试剂盒提取血清中外泌体的价值。方法方法学比较。收集2015年8至11月南方医科大学南方医院检验科健康者3名，采集静脉血至采血管，4℃静置12h使其自然凝固后离心取上清液为血清，采用超高速离心法、... 详细信息

目的评价超高速离心法、ExoQuick与TEI试剂盒提取血清中外泌体的价值。方法方法学比较。收集2015年8至11月南方医科大学南方医院检验科健康者3名，采集静脉血至采血管，4℃静置12h使其自然凝固后离心取上清液为血清，采用超高速离心法、ExoQuick与TEI试剂盒提取血清中外泌体，通过透射电子显微镜、蛋白印迹技术和NTA颗粒粒度分析仪检测外泌体形态结构、蛋白表达量和浓度与粒径分布，评估外泌体提取效率；采用超高速离心法＋Trizol LS法、ExoQuick＋SeraMir、TEI＋TER与ExoRNeasy试剂盒提取法分离3例血清中外泌体总RNA（exo—RNA），利用Agilent生物分析仪分析RNA片段分布，实时荧光定量PCR仪检测miRNA表达水平。组间蛋白浓度与miRNA表达量的比较采用方差分析。结果外泌体提取方法中，比较外泌体浓度和其蛋白浓度，ExoQuick与TEI试剂盒提取浓度高于超高速离心法；超高速离心法提取外泌体同时表达CD9、CD63和TSG101蛋白，而ExoQuick与TEI试剂盒提取外泌体仅表达TSG101。外泌体RNA提取方法中，不同方法影响RNA片段分布和miRNA表达，未影响miRNA相对表达趋势；ExoRNeasy提取RNA条带浓度较高，各miRNA表达水平较高；TEI＋TER法未见明显RNA条带，样本中各miRNA表达水平稳定；超高速离心法＋TrizolLS法与ExoQuick＋SeraMir法提取RNA可见范围较广的低浓度条带，此两法提取RNA中各miRNA表达无明显规律。结论外泌体提取方法中传统超高速离心法适用于蛋白组学方面研究，而ExoQuick与TEI试剂盒提取方法适用于血清等稀缺样本外泌体制备。

关键词：外泌体微RNAs 超速离心法

Comparison on Determination Results of Methane and Total Hydrocarbons by Glass Syringe Method and Air Bag Method

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Meteorological and Environmental Research 2019年第4期10卷 106-109页

作者： Chen Miao huang yiyao Guo Yan Chen Shuchi Shantou Environmental Protection Monitoring Station

Samples at different setting time were determined by glass syringe method and air bag method, and their results were analyzed. The results showed that concentrations of methane and total hydrocarbons obviously declined with the prolonging of setting time by glass syringe method, and recovery rate of sample declined to 60% after 8 h. In air bag method, analysis results of methane and total hydrocarbons were stabler, and recovery rate of sample was 93% after 8 h.

关键词： Syringe Air bag Methane Total hydrocarbons

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轻量化人体和手部网格重建

信号处理 2024年第7期40卷 1185-1196页

作者：安平刘熠尧周敏黄新彭杨超上海大学通信与信息工程学院特种光纤与光接入网重点实验室上海200444

三维人体网格重建在影视、虚拟现实等下游任务中有广泛应用。然而现有重建方式关注更好的重建精度和纹理表达,也因此更依赖高性能的计算或采集设备,缺乏对低成本、轻量化重建方式的研究。为降低人体重建任务的使用成本和硬件要求,本文... 详细信息

三维人体网格重建在影视、虚拟现实等下游任务中有广泛应用。然而现有重建方式关注更好的重建精度和纹理表达,也因此更依赖高性能的计算或采集设备,缺乏对低成本、轻量化重建方式的研究。为降低人体重建任务的使用成本和硬件要求,本文提出了一种轻量化的人体和手部网格重建方式,基于参数化模型对身体和手部重建任务进行解耦,针对身体和手部的不同特点分别设计了不同分支网络。身体重建分支和手部重建分支均为编码器-解码器结构。身体重建分支编码器为双阶段编码器,第一阶段通过Litehrnet和Canny算子获得热点图和边缘图,并对图片进行代理表示,第二阶段通过Shufflenet提取全局特征,解码器通过级联低维度多层感知器以概率分布的方式对人体参数进行回归;手部重建分支的编码器以Litehrnet为主干网络获取多分辨率特征分支,通过姿态池化对多分辨率特征分支进行融合得到全局特征,解码器通过深度可分离卷积网络获得手部顶点,并通过MLP对形状进行估计,利用顶点坐标基于逆向拓扑数学求解得到关节旋转参数。与现有方法相比,参数量和计算量显著减少,整体参数量为6.12M,计算量为433M,且具有较好的重建效果,在Human3.6M数据集中平均关节点误差(MPJPE)为86.7 mm,手部重建分支在FreiHand数据集上对齐后平均关节点误差(PA-MPJPE)为10.8 mm。此外该方法完成了在移动设备的推理,在骁龙8Gen3处理器推理速度为79.7 ms(12.5 fps),可以达到实时推理的效果。

关键词：人体重建轻量化网络 SMPL+H模型 MANO模型

Research Progress on the Monitoring of Precursor of Atmospheric Ozone——Volatile Organic Compounds

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Meteorological and Environmental Research 2020年第2期11卷 29-36页

作者： Shuchi CHEN yiyao huang Miao CHEN Juan LI Lianghong XIAO Yan GUO Shantou Environmental Protection Monitoring Station Shantou 515041China

Volatile organic compounds(VOCs)are important precursors of ozone and PM_(2.5).At present,VOCs have gradually become the focus of air pollution control after fine particles in China,and a series of documents,standards and planning on VOCs were issued from the state to each *** analysis on source apportionment and control of VOCs have also become a hot spot in atmospheric environmental protection research of China at present *** research work on VOCs in ambient air is the basis and premise of scientific and effective prevention and control of VOCs *** this paper,research progress on the monitoring of VOCs is introduced systemically,and main monitoring and evaluation methods of atmospheric VOCs are explored from monitoring analysis method,chemical reaction activity and health risk ***,concentration characteristics and source apportionment of VOCs in the regions at home and abroad that have carried out VOCs research work are compared and *** research could provide reference for source apportionment of VOCs in other cities of China.

关键词： Volatile organic compounds(VOCs) Ozone Chemical composition Source analysis