检索结果-南通市图书馆

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen gao Jing-Wen Li Hui Ye Xue-Zhi Zhang jian-Xiang liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu jian Zhang Ya gao Shuyue Li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin Li jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu Yue Taotao gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

Recent Advances in Fibrous Materials for Hydroelectricity Generation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun liu Chong gao Yong Du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Study of thermal decoherence of harmonic oscillators

在线全文

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第5期42卷 108-114页

作者： LI jian ZHOU gao-Liang YAN Zheng-Xin liu Wei WANG Zhao-Qi College of Science Xi’an University of Science and TechnologyXi’an 710054China

The thermal decoherence of harmonic oscillators is investigated *** quantum system presented here is a one-dimensional oscillator with angular frequency,which is surrounded by a thermal bath of environmental *** are various environmental oscillators with different angular frequency(below an ultraviolet cutoff).At the beginning,the quantum system is a pure state and the environmental oscillators are in thermodynamic equilibrium with *** a period,the system-environment interactions inspire significant decoherence of the quantum *** decoherence is displayed by explicit calculations of the purity and von Neumann entropy of the quantum *** is worth noting that the decoherence could be significant even in the weak coupling and low temperature case due to the large amount of environmental degrees of *** the decoherence process is inspired between the quantum system and an ordinary thermal environment here,the thermal decoherence result is quite general.

关键词： Quantum decoherence Grand canonical ensemble Oscillators

Influence of industrial organizational structure on farming performance of large yellow croaker farmers

在线全文

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2017年第3期2卷 134-139页

作者： Yan Yin jian gao yiyang liu College of Economics and Management Shanghai Ocean UniversityShanghai 201306China Institute of Marine Science Shanghai Ocean UniversityShanghai 201306China

This paper determines the cost-benefit levels of yellow croaker farming households by comparing and analysing responses to questionnaires distributed to 405 households located in nine breeding regions of three counties(cities)in the Chinese provinces of Fujian and Zhejiang.A transcendental logarithmic stochastic frontier production function model is used to perform a quantitative analysis on the large yellow croaker production technique efficiency of different forms of industry organisation,with the farming household as the basic production *** findings indicate that the average production technology efficiency of the farming households is 84.33% and room for improvement remains;and there are significant differences between the production technique efficiency of farming households from different regions and under different forms of *** analysis of the factors that affect farming household production technique efficiency found that capital input has a greater effect than labour *** participation and the number of individuals involved in the rearing of large yellow croakers,participation in technical training,and joining a closely-knit industry organisation all have a significant positive effect on increasing the production technique *** empirical results provide a basis and practical reference for optimising the development of the large yellow croaker farming industry,enhancing the degree of closeness of the organisations in the industry,and improving aquaculture performance.

关键词： Industry organisation Farming performance Large yellow croaker farming industry

The protective effect of icariin on glucocorticoid-damaged BMECs explored by microfluidic organ chip

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第6期33卷 3177-3182页

作者： Tengqi Li Qingyu Zhang Fuqiang gao Yadi liu Wei Sun yiyang Dong Department of Orthopedics Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Department of Orthopedics Peking University Shougang HospitalBeijing 100144China Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJi’nan 250021China Department of Orthopedics China-Japan Friendship HospitalBeijing 100029China Office of Academic Affairs Beijing University of Chemical TechnologyBeijing 100029China Department of Pharmaceutical Analysis College of Life Science and TechnologyBeijing University of Chemical TechnologyBeijing 100029China

Osteonecrosis of the femoral head(ONFH)is a devastating musculoskeletal disease characterized by the impaired circulation of *** purpose of this study was to explore the underlying mechanisms of the protective effect of icariin on the glucocorticoid-induced injury of bone microvascular endothelial cells(BMECs).Normal BMECs were extracted from the femoral heads by enzymatic isolation and magneticactivated cell sorting *** and icariin were used to intervene BMECs in microfluidic organ chips,and phalloidin staining was conducted to observe the cell morphology and *** next-generation transcriptome sequencing and real-time quantitative reverse transcription-polymerase chain reaction(q RT-PCR)were performed to identify the differentially expressed genes(DEGs)in different *** the microfluidic organ chip,it can be observed that after dexamethasone intervention,the filamentous structure in cell fibers disappeared and the cell morphology changed from spindle to round until *** could relieve these changes and showed a protective effect on glucocorticoiddamaged *** addition,201 DEGs were detected between the icariin protection group and the dexamethasone group,which were significantly enriched in 17 signaling pathways.8 of the top ten selected hub genes(IL6,PTGS2,VEGFA,etc.)were confirmed by q *** factors(TFs)-gene network showed 63 connections between 18 TFs and 12 *** instance,GATA2 could regulate 5 *** associations between 92 mi RNA and 12 DEGs were visualized in a mi RNA-gene *** hub mi RNA,has-mir-335–5 p was predicted to interact with 8 DEGs(PTGS2,VEGFA,etc.).Microfluidic organ chips could provide excellent morphological results for cell experiments,by which it could be observed that icariin showed a protective effect on the glucocorticoid-induced injury of ***,these DEGs,possible regulatory TF(GATA2,FOXC1,etc.)and mi RNA(has-mir-335–5 p)might be dysregulated in the ini

关键词： Osteonecrosis of the femoral head Bone microvascular endothelial cells Glucocorticoid Microfluidic chip Bioinformatic analysis

A Degenerate KAM Theorem for Partial Differential Equations with Unbounded Perturbations

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第11期40卷 2719-2734页

作者： Mei Na gao jian Jun liu School of Mathematics Physics and Statistics Shanghai Polytechnic UniversityShanghai201209P.R.China School of Mathematics Sichuan UniversityChengdu610065P.R.China

In this paper,an infinite dimensional KAM theorem with unbounded perturbations and double normal frequencies is established under qualitative non-degenerate *** is an extension of the degenerate KAM theorem with bounded perturbations by Bambusi,Berti,Magistrelli,and *** applications,for derivative nonlinear Schrödinger equation with periodic boundary conditions,quasi-periodic solutions around constant solutions are obtained.

关键词： KAM theorem derivative nonlinear Schrödinger equation quasi-periodic solutions

Exact Convergence Rate of the Local Limit Theorem for a Branching Random Walk in Z^(d)with a Random Environment in Time

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2024年第5期45卷 805-822页

作者： jian-xin liu Zhi-qiang gao School of Mathematical Sciences Beijing Normal UniversityBeijing 100875China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875China

Consider a branching random walk with a random environment in time in the d-dimensional integer *** branching mechanism is governed by a supercritical branching process,and the particles perform a lazy random walk with an independent,non-identical increment *** A■Z^(d),let Z_(n)(A)be the number of offsprings of generation n located in *** exact convergence rate of the local limit theorem for the counting measure Z_(n)(·)is *** partially extends the previous results for a simple branching random walk derived by gao(2017,*** Appl.).

关键词： Branching random walk Random environment Local limit theorems Exact convergence rate