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Fast-Charging Sodium-Ion Batteries Enabled by Molecular-Level Designed Nitrogen and Phosphorus Codoped Mesoporous Soft Carbon

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Research 2024年第2期2023卷 329-337页

作者： Lei Liu Zhuzhu Du Jiaqi Wang Hongfang Du Sheng Wu Mengjun Li yixuan zhang Jinmeng Sun Zhipeng Sun Wei Ai Frontiers Science Center for Flexible Electronics(FSCFE)and Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi'an 710072China Fujian Cross Strait Institute of Flexible Electronics(Future Technologies) Fujian Normal UniversityFuzhou 350117China School of Materials and Energy Guangdong University of TechnologyGuangzhou510006 GuangdongChina

Soft carbons have attracted extensive interests as competitive anodes for fast-charging sodium-ion batteries(SIBs);however,the high-rate performance is still restricted by their large ion migration barriers and sluggish reaction ***,we show a molecular design approach toward the fabrication of nitrogen and phosphorus codoped mesoporous soft carbon(NPSC).The key to this strategy lies in the chemical cross-linking reaction between polyphosphoric acid and p-phenylenediamine,associated with pyrolysis induced in-situ self-activation that creates mesoporous structures and rich heteroatoms within the carbon *** to the enlarged interlayer spacing,reduced ion diffusion length,and plentiful active sites,the obtained NPSC delivers a superb rate capacity of 215 mAh g-1 at 10 A g-1 and an ultralong cycle life of 4,700 cycles at 5 A g^(-1).Remarkably,the full cell shows 99%capacity retention during 100 continuous cycles,and maximum energy and power densities of 191 Wh kg^(-1)and 9.2 kW kg^(-1),*** believe that such a synthetic protocol could pave a novel venue to develop soft carbons with unique properties for advanced SIBs.

关键词： kinetics carbons linking

Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki Kazuhiko Fukui Lili Feng Meiling Sun Yamin Tang yixuan zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

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章太炎进化观的历时性研究

新疆社会科学 2024年第1期 21-33,164页

作者：张翊轩北京大学哲学系北京100871

1903—1906年间,章太炎的进化观发生了鲜明的“断裂”,在《訄书》时期,章太炎认同达尔文、斯宾塞的进化论;至《俱分进化论》时期,他提出了善恶苦乐并进的俱分进化观,并把“俱分”进一步推扩为“文明”的定语;到《民报》时期,特别是在《... 详细信息

1903—1906年间,章太炎的进化观发生了鲜明的“断裂”,在《訄书》时期,章太炎认同达尔文、斯宾塞的进化论;至《俱分进化论》时期,他提出了善恶苦乐并进的俱分进化观,并把“俱分”进一步推扩为“文明”的定语;到《民报》时期,特别是在《齐物论释》中,批判线性进化观背后的理论根源逐步呈现出来,表达为“齐文野”的思想旨趣及对目的论文明观的深刻反思,对进化概念本身的批判实则是对诸如文明、进步等观念被用以将强权和暴力合理化、合法化、合目的性的危险的格外警惕,这是理解章太炎一以贯之之道的方便法门。

关键词：章太炎断裂《俱分进化论》齐文野目的论

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization

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Science China(Life Sciences) 2024年第5期67卷 1010-1026页

作者： Ziyue Qin Yanxing Han Yifei Du yixuan zhang Yifeng Bian Ruyu Wang Haoran Wang Fanyi Guo Hua Yuan Yongchu Pan Jianliang Jin Qigang Zhou Yuli Wang Feng Han Yan Xu Jiandong Jiang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing 210029China State Key Laboratoryof BioactiveSubstances andFunction of Natural Medicine Instituteof Materia MedicaChinese Academyof MedicalSciencesandPeking Union MedicalCollegeBeijing100050China Gusu school Nanjing medical universitySuzhou 215002China Key Laboratory of Cardiovascular&Cerebrovascular Medicine Drug Target and Drug Discovery CenterSchool of PharmacyNanjing Medical UniversityNanjing 211166 China Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Human Anatomy Research Centre for Bone and Stem CellsKey Laboratory for Aging&DiseaseThe State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjing 211166China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing Jiangsu211166China Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Virology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Alveolar bone regeneration has been strongly linked to macrophage polarization.M1 macrophages aggravate alveolar bone loss,whereas M2 macrophages reverse this ***(BBR),a natural alkaloid isolated and refined from Chinese medicinal plants,has shown therapeutic effects in treating metabolic *** this study,we first discovered that culture supernatant(CS)collected from BBR-treated human bone marrow mesenchymal stem cells(HBMSCs)ameliorated periodontal alveolar bone *** from the BBR-treated HBMSCs contained bioactive materials that suppressed the M1 polarization and induced the M2 polarization of macrophages in vivo and in *** clarify the underlying mechanism,the bioactive materials were applied to different animal *** discovered macrophage colony-stimulating factor(M-CSF),which regulates macrophage polarization and promotes bone formation,a key macromolecule in the *** of pure M-CSF attenuated experimental periodontal alveolar bone loss in ***-stimulating factor 1 receptor(CSF1R)inhibitor or anti-human M-CSF(M-CSF neutralizing antibody,Nab)abolished the therapeutic effects of the CS of BBR-treated ***,AKT phosphorylation in macrophages was activated by the CS,and the AKT activator reversed the negative effect of the CSF1R inhibitor or *** results suggest that the CS of BBR-treated HBMSCs modulates macrophage polarization via the M-CSF/AKT *** studies also showed that CS of BBR-treated HBMSCs accelerated bone formation and M2 polarization in rat teeth extraction ***,our findings established an essential role of BBR-treated HBMSCs CS and this might be the first report to show that the products of BBR-treated HBMSCs have active effects on alveolar bone regeneration.

关键词： berberine human bone marrow mesenchymal stem cells alveolar bone regeneration macrophage colony-stimulating factor AKT phosphorylation

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思想政治教育现代化的内涵、动力与路径

思想理论教育 2024年第9期 56-61页

作者：许瑞芳张宜萱华东师范大学马克思主义学院上海200241

在中国式现代化进程中,思想政治教育始终发挥着重要的价值引领、思想凝聚、道德调节作用。思想政治教育现代化是以现代化观念为指导,充分运用现代科学技术手段,不断促进思想政治教育内部诸要素的现代化整合,以培养社会主义现代化建设所... 详细信息

在中国式现代化进程中,思想政治教育始终发挥着重要的价值引领、思想凝聚、道德调节作用。思想政治教育现代化是以现代化观念为指导,充分运用现代科学技术手段,不断促进思想政治教育内部诸要素的现代化整合,以培养社会主义现代化建设所需要的人才的一种理想图景与现实过程。思想政治教育现代化是回应中国式现代化重大理论与现实问题的应然诉求,是观照人的现代化发展中个体需求的必要手段,是构建思想政治教育自主知识体系的内在要求。推动思想政治教育现代化,需要打破传统思维方式,优化学科范式,通过历史回溯总结经验与规律,在与世界文明的交流互鉴中增强思想政治教育现代化的自觉性与包容性。

关键词：思想政治教育现代化中国式现代化

大中小学思想政治理论课一体化建设的回顾与展望

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思想理论教育 2024年第3期 17-23页

作者：许瑞芳张宜萱华东师范大学马克思主义学院上海200241

自学校思想政治理论课教师座谈会提出大中小学思想政治理论课一体化建设以来,在习近平新时代中国特色社会主义思想指导下,大中小学思政课一体化建设的战略意义得到明确,理论阐释不断深化,实践路径有序优化,共同体建设纳入轨道,师资队伍... 详细信息

自学校思想政治理论课教师座谈会提出大中小学思想政治理论课一体化建设以来,在习近平新时代中国特色社会主义思想指导下,大中小学思政课一体化建设的战略意义得到明确,理论阐释不断深化,实践路径有序优化,共同体建设纳入轨道,师资队伍建强夯实。五年来,大中小学思政课一体化建设积累了宝贵经验。在建设教育强国的背景下,大中小学思政课一体化建设要以教育高质量发展理念为引领,以信息技术赋能一体化建设,以教、学、评一体化提升思政课教学实效性,推进一体化建设的区域均衡发展。

关键词：思想政治理论课大中小学一体化建设

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唯识学“末那识”概念的现象学阐释

法音 2024年第6期 11-20页

作者：张轶璇中国人民大学佛教与宗教学理论研究所

早期佛教的“六识”说确立了佛教心识理论的最基本框架,其后各部派又不断地对之进行扩充与发展,而后起的唯识学在块择、会通诸说的基础之上,最终建立了“八识”说。其对意识结构与意识功能等所作的分析细致且深入。从这个角度来看,唯识... 详细信息

早期佛教的“六识”说确立了佛教心识理论的最基本框架,其后各部派又不断地对之进行扩充与发展,而后起的唯识学在块择、会通诸说的基础之上,最终建立了“八识”说。其对意识结构与意识功能等所作的分析细致且深入。从这个角度来看,唯识学的“八识”说可以被认为是佛教心识理论最为完善的形态,同时也是佛教“善自观心,善自知心”[2]这一思想取向最充分、最彻底的展现。

关键词：唯识学早期佛教末那识八识观心思想取向意识功能会通

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极地航行船舶防覆冰涂层研究进展

表面技术 2024年第6期53卷 1-10页

作者：张祎轩刘涛刘耀虎刘杰王健君中国科学院化学研究所北京100190 上海海事大学上海201306 中国科学院前沿科学与教育局北京100864 中国科学院理化技术研究所北京100190

两极地区是未来重要的能源和资源基地。然而,极地长年低温多冰,极大限制了我国对两极地区的科学考察、商业航运和能源开发进程。因此,发展长效稳定的防覆冰技术是推进极地发展战略的关键。系统阐明了船舶在极地航行过程中面临的结冰困境... 详细信息

两极地区是未来重要的能源和资源基地。然而,极地长年低温多冰,极大限制了我国对两极地区的科学考察、商业航运和能源开发进程。因此,发展长效稳定的防覆冰技术是推进极地发展战略的关键。系统阐明了船舶在极地航行过程中面临的结冰困境,分析了船舶积冰的类型,总结了目前解决船舶覆冰问题的多种防除冰技术及发展现状,包括主动防除冰技术(机械除冰、超声导波除冰、加热除冰、化学熔融除冰等)和被动防覆冰涂层技术(气体润滑防覆冰涂层、液体润滑防覆冰涂层、“类液体”润滑防覆冰涂层、界面可控断裂防覆冰涂层等),同时对各技术在极地船舶防冰应用中的优缺点和可行性进行了深入分析。展望了船舶装备对特种防冰涂层的关键需求,提出主、被动协同除冰技术是实现极地船舶防覆冰的重要策略。

关键词：极地船舶防冰涂层材料冰黏附

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超越赋能范式的数字乡村建设共同体何以形成

学习论坛 2024年第1期 112-120页

作者：陈桂生张艺萱天津师范大学政治与行政学院天津300387

数字中国战略下的数字技术赋能乡村振兴实践开启了乡村建设的新图景,但随着乡村高质量发展的深入开展,技术赋能范式已难以回应乡村数字化治理的新需求。基于权力、技术与行动者关系重塑的数字乡村共同体,具备了超越赋能范式的诸如耦合... 详细信息

数字中国战略下的数字技术赋能乡村振兴实践开启了乡村建设的新图景,但随着乡村高质量发展的深入开展,技术赋能范式已难以回应乡村数字化治理的新需求。基于权力、技术与行动者关系重塑的数字乡村共同体,具备了超越赋能范式的诸如耦合权力与技术场域的数字乡村建设、对接数字乡村治权共享需求、内涵共同体激励相容机制等演进功能,其有助于消弭赋能范式的梗阻。以数字乡村共同体建设的逻辑,需要从连线扩面地破解技术悬浮、兼顾“赋权”与“放权”的乡村治权共享、锚定“以人为中心”的多元需求等内容出发,持续超越赋能范式的治理限度而推进数字乡村建设高质量发展。

关键词：数字乡村治理共同体赋能范式