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Safety and efficacy of Yupingfeng granules in children with recurrent respiratory tract infection:A randomized clinical trial

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Pediatric Investigation 2022年第2期6卷 75-84页

作者： Baoping Xu Xinmin Li Siyuan Hu yixiao Bao Fengmei Chen Zhimin Chen Yonggang Du Enmei liu Yufeng liu Qinghui Mou Baoling Su Bo Wang Jianwen Xu Guiping Xu Qiaozhi Yang Liwei Gao Xiaohui liu Lei Li Rong Ma Kunling Shen China National Clinical Research Center of Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine ShanghaiChina Guangdong Women and Children Hospital and Health Institute GuangzhouGuangdongChina Children’s Hospital of Zhejiang University School of Medicine ZhejiangChina Changzhi People’s Hospital ChangzhiShanxiChina Children’s Hospital of Chongqing Medical University ChongqingChina The Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine ShenyangLiaoningChina Qilu Children’s Hospital of Shandong University JinanShandongChina Heji Hospital Affiliated to Changzhi Medical College ChangzhiShanxiChina The Third Affiliated Hospital of Xinxiang Medical College XinxiangHenanChina Huizhou Traditional Chinese Medicine Hospital GuangdongChina Liaocheng People’s Hospital ShandongChina Beijing Children’s Hospital Capital Medical UniversityNational Center for Children’s HealthBeijingChina Drug Research and Evaluation Technology Center Chinese Assocaiation of Traditional Chinese MedicineBeijingChina

Importance:Recurrent respiratory tract infection(RRTI)is common in *** RRTI treatment will lead to asthma and other diseases,thereby seriously affecting the growth and physical health of *** function modulation can prevent and alleviate childhood ***(YPF),a patented traditional Chinese medicine(TCM),has immunomodulatory effects and is widely used in China to treat children with ***:To evaluate the safety and efficacy of YPF monotherapy in treating children with ***:This multicenter,randomized,double-blind,double-simulation,noninferiority clinical trial was conducted from January 2015 to August 2017,with an 8-week treatment period and 52-week follow-up after the drug *** aged 2–6 years with RRTI meeting the inclusion and exclusion criteria were enrolled in 13 hospitals in China and divided randomly into three groups(2:2:1 ratio)to receive YPF,pidotimod,or *** primary outcome was the proportion of RRTI returning to normal standard level during the *** secondary outcomes were reduction in the number of RRTI recurrences,effect on clinical symptoms(in accord with TCM practice),effect per symptom,and *** trial was registered at the Chinese Clinical Trials Registry(***)under the unique identifier ***:Three hundred and fifty-one children were enrolled and randomly assigned to 3 groups;124,125,and 61 children in the YPF,pidotimod,and placebo groups,respectively,had completed the *** the follow-up,the proportion of RRTI returning to normal standard level was 73.13%,67.15%,and 38.81%with YPF,pidotimod,and placebo,respectively(P<0.0001).The proportion of cases who returned to normal standard level in the YPF group was 34.32%higher than that in the placebo *** safety profile did not significantly differ among the ***:YPF granules were noninferior to the active control drug pidotimod oral solution for the tr

关键词： Pidotimod Recurrent childhood respiratory tract infection Traditional Chinese medicine Yupingfeng

Persistent and enhanced spin-nematic squeezing in a spinor Bose–Einstein condensate

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Communications in Theoretical Physics 2022年第2期74卷 44-50页

作者： Xinfang Li Jianning liu Osei Seth Heng-Na Xiong Qing-Shou Tan yixiao Huang School of Science Zhejiang University of Science and TechnologyHangzhou 310023China School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310023China School of Physics&Electronic Science Hunan Institute of Science and TechnologyYueyang 414006China

We propose a simple scheme to realize the persistent spin-nematic squeezing in a spinor Bose–Einstein condensate by rapidly turning-off the external magnetic field at a time that maximal spinnematic squeezing *** observe that the optimal spin-nematic squeezing can be maintained in a nearly fixed *** a proper initial magnetic field,the optimal squeezing can be obviously *** further construct a spin-mixing interferometer,where the quantum correlation of the squeezed state(generated by our scheme)is fully utilized in the phase measurement,and show the phase sensitivity of the interferometer has a significant enhancement.

关键词： quantum metrology heisenberg limit interferometry

Atomic-resolution characterization on the structure of strontium doped barium titanate nanoparticles

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Nano Research 2021年第12期14卷 4802-4807页

作者： Haoyu Jiang Jizhen Qi Dongchang Wu Wei Lu Jiahui Qian Haifeng Qu yixiao Zhang Pei liu Xi liu Liwei Chen In-situ Center for Physical Sciences School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240China i-Lab CAS Center for Excellence in Nanoscience Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou215123China Suzhou Bao Shun Mei Technology Co. Ltd.Room 305Building 1199 Jinji Lake AvenueSuzhou Industrial ParkSuzhou215123China DTU Nanolab Technical University of DenmarkFysikvejBuilding 3072800LyngbyDenmark Shanghai Nanoport Thermo Fisher Scientific Building A2517 Jinke RoadPudong DistrictShanghai201203China

Ferroelectric barium titanate nanoparticles(BTO NPs)may play critical roles in miniaturized passive electronic devices such as multi-layered ceramic *** increasing experimental and theoretical understandings on the structure of BTO and doped BTO have been developed over the past decade,the majority of the investigation was carried out in thin-film materials;therefore,the doping effect on nanoparticles remains ***,doping-induced local composition and structure fluctuation across single nanoparticles have yet to be *** this work,we use electron microscopy-based techniques including high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM),integrated differential phase contrast(iDPC)-STEM,and energy dispersive X-ray spectroscopy(EDX)mapping to reveal atomically resolved chemical and crystal structure of BTO and strontium doped BTO *** X-ray diffraction(PXRD)results indicate that the increasing strontium doping causes a structural transition from tetragonal to cubic phase,but the microscopic data validate substantial compositional and microstructural inhomogeneities in strontium doped BTO *** work provides new insights into the structure of doped BTO NPs and will facilitate the materials design for next-generation high-density nano-dielectric devices.

关键词： barium titanate nanoparticles doping effect structural transition high-angle annular dark-field scanning transmission electron microscopy integrated differential phase contrast

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匡建军教授从伏邪化火论治痛风性关节炎经验

中国中医骨伤科杂志 2024年第8期32卷 89-91,96页

作者：刘科张乐张子鸣华盛汤祖宇赵浩茗熊逸啸陈柯如彭娜姿匡建军湖南中医药大学长沙410208 湖南省中医药研究院湖南省中医药研究院附属医院

本文从病因病机、分期论治等方面综合总结了匡建军教授从伏邪化火论治痛风性关节炎的临床经验。匡建军教授指出本病与伏邪相似,伏匿期以正虚为本,邪伏为标;发作期时伏邪受外因感召,内外互相作用,转而化火,从而由里出外,出现红肿热痛症状... 详细信息

本文从病因病机、分期论治等方面综合总结了匡建军教授从伏邪化火论治痛风性关节炎的临床经验。匡建军教授指出本病与伏邪相似,伏匿期以正虚为本,邪伏为标;发作期时伏邪受外因感召,内外互相作用,转而化火,从而由里出外,出现红肿热痛症状;治疗上伏匿期分邪伏三阴证、寒邪内伏证、痰湿伏脾证、瘀毒痼结证,根据不同证型特点,予以扶正、温寒、健脾、活血等法;伏邪化火期予以急清火毒,同时配合外治疗法,临床疗效甚佳。

关键词：痛风性关节炎痹证伏邪化火分期论治名医经验

Level and characteristics of polychlorinated dibenzo-p-dioxins and dibenzofurans in feed and feed additives

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Journal of Environmental Sciences 2017年第1期29卷 324-331页

作者： Lingyun Wang Gangdou Ding Zhiguang Zhou Xun liu yixiao Wang HeidQunhui Xie Tuan Xu Pu Wang Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China. University of Chinese Academy of Sciences BeijingChina Dioxin Laboratory Chinese Academy of Inspection and Quarantine Comprehensive Test CenterBeijing 100123China State Environmental Protection Key Laboratory of Dioxin Pollution Control National Research Center for Environmental Analysis and MeasurementBeijing 100029China

Feed security is a prerequisite for safe animal food *** this study,13 groups of feed and feed ingredients,totaling 2067 samples,were collected in the period of 2011 to 2014 from *** highest mean level of polychlorinated dibenzo-p-dioxins and dibenzofurans（PCDD/Fs） was found in fish meals and shell powders,with a concentration of 60.35 ng/kg,followed by mineral origin *** terms of the toxicity equivalent concentration,the fish oil group showed the highest PCDD/F levels because of their bio-accumulation through the aquatic food chain,with an average concentration of 1.26 ng WHO-TEQ/kg,while the lowest level was observed in compound feed for chickens and pigs,with an average value of0.16 ng WHO-TEQ/*** and OCDF were the predominant congeners in all groups except fish oils,in which the primary congeners were 2,3,4,7,8-PeCDF and 2,3,7,*** zinc chloride samples,different from other zinc-based compound samples,the main congeners were 1,2,3,4,6,7,8-HpCDF（17%）,1,2,3,4,7,8,9-HpCDF（15%）,1,2,3,4,7,8-HxCDF（12%） and OCDF（30%）.Considering toxicity equivalency factors,the dominant congeners were 2,3,4,7,8-PeCDF,1,2,3,4,7,8-HxCDF,2,3,7,8-TCDF and 1,2,3,7,8-PeCDD,and the contribution to the total TEQwas29%,16%,14%and 12%,***,2.1%（43 out of 2067） of all the analyzed samples exceeded the different individual ＇European Union maximum limited levels for PCDD/*** study is beneficial for the determination of the status of contamination levels of feed and feed ingredients.

关键词： PCDD/Fs Chinese feed Feed additives Characterization

根治性前列腺切除术后影响患者临床治愈和生化复发的危险因素分析

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中华泌尿外科杂志 2021年第9期42卷 644-649页

作者：范宇叶林·木拉提梁磊李秦汉张喆楠马冰磊张铨李志存吴天俣刘亿骁谌诚张骞虞巍张凯何志嵩周利群北京大学第一医院泌尿外科北京大学泌尿外科研究所北京100034

目的探讨影响根治性前列腺切除术(RP)后患者临床治愈和生化复发的危险因素。方法回顾性分析2001年4月至2020年12月北京大学第一医院收治的896例行RP患者的临床资料。年龄(65.90±6.3)岁,术前前列腺特异性抗原(PSA)10.75(0.36~264.20)ng/... 详细信息

目的探讨影响根治性前列腺切除术(RP)后患者临床治愈和生化复发的危险因素。方法回顾性分析2001年4月至2020年12月北京大学第一医院收治的896例行RP患者的临床资料。年龄(65.90±6.3)岁,术前前列腺特异性抗原(PSA)10.75(0.36~264.20)ng/ml,前列腺体积40.0(12.0~220.9)ml,PSA密度(PSAD)0.27(0.02~3.42)ng/(ml·g)。临床分期T1c期432例,T2a/b期333例,T2c期76例,≥T3期55例。术前穿刺病理Gleason评分3+3分193例,3+4分315例,4+3分162例,≥8分226例。手术方式为开放、腹腔镜或机器人辅助RP。以术后临床治愈和生化复发为研究终点。临床治愈定义为术后6周血清PSA水平下降至0.03ng/ml以下。生化复发定义为RP术后随访中,连续两次血清PSA检测>0.2ng/ml。采用多因素logistic回归分析术后临床治愈的独立危险因素。采用Kaplan-Meier法绘制无生化复发生存曲线,采用log-rank法进行单因素分析,单因素分析有意义的指标采用Cox比例风险模型行多因素分析。结果896例术后中位随访58(5~241)个月。896例中678例(75.7%)达到临床治愈。经单因素分析筛选变量后,多因素分析结果显示术前穿刺阳性针数占比是否>33%(P=0.007)和穿刺病理Gleason评分(P=0.041)是影响临床治愈的独立危险因素。共890例纳入生化复发的危险因素分析,其中172例(19.3%)发生生化复发。1、5、10年无生化复发生存率分别为98.1%、83.1%、68.4%。中位无生化复发生存时间尚未达到,截至末次随访平均无生化复发生存时间为181(95%CI 172~189)个月。多因素分析结果显示,术后是否达到临床治愈(P=0.001)和术后病理分期(P<0.001)是生化复发的独立危险因素。结论术前穿刺阳性针数占比和穿刺病理Gleason评分是影响RP术后临床治愈的独立危险因素。术后病理分期和术后是否达到临床治愈是RP术后影响生化复发的独立危险因素。

关键词：前列腺肿瘤根治性前列腺切除术生化复发临床治愈危险因素

Patterns and dietary intake of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in food products in China

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Journal of Environmental Sciences 2017年第1期29卷 165-172页

作者： Lingyun Wang Gangdou Ding Zhiguang Zhou Xun liu yixiao Wang Heidi Qunhui Xie Tuan Xu Pu Wang Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China. University of Chinese Academy of Sciences Beijing 100049China Dioxin Laboratory Chinese Academy of Inspection and Quarantine Comprehensive Test CenterBeijing 100223China State Environmental Protection Key Laboratory of Dioxin Pollution Control National Research Center for Environmental Analysis andMeasurementBeijing 100029China

The health risk of polychlorinated dibenzo-p-dioxins and dibenzofurans（PCDD/Fs） and dioxin-like PCBs（d1-PCBs） to human being should be assessed *** evaluate the contamination levels in various food products in the Chinese market and to assess the dietary exposure of the Chinese population,11 varieties of food groups totaling 534 samples including beef and mutton,chicken and duck,pork,fish and seafood,milk and dairy products were *** average concentrations of PCDD/Fs in all groups ranged from0.291 to 8.458 pg/g whole weight（w.w.）.The average toxic equivalency concentrations were from 0.012 pg TEQ/g *** cereal to 0.357 pg TEQ/g fat for marine *** and2,3,7,8-TCDF were the dominant congeners in *** dietary estimated mean intake for the Chinese rural and urban populations were 0.555 and 0.514 pg TEQ/kg body weight/day,respectively,however,the cereal group exposure were higher to the estimate daily intake and contributed 81%for rural and 48%for urban population,followed by fish and seafood which contributed 4%and 15%to the estimate daily *** estimated dietary intakes were compared with the toxicological reference values and showed that both rural and urban populations were well below those values.

关键词： PCDD/Fs Foodstuffs Dietary intake China

Mesoporous silica SBA-15 functionalized with phosphonate and amino groups for uranium uptake

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Science China Chemistry 2012年第9期55卷 1705-1711页

作者： WANG XiaoLiang YUANLiYong WANG YanFei LI ZiJie liu YaLan FENG yixiao ZHAO YuLiang CHAI ZhiFang SHI WeiQun Department of Applied Chemistry School of Chemistry and Chemical EngineeringUniversity of South ChinaHengyang 421001China Key Laboratory of Nuclear Analytical Techniques Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Mesoporous silicas have a very attractive ability of sorption and enrichment of metal ions due to their huge surface area and facile functionalization by organic *** this work,phosphonate-amino bifunctionalized mesoporous silica SBA-15(PA-SBA-15) as U(VI) sorbent was fabricated through post-grafting *** obtained mesoporous silica was characterized by SEM,XRD,NMR and nitrogen sorption/desorption experiments,which revealed the existence of ordered mesoporous structure with uniform pore diameter and large surface *** adsorptivity of PA-SBA-15 for U(VI) from aqueous solution was investigated using batch sorption technique under different experimental *** preliminary results show that the U(VI) sorption by PA-SBA-15 is very quick with equilibrium time of less than 1 h,and the U(VI) uptake is as large as 373 mg/g at pH 5.5 under 95 ℃.The sorption isotherm has been successfully modeled by the Langmuir isotherm,suggesting a monolayer homogeneous sorption of U(VI) in *** sorption is pH-dependent due to the pH-dependent charge of sorbent in the aqueous *** thermodynamics research shows that the sorption is a feasible and endothermic *** on these results,PA-SBA-15 could be a promising solid phase sorbent for highly-efficient removal of U(VI) ions from waste water and enrichment of U(VI) from a solution at a very low level.

关键词： SBA-15 吸收功能氨基酸膦酸酯介孔分子筛 Langmuir吸附介孔二氧化硅固相吸附剂

LNG冷能用于天然气电厂二级循环发电的研究

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煤气与热力 2017年第3期37卷 49-53页

作者：韩逸骁管延文刘文斌卢鉴莹杨云蔡磊郭启华吴勇华中科技大学环境科学与工程学院湖北武汉430074 中国市政工程中南设计研究总院有限公司湖北武汉430010

通过ASPEN PLUS软件构建新型二级循环发电系统,一级循环(蒸汽循环)的循环工质水通过换热器吸收烟气中的余热后进入蒸汽轮机做功,LNG作为二级循环(CO_2循环)的冷源,将蒸汽循环中水蒸气乏汽的余热作为CO_2循环的热源。通过敏感度分析对系... 详细信息

通过ASPEN PLUS软件构建新型二级循环发电系统,一级循环(蒸汽循环)的循环工质水通过换热器吸收烟气中的余热后进入蒸汽轮机做功,LNG作为二级循环(CO_2循环)的冷源,将蒸汽循环中水蒸气乏汽的余热作为CO_2循环的热源。通过敏感度分析对系统工况进行优化,二级循环发电系统净发电效率达到78.2%,与单级循环发电系统相比,系统净发电效率绝对值提高32.4%。

关键词： LNG冷能 ASPEN PLUS软件模拟二级循环发电循环工质