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Confinement of sulfur-doped NiO nanoparticles into N-doped carbon nanotube/nanofiber-coupled hierarchical branched superstructures:Electronic modulation by anion doping boosts oxygen evolution electrocatalysis

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Journal of Energy Chemistry 2021年第12期30卷 585-593,I0014页

作者： Tongfei Li Jingwen Yin Yu Li Ziqi Tian yiwei zhang Lin Xu Yanle Li Yawen Tang Huan Pang Jun Yang School of Chemistry and Chemical Engineering Southeast UniversityJiangsu Optoelectronic Functional Materials and Engineering LaboratoryNanjing 211189JiangsuChina School of Chemistry and Materials Science Jiangsu Key Laboratory of New Power BatteriesNanjing Normal UniversityNanjing 210023JiangsuChina Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201ZhejiangChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009JiangsuChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesNo.19A Yuquan RoadBeijing 100049China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100JiangsuChina

The search for non-precious and efficient electrocatalysts towards the oxygen evolution reaction(OER)is of vital importance for the future advancement of multifarious renewable energy conversion/storage *** modulation via heteroatom doping is recognized as one of the most forceful leverages to enhance the electrocatalytic ***,we demonstrate a delicate strategy for the in-situ confinement of S-doped Ni O nanoparticles into N-doped carbon nanotube/nanofiber-coupled hierarchical branched superstructures(labeled as S-Ni O@N-C NT/NFs).The developed strategy simultaneously combines enhanced thermodynamics via electronic regulation with accelerated kinetics via *** S-doping into Ni O lattice and the 1 D/1 D-integrated hierarchical branched carbon substrate confer the resultant S-Ni O@N-C NT/NFs with regulated electronic configuration,enriched oxygen vacancies,convenient mass diffusion pathways and superior architectural ***,the SNi O@N-C NT/NFs display outstanding OER properties with an overpotential of 277 m V at 10 m A cm^(-2)and impressive long-term durability in KOH *** functional theory(DFT)calculations further corroborate that introducing S-dopant significantly enhances the interaction with key oxygenate intermediates and narrow the band *** encouragingly,a rechargeable Zn-air battery using an air-cathode of Pt/C+S-Ni O@N-C NT/NFs exhibits a lower charge voltage and preferable cycling stability in comparison with the commercial Pt/C+Ru O_(2)*** study highlighting the concurrent consideration of electronic regulation,architectural design and nanocarbon hybridization may shed light on the future exploration of economical and efficient electrocatalysts.

关键词： Electrospinning Heteroatom doping Hierarchical architecture Oxygen evolution reaction DFT calculations

乡村振兴背景下天津市奶业发展现状与对策建议

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天津农林科技 2024年第2期 41-43页

作者：张一为郭爽张盛南王煦王永颖王鸿英天津市农业发展服务中心天津300061

在天津市全面实施乡村振兴的背景下,文章介绍了近几年天津市奶业发展现状,从养殖成本、奶牛存栏量、市场供需等方面对天津市奶业发展目前存在的主要问题进行了分析,在区域布局、良种培育、设施化水平、种养一体化、消费引导等方面提出... 详细信息

在天津市全面实施乡村振兴的背景下,文章介绍了近几年天津市奶业发展现状,从养殖成本、奶牛存栏量、市场供需等方面对天津市奶业发展目前存在的主要问题进行了分析,在区域布局、良种培育、设施化水平、种养一体化、消费引导等方面提出了天津市奶业发展的对策建议。

关键词：天津奶业发展对策建议

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Numerical analysis of wind effects on aerodynamic characteristics of a ducted fan

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Chinese Journal of Aeronautics 2024年第5期37卷 263-280页

作者： yiwei LUO Tianfu AI Yuhang HE Bin XU Yuping QIAN Yangjun zhang State Key Laboratory of Intelligent Green Vehicle and Mobility School of Vehicle and MobilityTsinghua UniversityBeijing 100084China Key Laboratory of Conveyance and Equipment Ministry of Education East China Jiaotong UniversityNanchang 330013China Vehicle Research Center School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

Ducted fans have been extensively used in Unmanned Aerial Vehicles(UAVs)for a variety of missions because of high efficiency,high safety and low ***,as a kind of typical meteorological condition,brings significant aerodynamic interference to the ducted fan,which seriously threatens flight stability and *** this work,the numerical simulation with the Unsteady Reynolds Averaged Navier-Stokes(URANS)method and the sliding mesh technique is performed to evaluate the steady wind *** results show that the wind will lead to serious unsteady effects in the flow field,and the thrust fluctuates at the blade passing frequency of 200 *** the wind speed increases,the rotor thrust increases,the duct thrust decreases,and the total thrust changes *** instability may occur when the wind speed exceeds 8 m/*** the angle of low-speed wind increases,the rotor thrust changes little,the duct thrust increases,and the total thrust *** addition,we figure out that cases with the same crosswind ratio are similar in results,and increasing the rotating speed or fan radius is beneficial to performance improvement in *** findings are essential to the ducted fan design and UAV flight control design for stable and safe operations in wind conditions.

关键词： Unmanned Aerial Vehicle(UAV) Ducted fan Wind effect Thrust fluctuations Computational Fluid Dynamics(CFD)

Sequential delivery of PD-1/PD-L1 blockade peptide and IDO inhibitor for immunosuppressive microenvironment remodeling via an MMP-2 responsive dual-targeting liposome

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2176-2187页

作者： Chuan Hu Yujun Song yiwei zhang Siqin He Xueying Liu Xiaotong Yang Tao Gong Yuan Huang Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China

Intelligent responsive drug delivery system opens up new avenues for realizing safer and more effective combination ***,a kind of tumor cascade-targeted responsive liposome(NLG919@Lip-pep1)is developed by conjugating polypeptide inhibitor of PD-1 signal pathway(AUNP-12),which is also a targeted peptide that conjugated with liposome carrier through matrix metalloproteinase-2(MMP-2)cleavable peptide(GPLGVRGD).This targeted liposome is prepared through a mature preparation process,and indoleamine-2,3-dioxygenase(IDO)inhibitor NLG919 was encapsulated into ***,mediated by the enhanced permeability and retention effect(EPR effect)and AUNP-12,NLG919@Lip-pep1 first targets the cells that highly express PD-L1 in tumor *** the same time,the over-expressed MMP-2 in the tumor site triggers the dissociation of AUNP-12,thus realizing the precise block of PD-1 signal pathway,and restoring the activity of T *** exposure of secondary targeting moduleⅡVRGDC-NLG919@Lip mediated tumor cells targeting,and further relieved the immunosuppressive ***,this study offers a potentially appealing paradigm of a high efficiency,low toxicity,and simple intelligent responsive drug delivery system for targeted drug delivery in breast cancer,which can effectively rescue and activate the body's anti-tumor immune response and furthermore achieve effective treatment of metastatic breast cancer.

关键词： Immunotherapy Cascade targeting Liposome MMP-2 responsive Breast cancer ICBs IDO inhibitors Immunosuppressive microenvironment

Enhancement of antitumor immunity by low-dose total body irradiation is associated with selectively decreasing the proportion and number of T regulatory cells

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Cellular & Molecular Immunology 2010年第2期7卷 157-162页

作者： Shudao Xiong Lei zhang yiwei Chu Department of Immunology Shanghai Medical College Institute for Immunobiology Key Laboratory of Molecular Medicine of Ministry of Education Fudan University ShanghaiChina

Low-dose total body irradiation （LTBI） is used in the treatment of some cancers mainly for immune enhancement rather than cell killing. However, the mechanism underlying LTBI remains unknown. In this study, by analyzing the immune patterns of lymphocytes, we found that the percentage and absolute number of CD4^＋CD25^＋Foxp3^＋ regulatory T cells are markedly decreased in naive mice following treatment with LTBI. On the contrary, the CD4^＋CD44^＋/CD8^＋CD44^＋ effector-memory T cells are greatly increased. Importantly, naive mice treated with dendritic cell-gp100 tumor vaccines under LTBI induced an enhancement of antigen-specific proliferation and cytotoxicity as well as interferon-γ, （IFN-γ） secretion against FIO melanoma tumor challenge, compared to treatment with either the tumor vaccine or LTBI alone. Consequently, the treatment resulted in a reduced tumor burden and prolonged mouse survival. Our data demonstrate that LTBI＇s enhancement of antitumor immunity was mainly associated with selectively decreasing the proportion and number of T regulatory cells, implying the potential application of the combination of LTBI and a tumor vaccine in antitumor therapy.

关键词： CD4^+CD25^+Foxp3^+ T cells CD4^+CD44^+/CD8^+CD44^+ effector-memory T cells low-dose total body irradiation LTBI tumor vaccine

布地奈德联合肺表面活性物质治疗新生儿胎粪吸入综合征有效性与安全性的系统评价

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药物流行病学杂志 2024年第1期33卷 85-94页

作者：张翊溦唐晓雨李胜刘涛雷亮谭璐胡娟武汉大学人民医院(武汉大学第一临床学院) 武汉430061 武汉大学泰康医学院(基础医学院) 武汉430071 武汉大学中南医院泌尿外科武汉430071 咸宁市第一人民医院药剂科湖北咸宁437000

目的系统评价布地奈德联合肺表面活性物质(PS)治疗新生儿胎粪吸入综合征(MAS)的有效性与安全性。方法计算机检索PubMed、Cochrane Central Register of Controlled Trials(Central)、Embase、Web of Science、SinoMed、VIP、WanFang Data和CNKI数据库,搜集关于布地奈德联合PS治疗新生儿MAS的随机对照试验(RCT),检索时限均从建库至2023年9月2日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.4软件进行Meta分析。结果共纳入6个RCT,包括544例患儿。Meta分析结果显示,与单用PS相比,布地奈德联合PS治疗患儿的总有效率较高[RR=1.29,95%CI(1.17,1.41),P0.05)。结论当前证据显示,布地奈德联合PS治疗新生儿MAS可改善患儿的症状、体征、血气分析指标,加快病情康复,缩短病程,有助于降低并发症、PPHN、肺出血的发生风险,而不会增加心力衰竭、败血症的发生风险。但受纳入研究数量的限制,上述结论尚需更多高质量、大样本的RCT予以验证。

关键词：布地奈德肺表面活性物质胎粪吸入综合征 Meta分析系统评价随机对照试验

Development of a pressure coring system for the investigation of deep underground exploration

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International Journal of Mining Science and Technology 2023年第11期33卷 1351-1364页

作者： Da Guo Ling Chen Zhongya Zhou Dingming Wang yiwei zhang Xun Yang Xin Fang Xiaojun Wang Heping Lu Lin Dai Heping Xie State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Sichuan UniversityChengdu 610065China Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization Institute of Deep Earth Sciences and Green EnergyCollege of Civil and Transportation EngineeringShenzhen UniversityShenzhen 518060China Petroleum Engineering Technology Research Institute of Sinopec Jianghan Oilfield Company Wuhan 430035China

To provide a more accurate evaluation of the scale of deep underground resources,a new pressure coring system was carefully developed and its strength and safety of the engineering were verified by theoretical analyses and numerical *** designed pressure coring system can obtain cores with length of 3 m and diameter of 50 mm at 70 *** results of the ball-drop operation experiment demonstrate that differential motion assembly can effectively cut a safety pin by applying a tensile force of 4852 N,and it can lift the core tube through the center pole to complete a series of mechanical actions to seal the ***,by maintaining pressures at 70 MPa for 30 min,the pressure sealing capacity of the system was ***,a core sample with a diameter of 50 mm was obtained through a core drilling experiment and the coring performance of the pressure coring system was *** study can not only enrich the existing onshore coring technology but also provide a theoretical guide and design criteria for the development of similar pressure coring systems to meet the demand for deeper underground exploration.

关键词： Underground exploration In-situ coring Pressure coring Oil and gas production

人工智能背景下化工专业课程教学改革研究与实践

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化工高等教育 2024年第3期41卷 9-13,105页

作者：吉远辉苏隽奕李弋穆立文张政李乃旭张一卫东南大学化学化工学院江苏省生物药物高技术研究重点实验室江苏南京211189 南京工业大学化工学院材料化学工程国家重点实验室江苏南京211816 沈阳化工大学化学工程学院辽宁沈阳110142

人工智能与其他学科的交叉融合是未来科技发展的趋势,也是我国教育发展的方向。文章以东南大学化学化工学院的教学改革为契机,阐述了人工智能对化工学科发展的积极影响和对化工专业教学改革的重要性,并分别从理论和实践教学两方面介绍... 详细信息

人工智能与其他学科的交叉融合是未来科技发展的趋势,也是我国教育发展的方向。文章以东南大学化学化工学院的教学改革为契机,阐述了人工智能对化工学科发展的积极影响和对化工专业教学改革的重要性,并分别从理论和实践教学两方面介绍了人工智能背景下化工专业的课程教学改革实践,以期为其他高校提供参考。

关键词：教学改革人工智能化学工程与工艺交叉学科

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失眠对大学生认知灵活性的影响

重庆医学 2024年第17期53卷 2603-2607页

作者：陈牧宇张一苇蒋军刘欣雨张莘朋彭李李敏陆军军医大学医学心理系军事心理学教研室重庆400038 陆军军医大学医学心理系基础心理学教研室重庆400038

目的探讨失眠对大学生认知灵活性的影响。方法采用整群抽样法,于2023年3—5月使用认知灵活性问卷(CFI)和匹兹堡睡眠指数(PSQI)对重庆某高校802名大学生进行问卷调查,回收有效问卷770份,并招募66名大学生志愿者作为研究对象,以PSQI≥8分... 详细信息

目的探讨失眠对大学生认知灵活性的影响。方法采用整群抽样法,于2023年3—5月使用认知灵活性问卷(CFI)和匹兹堡睡眠指数(PSQI)对重庆某高校802名大学生进行问卷调查,回收有效问卷770份,并招募66名大学生志愿者作为研究对象,以PSQI≥8分且经访谈后确认处于失眠状态的研究对象作为失眠组(n=28),以PSQI<8分且经访谈后确认不处于失眠状态的研究对象作为对照组(n=38)。所有研究对象参加行为研究(采用数字-字母转换任务评估被试者的认知灵活性),比较两组反应时间、准确率及转换成本的差异。结果该校大学生群体CFI和PSQI的总分为(70.43±12.85)、(6.37±3.29)分,失眠检出率为33.77%(260/770)。失眠组CFI得分明显低于对照组[(68.15±11.65)分vs.(71.59±13.28)分],差异有统计学意义(P<0.05)。Spearman偏相关分析提示,认知灵活性与PSQI总分(r=-0.22)、主观睡眠质量(r=-0.22)、睡眠潜伏期(r=-0.12)、睡眠紊乱(r=-0.16)、催眠药物使用(r=-0.14)和日间功能失调(r=-0.16)均呈负相关(P<0.05)。失眠组平均反应时间、重复试次反应时间、转换试次反应时间和转换成本长于对照组,CFI得分、转换试次准确率低于对照组,差异有统计学意义(P<0.05)。结论失眠大学生的认知灵活性低于睡眠正常大学生,应对失眠状况进行干预。

关键词：失眠认知灵活性数字-字母转换任务大学生执行功能

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