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半稳定单原子催化剂增强光热协同催化

Science Bulletin 2024年第12期69卷 1833-1838页

作者：付亦葳吕科见王怡司亦涛师进文李乃旭周致富刘茂昌 International Research Center for Renewable Energy State Key Laboratory of Multiphase FlowXi’an Jiaotong UniversityXi’an 710049China School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Suzhou Academy of Xi’an Jiaotong University Suzhou 215123China

Single-atom catalysts(SACs)have been extensively studied in photocatalysis,electrochemistry,and ***,their utilization in photothermal catalysis is still in the infancy and is worth investigating,as these catalysts are... 详细信息

关键词： field. catalysis. 单原子催化剂

Analytical Representation of Data-driven Transient Stability Constraint and Its Application in Preventive Control

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1085-1097页

作者： yiwei fu Xiaohua Zhang Lei Chen Zengyao Tian Kaiyuan Hou Haikuan Wang State Key Laboratory of Control and Simulation of Power System and Generation Equipment Department of Electrical EngineeringTsinghua UniversityBeijing 100084China State Grid Jibei Electric Power Company Beijing 100053China Northeast China Branch of State Grid Corporation of China Shenyang 110180China

Accurate transient stability assessment(TSA) and effective preventive control are important for the stable operation of power systems. With the superiorities in precision and efficiency, data-driven methods are widely used in TSA nowadays. Data-driven TSA model can be adopted in the stability constraints of preventive control optimization, but existing methods are mostly iteration-based ones, which may result in low efficiency, sometimes even non-convergence. In this paper,an analytical representation method of data-driven transient stability constraint is proposed based on a non-parametric regression model built for TSA. Key feature extraction and dominant sample selection are proposed to reduce the scale of the TSA model, and bi-level linearization is applied to further modify *** preventive control model is then formulated as a mixed-integer linear program(MILP) problem with the linearized analytical data-driven transient stability constraint, which can be solved without iterations. An overall procedure of datadriven TSA and preventive control is finally developed. Case studies show that the proposed method has high accuracy in TSA and can achieve effective preventive control of power system with high efficiency.

关键词： Data-driven critical clearing time transient stability constraint non-parametric regression optimal preventive control

C-C趋化因子配体5对代谢相关脂肪性肝纤维化的诊断价值

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中华肝脏病杂志 2024年第7期32卷 643-649页

作者：李妹齐越鹏付艺伟路丽霞任伟光王荣琦南月敏河北医科大学第三医院中西医结合肝病科石家庄050051 河北医科大学石家庄050011

目的探究血清C-C趋化因子配体5(CCL5)评估代谢相关脂肪性肝病(MAFLD)患者肝纤维化程度的诊断价值。方法诊断性试验。选择2021年10月至2023年6月就诊于河北医科大学第三医院中西医结合肝病科行肝穿刺活组织病理学检查的MAFLD患者71例,同... 详细信息

目的探究血清C-C趋化因子配体5(CCL5)评估代谢相关脂肪性肝病(MAFLD)患者肝纤维化程度的诊断价值。方法诊断性试验。选择2021年10月至2023年6月就诊于河北医科大学第三医院中西医结合肝病科行肝穿刺活组织病理学检查的MAFLD患者71例,同期该院体检中心71例健康体检者为对照组,采用酶联免疫吸附法检测血清CCL5水平;常规检测血常规及肝肾功能等,分析CCL5的表达水平及其与上述指标的相关性,计算天冬氨酸转氨酶/血小板比值指数(APRI)、基于4因子的纤维化指数(FIB-4)。采用SPSS 26.0软件进行统计学分析,应用受试者操作特征曲线下面积(AUC)评估CCL5对MAFLD纤维化程度的诊断效能,并进一步分析其与APRI及FIB-4联合诊断MAFLD纤维化程度的效能。结果在MAFLD患者中,血清CCL5的表达水平随着肝纤维化分期的升高,其水平逐渐升高,且差异有统计学意义(P<0.05)。血清CCL5诊断MAFLD患者显著肝纤维化的AUC值为0.775,敏感度为65.7%,特异度为80.6%,最佳截断值为49.845 ng/ml;CCL5与FIB-4联合应用时,对MAFLD患者显著肝纤维化的诊断价值最高,AUC为0.802,敏感度为91.4%,特异度为61.1%。结论CCL5对MAFLD患者显著肝纤维化有较高的诊断价值,有望成为评估MAFLD患者肝纤维化程度的无创诊断标志物。

关键词：肝纤维化代谢相关脂肪性肝病 C-C趋化因子配体5 诊断诊断效能

血清血管内皮生长因子对肝动脉化疗栓塞单独/联合靶免治疗在中晚期肝癌临床疗效中的评估价值

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中国全科医学 2024年第32期27卷 4033-4039页

作者：胡灵溪李妹付艺伟路丽霞马晓萱王荣琦南月敏河北医科大学第三医院中西医结合肝病科河北省石家庄市500000

背景中晚期肝癌治疗面临挑战,寻求有效评估及改善疗法成为研究重点,其中肝动脉化疗栓塞(TACE)结合免疫疗法显示出潜力,但需进一步验证其疗效与患者预后的生物标志物。目的探讨血清血管内皮生长因子(VEGF)对TACE单独/联合靶免治疗在中... 详细信息

背景中晚期肝癌治疗面临挑战,寻求有效评估及改善疗法成为研究重点,其中肝动脉化疗栓塞(TACE)结合免疫疗法显示出潜力,但需进一步验证其疗效与患者预后的生物标志物。目的探讨血清血管内皮生长因子(VEGF)对TACE单独/联合靶免治疗在中晚期肝癌临床疗效中的评估价值。方法收集2021年1月—2022年7月在河北医科大学第三医院住院的113例初治中晚期肝癌患者,按治疗方案分为TACE组(n=66)、TACE联合靶向治疗组(n=22)、TACE联合靶免治疗组(n=25),于治疗前后分别进行VEGF、甲胎蛋白(AFP)、异常凝血酶原(PIVKA-Ⅱ)等肿瘤标志物检测。根据改良的实体瘤反应评估标准(mRECIST)于治疗3、6、12个月后进行随访以评价中晚期肝癌临床疗效,分析患者的疾病缓解率(ORR)和疾病控制率(DCR);采用Kaplan-Meier法计算中位无进展生存期(PFS)并绘制生存曲线。应用受试者工作特征(ROC)曲线分析血清VEGF及相关联合血清肿瘤标志物对中晚期肝癌临床疗效的预测价值。结果 TACE组、TACE联合靶向治疗组及TACE联合靶免治疗组随访12个月的ORR分别为17.14%(6/35)、33.33%(4/12)、54.55%(6/11),DCR分别为28.57%(10/35)、41.67%(5/12)、72.73%(8/11),治疗12个月的TACE联合靶免治疗组的ORR和DCR高于TACE组(P<0.05)。TACE联合靶免治疗组中位PFS(15.039个月)高于TACE组(8.757个月)和TACE联合靶向治疗组(9.680个月)(P<0.05)。TACE联合靶免治疗组随访12个月行TACE次数低于TACE组和TACE联合靶向治疗组(P<0.05)。TACE联合靶向治疗组和TACE联合靶免治疗组治疗前后血清VEGF差值高于TACE组(P<0.05)。治疗前后血清VEGF差值预测中晚期肝癌临床疗效的ROC曲线下面积(AUC)为0.748(P<0.001),灵敏度和特异度分别为0.909、0.629。血清VEGF联合PIVKA-Ⅱ、VEGF联合AFP、VEGF联合AFP及PIVKA-Ⅱ预测中晚期肝癌临床疗效的AUC分别为0.781、0.869、0.872(P<0.001)。结论 TACE联合靶免治疗能提高中晚期肝癌患者的疗效,延长患者PFS。患者血清VEGF可作为临床疗效评估的生物学指标。

关键词：癌,肝细胞原发性肝癌血管内皮生长因子肝动脉化疗栓塞靶向治疗免疫治疗

维普期刊数据库博看期刊

基于胃镜及超声内镜下表现预测胃间质瘤恶性潜能评分系统的建立和临床验证

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中华消化内镜杂志 2024年第8期41卷 633-639页

作者：刘玲李杨姜阳阳仇苏妍周莹苏洁黄娟娟伏亦伟凌亭生南京中医药大学南京210029 江苏省中医院消化内镜中心南京210029 南京医科大学附属泰州市人民医院消化科泰州225300

目的建立一个术前基于胃镜及超声内镜下表现预测胃间质瘤恶性潜能的评分系统并进行验证。方法将2017年1月1日至2023年12月31日在江苏省中医院接受治疗并经术后病理证实为胃间质瘤的286例患者作为建模组,根据美国国立卫生研究院分类系统... 详细信息

目的建立一个术前基于胃镜及超声内镜下表现预测胃间质瘤恶性潜能的评分系统并进行验证。方法将2017年1月1日至2023年12月31日在江苏省中医院接受治疗并经术后病理证实为胃间质瘤的286例患者作为建模组,根据美国国立卫生研究院分类系统将227例极低/低风险患者纳入低恶性潜能(low malignant potential,LMP)组,将59例中/高风险患者纳入高恶性潜能(high malignant potential,HMP)组。采用LASSO回归分析筛选变量,探究HMP胃间质瘤的预测因素,并构建列线图预测模型。采用Bootstrap法在建模组中进行内部验证。使用2021年1月1日至2023年12月31日在泰州市人民医院接受治疗并术后病理证实为胃间质瘤的85例患者资料进行外部验证。在建模组和外部验证组中绘制受试者工作特征曲线、校准曲线及临床决策曲线。结果肿瘤长径(coef=0.755)、肿瘤形状(coef=0.015)、肿瘤位置(coef=0.008)、生长方式(coef=-0.026)、囊变性(coef=0.685)、肿瘤表面溃疡改变(coef=-0.545)是HMP胃间质瘤的独立预测因素。基于上述6个因素构建的预测模型列线图在建模组和外部验证组的受试者工作特征曲线下面积分别为0.959(95%CI:0.898~0.903)和0.959(95%CI:0.857~1.000)。采用Bootstrap法对模型进行内部验证,其准确度为0.917,Kappa=0.737。根据校准曲线及临床决策曲线所示,模型在建模组和外部验证组中均具有较好的校准度及较高的净获益度。结论肿瘤长径、肿瘤形状、肿瘤位置、生长方式、囊变性、肿瘤表面溃疡改变是HMP胃间质瘤的独立预测因素。基于上述因素构建的列线图模型具有较好的区分度及校准度,为临床医师术前预测胃间质瘤恶性潜能提供了有效便捷的可视化工具。

关键词：列线图胃间质瘤恶性潜能

Realizing compact three-dimensional charge transport networks of asymmetric electron acceptors for efficient organic solar cells

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Science China Chemistry 2023年第2期66卷 508-517页

作者： Jinlong Cai yiwei fu Chuanhang Guo Donghui Li Liang Wang Chen Chen Dan Liu Wei Li Tao Wang School of Materials Science and Engineering Wuhan University of TechnologyWuhan430070China

Asymmetry has been demonstrated an effective approach in recent years to tune the structural and energetic orders of nonfullerene electron acceptors(NFAs)to prepare efficient organic solar cells(OSCs).In this article,five asymmetric NFAs,namely C9BTP-BO-Th Cl-2F,C9BTP-BO-Cl-2F,C9BTP-BO-2Cl-2F,C7BTP-BO-2Cl-2F and C5BTP-BO-2Cl-2F possessing varied asymmetric end-groups and alkyl chains are synthesized to tune the charge transport networks formed within these *** found that the enhanced planarity in the asymmetric NFA can facilitate closerπ-πstacking distance in either the A-to-A or A-toD type NFA dimers,whilst the larger dipole moment can promote the formation of three-dimensional(3D)charge transport networks among *** those advantages,C7BTP-BO-2Cl-2F exhibit a compact 3D honeycomb network with a high packing coefficient of 72.1%and molecular packing density of 0.48 g/cm^(3),contributing to a superior power conversion efficiency of 18.0%when employing PM6 as the donor,with an open-circuit voltage of 0.85 V,short-circuit current of26.7 m A cm^(-2)and fill factor of 79.3%.Our work provides guidelines in engineering the end group and side chains of asymmetric NFAs to achieve compact charge transport networks for high efficiency OSCs.

关键词： organic solar cells asymmetric non-fullerene electron acceptor planarity dipole moment charge transport networks

肿瘤患者输液港使用真实体验质性研究的Meta整合研究

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实用临床医药杂志 2024年第16期28卷 128-135页

作者：李蓉张国琴周丽娟毛婷武燕伏亦伟泰州市第三人民医院康复医学科江苏泰州225321 泰州市人民医院护理部江苏泰州225300 泰州市人民医院肿瘤科江苏泰州225300

目的分析并总结国内外肿瘤患者使用输液港的真实体验。方法检索Cochrane Library、Embase、CINAHL、PubMed、Web of Science、全球博硕论文数据库(PQDT)学位论文库、中国知网、万方数据库、维普网、中国生物医学文献数据库,截止时间为2... 详细信息

目的分析并总结国内外肿瘤患者使用输液港的真实体验。方法检索Cochrane Library、Embase、CINAHL、PubMed、Web of Science、全球博硕论文数据库(PQDT)学位论文库、中国知网、万方数据库、维普网、中国生物医学文献数据库,截止时间为2023年5月1日。对获得文献审慎评价后,分析并整合携港肿瘤患者真实体验相关主题。结果共纳入13篇文献,其中中文6篇,外文7篇;共提炼出64项研究结果,综合概括为7个类别,并整合为3项结果,即肿瘤患者携港不同阶段需求不同、肿瘤患者携港期间正负性心理随着面临的事件而动态交织、输液港为肿瘤患者带来生活新常态。结论临床护理人员应识别并正视携带输液港的肿瘤患者各个阶段的需求,强化其正性体验,疏导其负性体验,帮助其适应携港生活,提高护理服务质量,提升患者的幸福感。

关键词：肿瘤输液港使用体验质性研究 Meta整合

Application of Aerodynamic Optimization Design and Dynamic Numerical Simulation in UAV Design

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Aerospace China 2020年第3期21卷 38-45页

作者： SUN Kaijun YU Yueyang fu yiwei CH UAV Technology Co.Ltd CAAABeijing 100074

In the past two decades,the world’s unmanned aerial vehicle(UAV)industry has developed *** kinds of UAVs have been used in military and civilian *** on the characteristics of UAVs and the development of aerodynamics,this article analyzes the development of aerodynamic optimization design and dynamic numerical simulation technology,then lists engineering *** aerodynamic optimization design and dynamic numerical simulation have greatly shortened the UAV design period and reduced the research and design *** two methods gradually replace traditional methods such as wind tunnel test.

关键词： aerodynamic optimization design dynamic numerical simulation UAV

Oxidative stress-initiated one-carbon metabolism drives the generation of interleukin-10-producing B cells to resolve pneumonia

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Cellular & Molecular Immunology 2024年第1期21卷 19-32页

作者： Ying fu Baichao Yu Qi Wang Zhou Lu Hushan Zhang Dan Zhang Feifei Luo Ronghua Liu Luman Wang yiwei Chu Department of Immunology School of Basic Medical SciencesShanghai Key Laboratory of Medical Epigenetics and MetabolismInstitutes of Biomedical SciencesFudan UniversityShanghaiChina Zhongshan Hospital Institute of Clinical Science Zhongshan HospitalShanghaiChina Zhaotong Health Vocational College ZhaotongYunnanChina Department of Digestive Diseases Huashan HospitalFudan UniversityShanghaiChina Shanghai Fifth People’s Hospital Fudan UniversityShanghaiChina

The metabolic reprogramming underlying the generation of regulatory B cells during infectious diseases remains *** a Pseudomonas aeruginosa-induced pneumonia model,we reported that IL-10-producing B cells(IL-10+B cells)play a key role in spontaneously resolving infection-mediated *** cytosolic reactive oxygen species(ROS)during inflammation were shown to drive IL-10+B-cell generation by remodeling one-carbon *** of the enzyme serine hydroxymethyltransferase 1(Shmt1)led to inadequate one-carbon metabolism and decreased IL-10+B-cell ***,increased one-carbon flux elevated the levels of the methyl donor S-adenosylmethionine(SAM),altering histone H3 lysine 4 methylation(H3K4me)at the Il10 gene to promote chromatin accessibility and upregulate Il10 expression in B ***,the one-carbon metabolism-associated compound ethacrynic acid(EA)was screened and found to potentially treat infectious pneumonia by boosting IL-10+B-cell ***,these findings reveal that ROS serve as modulators to resolve inflammation by reprogramming one-carbon metabolism pathways in B cells.

关键词： IL-10-producing B cell Reactive oxygen species One-carbon metabolism H3K4me Pneumonia