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生物医学工程新技术在慢性心力衰竭远程监测中的应用进展

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中国循环杂志 2024年第4期39卷 403-409页

作者：杨举微胡奕然华伟中国医学科学院北京协和医学院国家心血管病中心阜外医院心律失常中心心血管疾病国家重点实验室北京100037 首都医科大学附属北京天坛医院心脏及大血管病中心北京100071

作为各类心脏疾病的终末阶段,慢性心力衰竭不仅为患者带来沉重的生活负担,也对医疗系统构成了巨大的挑战。通过智能电子设备、传感器和云计算等技术,远程监测实现了对心力衰竭患者数据的实时收集和传输,并结合人工智能和数据分析为患者... 详细信息

作为各类心脏疾病的终末阶段,慢性心力衰竭不仅为患者带来沉重的生活负担,也对医疗系统构成了巨大的挑战。通过智能电子设备、传感器和云计算等技术,远程监测实现了对心力衰竭患者数据的实时收集和传输,并结合人工智能和数据分析为患者提供个性化的治疗建议。本综述聚焦于生物医学工程新技术在慢性心力衰竭远程监测中的应用,总结该领域的发展现状,并展望这一技术在改善心力衰竭管理和治疗水平方面的潜在价值。

关键词：生物医学工程远程监测慢性心力衰竭移动医疗

ENSO组合模态可预测性的季节-年代际变化

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海洋预报 2024年第2期41卷 83-91页

作者：徐怡然郑飞杨若文云南大学云南昆明650091 中国科学院大气物理研究所国际气候与环境研究中心北京100029

厄尔尼诺-南方涛动组合模态(C-mode)是厄尔尼诺衰减期西北太平洋上空异常反气旋发展的主要驱动力,通常可以形成水汽输送通道,导致我国南部地区降水增多并发生严重的洪涝灾害,而在拉尼娜期间则情况相反。利用1981—2020年美国国家环境预... 详细信息

厄尔尼诺-南方涛动组合模态(C-mode)是厄尔尼诺衰减期西北太平洋上空异常反气旋发展的主要驱动力,通常可以形成水汽输送通道,导致我国南部地区降水增多并发生严重的洪涝灾害,而在拉尼娜期间则情况相反。利用1981—2020年美国国家环境预报中心和美国国家大气研究中心再分析数据集的表面风场资料分析了C-mode可预测性的季节-年代际变化。结果表明:C-mode在2000年以后的可预测性明显下降,主要原因是其变率减小、强度减弱、信噪比降低等。在季节尺度上,C-mode存在“秋季预报障碍”,这与信号的季节循环密切关联,当C-mode在秋季进入衰退期时,信号强度最弱、变率最小,因此其秋季的可预测性降低。

关键词： ENSO组合模态 C-mode可预测性季节-年代际

LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： Juan Zhou yiran Xu Luyao Wang Yu Cong Ke Huang Xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei Xu Xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child Health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

Conjugated microporous polymers-scaffolded enzyme cascade systems with enhanced catalytic activity

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Chinese Journal of Catalysis 2024年第8期63卷 213-223页

作者： Zhenhua Wu Jiafu Shi Boyu Zhang Yushuai Jiao Xiangxuan Meng Ziyi Chu Yu Chen yiran Cheng Zhongyi Jiang School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China College of Chemical Engineering Fuzhou UniversityFuzhou 350108FujianChina Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207FujianChina

Enhancing catalytic activity of multi-enzyme in vitro through substrate channeling effect is promis-ing yet ***,conjugated microporous polymers(CMPs)-scaffolded integrated en-zyme cascade systems(I-ECSs)are constructed through co-entrapping glucose oxidase(GOx)and horseradish peroxidase(HRP),in which hydrogen peroxide(H_(2)O_(2))is the intermediate *** interplay of low-resistance mass transfer pathway and appropriate pore wall-H_(2)O_(2)interactions facilitates the directed transfer of H_(2)O_(2),resulting in 2.4-fold and 5.0-fold elevation in catalytic activ-ity compared to free ECSs and separated ECSs,*** substrate channeling effect could be regulated by altering the mass ratio of GOx to ***,I-ECSs demonstrate excellent stabili-ties in harsh environments and multiple recycling.

关键词： Biocatalysis Immobilization Enzyme cascade system Substrate channeling effect Conjugated microporous polymers

舒眠胶囊联合米氮平对抑郁症伴失眠患者的影响

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中国医学创新 2023年第31期20卷 72-75页

作者：王娟杨毅然内蒙古包头市第六医院内蒙古包头014040

目的:研究分析舒眠胶囊联合米氮平治疗抑郁症伴失眠患者的应用价值。方法:选择包头市第六医院2020年6月—2022年3月收治的90例抑郁症伴失眠患者作为本次研究对象,以随机数字表法分为对照组和观察组,每组45例。对照组患者接受米氮平治疗... 详细信息

目的:研究分析舒眠胶囊联合米氮平治疗抑郁症伴失眠患者的应用价值。方法:选择包头市第六医院2020年6月—2022年3月收治的90例抑郁症伴失眠患者作为本次研究对象,以随机数字表法分为对照组和观察组,每组45例。对照组患者接受米氮平治疗,观察组在对照组基础上加用舒眠胶囊治疗。对比两组临床治疗效果、睡眠质量、抑郁情况、生活质量、不良反应。结果:观察组临床疗效显著高于对照组,差异有统计学意义(P0.05)。结论:针对抑郁症伴失眠患者,应用舒眠胶囊联合米氮平的治疗方案的临床效果理想,不仅抑郁症状得到缓解,其睡眠质量也得到了有效提高,且用药安全性高。

关键词：舒眠胶囊米氮平抑郁症失眠生活质量

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玉米淀粉添加对低脂乳化香肠持水力的影响

粮食与食品工业 2021年第1期28卷 33-36,41页

作者：杨依然祝莹江苏大学食品与生物工程学院镇江212013

乳化香肠的低脂化是当前的发展趋势,本论文拟研究不同添加量玉米淀粉(2%、4%、6%)替代脂肪对低脂乳化香肠品质特性的影响。研究结果表明:随着玉米淀粉添加量的增加,乳化肉糜的乳化稳定性和蒸煮损失率均得到改善;乳化香肠的压力持水力和... 详细信息

乳化香肠的低脂化是当前的发展趋势,本论文拟研究不同添加量玉米淀粉(2%、4%、6%)替代脂肪对低脂乳化香肠品质特性的影响。研究结果表明:随着玉米淀粉添加量的增加,乳化肉糜的乳化稳定性和蒸煮损失率均得到改善;乳化香肠的压力持水力和感官品质均呈现增加的趋势,蒸煮损失率则呈现降低的趋势;同时还发现玉米淀粉的添加对乳化香肠的色泽、水分含量和水分含量无不良影响。以上结果表明,在乳化香肠制作中玉米淀粉可部分替代脂肪,且对香肠的感官品质没有显著影响,尤其以6%添加量为最佳。

关键词：玉米淀粉乳化香肠品质特性持水力

Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

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Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang Rui Dong Sze Wan Hung yiran Li Yuezhen Lin Ling Wu Tao Zhang Gene Chi Wai Man Hui Xu Jacqueline Pui Wah Chung Chi Chiu Wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

Analysis of the Immune Response by Standardized Whole‑Blood Stimulation with Metabolism Modulation

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Phenomics 2024年第1期4卷 81-89页

作者： Jialin Zhao Xuling Han Helian Li Yali Luo Yan Fang Yun Wang Jian Gao yiran Zhao Jingxuan Han Feng Qian State Key Laboratory of Genetic Engineering ShanghaiPublic Health Clinical CenterHuman PhenomeInstituteZhangjiang Fudan International InnovationCenter and School of Life SciencesFudan UniversityShanghai 200438China Ministry of Education Key Laboratory of ContemporaryAnthropology School of Life SciencesFudan UniversityShanghai 200438China Institute of Immunophenome International Human PhenomeInstitutes(Shanghai)Shanghai 200433China

The immune system defends the body from infection and plays a vital role in a wide range of health *** afects a series of physiological processes,including those linked to the function of human immune *** metabolism modulates immune cell activation and cytokine *** the relationship between metabolism and immune response has important implications for the development of immune-based ***,the deployment of large-scale functional assays to investigate the metabolic regulation of immune response has been limited by the lack of standardized ***,we present a protocol for the analysis of immune response using standardized whole-blood stimulation with metabolism *** immune stimuli including pattern recognition receptor(PRR)ligands and microbial stimuli were incubated with fresh human whole *** metabolic inhibitors were used to modulate metabolic status in the immune *** variable immune responses after metabolic interventions were *** described in detail the main steps involved in the whole-blood stimulation and cytokines quantifcation,namely,collection and treatment of whole blood,preparation of samples and controls,cytokines detection,and stimulation with metabolic *** metabolic inhibitors for anabolic pathways and catabolic pathways exert selective efects on the production of cytokines from immune *** addition to a robust and accurate assessment of immune response in cohort studies,the standardized whole-blood stimulation with metabolic regulation might provide new insights for modulating immunity.

关键词： Immune response Whole blood stimulation Cytokines Immunometabolism

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智能化服装搭配推荐研究进展

浙江理工大学学报（自然科学版） 2021年第1期45卷 1-12页

作者：杨怡然吴巧英浙江理工大学服装学院杭州310018 浙江理工大学国际教育学院杭州310018 浙江理工大学浙江省服装工程技术研究中心杭州310018

针对服装款式的个性化智能搭配推荐,从服装搭配推荐的基础算法、关键技术、个性化发展三个方面综述了该领域的研究进展,分析了提升推荐精准度与个性化程度的方法。通过对服装图像特征进行提取与筛选实现降维,并在传统推荐算法中融入深... 详细信息

针对服装款式的个性化智能搭配推荐,从服装搭配推荐的基础算法、关键技术、个性化发展三个方面综述了该领域的研究进展,分析了提升推荐精准度与个性化程度的方法。通过对服装图像特征进行提取与筛选实现降维,并在传统推荐算法中融入深度学习,是提升系统运算速率和精准度的有效途径,结合低层传统特征与高级语义特征能使图像处理达最优效率;套装图像分割技术的优选、智能化服装搭配模型的结构优化与结果搭配度的衡量,是智能化服装搭配实现精准推荐的三个有效措施;个性化服装搭配推荐的研究现状表明,以用户为核心进行推荐具有指导性作用。若将用户需求与机器学习相结合,实现较高精准度的同时获得良好的个人体验感,将会多维度地提升系统推荐效果。

关键词：服装搭配款式推荐机器学习神经网络特征提取