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乡村旅游视角下海岛渔村聚落空间更新策略研究——以珠海大万山岛万山村为例

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华中建筑 2024年第1期42卷 98-102页

作者：王存媛杨勐石殷忆陈果广州市城市建设开发有限公司华南理工大学建筑设计研究院有限公司广东省建筑设计研究院有限公司广州市城市规划勘测设计研究院

要海岛渔村是我国的典型乡村类型之一,拥有传统渔业文明及聚落空间形态等宝贵文化遗产,是发展乡村旅游的重要阵地。该文以珠海大万山岛万山村为例,揭示当前产业发展情况,深入解析渔村聚落空间形态特征,总结在产业发展与空间规划两个层... 详细信息

要海岛渔村是我国的典型乡村类型之一,拥有传统渔业文明及聚落空间形态等宝贵文化遗产,是发展乡村旅游的重要阵地。该文以珠海大万山岛万山村为例,揭示当前产业发展情况,深入解析渔村聚落空间形态特征,总结在产业发展与空间规划两个层面的现状问题,并依次从选择产业发展方向、优化功能布局、整合新旧空间肌理、探索渔村综合体四方面提出空间更新策略,以期为相关的规划设计提供参考,从而促进海岛渔村旅游产业高质量发展。

关键词：海岛渔村传统聚落空间更新大万山岛乡村旅游

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Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1205-1215页

作者： Xiaoyan Liu Zhe Li Shuai Liu Jing Sun Zhanghua Chen Min Jiang Qingling Zhang Yinghua Wei Xin Wang Yi-You Huang yinyi shi Yanhui Xu Huifang Xian Fan Bai Changxing Ou Bei Xiong Andrew M.Lew Jun Cui Rongli Fang Hui Huang Jincun Zhao Xuechuan Hong Yuxia Zhang Fuling Zhou Hai-Bin Luo Department of Hematology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Dawu County People’s Hospital Xiaogan 432826China State Key Laboratory of Respiratory Diseases National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Guangzhou Institute of Pediatrics Guangzhou Women and Children’s Medical CenterState Key Laboratory of Respiratory DiseasesGuangzhou Medical UniversityGuangzhou 510623China Biomedical Pioneering Innovation Center(BIOPIC) School of Life SciencesPeking UniversityBeijing 100871China Department of Infectious Disease and Department of Pediatrics The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Center for Innovative Marine Drug Screening&Evaluation(QNLM) School of Medicine and PharmacyOcean University of ChinaQingdao 266100China Walter and Eliza Hall Institute of Medical Research and Department of Microbiology&Immunology University of MelbourneParkvilleVic 3052Australia School of Life Sciences Sun Yat-sen UniversityGuangzhou 510006China Cardiovascular Department The Eighth Affiliated HospitalSun Yat-sen UniversityShenzhen 518000China State Key Laboratory of Virology College of ScienceInnovation Center for Traditional Tibetan Medicine Modernization and Quality ControlMedical CollegeTibet UniversityLhasa 850000China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE) Hubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan University School of Pharmaceutical SciencesWuhan 430071China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection can cause acute respiratory distress syndrome,hypercoagulability,hypertension,and multiorgan *** antivirals with safe clinical profile are urgently needed to improve the overall *** an analysis of a randomly collected cohort of 124 patients with COVID-19,we found that hypercoagulability as indicated by elevated concentrations of D-dimers was associated with disease *** virtual screening of a *** approved drug library,we identified an anticoagulation agent dipyridamole(DIP)in silico,which suppressed SARS-CoV-2 replication in *** a proof-of-concept trial involving 31 patients with COVID-19,DIP supplementation was associated with significantly decreased concentrations of D-dimers(P<0.05),increased lymphocyte and platelet recovery in the circulation,and markedly improved clinical outcomes in comparison to the control *** particular,all 8 of the DIP-treated severely ill patients showed remarkable improvement:7 patients(87.5%)achieved clinical cure and were discharged from the hospitals while the remaining 1 patient(12.5%)was in clinical remission.

关键词： Dipyridamole SARS-CoV-2 COVID-19 Treatment D-dimer Severe cases

书院制模式下高校学生宿舍功能复合化设计研究

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新建筑 2023年第4期 70-75页

作者：王存媛杨勐石殷忆广州市城市建设开发有限公司广州510000 华南理工大学建筑学院广州510641 华南理工大学亚热带建筑与城市科学国家重点实验室广州510640

基于书院制模式的本质内涵及其育人特点,结合国内外典型书院制宿舍功能配置的现状调研和文献研究,揭示当前书院制模式下高校学生宿舍的功能复合化设计发展趋势,剖析现代书院制学生宿舍的功能构成要素体系,归纳其现存及未来的功能复合类... 详细信息

基于书院制模式的本质内涵及其育人特点,结合国内外典型书院制宿舍功能配置的现状调研和文献研究,揭示当前书院制模式下高校学生宿舍的功能复合化设计发展趋势,剖析现代书院制学生宿舍的功能构成要素体系,归纳其现存及未来的功能复合类型,并依次从选择功能类型、优化功能要素、配置功能指标及选用复合方式4个方面提出设计策略,旨在构建一套具有系统性和逻辑性的功能复合化设计方法,为相关设计实践提供借鉴参考,助推高校书院实体育人功能落实。

关键词：书院制高校学生宿舍功能复合设计策略

热带印度洋海表面温度与海面净热通量耦合主模态的气候演变特征

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海洋湖沼通报 2024年第2期46卷 22-31页

作者：杨梦兮胡瑞金刘梅张银意史达伟江苏省泰州市气象局江苏泰州225300 中国海洋大学物理海洋实验室和山东省高校海洋-大气相互作用与气候重点实验室山东青岛266100 江苏省气象台江苏南京210008 江苏省连云港市气象局江苏连云港222002

利用1960年1月—2008年12月共49 a的SODA的SST资料和ECWMF的海面净热通量的资料,采用滑动SVD方法,对热带印度洋上两场异常耦合主模态的气候演变特征进行了分析,并对显著变化的时间、地点分别进行了判定。结果表明:(1)耦合作用在演变过... 详细信息

利用1960年1月—2008年12月共49 a的SODA的SST资料和ECWMF的海面净热通量的资料,采用滑动SVD方法,对热带印度洋上两场异常耦合主模态的气候演变特征进行了分析,并对显著变化的时间、地点分别进行了判定。结果表明:(1)耦合作用在演变过程中有逐渐加强的趋势,两场的相关性一直保持的较好。(2)整个演变过程中,海面净热通量异常可以较好地解释大部分时段内海表面温度异常(SSTA)场本身的变化,变化幅度最大的地方位于苏门答腊-爪哇沿岸和20°S以南的海域;并且在其影响下,海盆在大部分时段内呈增温趋势。(3)耦合主模态两个场的空间分布都在1961—1970年到1962—1971年之间发生了唯一一次显著的变化,显著影响时间都为1971年。(4)SSTA场变化显著的地点主要位于东北印度洋和南海,为明显的正变化区,而20°S以南的海域呈明显的负变化;海面净热通量异常场分别在南海海域和赤道东印度洋及马达加斯加偏东的部分海域呈明显的正、负变化。

关键词：热带印度洋 SSTA 海面净热通量滑动SVD 主模态时空演变

Artificial intelligence for geoscience:Progress,challenges,and perspectives

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The Innovation 2024年第5期5卷 136-160,135页

作者： Tianjie Zhao Sheng Wang Chaojun Ouyang Min Chen Chenying Liu Jin Zhang Long Yu Fei Wang Yong Xie Jun Li Fang Wang Sabine Grunwald Bryan MWong Fan Zhang Zhen Qian Yongjun Xu Chengqing Yu Wei Han Tao Sun Zezhi Shao Tangwen Qian Zhao Chen Jiangyuan Zeng Huai Zhang Husi Letu Bing Zhang Li Wang Lei Luo Chong shi Hongjun Su Hongsheng Zhang Shuai Yin Ni Huang Wei Zhao Nan Li Chaolei Zheng Yang Zhou Changping Huang Defeng Feng Qingsong Xu Yan Wu Danfeng Hong Zhenyu Wang yinyi Lin Tangtang Zhang Prashant Kumar Antonio Plaza Jocelyn Chanussot Jiabao Zhang Jiancheng shi Lizhe Wang Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Computer Science China University of GeosciencesWuhan 430078China State Key Laboratory of Mountain Hazards and Engineering Resilience Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China Data Science in Earth Observation Technical University of Munich80333 MunichGermany The National Key Laboratory of Water Disaster Prevention Yangtze Institute for Conservation and DevelopmentHohai UniversityNanjing 210098China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China School of Geographical Sciences Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Soil Water and Ecosystem Sciences DepartmentUniversity of FloridaPO Box 110290GainesvilleFLUSA Materials Science Engineering Program Cooperating Faculty Member in the Department of Chemistry and Department of Physics Astronomy University of CaliforniaCaliforniaRiversideCA 92521USA Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China College of Geography and Remote Sensing Hohai UniversityNanjing 211100China Department of Geography The University of Hong KongHong Kong 999077SARChina Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing 210044China School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044China Collaborative Inno

This paper explores the evolution of geoscientific inquiry,tracing the progression from traditional physics-based models to modern data-driven approaches facilitated by significant advancements in artificial intelligence(AI)and data collection *** models,which are grounded in physical and numerical frameworks,provide robust explanations by explicitly reconstructing underlying physical ***,their limitations in comprehensively capturing Earth’s complexities and uncertainties pose challenges in optimization and real-world *** contrast,contemporary data-driven models,particularly those utilizing machine learning(ML)and deep learning(DL),leverage extensive geoscience data to glean insights without requiring exhaustive theoretical *** techniques have shown promise in addressing Earth science-related ***,challenges such as data scarcity,computational demands,data privacy concerns,and the“black-box”nature of AI models hinder their seamless integration into *** integration of physics-based and data-driven methodologies into hybrid models presents an alternative *** models,which incorporate domain knowledge to guide AI methodologies,demonstrate enhanced efficiency and performance with reduced training data *** review provides a comprehensive overview of geoscientific research paradigms,emphasizing untapped opportunities at the intersection of advanced AI techniques and *** examines major methodologies,showcases advances in large-scale models,and discusses the challenges and prospects that will shape the future landscape of AI in *** paper outlines a dynamic field ripe with possibilities,poised to unlock new understandings of Earth’s complexities and further advance geoscience exploration.

关键词： Earth utilizing landscape

单孔腹腔镜胆囊切除术中转开腹或传统腹腔镜手术的影响因素

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腹腔镜外科杂志 2024年第6期29卷 445-450,456页

作者：张鑫石明炜罗银义徐辉闫军山西医科大学第一临床医学院山西太原030000 山西医科大学第一医院肝胆胰外科山西太原030000

目的:探讨单孔腹腔镜胆囊切除术(SILC)中转手术的影响因素。方法:回顾分析2011年1月至2021年12月为916例患者行SILC的临床资料,其中883例成功完成SILC,33例中转手术,分析中转原因并对相应指标进行单因素、多因素Logistic分析。结果:33... 详细信息

目的:探讨单孔腹腔镜胆囊切除术(SILC)中转手术的影响因素。方法:回顾分析2011年1月至2021年12月为916例患者行SILC的临床资料,其中883例成功完成SILC,33例中转手术,分析中转原因并对相应指标进行单因素、多因素Logistic分析。结果:33例中转患者中18例中转传统腹腔镜胆囊切除术(胆管变异7例、胆囊动脉变异2例、腹腔粘连3例、胆囊体积大3例、胆囊壁厚2例、肥胖1例),15例中转开腹(胆管变异7例、腹腔粘连8例)。单因素分析结果显示,BMI、腹部手术史、腹腔粘连、胆囊长径>8 cm、胆囊壁厚度>3 mm、解剖变异是中转手术的影响因素(P8 cm(OR=3.275,95%CI=1.266~8.467,P=0.014)、胆囊壁厚度>3 mm(OR=3.520,95%CI=1.321~9.384,P=0.012)是SILC中转的独立危险因素(P0.05)。结论:BMI、解剖变异、胆囊长径>8 cm、胆囊壁厚度>3 mm、腹腔粘连是SILC中转的独立危险因素,术前应充分评估患者情况,选择合理的手术方案,预估术中风险。

关键词：胆囊切除术,腹腔镜单孔中转开腹手术中转传统腹腔镜手术影响因素分析

The role of autophagic and lysosomal pathways in ischemic brain injury

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Neural Regeneration Research 2013年第23期8卷 2117-2125页

作者： Zhaohua Gu yinyi Sun Kangyong Liu Fen Wang Ting Zhang Qiang Li Liwei Shen Ling Zhou Liang Dong Nan shi Qian Zhang Wei Zhang Meizhen Zhao Xiaojiang Sun Department of Neurology Shanghai Pudong New Area Zhoupu Hospital Department of Neurology the Sixth People's Hospital of Shanghai Shanghai Jiao Tong University Department of Neurobiology Suzhou University School of Medicine Department of Neurology the Fifth People's Hospital of Shanghai Fudan University

Autophagy is involved in neural cell death after cerebral ischemia. Our previous studies showed that rapamycin-induced autophagy decreased the rate of apoptosis, but the rate of apoptosis was in- creased after the autophagy inhibitor, 3-methyladenine, was used. In this study, a suture-occluded method was performed to generate a rat model of brain ischemia. Under a transmission electron microscope, autophagic bodies and autophagy lysosomes were markedly accumulated in neurons at 4 hours post brain ischemic injury, with their numbers gradually reducing over time. Western blotting demonstrated that protein levels of light chain 3-11 and cathepsin B were significantly in- creased within 4 hours of ischemic injury, but these levels were not persistently upregulated over time. Confocal microscopy showed that autophagy was mainly found in neurons with positive light chain 3 signal. Injection of rapamycin via tail vein promoted the occurrence of autophagy in rat brain tissue after cerebral ischemia and elevated light chain 3 and cathepsin B expression. However, in- jection of 3-methyladenine significantly diminished light chain 3-11 and cathepsin B expression. Results verified that autophagic and lysosomal activity is increased in ischemic neurons. Abnormal components in cells can be eliminated through upregulating cell autophagy or inhibiting autophagy after ischemic brain injury, resulting in a dynamic balance of substances in cells. Moreover, drugs that interfere with autophagy may be potential therapies for the treatment of brain injury.

关键词： neural regeneration brain injury autophagy lysosome light chain 3 cathepsin B cerebral ischemia neuron neuroprotection grants-supported paper neuroregeneration

基于机器学习的大雾天气背景下特强浓雾本地化诊断研究

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灾害学 2018年第2期33卷 193-199页

作者：史达伟李超史逸民张银意江苏省连云港市气象局江苏连云港222006 江苏省气象台江苏南京210008

低能见度的大雾天气是造成许多交通事故的重要气象灾害。极低能见度的强浓雾预报预测是气象工作中的难点问题。利用连云港地区2014-2016年逐小时气象观测资料,选取大雾发生时次,基于机器学习中的多种算法对能见度低于50 m特强浓雾建立... 详细信息

低能见度的大雾天气是造成许多交通事故的重要气象灾害。极低能见度的强浓雾预报预测是气象工作中的难点问题。利用连云港地区2014-2016年逐小时气象观测资料,选取大雾发生时次,基于机器学习中的多种算法对能见度低于50 m特强浓雾建立气象要素诊断模型。结果表明:基于CART决策树算法的诊断模型能够较为直观准确的对强浓雾进行诊断,并且该模型具有较高的泛化能力,利用约占研究样本75%的数据进行学习,模型的学习准确率为90.04%,剩余25%左右的样本数据对模型的泛化能力进行测试,测试准确率为82.25%;5种机器学习算法中LSVM算法对于特强浓雾的诊断模型测试效果最好,但算法可理解度较低、复杂度较高,不如CART算法易于使用。

关键词：大雾特强浓雾机器学习本地化诊断模型 CART决策树算法

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酪氨酸氧化产物诱导大鼠空间学习记忆损伤

食品与生物技术学报 2019年第2期38卷 1-7页

作者：冉玉梅李竹青丁寅翼赵琪施用晖乐国伟江南大学食品学院江苏无锡214122 食品科学与技术国家重点实验室江南大学江苏无锡214122

探究长期摄入酪氨酸氧化产物对大鼠空间学习记忆及其对海马组织的影响。采用4周龄清洁级SD大鼠40只,随机分为Control组(正常日粮)、Tyr组(添加0.44%酪氨酸)、TOP1组(添加0.22%酪氨酸氧化产物)、TOP2组(添加0.44%酪氨酸氧化产物)。饲喂2... 详细信息

探究长期摄入酪氨酸氧化产物对大鼠空间学习记忆及其对海马组织的影响。采用4周龄清洁级SD大鼠40只,随机分为Control组(正常日粮)、Tyr组(添加0.44%酪氨酸)、TOP1组(添加0.22%酪氨酸氧化产物)、TOP2组(添加0.44%酪氨酸氧化产物)。饲喂24周后,用Morris水迷宫检测大鼠空间学习与记忆能力,测定海马组织中蛋白质和脂质氧化产物的含量,用RTPCR检测海马组织抗氧化和炎症相关基因的表达。结果显示,饲喂24周后,与Control组和Tyr组相比,TOP1组和TOP2组大鼠出现空间学习与记忆障碍;海马组织中MDA、4-HNE、Dityr、3-NT、Aβ40含量都显著升高(p<0.05);Nrf2、NF-κB和i NOS的mRNA表达也显著上调(p<0.05)。因此,酪氨酸氧化产物导致大鼠海马组织氧化损伤,蛋白质和脂质氧化产物积累,造成大鼠空间学习记忆能力受损。

关键词：酪氨酸氧化产物氧化应激海马学习记忆 Morris水迷宫