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Noncommunicable chronic disease prevention should start from childhood

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Pediatric Investigation 2021年第1期5卷 3-5页

作者： yinkun yan Jie Mi Department of Non-communicable Disease Management Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina

Noncommunicable chronic diseases(NCDs),such as cardiovascular disease(CVD),diabetes,cancers,and osteoporosis,are the leading causes of death and health *** to the 2020 Report on Chinese Resident’s Chronic Disease and... 详细信息

关键词： prevention cardiovascular diseases

Can spot urine measurement be a substitute for 24-hour urine measurement to estimate sodium intake in adolescents?

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Pediatric Investigation 2021年第1期5卷 12-20页

作者： Jie Dong Xiaoyuan Zhao Hongbo Dong yinkun yan Jie Mi Pediatrics Research Institute of Hunan Province Hunan Children's HospitalChangshaHunanChina Department of Epidemiology Capital Institute of PediatricsBeijingChina Department of Non-communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Several methods have been established in recent decades that allow use of spot urine to estimate dietary sodium ***,their accuracies have been controversial in ***:To validate the performance of three commonly used methods-the Kawasaki,Tanaka,and International Cooperative Study on Salt,Other Factors,and Blood Pressure(INTERSALT)***,this study explored the accuracies of the Tanaka and INTERSALT methods by using spot urine samples taken at four separate ***:Forty-one adolescents aged 14 to 16 years completed two non-consecutive 24-hour urine collections and their mean values were used as reference *** second-morning urine was used for assessment with the Kawasaki method;a casual spot urine and spot urine samples taken at four separate times(morning,afternoon,evening,and overnight)were used for assessment with the Tanaka and INTERSALT ***:The mean differences were 1801 mg,542 mg,47 mg,and-31 mg for the Kawasaki,Tanaka,INTERSALT 1(with potassium),and INTERSALT2(without potassium)methods with their required spot urine,*** proportions of relative difference levels within±10%were 4.9%for the Kawasaki method,19.5%for the Tanaka method,36.6%for the INTERSALT 1 method,and 36.6%for the INTERSALT2 ***:The INTERSALT method seemed to provide minimally biased estimations of mean population sodium intake with casual spot ***,there is a need to be cautious regarding inconsistencies in estimation among different levels of sodium *** methods assessed in this study were unable to accurately estimate sodium intake at the individual level.

关键词： Adolescents Spot urine Sodium 24-hour urine

The impact of body weight trajectory from childhood on chronic inflammation in adulthood: The Bogalusa Heart Study

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Pediatric Investigation 2021年第1期5卷 21-27页

作者： yinkun yan Shengxu Li yang Liu Lydia Bazzano Jiang He Jie Mi Wei Chen Department of Non-communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLAUSA Children's Minnesota Research Institute Children’s Hospitals and Clinics of MinnesotaMinneapolisMNUSA Department of Cardiology The First Affiliated Hospital of Soochow UniversitySuzhouChina

Importance:The impact of long-term burden of excessive body weight,beginning in childhood,on inflammatory status in adulthood has been poorly ***:To characterize the longitudinal body mass index(BMI)trajectory from childhood and examine its relationship with inflammatory status in ***:We included 1285 adults who had 4-15 repeat measurements of BMI from childhood to *** area under the curve(AUC)of growth curves was calculated to characterize long-term burden(total AUC)and trends(incremental AUC)of ***:After adjusting for covariates,higher values of BMI in terms of childhood and adulthood,as well as total and incremental AUC,were strongly associated with elevated levels of adult C-reactive protein(CRP)in the four race-sex *** were significant differences in linear and nonlinear curve parameters between the normal and high CRP groups for all race-sex groups(P<0.01).Compared with participants who had consistently low BMI in both childhood and adulthood,participants with high BMI in adulthood had higher CRP levels(P<0.001),irrespective of their childhood BMI status;participants with high BMI in childhood but low BMI in adulthood had similar adult CRP ***:The impact of excessive body weight on inflammation is cumulative and exacerbated over *** influence of childhood overweight/obesity on inflammatory status in adulthood can be alleviated by reducing adiposity in adulthood.

关键词： Body mass index C-reactive protein Childhood Longitudinal study

论著肥胖和消瘦儿童间生活行为对FAIM2启动子甲基化的影响：人群研究

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英国医学杂志中文版 2015年第8期18卷 438-446页

作者： Lijun Wu Xiaoyuan Zhao Yue Shen Guimin Huang Meixian Zhang yinkun yan Dongqing Hou Linghui Meng Junting Liu Hong Cheng Jie Mi Department of Epidemiology Capital Institute of Pediatrics Beijing China. National Research Institute for Family Planning Beijing China.

目标肥胖相关基因Fas细胞凋亡抑制分子2（FAIM2）可以被营养状况调控，并且其启动子甲基化水平与肥胖显著相关。生活行为因素，如静态生活行为和运动，可以修饰与肥胖相关的表观遗传状态。但是，FAIM2影响肥胖的分子机制是否与生活行为... 详细信息

目标肥胖相关基因Fas细胞凋亡抑制分子2（FAIM2）可以被营养状况调控，并且其启动子甲基化水平与肥胖显著相关。生活行为因素，如静态生活行为和运动，可以修饰与肥胖相关的表观遗传状态。但是，FAIM2影响肥胖的分子机制是否与生活行为相关还不清楚。本研究检测了肥胖和消瘦儿童间FAIM2启动子甲基化水平与静态生活行为和运动的潜在差异。

关键词：队列研究生活方式甲基化启动子儿童肥胖

维普期刊数据库评论

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维普期刊数据库

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城市轻轨车站的建筑设计研究

城市建筑 2020年第24期17卷 81-83页

作者：严寅坤同济大学建筑与城市规划学院上海200092 上海申铁投资有限公司上海200092

随着我国城市化进程的加速、土地开发强度的提高,城市人口规模不断扩大,城市中心区空间逐渐集聚,城市轨道交通系统已在城市发展进程中担任了越来越重要的角色,是城市发展的必然产物。具备一定条件的城市已把轨道交通作为城市公共交通的... 详细信息

随着我国城市化进程的加速、土地开发强度的提高,城市人口规模不断扩大,城市中心区空间逐渐集聚,城市轨道交通系统已在城市发展进程中担任了越来越重要的角色,是城市发展的必然产物。具备一定条件的城市已把轨道交通作为城市公共交通的重点领域,积极开展规划和推进建设,本文顺应时代发展背景,重点研究城市轨道交通中地面或地上轻轨车站的几点建筑设计思路,剖析轻轨车站主体、附属、人性化及物业开发四方面建筑设计技术特点,以期为城市轻轨车站建筑设计研究提供借鉴。

关键词：城市轻轨车站建筑设计技术要点

Characteristics of pediatric inpatients with primary and secondary hypertension

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Pediatric Investigation 2021年第1期5卷 28-32页

作者： Yijun Chen Peiyu Ye Xiaorong Liu Chunxiu Gong Caifeng Li Yue Yuan Huyong Zheng Xin Xu Hongbo Dong Qin Kong yinkun yan Jie Mi Department of Non-communicable Disease Management Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Endocrinology Genetics and MetabolismBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Rheumatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Department of Cardiology Beijing Children's HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Hematology Oncology Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Information Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Extensive population-based studies have explored the prevalence of primary hypertension(HTN)in children and ***,there is little published data on the characteristics of different types of pediatric HTN and the causes of secondary ***:To investigate the characteristics of different types of pediatric HTN and the causes of secondary HTN in a hospital ***:The study cohort comprised pediatric inpatients(<18 years of age)discharged with a diagnosis of HTN from Beijing Children's Hospital during *** patients with HTN were allocated to secondary and primary HTN groups on the basis of comprehensive analyses of their diagnoses,family history of HTN,and findings on physical examination,as documented in their medical *** Mann-Whitney U test,χ^(2) and Fisher's exact test were used to assess differences in characteristics of patients with different HTN types and causes of secondary ***:Data of 1470 inpatients with HTN from 18 clinical departments were included in the *** them,458(31.2%)had primary HTN,and 1012(68.8%)had secondary *** with patients had primary HTN,children with secondary HTN were younger and had lower body mass indexes and longer lengths of ***,children with primary HTN had mostly been managed by the Endocrinology and Cardiology Departments,75.8%of them having obesity-related *** contrast,most patients with secondary HTN had been managed by the Nephrology Department,renal diseases being the leading cause of their HTN(46.3%).Interpretation:Secondary HTN is more common than primary HTN in pediatric clinical settings,renal diseases being the leading cause of secondary HTN.

关键词： Hypertension Pediatric Secondary hypertension

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某框架结构办公楼的改造加固设计

工业建筑 2011年第2期41卷 123-126,122页

作者：张学伟刘卫东张理赵彦严寅坤上海理工大学土木工程系上海200093 上海建工设计研究院上海200093 上海大学建筑系上海200093

介绍某框架结构办公楼扩建加层改造的加固方案设计。首先,分析了直接扩建加层结构计算模型的动力特性,确定需要加固的部位。经分析,原框架结构主要存在刚度偏小、承载力不足和构造措施偏弱等问题;其次,对相应的部位进行抗震加固设计,在... 详细信息

介绍某框架结构办公楼扩建加层改造的加固方案设计。首先,分析了直接扩建加层结构计算模型的动力特性,确定需要加固的部位。经分析,原框架结构主要存在刚度偏小、承载力不足和构造措施偏弱等问题;其次,对相应的部位进行抗震加固设计,在设计时要注意与建筑、水电暖等专业的配合;最后,验算加固后加层扩建结构模型的各项性能指标。结果表明:均能满足现行规范的各项要求。此设计为该工程加固方案之一,可供相关工程参考。

关键词：框架结构加层轴压比层间位移角抗震加固

基因多态性对儿童BMI和肥胖状态变化的影响

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中华预防医学杂志 2017年第7期51卷 635-641页

作者：张美仙程红赵小元吴丽君闫银坤米杰首都儿科研究所流行病学研究室北京100020

目的前瞻性验证12个肥胖相关基因多态性与儿童BMI和肥胖状态变化的关联.方法基于2004年4—10月开展的北京儿童青少年代谢综合征研究,2010年12月对其中1624名基线年龄为6-11岁且具有BMI和基因位点数据的儿童进行随访,成功随访到777名儿... 详细信息

目的前瞻性验证12个肥胖相关基因多态性与儿童BMI和肥胖状态变化的关联.方法基于2004年4—10月开展的北京儿童青少年代谢综合征研究,2010年12月对其中1624名基线年龄为6-11岁且具有BMI和基因位点数据的儿童进行随访,成功随访到777名儿童（基线肥胖者246名,非肥胖者531名）.将BMI转化为Z评分（BMIZ）,并计算随访期间的变化量.采用国际肥胖问题工作组推荐的儿童青少年超重、肥胖筛查BMI值分类标准诊断肥胖.使用实时荧光定量PCR对12个位点单核苷酸多态性（SNP）（rs9939609,rs6499640,rs7138803,rs1805081,rs17782313,rs6265,rs10938397,rs6235,rs29941,rs2844479,rs10913469和rs4788102）进行分型检测,并用简单相加法计算个体的肥胖遗传风险评分（GRS）.分别以多元线性回归和多因素logistic回归模型分析SNP对儿童BMIZ变化量及肥胖的影响.结果经过6年随访,持续性肥胖158例,一过性肥胖88例;新发肥胖58例,持续非肥胖473名.基线和随访时BMIZ分别为1.41±0.05和1.57±0.06.除rs6499640（P=0.033）和rs6265（P=0.041）位点外,其余10个位点SNP均符合哈迪-温伯格平衡（P〉0.05）.rs9939609位点与随访期间BMIZ变化量的关联有统计学意义（β=0.205,P=0.014）,即每增加1个A等位基因可引起随访期间BMIZ增加0.205;rs17782313与基线BMIZ水平的关联有统计学意义（β=0.268,P=0.003）,即每增加1个C等位基因可引起基线BMIZ增加0.268个单位.rs9939609位点A等位基因增加肥胖风险（OR=2.37,95%CI：1.45-3.88）;rs17782313位点C等位基因增加儿童期一过性肥胖风险（OR=1.79,95%CI：1.24-2.60）;rs1805081位点A等位基因增加持续性肥胖风险（OR=1.45,95%CI：1.04-2.03）.GRS每增加1个风险等位基因,儿童一过性肥胖风险增加0.18倍（OR=1.18,95%CI：1.05-1.33）,随访6年肥胖新发风险增加0.22倍（OR=1.22,95%CI：1.06-1.42）,但随访期间持续性肥胖风险增加无统计学意义（OR=1.09,95%CI：0.99-1.20）.结论儿童BMI和肥胖状态的变化受不同遗传因素的影响.多个肥胖相关基因的综合效应对肥胖罹患风险的影响不可忽视.

关键词：肥胖症人体质量指数多态性,单核苷酸随访儿童

儿童期至成年期的血压变化对成年期肾脏早期损害影响的队列研究

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中华预防医学杂志 2018年第11期52卷 1140-1145页

作者：闫银坤侯冬青刘军廷程红赵小元米杰首都儿科研究所流行病学研究室北京100020

目的探讨儿童期至成年期血压变化对肾脏早期损害的影响。方法研究对象来源于国家“七五”科技攻关项目“北京儿童血压队列”，采用整群抽样方法，于1987年在北京市朝阳区、西城区及海淀区抽取中、小学校各6所，将3198名6-18岁学生纳入... 详细信息

目的探讨儿童期至成年期血压变化对肾脏早期损害的影响。方法研究对象来源于国家“七五”科技攻关项目“北京儿童血压队列”，采用整群抽样方法，于1987年在北京市朝阳区、西城区及海淀区抽取中、小学校各6所，将3198名6-18岁学生纳入研究，并于2010--2012年进行随访和体检，最终共纳入1222名研究对象。研究内容主要包括基线期的身高、体重和血压的测量，以及随访期的尿微量白蛋白、肌酐、胱抑素C和血压的测定。根据儿童期及成年期血压状态，将研究对象分为4组：儿童期（基线时点）至成年期（随访时点）持续血压正常组、儿童期血压正常高值／高血压一成年期血压正常组、儿童期血压正常一成年期血压正常高值／高血压组及儿童至成年期持续血压正常高值／高血压组，采用多元线性回归分析儿童至成年期血压变化与成年期肾脏损害相关指标的关联。结果儿童期、成年期的血压正常高值／高血压检出率分别为17．9％（219例）、39．9％（486例）。成年期尿微量白蛋白的P50（P25-P75）为5．7（3．0-12．0）mg／L，肾小球滤过率及胱抑素C分别为（118．0±19．8）％、（0．734±0．184）mg／L。以儿童期至成年期持续血压正常组为参照，调整性别及年龄后，儿童期血压正常．成年期血压正常高值／高血压组的尿微量白蛋白及胱抑素C的B（95％CI）值分别为0．502（0．320-0．684）、0．049（0．025-0．073）。进一步调整性别、年龄、成年BMI、吸烟及饮酒后，儿童期血压正常成年期血压正常高值／高血压组尿微量白蛋白和胱抑素C的B（95％CI）值分别为0．322（0．128-0．516）、0．032（0．007-0．057）。结论血压正常的儿童在成年期血压若升高，其肾脏损害的危险增高，维持正常血压水平对于预防慢陛肾病有重要意义。

关键词：血压肾功能不全慢性儿童队列研究