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Journal of Integrative Agriculture 2024年第12期23卷 4136-4146页

作者： yingzhe yuan Tao Peng Aijun Huang Jun He Chenyang yuan Tianyuan Liu Long Yi Xuejin Cui Xuefeng Wang Changyong Zhou National Citrus Engineering and Technology Research Center Citrus Research InstituteSouthwest UniversityChongqing 400712China College of Life Sciences Yulin CollegeYulin 719000China National Navel Orange Engineering Research Center Gannan Normal UniversityGanzhou 341000China Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionSouthwest UniversityChongqing 400715China

Asian citrus psyllid(ACP,Diaphorina citri)is the major vector of Candidatus Liberibacter asiaticus(CLas),which is a bacterial pathogen causing the devastating citrus Huanglongbing(HLB)*** citri is known to carry CLas in a persistent and propagative *** studies have suggested that CLas may use the vesicular structures of *** cells as its propagation ***,the mechanisms by which CLas enters the *** cells and how vesicle-mediated trafficking is involved remain *** this study,we monitored the titer change of CLas in *** nymphs during the process of CLas acquisition from feeding on infected citrus *** found that the titer of CLas increased with the acquisition access *** infection,there was a significant upregulation in the expression of several vesicular transport-related genes in *** titer of CLas was significantly reduced in the midgut and whole insect body when endocytosis and the endosome network in *** were ***,silencing the *** clathrin-heavy chain gene also led to a reduction in the CLas titer in *** results suggest that CLas infection upregulates the genes related to vesicular transport in ***,which facilitates the invasion of endocytosis-dependent pathogens.

关键词： Huanglongbing endocytosis vesicular trafficking CLas acquisition

《夏洛克是我的名字》中的身份焦虑与伦理混乱

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外语研究 2022年第2期39卷 106-111页

作者：袁英哲田俊武北京航空航天大学外国语学院北京100191

作为书写当代英国犹太群体生存困境的行家里手,雅各布森在其改编的新作《夏洛克是我的名字》中刻画了犹太人在多元文化冲击下的身份焦虑和伦理混乱。通过引入文学伦理学批评,本文着力考察书中斯特鲁洛维奇和夏洛克面临的认同困惑与身份... 详细信息

作为书写当代英国犹太群体生存困境的行家里手,雅各布森在其改编的新作《夏洛克是我的名字》中刻画了犹太人在多元文化冲击下的身份焦虑和伦理混乱。通过引入文学伦理学批评,本文着力考察书中斯特鲁洛维奇和夏洛克面临的认同困惑与身份焦虑,并在此基础上深入分析他们陷入身份危机与伦理混乱的真正缘由,探讨其在族裔与公民、自我与他者、传统与现代等对立冲突中做出的伦理思考和伦理选择,揭示雅各布森在喜剧帘幕之下精心编制的伦理之帷。

关键词：霍华德·雅各布森《夏洛克是我的名字》犹太人身份危机伦理混乱

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刘徽的数学思想

曲阜师范大学学报(自然科学版) 1987年第4期 99-108页

作者：董英哲姚远西北大学

魏晋时代的伟大数学家刘徽,开辟了我国古代数学理论化的道路,在数学的很多领域内做出了重要贡献。从《九章算术注》和《海岛算经》中可以看出,他已经熟练地运用了形象思维和逻辑思维,解决了很多重要的数学问题,并且他已使自己的数学思... 详细信息

魏晋时代的伟大数学家刘徽,开辟了我国古代数学理论化的道路,在数学的很多领域内做出了重要贡献。从《九章算术注》和《海岛算经》中可以看出,他已经熟练地运用了形象思维和逻辑思维,解决了很多重要的数学问题,并且他已使自己的数学思维沿着辩证法的道路向纵深发展,从而建立了多样性和一体化的思维结构。

关键词：刘徽数学家逻辑思维辩证思维《九章算术注》句股弧田形象思维古代数学方亭《海岛算经》数学思想

组合赋权聚类-双基点模型的井下人体热舒适评价

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辽宁工程技术大学学报（自然科学版） 2021年第6期40卷 503-509页

作者：贾进章牛鑫佟兴东袁应喆辽宁工程技术大学安全科学与工程学院辽宁阜新123000 辽宁工程技术大学矿山热动力灾害与防治教育部重点实验室辽宁葫芦岛125105 凌钢股份北票保国铁矿有限公司安全科辽宁凌源122104 天津津普利环保科技股份有限公司系统集成部天津301899

针对井下人体热舒适性评价不准确、评价指标少等问题,以蒋家河煤矿工作面为例,选取环境温度等13个评价指标,构建井下人体热舒适评价指标模型.采用主客观赋权的方法计算各指标权重,引入拉格朗日函数,优化决策模型,通过欧式距离建立两者联... 详细信息

针对井下人体热舒适性评价不准确、评价指标少等问题,以蒋家河煤矿工作面为例,选取环境温度等13个评价指标,构建井下人体热舒适评价指标模型.采用主客观赋权的方法计算各指标权重,引入拉格朗日函数,优化决策模型,通过欧式距离建立两者联系,确定两种方法偏重系数,计算各指标的理想组合权重,构建组合赋权聚类-双基点综合评价模型,利用矩阵实验室软件计算准则层指标贴进度矩阵.研究结果表明:井下热舒适影响较大的前5个因素排序为环境温度>皮肤温度>风速>湿度>口腔温度;该工作面热舒适评价值为0.619,人体热舒适性为"舒适"等级.

关键词：热舒适评价环境温度组合权重聚类-双基点评价模型舒适度

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梨火疫病菌活菌快速定量检测方法的建立

果树学报 2020年第9期37卷 1425-1433页

作者：袁英哲韩剑王岩罗明包慧芳张春竹黄伟新疆农业大学农学院乌鲁木齐830052 新疆维吾尔自治区高校农林有害生物监测与安全防控重点实验室乌鲁木齐830052 新疆林业科学院现代林业研究所乌鲁木齐830000 新疆农业科学院微生物应用研究所乌鲁木齐830000 新疆巴州农业科学研究院新疆库尔勒841003

【目的】将叠氮溴化丙啶(PMA)与实时荧光定量PCR技术(qPCR)相结合,建立一种快速检测梨火疫病菌活菌的方法,为病害的检疫和早期诊断,开展病原学、流行规律研究及制定科学防控措施严防病害入侵提供技术支持。【方法】以梨火疫病菌(Erwinia... 详细信息

【目的】将叠氮溴化丙啶(PMA)与实时荧光定量PCR技术(qPCR)相结合,建立一种快速检测梨火疫病菌活菌的方法,为病害的检疫和早期诊断,开展病原学、流行规律研究及制定科学防控措施严防病害入侵提供技术支持。【方法】以梨火疫病菌(Erwinia amylovora)质粒pEA29设计特异性引物EaP29F1/EaP29R1,通过优化PMA的质量浓度和曝光时间,确定区分梨火疫病菌死活菌的PMA预处理最优反应条件,再以活菌DNA为模板进行qPCR的特异性扩增。设置不同比例死活菌混合体系,验证PMA-qPCR反应的可靠性。【结果】当梨火疫病菌浓度为1×10^8 CFU·mL^-1、PMA浓度为25μmol·L^-1、曝光时间为10 min时,能完全抑制死菌的扩增,仅以活菌体DNA为靶标进行选择性扩增。当活菌比例为10%~100%时(浓度为6.0×10^7~6.0×10^8 CFU·mL^-1),PMA-qPCR测得的活菌数与理论活菌数值均在同一个数量级,二者存在良好的线性关系(R^2=0.9928)。灵敏度检测结果表明,6.0×10^3~6.0×10^8 CFU·mL^-1范围内,梨火疫病菌活菌数与Ct值线性相关(R^2=0.9947),检测灵敏度下限为6×10^3 CFU·mL^-1(12 CFU/qPCR反应)。用建立的PMAqPCR方法检测人工接种发病的香梨、苹果、杜梨枝条,PMA-qPCR能准确检测其中的活菌,结果与菌落计数结果相符。【结论】本研究建立的PMA-qPCR检测方法能定量检测梨火疫病菌病活菌数量,具有灵敏、准确和高效的优点,避免了常规qPCR检测死菌导致的“假阳性”。

关键词：梨火疫病菌叠氮溴化丙啶(PMA) 实时荧光定量PCR(qPCR) 活菌

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Toward Analytical Homogenized Relaxation Modulus for Fibrous Composite Material with Reduced Order Homogenization Method

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Computers, Materials & Continua 2025年第1期82卷 193-222页

作者： Huilin Jia Shanqiao Huang Zifeng yuan HEDPS Center for Applied Physics and Technology(CAPT)Department of Mechanics and Engineering SciencePeking UniversityBeijing100871China State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100871China

In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational *** method is based on the reduced-order homogenization(ROH)*** ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization *** to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained *** the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive *** method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical *** approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading *** sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic ***,the model is validated against experimental measurements,confirming its accuracy and reliability.

关键词： Homogenized relaxation modulus viscoelastic standard solid model reduced order homogenization fibrous composite material

Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan Chen yuan Jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

Sex differences in aging and injured brain

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Neural Regeneration Research 2025年第10期20卷 2901-2902页

作者： Jordan N.Williamson yuan Yang University of Illinois Urbana-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foundation Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA University of Illinois Urbana-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA Northwestern University Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Huntington’s disease)differ substantially between males and *** higher prevalence of these brain disorders has been attributed to females having a greater longevity compared with *** one of the greatest risk factors of acquired brain injury(such as stroke,traumatic brain injury caused by fall)and neurodegenerative disease is age.

关键词： Huntington prevalence traumatic

Decision making module based on stochastic magnetic tunnel junctions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li Zhao Yajun Zhang Zhe yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks