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Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism

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Neural Regeneration Research 2024年第3期19卷 650-656页

作者： Jie Li Wen jiang Yuefang Cai Zhenqiu Ning yingying Zhou Chengyi Wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng Guangzhou University of Traditional Chinese Medicine GuangzhouGuangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Research on Emergency in TCM GuangzhouGuangdong ProvinceChina Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anatomy Sun Yat-Sen School of MedicineSun Yat-Sen UniversityShenzhenGuangdong ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao Special Administration RegionChina

Vascular etiology is the second most prevalent cause of cognitive impairment ***-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of ***,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well ***,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery *** proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic ***,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway *** chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic ***,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction.

关键词： astrocytic endothelin-1 dentate gyrus differentially expressed proteins hippocampus ischemic stroke learning and memory deficits lipid metabolism neural stem cells neurogenesis proliferation

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基于混合量子粒子群算法的DFIG参数辨识

系统仿真学报 2016年第5期28卷 1054-1062页

作者：蒋莹莹纪志成江南大学轻工过程先进控制教育部重点实验室江苏无锡214122

为了确保双馈感应发电机(Doubly Fed Induction Generator,DFIG)参数的准确性,提高发电机的控制性能,提出了基于混合量子粒子群算法的参数辨识方法。在dq坐标系下建立了DFIG参数辨识的模型。对量子粒子群算法进行改进并与模拟退火算法... 详细信息

为了确保双馈感应发电机(Doubly Fed Induction Generator,DFIG)参数的准确性,提高发电机的控制性能,提出了基于混合量子粒子群算法的参数辨识方法。在dq坐标系下建立了DFIG参数辨识的模型。对量子粒子群算法进行改进并与模拟退火算法进行混合,得到混合量子粒子群辨识算法。在Matlab/Simulink中将所提出的混合算法用于DFIG的参数辨识,并与粒子群算法、量子粒子群算法和改进量子粒子群算法进行了对比验证。仿真结果表明所提出的算法能提高定子电阻、定子电感、转子电阻、转子电感以及定转子互感五个参数的辨识精度。

关键词：双馈风力发电机参数辨识量子粒子群算法模拟退火算法混合算法

Music-stylized hierarchical dance synthesis with user control

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虚拟现实与智能硬件（中英文） 2024年第5期6卷 339-357页

作者： Yanbo CHENG Yichen jiang yingying WANG Department of Computing and Software McMaster UniversityON L8S 4L8Canada

Background Synthesizing dance motions to match musical inputs is a significant challenge in animation *** to functional human motions,such as locomotion,dance motions are creative and artistic,often influenced by music,and can be independent body language *** choreography requires motion content to follow a general dance genre,whereas dance performances under musical influence are infused with diverse impromptu motion *** the high expressiveness and variations in space and time,providing accessible and effective user control for tuning dance motion styles remains an open *** In this study,we present a hierarchical framework that decouples the dance synthesis task into independent *** use a high-level choreography module built as a Transformer-based sequence model to predict the long-term structure of a dance genre and a low-level realization module that implements dance stylization and synchronization to match the musical input or user *** novel framework allows the individual modules to be trained *** of the decoupling,dance composition can fully utilize existing high-quality dance datasets that do not have musical accompaniments,and the dance implementation can conveniently incorporate user controls and edit motions through a decoder *** module is replaceable at runtime,which adds flexibility to the synthesis of dance *** Synthesized results demonstrate that our framework generates high-quality diverse dance motions that are well adapted to varying musical conditions and user controls.

关键词： Deep learning Character animation Motion synthesis Motion stylization Multimodal synchronization User control

Peaches pulp(Prunus persica L.) mitigate type 2 diabetic mice by modulating of glucose metabolism and gut microbiota

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Food Science and Human Wellness 2024年

作者： Leyi Zhou Jianfen Ye yingying Wei Mouayche Salma Shu jiang Yi Chen Xingfeng Shao State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition， College of Food Science and Engineering， Ningbo University

Peach are a fruit with high nutritional and economic value， but their safety and suitability for diabetic patients have been questioned. This study investigated the effects and potential mechanisms of peach pulp (PP) on type 2 diabetes mellitus (T2DM) in mice induced by a high-fat diet (HFD) combined with streptozotocin (STZ). The results showed that PP alleviated hyperglycemia， hyperlipidemia， hyperuricemia， and tissue dysfunction in T2DM mice through the synergistic effect of nutrients and non-nutrient compounds. Analysis of mRNA expression levels revealed that PP improved glucose metabolism in T2DM mice by promoting glycogen synthesis and inhibiting gluconeogenesis. Furthermore， elevated levels of PP resulted in an increase in acetic acid content following a 4 weeks intervention period. Additionally， it led to the restoration of gut microbiota balance by decreasing the Firmicutes/Bacteroidota (F/B) ratio and enhancing the presence of Romboutsia， Allobaculum， Alloprevotella， and Bacteroides after an 8 weeks intervention. Ultimately， our results suggest that PP may offer advantages for individuals with diabetes.

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Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance

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Research 2023年第3期6卷 377-387页

作者： Chunchen Liu Mengfei Li Huilong Ma Zhubin Hu Xinyuan Wang Rui Ma yingying jiang Haitao Sun Shoujun Zhu Yongye Liang Department of Materials Science and Engineering Shenzhen Key Laboratory of Printed Organic ElectronicsSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Department of Chemistry and Bio-X Stanford UniversityStanfordCA 94305USA Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China

The second near-infrared(NIR-II,1,000 to 1,700 nm)molecular fluorophores containing donor–acceptor–donor conjugated backbone have attracted substantial attention due to their outstanding advantages,such as stable emission and facilely tuned photophysical ***,it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and ***,furan is adopted as the D unit to construct NIR-II fluorophores,demonstrating red shift of absorption,enhanced absorption coefficient,and fluorescent quantum yield when compared with the generally used thiophene *** high brightness and desirable pharmacokinetics of the optimized fluorophore,IR-FFCHP,endows improved performance for angiography and tumor-targeting ***,dual-NIR-II imaging of tumor and sentinel lymph nodes(LNs)has been achieved with IR-FFCHP and PbS/CdS quantum dots,enabling the in vivo imaging navigated LN surgery in tumor-bearing *** work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.

关键词： properties donor absorption

核苷(酸)类似物治疗慢性乙型肝炎发生HBeAg血清学转换的预测标志物

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临床肝胆病杂志 2020年第6期36卷 1358-1361页

作者：蒋莹莹郑素军首都医科大学附属北京佑安医院肝病重症医学科北京100069 首都医科大学附属北京佑安医院疑难肝病及人工肝中心北京100069 首都医科大学附属北京佑安医院肝衰竭与人工肝治疗研究北京市重点实验室北京100069

核苷(酸)类似物(NAs)是HBV复制的有效抑制剂,是目前大多数慢性乙型肝炎(CHB)患者抗病毒治疗的首选治疗方案。HBeAg血清学转换是评价HBeAg阳性CHB患者抗病毒治疗的持久性和有效性的重要指标。寻找能够预测NAs治疗CHB患者后发生HBeAg阴转... 详细信息

核苷(酸)类似物(NAs)是HBV复制的有效抑制剂,是目前大多数慢性乙型肝炎(CHB)患者抗病毒治疗的首选治疗方案。HBeAg血清学转换是评价HBeAg阳性CHB患者抗病毒治疗的持久性和有效性的重要指标。寻找能够预测NAs治疗CHB患者后发生HBeAg阴转/血清学转换的生物标志物,对于抗病毒治疗药物的选择、方案的调整、实现个体化治疗至关重要。综述了HBV DNA、HBV RNA、抗-HBc、HBcrAg等标志物对于预测NAs治疗CHB患者HBeAg转阴/血清学转换的价值。

关键词：乙型肝炎,慢性肝炎e抗原,乙型核苷类核苷酸类

Ruby:一个基于移动设备的个人信息管理系统

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计算机辅助设计与图形学学报 2010年第9期22卷 1475-1482页

作者：陈明炫姜映映田丰戴国忠中国科学院软件研究所人机交互技术与智能信息处理实验室北京100190 中国科学院研究生院北京100049

为满足移动环境对非结构化个人信息管理的自然性和高效性的需求,提出一个基于移动设备的个人信息管理系统Ruby.首先分析了移动环境对个人信息管理的需求,描述了系统框架,接着介绍了系统界面和交互过程,并阐述了支持该系统的2个主要技术... 详细信息

为满足移动环境对非结构化个人信息管理的自然性和高效性的需求,提出一个基于移动设备的个人信息管理系统Ruby.首先分析了移动环境对个人信息管理的需求,描述了系统框架,接着介绍了系统界面和交互过程,并阐述了支持该系统的2个主要技术:非结构化笔记编辑技术和基于笔迹标签的检索技术.对2个技术和整个系统的评估结果表明,该系统能够满足移动环境对自然交互、非结构化信息采集加工及个人信息自然检索的需求.

关键词：个人信息管理移动计算 Post-WIMP 非结构化笔记笔迹标签

Performance Analysis of Robust Tightly Coupled GNSS/INS Integration Positioning Based on M Estimation in Challenging Environments

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Performance Analysis of Robust Tightly Coupled GNSS/INS Inte...

Effects of Dietary Changes on the Gut Microbiota of Cynops orientalis

第十三届中国卫星导航年会

作者： yingying jiang Shuguo Pan Qian Meng Min Zhang Wang Gao Chun Ma School of Instrument Science and Engineering Southeast University State Key Laboratory of Smart Grid Protection and Control Nari Group Corporation

The phenomena of limited satellite visibility and multipath is serious in challenging environments,which causes to decrease of the positioning accuracy *** effective solution is tightly coupled integration of Global Navigation Satellite Systems（GNSS） and Inertial Navigation System（INS） based on robust M ***,the robust performance is directly influenced by both the selection of equivalent weight functions and the INS accuracy *** this paper,theoretical analysis and experiment validation of positioning accuracy and reliability for the robust integration system are implemented under the condition of various equivalent weight functions and different INS ***,for constructing equivalent least square form of EKF,we combine classical EKF observation equation with redundant observation equation established by predicted state and corresponding covariance in propagation ***,robust extended Kalman filter（REKF） algorithm which is based on M estimation is introduced for purpose of weakening the influence of faults on ***,the features of three typical equivalent weight functions（Huber,Tukey,IGG-Ⅲ） are analyzed ***,a simulation experiment platform is built to analyze the influence of the choice of equivalent weight functions and the IMU grades on positioning accuracy and reliability,which is realized by integrating GNSS and various grades IMU to locate with three REKF solutions against traditional *** experimental results show significant enhancements for REKF based on M estimation in terms of precision and reliability of tightly coupled ***,in the setting failure scenario,the solution scheme based on IGG-Ⅲ equivalent weight function can obtain the optimal robust effect in comparison with REKF（Huber） and REKF（Tukey）,whose horizontal positioning accuracy is kept within-0.5 m ～ 0.5 m and vertical positioning accuracy is no more than 1 ***,compared with consumer grad

关键词： Extended Kalman Filter Equivalent Least Square M Estimation Equivalent Weight Function INS

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG Yuning XIE Siyu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi SHI yingying SHI Zhirong HE Chunna ZHANG Yixin jiang Na ZHAO Jiaqi LI Supen WANG College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully *** this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order ***,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRNA amplicon sequencing ***,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive ***,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various ***,we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of *** in a large-scale spatiotemporal *** study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16S rRNA Caudata core microbiota diet gut microbiota