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Genes & Diseases 2023年第5期10卷 1806-1808页

作者： Lisha Mou Lin Liu Yumiao Qiu yingying liang Zuhui Pu Imaging Department Shenzhen Institute of Translational MedicineHealth Science CenterThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenGuangdong 518035China

Single-cell RNA sequencing (scRNA-seq) and machine learning technologies, developed rapidly in recent years, offer an unparalleled opportunity to study the mechanism of tumorigenesis. Changes in metabolism-related genes (MRGs) result in hepatocellular carcinoma (HCC) progression, and MRGs have the potential to be used as a clinical prognostic indicator. In this study, a machine learning model was built using LASSO regression to find prognostic genes and create a new MRG risk signature of HCC patients. The patients were divided into the MRG high- and low-risk groups based on their risk scores. Significant overall survival advantages were observed in the MRG low-risk group. In addition, risk score and cancer status were used to establish a nomogram with high accuracy. The calibration curves and decision curves further demonstrated the satisfactory agreement between the predicted and observed values in the probability of overall survival. Subsequently, we discovered the different characteristics of the MRG high- and low-risk group patients based on tumor mutation burden, gene set enrichment, and immune infiltration. Our study identifies a novel MRG signature for risk-stratification and accurate identification of HCC patients with poor subtypes, which could precisely predict the prognosis of HCC and may guide personalized treatment for HCC patients.

关键词： metabolism hepatocellular signature

A high mobility air-stable n-type organic small molecule semiconductor with high UV-visible-to-NIR photoresponse

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Light(Science & Applications) 2022年第9期11卷 2140-2146页

作者： YING-SHI GUAN JING QIAO yingying liang HARI KRISHNA BISOYI CHAO WANG WEI XU DAOBEN ZHU QUAN LI Institute of Advanced Materials and School of Chemistry and Chemical Engineering Southeast University211189 NanjingChina Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences100190 BeijingChina Advanced Materials and Liquid Crystal Institute and Chemical Physics Interdisciplinary Program Kent State UniversityKentOH 44242USA

An organic semiconductor with high carrier mobility and efficient light absorption over a wide spectral range is of the most important yet challenging material for constructing a broadband responsive organic ***,the development of such organic semiconductors,especially for air-stable n-type organic small molecule semiconductors,is still at an early *** we report the fabrication of high-performance n-type semiconducting crystalline nanosheets and the development of air-stable field-effect transistors,phototransistors,with high response over a broad *** n-type small molecule semiconductor is assembled into a crystalline nanosheet based on the solvent-phase interfacial self-assembly method.N-type field-effect transistors with high electron mobility are fabricated and their electrical performances exhibit excellent air ***,the demonstrated phototransistors exhibit an ultrahigh responsivity over a wide spectral range from 365 to 940 nm,with a maximum photoresponsivity of 9.2×10^(5) AW-1 and specific detectivity of 5.26×10^(13) Jones,which is the best performance among the reported n-type organic small molecule-based phototransistors.

关键词： high visible crystalline

Multi-ratio optical thermometry and energy storage characteristics of Yb^(3+)/Er^(3+)/Tm^(3+)doped BaNb_(2)O_(6)transparent glass-ceramics

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Journal of Materials Science & Technology 2023年第7期138卷 138-148页

作者： Junhao Xing Feng Luo Yaoyi Qin Xiaolu Chen yingying liang Zhixin Gao Fei Shang Huarui Xu Guohua Chen School of Material Science and Engineering Guangxi Key Laboratory of Information MaterialsGuilin University of Electronic TechnologyGuilin 541004China

In order to meet the needs of new materials gradually developing towards miniaturization,integration,and light weight,multifunctional BaNb_(2)O_(6):Yb^(3+)/Er^(3+)/Tm^(3+)transparent glass-ceramics were success-fully prepared by melt quenching and controllable *** structure,luminescence,and en-ergy transmission were *** the opposite temperature dependence of the Tm^(3+)emission band and the corresponding large energy level gap,a maximum relative sensitivity of 2.3%K^(-1)based on thermal coupling levels(TCLs)is obtained in a wide temperature range(298-673 K).The multi-ratio optical thermometry based on TCLs and non-TCLs is successfully realized by using the different emission bands of double emission centers,which makes it possible for self-reference optical temperature measurement *** addition,the transparent glass-ceramic exhibits excellent electrical properties under 700 kV cm^(-1)electric field:high discharge energy density(W_(d)=0.99 J cm^(-3)),huge instantaneous power density(225.3 MW cm^(-3)),and ultra-fast discharge rate(T_(0.9)≤15.8 ns).The prepared glass-ceramic is expected to be a new type of lead-free multifunctional photoelectric material for temperature sensors and transparent electronic devices.

关键词： Glass ceramics Luminescence Optical thermometry Energy storage

基于改进因子图模型的航天器组合姿态确定算法

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系统工程与电子技术 2021年第8期43卷 2273-2281页

作者：华冰梁莹莹倪瑞南京航空航天大学航天学院江苏南京211000

航天器姿态确定是航天器姿轨控制、在轨正常运行的关键,针对航天器多姿态传感器存在测量噪声非高斯分布、可能出现敏感器失效和故障等问题,提出了一种基于改进因子图模型的航天器组合姿态确定方法。通过建立因子图模型,将地磁/星敏/陀... 详细信息

航天器姿态确定是航天器姿轨控制、在轨正常运行的关键,针对航天器多姿态传感器存在测量噪声非高斯分布、可能出现敏感器失效和故障等问题,提出了一种基于改进因子图模型的航天器组合姿态确定方法。通过建立因子图模型,将地磁/星敏/陀螺测量信息作为因子节点加入因子图模型,利用观测蒸馏法对观测数据集进行提炼以及自适应调整,实现对航天器的姿态确定。在复杂条件下,该方法扩展性强,可以实现即插即用,合理而充分的利用其他姿态测量信息,避免了基于卡尔曼滤波算法中的复杂系统重构过程,从而有利于多传感器融合。实验结果表明,在进行复杂条件下的地磁/星敏/陀螺组合定姿仿真时,该算法可行有效;有传感器切换时,具有较好的动态稳定性,实现了即插即用。该方法灵活度高,为解决复杂条件下的多传感器组合定姿提供了新思路。

关键词：航天器姿态确定因子图星敏感器磁强计

Evaluation on therapeutic effects of orthotopic liver transplantation by megnetic resonance imaging in patients with portal hypertension

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Chinese Medical Journal 2014年第19期127卷 3383-3388页

作者： Wang Jin liang yingying Yan Ronghua Jiang Zaibo Liu Jingjing Hu Bing He Bingjun Ren Linglan Chen Jingbiao Shan Hong Department of Medical Radiology Third Affiliated Hospital of SunYat-Sen University Guangzhou Guangdong 510630 China Department of Medical Radiology Guangzhou First People'sHospital Guangzhou Guangdong 510180 China

Background Orthotopic liver transplantation （OLT） has become the therapeutic option of choice for end-stage liver disease. The aim of this study was to investigate the changes of splenic morphology, signal-to-noise ratio （SNR）, contrast- to-noise ratio （CNR）, apparent diffusion coefficient （ADC） values and explore their value in evaluating the therapeutic effects of orthotopic liver transplantation （OLT） on portal hypertension at 1.5 Tesla MRI. Methods Twenty patients with portal hypertension undergoing OLT were included in this study. Conventional MRI and diffusion-weighted image （DWI）（b value=600 s/mm2） sequences were applied on each patient before and after OLT, and these patients were referred to as the preoperative and postoperative groups. Twenty healthy individuals were selected as the normal group. After image acquisition, the splenic width （W）, thickness （T）, length （L）, the diameter of the portal vein （PD） and splenic vein （SD） were measured and the splenic volume （V） was calculated. The SNR and CNR were measured on T2WI. The ADC maps were calculated using the bs00 in DWIs and the ADC values were measured. Results Compared with the preoperative group, the splenic V, PD and SD decreased significantly in the postoperative group （P 〈0.05）. All splenic morphological values were significantly different between preoperative and normal groups （P 〈0.05）. The splenic L and V were significantly different （P 〈0.05） between postoperative and normal groups. The SNR and CNR values were 17.66＋4.62 and 13.18＋3.12, 11.50＋1.64 and 7.44＋4.32, 4.24＋1.24 and 3.03＋2.41 in the preoperative, postoperative and normal groups, respectively. Both SNR and CNR decreased after OLT, but they was still higher than the normal values. The SNR was significantly different between any two groups （P 〈0.05）. The CNR was significantly different （P 〈0.05） between the preoperative and postoperative groups, preoperative and normal groups. The splenic ADC values were （1.339＋0.482）×10^-3 mm2/s, （1.12

关键词： MRI apparent diffusion coefficient orthotopic liver transplantation splenomegaly

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土耳其与北约关系:战略自主还是联盟至上

西亚非洲 2023年第1期 110-130,159,160页

作者：郭长刚梁莹莹上海社会科学院历史研究所上海大学土耳其研究中心

近年来,土耳其在购买俄罗斯“S-400”导弹系统、在叙利亚的军事行动、围绕东地中海油气资源的开发等问题上都与北约盟友激烈对立,引发盟友对其北约身份的质疑。2022年乌克兰危机升级,再次引发了土耳其作为北约成员国资格的讨论。土耳其... 详细信息

近年来,土耳其在购买俄罗斯“S-400”导弹系统、在叙利亚的军事行动、围绕东地中海油气资源的开发等问题上都与北约盟友激烈对立,引发盟友对其北约身份的质疑。2022年乌克兰危机升级,再次引发了土耳其作为北约成员国资格的讨论。土耳其与北约之间的这些矛盾可以追溯到20世纪60年代,其核心是土耳其认为北约的“集体威慢”并不能给自己带来安全保障,土耳其的国家利益与北约联盟的利益并不处在同一轨道上。冷战结束后,当年迫使土耳其加入北约的地缘政治环境正在加速变化,北约联盟新的集体威慢对象也变成了所谓“恐怖主义”。但在应对全球及地区恐怖主义威胁时,土耳其的国家安全利益与美国及北约的联盟利益形成了根本对立,土耳其成为令北约“头疼的伙伴”。究竟土耳其是否继续留在北约联盟,以及北约是否继续容纳土耳其,既要看土耳其的外交战略选择,又要看国际地缘政治格局的变化,更要依赖彼此间的分歧管控智慧。

关键词：土耳其外交北约安全共同体约翰逊信函埃尔多安战略自主

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The Application of Quality Control Circles to Reduce the Cost of Non-priced Consumables in Department of Oncology

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Journal of Clinical and Nursing Research 2021年第3期5卷 140-143页

作者： Xiaofang Zhang Jinglan Luo Rui Dai Lu Wang Jieli Wei yingying liang Qiugui Huang Yuyao Liu Department of Oncology The First Affiliated Hospital of Jinan UniversityGuangzhou 510630Guangdong ProvinceChina

Objective:To investigate the effectiveness of using quality control circle(QCC)techniques to reduce the cost of non-priced consumables in medical ***:Analytic statistics were compiled on the performance appraisal *** at the key points of improvement with respect to the excess cost of non-valuable consumables,the reasons were analyzed,and corresponding measures were formulated to compare the cost before and after the ***:After the QCC activity,the cost of non-priced consumables decreased from RMB 6.57/bed day to RMB 3.96/bed ***:QCC has effectively reduced the cost of non-priced consumables in the oncology department,and it is worthy of promotion.

关键词： Quality control circles Reduction non-priced consumables Cost

The spirocyclopiperazinium salt compound LXM-15 alleviates chronic inflammatory and neuropathic pain in mice and rats

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Journal of Chinese Pharmaceutical Sciences 2019年第6期28卷 371-380页

作者： Ning Li yingying liang Qi Sun Yimin Jiang Runtao Li Jia Ye Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking University Health ScienceCenterBeijing100191China Department of Chemical Biology School of Pharmaceutical SciencesPeking University Health Science CenterBeijing100191China Department of Medical and Healthy Analysis Center Peking University Health Science CenterBeijing100191China

In the present study,we aimed to evaluate the effect of the spirocyclopiperazinium salt compound LXM-15 on chronic inflammatory pain and chronic neuropathic pain induced by complete Freund’s adjuvant(CFA)or chronic constriction injury(CCI)in mice and *** results showed that administration with LXM-15 significantly reduced paw edema and ankle swelling and increased the mechanical withdrawal threshold and paw withdrawal latency after CFA injection in ***-15 significantly alleviated the mechanical allodynia and thermal hyperalgesia in CCI *** effect was abolished by pretreatment with hexamethonium(a peripheral nAChR antagonist)or methyllycaconitine citrate(anα7 nAChR antagonist).Furthermore,LXM-15 significantly inhibited the phosphorylation of JAK2 and STAT3,and suppressed the expressions of TNF-αand c-fos in dorsal root ganglia of CCI ***,we reported that LXM-15 relieved chronic inflammatory pain in CFA mice and chronic neuropathic pain in CCI *** underlying mechanism might be related to the activation of peripheralα7 nicotinic receptor,further inhibiting JAK2/STAT3 signaling pathway,and eventually suppressing the expressions of TNF-αand c-fos.

关键词： Spirocyclopiperazinium salt compound LXM-15 Chronic pain α7 nicotinic receptor JAK2/STAT3 signaling pathway

基于Sentinel-2遥感影像的黄土高原覆膜农田识别

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疼痛控制护理在膝关节骨折手术患者中的应用效果分析

农业机械学报 2023年第8期54卷 180-192页

作者：赵成梁盈盈冯浩王钊于强何建强西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100 西北农林科技大学中国旱区节水农业研究院陕西杨凌712100 西北农林科技大学中国旱区节水农业研究院陕西杨凌712100 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 陕西省气象局秦岭和黄土高原生态环境气象重点实验室西安710016 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100 陕西省气象局秦岭和黄土高原生态环境气象重点实验室西安710016 西北农林科技大学旱区农业水土工程教育部重点实验室陕西杨凌712100 陕西省气象局秦岭和黄土高原生态环境气象重点实验室西安710016

及时、准确地获取覆膜农田的空间分布信息是防治地膜微塑料污染的基础.为准确地识别黄土高原地区的覆膜农田,本研究构建了基于Sentinel-2 遥感影像和随机森林算法的适用于黄土高原覆膜农田遥感识别的特征集组合与多时相组合方案.以甘肃... 详细信息

及时、准确地获取覆膜农田的空间分布信息是防治地膜微塑料污染的基础.为准确地识别黄土高原地区的覆膜农田,本研究构建了基于Sentinel-2 遥感影像和随机森林算法的适用于黄土高原覆膜农田遥感识别的特征集组合与多时相组合方案.以甘肃省临夏县、宁夏回族自治区彭阳县和山西省山阴县作为测试区,陕西省旬邑县作为验证区开展识别研究.首先,基于随机森林算法,针对3 个不同的作物生育期(播期、生长旺盛期和收获期),在7种不同的特征集组合方案中优选出各时期识别精度最高的方案.然后,基于不同作物生育期的遥感影像及其对应的最优特征集组合方案,构建不同的多时相组合来进行覆膜农田识别并优选多时相组合.最后,利用旬邑县来验证构建的优选特征集组合与多时相组合识别覆膜农田的有效性,并绘制各研究区的覆膜农田空间分布图.结果表明:相比于其他遥感识别特征因子,Sentinel-2 遥感影像光谱特征集中的可见光波段(B2、B3 和B4)和短波红外波段(B11 和B12),指数特征集中的归一化差值裸地与建筑用地指数(NDBBI)、归一化水体指数(NDWI)、裸土指数(BSI)、归一化建筑物指数(NDBI)和改进的归一化水体指数(MNDWI),纹理特征集中的和平均(savg)和相关性(corr)可以作为覆膜农田识别的优选输入特征变量.在7 种特征集组合方案中,光谱+指数方案是播期和收获期识别覆膜农田的优选方案,在这两个时期对4 个研究区的覆膜农田进行识别的F1 值分别大于87％和57％,而光谱+指数+纹理方案是生长旺盛期识别覆膜农田的优选方案,该方案识别4 个研究区覆膜农田的F1 值均大于71％.基于多时相遥感影像的覆膜农田识别精度高于仅基于单时相遥感影像的精度,其中播期+生长旺盛期+收获期多时相组合可作为黄土高原覆膜农田识别的优选多时相组合,该组合在4 个研究区识别覆膜农田的F1 值均大于92％.总体而言,基于随机森林算法和本研究优选的特征集组合与多时相组合方案能够较为精准地识别黄土高原地区的覆膜农田.

关键词：覆膜农田遥感识别多时相遥感影像特征优选 Google Earth Engine 随机森林

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中国医药指南 2022年第12期20卷 174-176页

作者：梁颖颖辽宁省朝阳市中心医院辽宁朝阳122000

目的论疼痛控制护理措施应用在膝关节骨折手术患者中所发挥的护理效果。方法将2020年1月至2021年3月到我院治疗的102例膝关节骨折手术的患者随机分为观察组和对照组,每组平均51例。观察组,通过常规护理和疼痛护理相结合的护理方法实施干... 详细信息

目的论疼痛控制护理措施应用在膝关节骨折手术患者中所发挥的护理效果。方法将2020年1月至2021年3月到我院治疗的102例膝关节骨折手术的患者随机分为观察组和对照组,每组平均51例。观察组,通过常规护理和疼痛护理相结合的护理方法实施干预,对照组则予以常规护理,不同护理以后的整体护理效果进行统计学比较和分析。结果①观察组(3例,5.88%)护理以后与对照组(13例,25.49%)相比具有更低水平的并发症发生率,具有统计学差异(P0.05),术后4~7 d,观察组的疼痛相比对照组有明显的减轻趋势(P0.05),护理开展以后,观察组的生活质量得到明显的改进,相比对照组具有更好的优势(P<0.05)。④观察组(49例,96.08%)患者相比对照组(44例,86.27%)对护理的满意程度具有更高的评估质量(P<0.05)。结论将疼痛控制护理应用在膝关节骨折手术患者中能够降低并发症出现的风险,改善术后的疼痛程度,能更好的提高患者的生活质量和满意度。

关键词：疼痛控制膝关节骨折手术并发症常规护理生活质量满意度