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Quantitative Trait Loci for Panicle Layer Uniformity Identified in Doubled Haploid Lines of Rice in Two Environments

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Journal of Integrative Plant Biology 2009年第9期51卷 818-824页

作者： Liangyong Ma Jinsong Bao Longbiao Guo Dali Zeng Ximing Li Zhijuan Ji yingwu Xia Changdeng Yang Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China Key Laboratory of Zhejiang Province and Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences Institute of Nuclear Agricultural Sciences Zhejiang University Hua Jiachi Campus Hangzhou 310029 China

Uniformity of stem height in rice directly affects crop yield potential and appearance, and has become a vital index for rice improvement. In the present study, a doubled haploid （DH） population, derived from a cross between japonica rice Chunjiang 06 and indica rice TN1 was used to analyze the quantitative trait locus （QTL） for three related traits of paniclelayer-uniformity; that is, the tallest panicle height, the lowest panicle height and panicle layer disuniforrnity in two locations：Hangzhou （HZ） and Hainan （HN）. A total of 16 QTLs for three traits distributed on eight chromosomes were detected in two different environments. Two QTLs, qTPH-4 and qTPH-8 were co-located with the QTLs for qLPH-4 and qLPH-8, which were only significant in the HZ environment, whereas the qTPH-6 and qLPH-6 located at the same interval were only significant in the HN environment. Two QTLs, qPLD-10.1 and qPLD-10.2, were closely linked to qTPH-10, and they might have been at the same locus. One QTL, qPLD-3, was detected in both environments, explaining more than 23% of the phenotypic variations. The CJ06 allele of qPLD-3 could increase the panicle layer disuniformity by 9.23 and 4.74 cm in the HZ and HN environments. Except for qPLD-3, almost all other QTLs for the same trait were detected only in one environment, indicating that these three traits were dramatically affected by environmental factors. The results may be useful for elucidation of the molecular mechanism of panicle-layer-uniformity and marker assisted breeding for super-rice.

关键词： double haploid population panicle layer uniformity plant height quantitative trait loci rice.

四川省金川县龙古锂矿床伟晶岩分带特征及找矿潜力分析

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矿产勘查 2024年第6期15卷 969-978页

作者：邹林包文祥彭杰张伟段威范映武杨大强四川省地质矿产勘查开发局化探队四川德阳618000

龙古矿床是川西可尔因花岗伟晶岩田内近年来新发现的一处中型锂矿床,为了进一步发掘该矿床锂找矿潜力,本文在矿床详查工作的基础上,研究了该矿床代学和阿拉伯两个矿段不同类型花岗伟晶岩的空间分布特征,发现了不同类型伟晶岩围绕可尔因... 详细信息

龙古矿床是川西可尔因花岗伟晶岩田内近年来新发现的一处中型锂矿床,为了进一步发掘该矿床锂找矿潜力,本文在矿床详查工作的基础上,研究了该矿床代学和阿拉伯两个矿段不同类型花岗伟晶岩的空间分布特征,发现了不同类型伟晶岩围绕可尔因岩体呈三维立体分带的特征,对比分析了代学和阿拉伯两个矿段各类伟晶岩表现出不同的分带结构。据此通过判断伟晶岩类型,依据伟晶岩类型分带结构,定位伟晶岩地质位置,推断锂成矿有利方向,指导矿床进一步找矿,且对可尔因低剥蚀地区稀有金属找矿工作提供了一定的指导意义。

关键词：龙古可尔因锂辉石伟晶岩分带锂矿床

SPRR-300反应堆生物屏蔽层剂量场三维仿真

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核安全 2024年第2期23卷 12-16页

作者：但贵萍樊英武陈明陈师张鹏昊曾俊辉中国工程物理研究院核物理与化学研究所绵阳621900 武汉核动力运行研究所武汉430074

反应堆生物屏蔽层的拆除是反应堆退役阶段的重要任务之一,生物屏蔽层辐射场的数字化可为反应堆退役中的辐射防护和废物管理提供重要信息。本文通过构建三维辐射场计算模型,采用粒子输运计算程序(MCNP)获得了SPRR-300反应堆生物屏蔽层三... 详细信息

反应堆生物屏蔽层的拆除是反应堆退役阶段的重要任务之一,生物屏蔽层辐射场的数字化可为反应堆退役中的辐射防护和废物管理提供重要信息。本文通过构建三维辐射场计算模型,采用粒子输运计算程序(MCNP)获得了SPRR-300反应堆生物屏蔽层三维辐射剂量场;运用3Dmax、Pro/E等建模工具建立了生物屏蔽层剂量场三维仿真场景和模型,直观地展示了生物屏蔽层活度状况和剂量分布,实现放射性水平分布可视化。

关键词：生物屏蔽层剂量场三维剂量仿真反应堆退役

Acrolein Induces Systemic Coagulopathy via Autophagy-dependent Secretion of von Willebrand Factor in Mice after Traumatic Brain Injury

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Neuroscience Bulletin 2021年第8期37卷 1160-1175页

作者： Wenxing Cui Xun Wu Dayun Feng Jianing Luo yingwu Shi Wei Guo Haixiao Liu Qiang Wang Liang Wang Shunnan Ge Yan Qu Department of Neurosurgery Tangdu HospitalFourth Military Medical UniversityXi’an710038China

Traumatic brain injury(TBI)-induced coagulopathy has increasingly been recognized as a significant risk factor for poor outcomes,but the pathogenesis remains poorly *** this study,we aimed to investigate the causal role of acrolein,a typical lipid peroxidation product,in TBI-induced coagulopathy,and further explore the underlying molecular *** found that the level of plasma acrolein in TBI patients suffering from coagulopathy was higher than that in those without *** a controlled cortical impact mouse model,we demonstrated that the acrolein scavenger phenelzine prevented TBI-induced coagulopathy and recombinant ADAMTS-13 prevented acrolein-induced coagulopathy by cleaving von Willebrand factor(VWF).Our results showed that acrolein may contribute to an early hypercoagulable state after TBI by regulating VWF *** sequencing(mRNA-seq)and transcriptome analysis indicated that acrolein over-activated autophagy,and subsequent experiments revealed that acrolein activated autophagy partly by regulating the Akt/mTOR *** addition,we demonstrated that acrolein was produced in the perilesional cortex,affected endothelial cell integrity,and disrupted the blood-brain *** conclusion,in this study we uncovered a novel pro-coagulant effect of acrolein that may contribute to TBI-induced coagulopathy and vascular leakage,providing an alternative therapeutic target.

关键词： Traumatic brain injury Coagulopathy Autophagy Acrolein Von Willebrand factor

Mode-I fracture and durability of FRP-concrete bonded interfaces

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Water Science and Engineering 2008年第4期1卷 47-60页

作者： Qiao Pizhong Xu yingwu Department of Civil and Environmental Engineering Washington State University Pullman WA 99164-2910 U.S.A. Department of Engineering Mechanics College of Civil Engineering Hohai University Nanjing 210098 P. R. China Department of Civil Engineering The University of Akron Akron OH 44325-3905 U. S. A.

In this study, a work-of-fracture method using a three-point bend beam （3PBB） specimen, which is commonly used to determine the fracture energy of concrete, was adapted to evaluate the mode-I fracture and durability of fiber-reinforced polymer （FRP） composite-concrete bonded interfaces. Interface fracture properties were evaluated with established data reduction procedures. The proposed test method is primarily for use in evaluating the effects of freeze-thaw （F-T） and wet-dry （W-D） cycles that are the accelerated aging protocols on the mode-I fracture of carbon FRP-concrete bonded interfaces. The results of the mode-I fracture tests of F-T and W-D cycle-conditioned specimens show that both the critical load and fracture energy decrease as the number of cycles increases, and their degradation pattern has a nearly linear relationship with the number of cycles. However, compared with the effect of the F-T cycles, the critical load and fracture energy degrade at a slower rate with W-D cycles, which suggests that F-T cyclic conditioning causes more deterioration of carbon fiber-reinforced polymer （CFRP）-concrete bonded interface. After 50 and 100 conditioning cycles, scaling of concrete was observed in all the specimens subjected to F-T cycles, but not in those subjected to W-D cycles. The examination of interface fracture surfaces along the bonded interfaces with varying numbers of F-T and W-D conditioning cycles shows that （1） cohesive failure of CFRP composites is not observed in all fractured surfaces; （2） for the control specimens that have not been exposed to any conditioning cycles, the majority of interface failure is a result of cohesive fracture of concrete （peeling of concrete from the concrete substrate）, which means that the cracks mostly propagate within the concrete; and （3） as the number of F-T or W-D conditioning cycles increases, adhesive failure along the interface begins to emerge and gradually increases. It is thus concluded that the fracture proper

关键词： repair and strengthening of concrete structures FRP composites FRP-concrete bonded interface mode-l fracture durability freeze-thaw wet-dry interface energy

The Prospective Two-Dimensional Graphene Nanosheets: Preparation, Functionalization, and Applications

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Nano-Micro Letters 2012年第1期4卷 1-9页

作者： Zhi Yang Rungang Gao Nantao Hu Jing Chai yingwu Cheng Liying Zhang Hao Wei Eric Siu-Wai Kong Yafei Zhang Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University

Graphene, as an intermediate phase between fullerene and carbon nanotube, has aroused much interests among the scientific community due to its outstanding electronic, mechanical, and thermal *** excellent electrical conductivity of 6000 S/cm, which is independent on chirality, graphene is a promising material for high-performance nanoelectronics, transparent conductor, as well as polymer composites. On account of its Young's Modulus of 1 TPa and ultimate strength of 130 GPa, isolated graphene sheet is considered to be among the strongest materials ever measured. Comparable with the single-walled carbon nanotube bundle,graphene has a thermal conductivity of 5000 W/(m·K), which suggests a potential application of graphene in polymer matrix for improving thermal properties of the graphene/polymer composite. Furthermore, graphene exhibits a very high surface area, up to a value of 2630 m^2/g. All of these outstanding properties suggest a wide application for this nanometer-thick, two-dimensional carbon material. This review article presents an overview of the significant advancement in graphene research: preparation, functionalization as well as the properties of graphene will be discussed. In addition, the feasibility and potential applications of graphene in areas, such as sensors, nanoelectronics and nanocomposites materials, will also be reviewed.

关键词： Graphene Graphite oxide Functionalization Sensors Transparent conductive films Nanocom posites

Growth and characterization of 2-inch high quality β-Ga2O3 single crystals grown by EFG method

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Journal of Semiconductors 2018年第8期39卷 27-31页

作者： Shengnan Zhang Xiaozheng Lian Yanchao Ma Weidan Liu yingwu Zhang Yongkuan Xu Hongjuan Cheng Electronic Material Research Institute of Tianjin Tianjin 300220 China

β-GaOis an ultra-wide band-gap semiconductor with promising applications in UV optical detectors,Schottky barrier diodes, field-effect transistors and substrates for light-emitting diodes. However, the preparation of large β-GaOcrystals is undeveloped and many properties of this material have not been discovered yet. In this work, 2-inch β-GaOsingle crystals were grown by using an edge-defined film-fed growth method. The high quality of the crystal has been proved by high-resolution X-ray diffraction with 19.06 arcsec of the full width at half maximum. The electrical properties and optical properties of both the unintentionally doped and Si-doped β-GaOcrystals were investigated systematically.

关键词： β-Ga_2O_3 single crystal high quality doping electrical properties optical properties

人工金属酶分子设计新进展:肌红蛋白研究实例分析

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化学进展 2018年第10期30卷 1464-1474页

作者：林英武南华大学化学化工学院衡阳421001 南华大学蛋白质结构与功能实验室衡阳421001

金属酶在生物体中发挥着多种至关重要的作用,而人工金属酶的分子设计能够调控和拓展天然金属酶的功能,甚至创造出功能更为优越的新型酶分子。肌红蛋白(Mb)是作为血红素蛋白或其他金属蛋白分子设计的理想蛋白模型。近些年,基于Mb蛋白骨... 详细信息

金属酶在生物体中发挥着多种至关重要的作用,而人工金属酶的分子设计能够调控和拓展天然金属酶的功能,甚至创造出功能更为优越的新型酶分子。肌红蛋白(Mb)是作为血红素蛋白或其他金属蛋白分子设计的理想蛋白模型。近些年,基于Mb蛋白骨架的人工金属酶的分子设计逐渐发展了多种研究策略,包括设计氢键网络、金属结合位点、分子内二硫键、利用蛋白翻译后修饰、引入非天然氨基酸和非天然辅基等。本文着重综述这些方面的最新研究进展,可以帮助我们深刻认识金属酶的结构与功能关系,同时掌握人工金属酶分子设计的思路与方法,从而有助于推动这一领域的快速发展。

关键词：金属蛋白金属酶血红素蛋白肌红蛋白分子设计

Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2003年第11期9卷 2395-2399页

作者： ChunLi Ming-YaoWu Xian-yingwu ying-RuiLiang DepartmentofPathology MedicalCollegeShantouUniversityShantou515031GuangdongProvinceChina DepartmentofPathology FoshanFirstPeople'sHospitalFoshan528000GuangdongProvinceChina

AIM: To investigate telomerase activity and hTERT, TP-1 expression and their relationships in esophageal squamouscell carcinoma (ESCC).METHODS: Telomerase activity was measured in 60 ESCCtissues using telomeric repeat amplification protocol (TRAP)assay by silver staining. In situ hybridization was used for detecting hTERT and ***: The telomerase activity was detected in 83.3 % of ESCC tissues. The difference of telomerase activity was significant between well and poorly cancer differentiated lesions (P<0.05). The positive rate of telomerase activity was higher in patients with lymphatic metastasis than in patients without lymphatic metastasis. In cancer tissues hTERT mRNA expression was 75 % and TP-1 mRNA expression was 71.7 %. The expression of hTERT, TP-1 mRNA in well and poorly differentiated carcinoma was not significant. The expression of hTERT mRNA was correlated with telomerase activity, but TP-1 mRNA expression was not correlated with ***: Telomerase activity and hTERT, TP-1 mRNA expression are up-regulated in ESCC. Telomerase activity in ESCC is correlated with lymphatic metastasis and cancer differentiation. Telomerase activity may be used as a prognostic marker in ESCC. hTERT mRNA expression is correlated with telomerase activity. Enhanced hTERT mRNA expression may initially comprehend the telomerase activity level, but it is less sensitive than TRAP assay.

关键词：食道鳞状细胞癌端粒酶肿瘤生物学 hTERT TP-lmRNA 淋巴结转移