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乳腺鳞状细胞癌临床病理特征及其免疫微环境分析

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中华病理学杂志 2024年第4期53卷 337-343页

作者：梁佳毅王映梅文珠张雯慧高子昭王哲郭双平空军军医大学第一附属医院病理科西安710000

目的探讨乳腺鳞状细胞癌临床病理学特征,分析其免疫微环境肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes,TILs)与预后的关系。方法收集空军军医大学第一附属医院2006年1月至2022年7月诊治的乳腺鳞状细胞癌44例,分析其临床病理学特点... 详细信息

目的探讨乳腺鳞状细胞癌临床病理学特征,分析其免疫微环境肿瘤浸润淋巴细胞(tumor infiltrating lymphocytes,TILs)与预后的关系。方法收集空军军医大学第一附属医院2006年1月至2022年7月诊治的乳腺鳞状细胞癌44例,分析其临床病理学特点,评估TILs、免疫组织化学检测TILs的细胞组成(主要包括B淋巴细胞、T淋巴细胞及浆细胞),并分析和预后的关系。结果44例患者均为女性,均为浸润性癌。8例(8/44,18.2%)为单纯性鳞状细胞癌,36例(36/44,81.8%)为混合性鳞状细胞癌,混合性成分主要为非特殊型浸润性癌和梭形细胞化生性癌(各17例),1例仅合并乳腺导管原位癌成分,1例合并小管癌,鳞状细胞癌的成分占比10%~90%。单纯性鳞状细胞癌常有大的囊腔,囊腔内衬不同异型程度的鳞状上皮,囊腔周围乳腺组织中可见浸润性生长的鳞状细胞癌巢。免疫组织化学染色显示,鳞状细胞癌成分均表达p63和细胞角蛋白5/6,除1例HER21+外,均不表达雌激素受体、孕激素受体和HER2;TRPS1表达率76%;PD-L1表达均0.05)。高TILs组患者预后相比低TILs组较好,单纯性鳞状细胞患者预后相比混合性鳞状细胞癌较好,差异无统计学意义(P>0.05)。结论乳腺鳞状细胞癌分为单纯性鳞状细胞癌和混合性鳞状细胞癌。乳腺单纯性和混合性鳞状细胞癌的大体检查、组织学有差异,应充分取材避免漏诊占比少的肿瘤成分。高TILs组患者预后相比低TILs组较好,但PD-L1表达低,提示不适合免疫治疗。乳腺原发鳞状细胞癌TRPS1表达率较高,可协助与转移性鳞状细胞癌鉴别。

关键词：乳腺肿瘤预后免疫组织化学

充液率和倾角对多年冻土区重力热管传热性能的影响

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冰川冻土 2024年第2期46卷 722-730页

作者：王英梅王茜王俊程马殷军徐安花刘永恒陈继兰州理工大学能源与动力工程学院甘肃兰州730050 中国科学院西北生态环境资源研究院冻土工程国家重点实验室/青藏高原北麓河冻土工程与环境综合观测研究站甘肃兰州730000 甘肃省太阳能与生物质能互补多联供系统重点实验室甘肃兰州730050 中国铁路青藏集团有限公司青海西宁810000 青海交通职业技术学院青海西宁810003

为探讨热管最佳工况,搭建了适用于多年冻土区的氨-钢热管试验台。通过监测热管内部轴向、外壁的温度分布以及外壁面的热流密度变化,在负温条件下开展了不同充液率(20%、30%、40%)和倾角(10°、30°、50°、70°、90°)对热管传热性能影... 详细信息

为探讨热管最佳工况,搭建了适用于多年冻土区的氨-钢热管试验台。通过监测热管内部轴向、外壁的温度分布以及外壁面的热流密度变化,在负温条件下开展了不同充液率(20%、30%、40%)和倾角(10°、30°、50°、70°、90°)对热管传热性能影响的试验。试验结果表明:在三种充液率下,热管处于10°倾角时均温性最佳;充液率为30%和40%的热管倾角50°时总热阻最小、传热效率最高,充液率为20%条件下热管的总热阻和传热效率在倾角30°时分别达到极小值和最高值。总体而言,充液率为30%的热管具有最佳传热表现。

关键词：重力热管管内温度监测倾角充液率传热性能

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妊娠晚期子宫血管自然破裂出血1例

中华围产医学杂志 2024年第4期27卷 328-331页

作者：赵晨旭孙艳李廼珺李洁王颖梅天津医科大学总医院妇产科天津300041 天津市女性生殖健康与优生重点实验室天津300041 山东省潍坊市人民医院妇科潍坊261000

本文报告了1例妊娠晚期子宫血管自然破裂出血的病例。患者因妊娠晚期不规律腹痛入院,考虑有活动性腹腔内出血,行开腹探查术+剖宫产术。术中见近子宫下段右侧壁表面2根血管破裂。先行子宫下段剖宫产术娩出一活婴,新生儿生后1、5和10 min ... 详细信息

本文报告了1例妊娠晚期子宫血管自然破裂出血的病例。患者因妊娠晚期不规律腹痛入院,考虑有活动性腹腔内出血,行开腹探查术+剖宫产术。术中见近子宫下段右侧壁表面2根血管破裂。先行子宫下段剖宫产术娩出一活婴,新生儿生后1、5和10 min Apgar评分分别为7、9、9分。新生儿娩出后,缝扎子宫表面破裂血管,探查腹腔未见其他异常,清理盆腹腔未再见活动性出血,腹腔内出血共1600 ml。术后诊断为子宫表面血管破裂出血、腹腔内出血、子宫多发性平滑肌瘤。术后母儿恢复良好。

关键词：子宫出血腹腔积血妊娠末期

基于CiteSpace的热工基础学科研究热点及趋势分析

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高教学刊 2024年第11期10卷 18-23页

作者：王英梅马高生刘杰兰州理工大学能源与动力工程学院兰州730050 甘肃省生物质能与太阳能互补供能系统重点实验室兰州730050 兰州理工大学西部能源与环境研究中心兰州730050

热工基础是热力学和传热学基础学科,它涉及热力学基本概念、热平衡、热力学循环、传热基本理论等方面。热工基础是工程热物理、热能工程以及新能源科学与工程专业中的一门核心课程,对于工业生产和能源利用具有重要意义。为了解热工基础... 详细信息

热工基础是热力学和传热学基础学科,它涉及热力学基本概念、热平衡、热力学循环、传热基本理论等方面。热工基础是工程热物理、热能工程以及新能源科学与工程专业中的一门核心课程,对于工业生产和能源利用具有重要意义。为了解热工基础学科研究热点与发展趋势,以中国知网(CNKI)收录的177篇发表在北大中文核心期刊和CSSCI期刊上的有关热工基础的文献数据作为样本,借助文献计量学分析软件CiteSpace绘制图谱,对热工基础学科进行可视化分析、热点与前沿分析。最后对相关研究成果进行归纳总结,并对未来该领域的发展提出相关建议。

关键词：热工基础文献计量学分析可视化分析 CiteSpace 知识谱图

基于“医舞融合”理念的中医药特色美育课程探索与实践——以北京中医药大学为例

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中医教育 2024年第2期43卷 120-123页

作者：王英楣叶明花周晓菲陈子杰北京中医药大学北京102488

以北京中医药大学舞蹈特色美育课程为例,在“医舞融合”理念下,以中国古代哲学思想为引领,充分挖掘舞蹈与中医在整体协调、形神兼备、阴阳并举、气韵贯通4个方面的相通之处,并以此为基础,通过理论研究、精心设计,开设具有中医药特色的... 详细信息

以北京中医药大学舞蹈特色美育课程为例,在“医舞融合”理念下,以中国古代哲学思想为引领,充分挖掘舞蹈与中医在整体协调、形神兼备、阴阳并举、气韵贯通4个方面的相通之处,并以此为基础,通过理论研究、精心设计,开设具有中医药特色的国韵养生舞美育课程,使学生在培养健康形体美、塑造人格精神美和展现文化自信美的同时,促进学生对于相关中医思维的体悟,切实提升舞蹈美育课程的教学成效,并在继承与弘扬中国优秀传统文化的基础上,探索具有中医药特色的美育课程有效实施路径。

关键词：中医药特色美育课程医舞融合

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Comparison of the water change characteristics between the formation and dissociation of methane hydrate and the freezing and thawing of ice in sand

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Journal of Natural Gas Chemistry 2009年第2期18卷 205-210页

作者： Peng Zhang Qingbai Wu yingmei wang State Key Laboratory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Lanzhou 730000 Gansu China

Hydrate formation and dissociation processes are always accompanied by water migration in porous media, which is similar to the ice. In our study, a novel pF-meter sensor which could detect the changes of water content inside sand was first applied to hydrate formation and dissociation processes. It also can study the water change characteristics in the core scale of a partially saturated silica sand sample and compare the differences of water changes between the processes of formation and dissociation of methane hydrate and freezing and thawing of ice. The experimental results showed that the water changes in the processes of formation and dissociation of methane hydrate were basically similar to that of the freezing and thawing of ice in sand. When methane hydrate or ice was formed, water changes showed the decrease in water content on the whole and the pF values rose following the formation processes. However, there were very obvious differences between the ice thawing and hydrate dissociation.

关键词： methane hydrate ice formation and dissociation process freezing and thawing process water change

Network Coding Anti-eavesdropping Algorithm for Ad hoc Networks

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Chinese Journal of Electronics 2015年第3期24卷 639-641页

作者： LIU Jun LIU Yi'nan LIU Hui wang yingmei School of Information Science Engineering Northeastern University

Aiming at the anti-eavesdrop security demand and potential safety hazard in Ad hoc, a secure random linear network coding algorithm was proposed. The algorithm has secure source coding and protecting the coding vectors. The information source secure coding method and optimizing the finite region is defined to guarantee that the information is properly protected. Different coding vectors protecting schemes were designed for adapting security path and without. We applied the secure random linear network coding algorithm in Ad Hoc Networks to meet the demand on anti-eavesdrop. The anti-eavesdrop algorithm based on network coding is simulated and analyzed in NS2 platform, the results shown that comparing with the encryption algorithm, the anti-eavesdrop algorithm based on network coding has better performance in end-to-end delay and encryption speed.

关键词： Ad hoc networks Security Antieavesdrop Network coding

Effect of rapidly depressurizing and rising temperature on methane hydrate dissociation

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Journal of Natural Gas Chemistry 2012年第1期21卷 91-97页

作者： Qingbai Wu yingmei wang Jing Zhan State Key Laboratory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of ScienceLanzhou 730000GansuChina

Two methods, rapidly depressurizing to 0.1 MPa at a constant temperature and rising temperature under equilibrium P , T conditions, were used to study the dissociation of pure CH 4 hydrate formed below the ice point. At a constant temperature with rapidly depressurizing to 0.1 MPa, CH 4 hydrate dissociated rapidly at initial dissociation and then the dissociation rate gradually decreased. However, the dissociation of CH 4 hydrate at temperatures of 261 to 266 K was much faster than that at temperatures of 269 to 272 K, indicating its anomalous preservation. Under an equilibrium P , T conditions, rising temperature had extensively controlling impact on dissociation of CH 4 hydrate at equilibrium pressures of 2.31, 2.16 and 1.96 MPa. In this study, we report the effect of pressure on CH 4 hydrate dissociation, especially the effect of equilibrium pressure on dissociation at various melting temperatures. And we find that the ice particles size of CH 4 hydrate formed may dominant the CH 4 hydrate dissociation. Dissociation of CH 4 hydrate formed from ice particles of smaller than 250 μm may not have an anomalous preservation below the ice point, while particles larger than 250 μm may have more extensive anomalous preservation.

关键词： dissociation of CH4 hydrate method of rapid depressurization method of rising temperature

Water transfer characteristics in the vertical direction during methane hydrate formation and dissociation processes inside non-saturated media

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Journal of Natural Gas Chemistry 2010年第2期19卷 139-145页

作者： Peng Zhang Qingbai Wu Guanli Jiang Jing Zhan yingmei wang State Key Laboratory Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 Gansu China

In order to study water transfer characteristics inside non-saturated media during methane hydrate formation and dissociation processes, water changes on the top, middle and bottom locations of experimental media during the reaction processes were continuously followed with a novel apparatus with three pF-meter sensors. Coarse sand, fine sand and loess were chosen as experimental media. It was experimentally observed that methane hydrate was easier formed inside coarse sand and fine sand than inside loess. Methane hydrate formation configuration and water transfer characteristics during methane hydrate formation processes were very different among the different non-saturated media, which were important for understanding methane hydrate formation and dissociation mechanism inside sediments in nature.

关键词： water transfer methane hydrate formation and dissociation processes non-saturated