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Highly anticipated natural diterpenoids as an important source of new drugs in 2013-2023

Chinese Chemical Letters 2025年第1期36卷 119-136页

作者： yingjie wang Peng Tang Wenchao Tu Qi Gao Cuizhu wang Luying Tan Lixin Zhao Hongye Han Liefeng Ma Kouharu Otsuki Weilie Xiao Wenli wang Jinping Liu Yong Li Zhajun Zhan Wei Li Xianli Zhou Ning Li School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning provinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Key Laboratory of Research and Development for Natural ProductsSchool of Pharmacy and School of Chemical Science and TechnologyState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanYunnan UniversityKunming 650091China School of Pharmacy Nantong UniversityNantong 226001China School of Pharmaceutical Sciences Jilin UniversityChangchun 130021China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Pharmaceutical Sciences Zhejiang University of TechnologyHangzhou 310014China Faculty of Pharmaceutical Sciences Toho UniversityFunabashiChiba 274-8510Japan School of Life Science and Engineering Southwest Jiaotong UniversityChengdu 610031China

This review covers the structures of diterpenoids,including chain(72),monocyclic(9),labdane-type(67),clerodane-type(127)abietane-type(716),ent-kaurane-type(89),grayanane-type(331),ingenanetype(55),tigliane-type(154),daphnane-type(237),and aconitine-type diterpene alkaloids(265)with rich biological activities reported in *** the drugs in clinical use or under clinical investigation of diterpenoids and leading compounds were summarized.

关键词： Natural diterpenoids Structures Bioactivities Druggability Leading compounds New drugs

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Viscous Flow Activation Energy and Short-Term Aging Resistance of SBS-Modified Asphalt Enhanced by PPA Oil-Grinding Activated MoS_(2)

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Fluid Dynamics & Materials Processing 2025年第2期21卷 387-404页

作者： Shun Chen yingjie wang Xingyang He Ying Su Yingyuan Pan Yimin Cao Wentian wang Chao Yang Bo Jiang Shaolin Zhang School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan430068China Building Waterproof Engineering and Technology Research Center of Hubei Province Hubei University of TechnologyWuhan430068China Key Laboratory of Intelligent Health Perception and Ecological Restoration of Rivers and Lakes Ministry of EducationHubei University of TechnologyWuhan430068China China Construction Third Bureau First Engineering Co. Ltd.China

Styrene-butadiene-styrene(SBS)modified asphalt(SA)has long found effective applications in road construction *** combined with fillers,SBS-modified asphalt has demonstrated promising resistance to fatigue cracking caused by temperature fluctuations and *** this study,molybdenum disulfide(MoS_(2))and polyphosphoric acid(PPA)were ground in naphthenic oil(NO)and subjected to mechanical activation to create PPAmodified MoS_(2),referred to as *** blending various ratios of OMS-PPA with SBS-modified asphalt,composite-modified asphalts were successfully developed to enhance their overall *** assess the mechanical characteristics and stability of these modified asphalts,various methods were employed,including penetration factor,flow activation energy,fluorescence microscopy,and dynamic shear ***,the short-term aging performance was evaluated using Fourier transform infrared(FTIR)spectroscopy and nanoindentation *** results revealed a 3.7%decrease in the penetration-temperature coefficient for SAOMS compared to SA,while 1-SA-OMS-PPA showed an even greater reduction of 7.1%.Furthermore,after short-term aging,carboxyl group generation in SA increased by 5.93%,while SA-OMS exhibited a smaller rise of 1.36%,and 1-SA-OMS-PPA saw an increase of just 0.93%.The study also highlighted significant improvements in the hardness of these *** hardness change ratio for SA-OMS decreased by 43.08%,while the ratio for 1-SA-OMS-PPA saw a notable reduction of 65.16% compared to unmodified *** findings suggest that OMS-PPA contributed to improvements in temperature sensitivity,particle dispersibility,and resistance to shortterm aging in *** results hold significant promise for the future development of advanced asphalt-based materials with potential high-value applications in flexible pavements for highways.

关键词： Composite-modified asphalt grinding viscous flow activation energy short-term aging collaborated

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自我调节视域下幼儿体育活动理论意蕴、模型建构与实施路径

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河北体育学院学报 2025年第2期39卷 84-90页

作者：王英杰石家庄幼儿师范高等专科学校石家庄050000

依托Zimmerman自我调节理论,结合幼儿的认知发展特点与实际需求,构建涵盖计划-行动-反馈三个阶段的自我调节模型。在计划阶段,重点通过兴趣激发与活动理解,减轻幼儿的认知负担,提高参与积极性。行动阶段则聚焦于动作适应与专注观察,帮... 详细信息

依托Zimmerman自我调节理论,结合幼儿的认知发展特点与实际需求,构建涵盖计划-行动-反馈三个阶段的自我调节模型。在计划阶段,重点通过兴趣激发与活动理解,减轻幼儿的认知负担,提高参与积极性。行动阶段则聚焦于动作适应与专注观察,帮助幼儿在实践中增强行为控制力,提升注意力集中水平。反馈阶段强调自我发现与自我调整,引导幼儿在活动中培养自我认知与反思能力。该模型为幼儿体育活动的设计与实施提供了清晰的实践路径,不仅重视幼儿的个性化发展,也关注其自我调节能力的全面提升,可为学前教育实践提供理论基础和指导策略。

关键词：自我调节能力体育活动学前教育行为控制情绪管理

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双盘轮播式水稻精量穴播机设计与试验

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中国农机化学报 2025年第2期46卷 27-34页

作者：王英杰朱景建刘国文湖州职业技术学院智能制造与电梯学院浙江湖州313000 上海东海职业技术学院机电学院上海市200241

针对水稻精量穴播存在播种效率低、穴合格率低和漏播率大等问题,设计一种带有智能监测装置的双盘轮播式水稻精量穴播机。根据稻种在导种通道的运动轨迹,确定核心部件导种通道的结构,基于光栅对射法设计带有四排对射光电传感器的监测装置... 详细信息

针对水稻精量穴播存在播种效率低、穴合格率低和漏播率大等问题,设计一种带有智能监测装置的双盘轮播式水稻精量穴播机。根据稻种在导种通道的运动轨迹,确定核心部件导种通道的结构,基于光栅对射法设计带有四排对射光电传感器的监测装置,并基于C语言编写控制软件,在监测过程中实现稻种数量数据信号的精确采集和处理,有效提升双盘轮播式精量穴播机的播种性能。利用自制的播种性能检测试验台,对播种盘转速和振动电压进行单因素、两因素三水平试验,确定较优的性能指标:振动电压为80~85 V、播种盘转速为2.5~3.5 r/min时,穴播机的穴合格率均值超过91%,漏播率不超过3.5%,重播率不超过3.6%。可为其他同类装置的设计提供参考。

关键词：水稻双盘轮播精量穴播监测装置导种通道

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The geo-pattern of course shifts of the Lower Yellow River

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Journal of Geographical Sciences 2011年第6期21卷 1019-1036页

作者： wang yingjie SU Yanjun State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

The changing pattern of the Lower Yellow River （LYR） obtained from the traditional studies, which mainly did literal analysis based on historical documents related to the LYR are too macroscopic and absent of intuitiveness. This paper integrates all the records in historical documents related to course shift, flood and overflow of the last 3000 years and stores them in a GIS database. Then, all the data will be visualized in the form of map, which is helpful to show and understand the rules those events conform more intuitively and accurately. Taking these data as foundation, this study summarizes characteristics of the LYR＇s courses and influence scope, and classifies them both into three types; divides the flow directions of the LYR＇s courses into two periods, and proposes its changing pattern; concludes the character- istic of diversion points of courses shift events; calculates the velocity of courses shifts, gra- dient and sinuosity, and analyzes their changing patterns. Finally, this study classifies factors that may influence the occurrence of a course shift into two types： the internal factors, such as sediment rate, gradient and sinuosity of the river, and the external factors, such as precipita- tion and human activities.

关键词： Lower Yellow River course shift visualization geo-pattern

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Predicting the probability distribution of Martian rocks mechanical property based on microscale rock mechanical experiments and accurate grain-based modeling

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International Journal of Mining Science and Technology 2024年第9期34卷 1327-1339页

作者： Shuohui Yin yingjie wang Jingang Liu Engineering Research Center of Complex Tracks Processing Technology and Equipment of Ministry of Education Xiangtan UniversityXiangtan 411105China School of Mechanical Engineering and Mechanics Xiangtan UniversityXiangtan 411105China

The exploration of Mars would heavily rely on Martian rocks mechanics and engineering *** the mechanical property of Martian rocks is uncertain,it is of utmost importance to predict the probability distribution of Martian rocks mechanical property for the success of Mars *** this paper,a fast and accurate probability distribution method for predicting the macroscale elastic modulus of Martian rocks was proposed by integrating the microscale rock mechanical experiments(micro-RME),accurate grain-based modeling(AGBM)and upscaling methods based on reliability ***,the microstructure of NWA12564 Martian sample and elastic modulus of each mineral were obtained by micro-RME with TESCAN integrated mineral analyzer(TIMA)and *** best probability distribution function of the minerals was determined by Kolmogorov-Smirnov(K-S)***,based on best distribution function of each mineral,the Monte Carlo simulations(MCS)and upscaling methods were implemented to obtain the probability distribution of upscaled elastic ***,the correlation between the upscaled elastic modulus and macroscale elastic modulus obtained by AGBM was *** accurate probability distribution of the macroscale elastic modulus was obtained by this correlation *** proposed method can predict the probability distribution of Martian rocks mechanical property with any size and shape samples.

关键词： Probability distribution Martian rocks Microscale rock mechanic experiment Nanoindentation Accurate grain-based modeling

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Ideals in the Roe Algebras of Discrete Metric Spaces with Coefficients in B(H)

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Chinese Annals of Mathematics,Series B 2009年第2期30卷 139-144页

作者： yingjie HU Qin wang Department of Applied Mathematics Donghua University Shanghai 201620 China

The notion of an ideal family of weighted subspaces of a discrete metric space X with bounded geometry is introduced. It is shown that, if X has Yu’s property A, the ideal structure of the Roe algebra of X with coefficients in B(H) is completely characterized by the ideal families of weighted subspaces of X, where B(H) denotes the C*-algebra of bounded linear operators on a separable Hilbert space H.

关键词： Roe algebra Ideal Metric space Coarse geometry Band-dominatedoperator

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In-plane dynamics of a fluid-conveying corrugated pipe supported at both ends

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Applied Mathematics and Mechanics(English Edition) 2019年第8期40卷 1119-1134页

作者： yingjie wang Qichang ZHANG Wei wang Tianzhi YANG Tianjin Key Laboratory of Nonlinear Dynamics and Control Department of MechanicsSchool of Mechanical EngineeringTianjin University

The dynamics and stability of fluid-conveying corrugated pipes are investigated. The flow velocity is assumed to harmonically vary along the pipe rather than with time. The dimensionless equation is discretized with the differential quadrature method (DQM). Subsequently, the effects of the mean flow velocity and two key parameters of the corrugated pipe, i.e., the amplitude of the corrugations and the total number of the corrugations, are studied. The results show that the corrugated pipe will lose stability by flutter even if it has been supported at both ends. When the total number of the corrugations is sufficient, this flutter instability occurs at a micro flow velocity. These phenomena are verified via the Runge-Kutta method. The critical flow velocity of divergence is analyzed in detail. Compared with uniform pipes, the critical velocity will be reduced due to the corrugations, thus accelerating the divergence instability. Specifically, the critical flow velocity decreases if the amplitude of the corrugations increases. However, the critical flow velocity cannot be monotonously reduced with the increase in the total number of the corrugations. An extreme point appears, which can be used to realize the parameter optimization of corrugated pipes in practical applications.

关键词： fluid-structure interaction fluid-conveying corrugated pipe differential quadrature method (DQM) bifurcation flutter

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父母养育心理灵活性的概念、影响和作用后效

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湖州师范学院学报 2025年第1期47卷 41-49页

作者：沈靖怡王英杰湖州师范学院教育学院(教师教育学院) 浙江湖州313000

父母养育心理灵活性是指在养育孩子的过程中,父母有意觉察且接纳当下自己对孩子的负面想法、情绪及冲动,以及通过调节自身与坚持正确的价值观来改变消极行为促进儿童健康发展的一种能力。对父母养育心理灵活性的概念辨析、影响因素和作... 详细信息

父母养育心理灵活性是指在养育孩子的过程中,父母有意觉察且接纳当下自己对孩子的负面想法、情绪及冲动,以及通过调节自身与坚持正确的价值观来改变消极行为促进儿童健康发展的一种能力。对父母养育心理灵活性的概念辨析、影响因素和作用后效进行整理,认为未来研究需要拓展研究对象和方法、挖掘父母养育心理灵活性对儿童发展的作用机制、重视我国文化背景下父母养育心理灵活性训练,以及深入探讨父亲的养育心理灵活性。

关键词：养育心理灵活性正念养育养育效能感

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Multi-Objective Task Assignment for Maximizing Social Welfare in Spatio-Temporal Crowdsourcing

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China Communications 2021年第11期18卷 11-25页

作者： Shengnan Wu yingjie wang Xiangrong Tong School of Computer and Control Engineering Yantai UniversityYantai 264005China

With the development of the Internet of Things(IoT),spatio-temporal crowdsourcing(mobile crowdsourcing)has become an emerging paradigm for addressing location-based sensing ***,the delay caused by network transmission has led to low data processing ***,edge computing can solve this problem,effectively reduce the delay of data transmission,and improve data processing capacity,so that the crowdsourcing platform can make better decisions ***,this paper combines spatio-temporal crowdsourcing and edge computing to study the Multi-Objective Optimization Task Assignment(MOO-TA)problem in the edge computing *** proposed online incentive mechanism considers the task difficulty attribute to motivate crowd workers to perform sensing tasks in the unpopular *** this paper,the Weighted and Multi-Objective Particle Swarm Combination(WAMOPSC)algorithm is proposed to maximize both platform’s and crowd workers’utility,so as to maximize social *** algorithm combines the traditional Linear Weighted Summation(LWS)algorithm and Multi-Objective Particle Swarm Optimization(MOPSO)algorithm to find pareto optimal solutions of multi-objective optimization task assignment problem as much as possible for crowdsourcing platform to *** comparison experiments on real data sets,the effectiveness and feasibility of the proposed method are evaluated.

关键词： spatio-temporal crowdsourcing edge computing task assignment multi-objective optimization particle swarm optimization Pareto optimal solution

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