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Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2024年第9期19卷 2081-2088页

作者： Xiaoli Fang Sha Liu Bilal Muhammad Mingxuan Zheng Xing Ge Yan Xu Shu Kan Yang Zhang yinghua yu Kuiyang Zheng Deqin Geng Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Disease and Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal *** dysfunction can precede the onset of motor symptoms by several *** microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain ***/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease *** this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota *** found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor ***,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with ***,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and *** of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier *** results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s ***,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that c

关键词： C/EBP/AEP signaling pathway endotoxemia fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease

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Characteristics of geological structures in Shiling and Zhuanshanhu areas of Yehe Uplift,NE China

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Global Geology 2024年第2期27卷 105-120页

作者： GUAN yue yu yinghua ZHANG Yaxiong yuAN Hongqi Key Laboratory of Oil and Gas Reservoir Formation Mechanism and Resource Evaluation in Heilongjiang Province Daqing 163318HeilongjiangChina Sinopec Petroleum Exploration and Production Research Institute Beijing 100083China

The basin marginal fault system is the key to understand the formation and evolution of Songliao *** order to investigate the influence of marginal fault system on the structural evolution of Songliao Basin,a comprehensive study was conducted on Shiling Town and Zhuanshanhu area of Yehe Town in Siping City of Jilin Province,where is the southeastern margin of the Songliao Basin and there are a series of well-exposed fault,fold and intrusive bodies belonging to the main marginal fault system of the Songliao Basin known as the Jiamusi-Yitong(Jia-Yi)fault *** profile measurement and field investigation,samples with various lithologies and distinctive features were *** field and laboratory works include component and microstructure analysis of these samples,rock-rock contact analysis,main strike measurement and statistics *** data reveal the structural characteristics of the fold,fault and intrusive bodies in the study *** research results show that the folds are distributed in the Mesozoic strata near the main fault of the eastern branch of the Jia-Yi fault zone,and the folded strata involve the Cretaceous Denglouku and Quantou *** addition,the section is dominated by high-angle strikeslip thrust ***-colored veins and dark-colored veins are extensively distributed in the exposed *** analysis of joint and fault attitudes in the study area reveals a right-lateral strike-sliping along the main *** large-scale right-lateral strike-slip and thrust fault system in Shiling Town occurred in right-lateral transpressive stage in Late *** on the results above,tectonic evolution sequence in Shiling section of the Jia-Yi fault zone during the Mesozoic can be divided into five stages:Middle Jurassic left-lateral ductile strike-slip stage,Late Jurassic compression stage,Early Cretaceous tension stage,Early Cretaceous extension stage and Late Cretaceous right-lateral transpressive stage

关键词： Jia-Yi fault structural characteristics evolution sequence Shiling Zhuanshanhu northern segment Tanlu fault

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断裂破坏区域性泥岩盖层程度研究方法的改进

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地质科学 2024年第4期59卷 1048-1056页

作者：刘云鑫于英华袁红旗东北石油大学黑龙江省油气成藏形成机理与资源评价重点实验室黑龙江大庆163318

为了更加准确地研究断裂破坏区域性泥岩盖层程度,基于断裂破坏区域性泥岩盖层机理及程度的影响因素,通过断层岩和区域性泥岩盖层压实成岩程度代替其排替压力,改进了断裂破坏区域性泥岩盖层程度的研究方法,并将改进前后方法分别应用于研... 详细信息

为了更加准确地研究断裂破坏区域性泥岩盖层程度,基于断裂破坏区域性泥岩盖层机理及程度的影响因素,通过断层岩和区域性泥岩盖层压实成岩程度代替其排替压力,改进了断裂破坏区域性泥岩盖层程度的研究方法,并将改进前后方法分别应用于研究海拉尔盆地贝尔凹陷呼和诺仁构造F1断裂破坏大一下段区域性泥岩盖层程度。结果表明:改进前后方法研究均得到测点9处F1断裂破坏大一下段区域性泥岩盖层程度最大,测点13处最小,其余测点介于二者之间,在测点1~8和12~15处有利于南一段源岩生成油气在大一下段区域性泥岩盖层之下南二段聚集与保存,但测点1~6无油气发现,是由于其构造位置低,油气供给不足,未充满所致,与目前F1断裂处南二段已发现油气分布相吻合。改进前方法研究成果虽与改进后方法研究成果具有相同的变化规律,但其值相对较大,低估了F1断裂破坏大一下段区域性泥岩盖层程度,表明改进后方法研究结果可能更符合地下实际,而且方便易行。

关键词：断裂区域性泥岩盖层破坏程度改进方法

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织构化盘式摩擦副性能及优化设计研究

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中国机械工程 2024年第10期35卷 1774-1782页

作者：徐平罗晶于英华沈佳兴黎文利辽宁工程技术大学机械工程学院阜新123000

为探索提高盘式摩擦副抗摩擦磨损性能的有效途径,以斜盘柱塞泵配流副为研究对象,综合运用仿真分析及试验研究方法对比分析了面积织构率和截深形状相同条件下,椭圆开口和圆形开口离散凹坑微织构及沟槽形微织构配流副的摩擦因数随织构形... 详细信息

为探索提高盘式摩擦副抗摩擦磨损性能的有效途径,以斜盘柱塞泵配流副为研究对象,综合运用仿真分析及试验研究方法对比分析了面积织构率和截深形状相同条件下,椭圆开口和圆形开口离散凹坑微织构及沟槽形微织构配流副的摩擦因数随织构形貌、转速和压力的变化规律。研究结果表明:摩擦因数随转速的增大而显著降低,随压力的增大而降低,椭圆开口离散凹坑微织构为三种微织构中提高配流副性能最优者。对椭圆开口离散凹坑微织构进行多目标参数优化,得出的最优参数为:椭圆开口长轴半径为452μm、短半轴为187μm、径向中心距为0.7 mm。试验结果表明,优化后的织构在不同工况下较优化前摩擦因数和磨损量均有不同程度的降低。

关键词：盘式摩擦副微织构摩擦磨损参数优化转速应力

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BFPC固定结合面虚拟材料热特性参数建模

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辽宁工程技术大学学报（自然科学版） 2024年第1期43卷 62-67页

作者：于英华朱华杰曹泉沈佳兴阮文新辽宁工程技术大学机械工程学院辽宁阜新123000 珠海格力电器股份有限公司广东珠海519070

为确定含有玄武岩纤维树脂混凝土(basalt fiber polymer concrete,BFPC)固定结合面的机床基础件热特性参数,基于虚拟材料法建立了含有BFPC固定结合面组件的仿真模型,并对其热特性进行仿真分析;设计制造了含有BFPC固定结合面的组件,通过... 详细信息

为确定含有玄武岩纤维树脂混凝土(basalt fiber polymer concrete,BFPC)固定结合面的机床基础件热特性参数,基于虚拟材料法建立了含有BFPC固定结合面组件的仿真模型,并对其热特性进行仿真分析;设计制造了含有BFPC固定结合面的组件,通过实验方法研究组件的热特性。将仿真分析和实验研究的结果进行对比,分析表明:两种方法得到的组件在不同时刻的温度场具有一致性,且仿真与对应实验点温度的误差不大于8.57%,证明了所建立的BFPC固定结合面虚拟材料参数模型的准确性,以及基于此采用虚拟材料法对含有BFPC固定结合面组件进行热特性仿真分析的精确性和有效性。

关键词：玄武岩纤维树脂混凝土结合面热特性虚拟材料

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轴向柱塞泵配流副椭圆开口偏置类抛物线微织构多目标优化

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机械科学与技术 2024年第7期43卷 1189-1198页

作者：徐平罗晶董立鹏于英华沈佳兴黎文利辽宁工程技术大学机械工程学院辽宁阜新123008 重庆铁马工业集团有限公司重庆400709

为了提高轴向柱塞泵配流副承载性能、抗摩擦磨性能及容积效率,以某型斜盘式轴向柱塞泵配流盘为原型开展研究。首先,依据正交实验理论采用CFD方法研究椭圆开口偏置抛物线微织构(Elliptic opening offset parabola micro texture, EOOPT)... 详细信息

为了提高轴向柱塞泵配流副承载性能、抗摩擦磨性能及容积效率,以某型斜盘式轴向柱塞泵配流盘为原型开展研究。首先,依据正交实验理论采用CFD方法研究椭圆开口偏置抛物线微织构(Elliptic opening offset parabola micro texture, EOOPT)形状参数对轴向柱塞泵配流副承载压强、摩擦因数的影响规律,并联合运用神经网络和遗传算法对EOOPT的形状参数进行优化设计。其次,运用响应面分析方法研究EOOPT分布参数对配流副承载压强、摩擦因数和泄漏量的影响规律,并对形状参数进行优化设计。最后对最优特征参数EOOPT织构化的柱塞泵配流副和未织构的相关性能进行对比分析,结果表明,前者的承载压强较后者提高11.23%,摩擦因数和泄漏量分别减低16.67%和2.96%。

关键词：配流副微织构承载压强泄漏量多目标优化

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“中文+职业技能”短期培训融合教学的实施策略--以北京经济管理职业学院为例

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北京财贸职业学院学报 2024年第3期40卷 47-51页

作者：赵蓉杨光罗祥远于英华北京经济管理职业学院北京100102

“中文+职业技能”教育是助力中国职业教育“走出去”的重要部分,但目前仍处于起步阶段,面临诸多挑战,其中之一是存在着中文课与职业技能课两者割裂的“两张皮”现象。以北京经济管理职业学院短期培训为例,提出中文与职业技能双向内嵌... 详细信息

“中文+职业技能”教育是助力中国职业教育“走出去”的重要部分,但目前仍处于起步阶段,面临诸多挑战,其中之一是存在着中文课与职业技能课两者割裂的“两张皮”现象。以北京经济管理职业学院短期培训为例,提出中文与职业技能双向内嵌为核心,实施“双嵌入”融合教学策略,围绕具体的中文和职业技能双目标,将中文学习嵌入技能教学,技能学习嵌入中文教学,形成易操作、可复制的教学模式,使学习者同时获得语言和职业技能的双重收益。

关键词：中文+职业技能融合教学短期培训

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Homochiral design of titanium-organic cage for circularly polarized luminescence-based molecular detection

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中国科学:化学英文版 2023年第9期66卷 2558-2562页

作者： Guang-Hui Chen Yan-Ping He yinghua yu Qiao-Hong Li Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Post-assembly modification strategy is used as an effective approach to improve the functional applications of metal-organic cages. The active vertex of the racemic tetrahedral Ti4L6(L = embonate) cages traps four chiral diamine chelated dinuclear silver ions, obtaining homochiral cages which exhibit helical perovskite stacks. Such a surface modification engineering enables the structural precise cages presenting homochirality and circularly polarized luminescence(CPL) response, further achieving enantioselective recognition toward chiral Camphorquinone molecules and displaying enhanced temperature-dependent effects of CPL output.

关键词： chiral recognition circularly polarized luminescence post-assembly modification titanium-organic cages

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Water Role and Its Influence on Hydrogen Isotopic Composition of Natural Gas during Gas Generation

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Acta Geologica Sinica(English Edition) 2011年第5期85卷 1203-1210页

作者： Jijun LI Shuangfang LU Wei WU Haitao XUE Qingxia XU Jie GENG yinghua yu College of Earth Sciences Northeast Petroleum University Daqing Heilongjiang 163318 China Luliang Operating District of Xinjiang Oilfield Company Karamay Xinjiang 834000 China Exploration and Development Research Institute Daqing Oilfield Company Ltd. Daqing Heilongjiang 163712 China

In order to discuss the role and influence of water during the generation of natural gas,the participation mechanism of water during the evolution of organic matter and its influences were *** addition,we carried out an anhydrous cracking experiment of oil extracted from the Feixianguan Formation source rock in a closed system,which led to the establishment of the kinetic models for describing carbon and hydrogen isotopic fractionation during gas generation from organic *** models were calibrated and then applied to the northeastern Sichuan *** combining a series of gas generation experiments from octadecane pyrolysis without water or with distilled water in varying mass proportions,several results were proved:(1) the hydrogen isotopic composition of natural gas becomes lighter with the participation of formation water;(2) we can quantitatively study the hydrogen isotopic fractionation with the kinetic model for describing carbon isotopic fractionation; (3) more abundant and reliable geological information can be obtained through the combined application of carbon and hydrogen isotopic indices.

关键词： natural gas formation water free radical carbonium ion carbon and hydrogen isotopic fractionation kinetics

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Activated PKB/GSK-3β synergizes with PKC-δ signaling in attenuating myocardial ischemia/reperfusion injury via potentiation of NRF2 activity: Therapeutic efficacy of dihydrotanshinone-Ⅰ

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Acta Pharmaceutica Sinica B 2021年第1期11卷 71-88页

作者： Hao Zengy Lingling Wangy Jiawei Zhang Ting Pan yinghua yu Jingxia Lu Ping Zhou Hua Yang Ping Li State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Disrupted redox status primarily contributes to myocardial ischemia/reperfusion injury(MIRI).NRF2,the endogenous antioxidant regulator,might provide therapeutic ***-Ⅰ(DT)is an active component in Salvia miltiorrhiza with NRF2 induction *** study seeks to validate functional links between NRF2 and cardioprotection of DT and to investigate the molecular mechanism particularly emphasizing on NRF2 cytoplasmic/nuclear *** potently induced NRF2 nuclear accumulation,ameliorating post-reperfusion injuries via redox *** cardioprotection in NRF2-deficient mice and cardiomyocytes strongly supports NRF2-dependent cardioprotection of ***,DT phosphorylated NRF2 at Ser40,rendering its nuclear-import by dissociating from KEAP1 and inhibiting ***,we identified PKC-δ-(Thr505)phosphorylation as primary upstream event triggering NRF2-(Ser40)*** of PKC-δdramatically retained NRF2 in cytoplasm,convincing its pivotal role in mediating NRF2 ***2 activity was further enhanced by activated PKB/GSK-3βsignaling via nuclear-export signal blockage independent of PKC-δ*** demonstrating independent modulation of PKC-δand PKB/GSK-3β/Fyn signaling,we highlight the ability of DT to exploit both nuclear import and export regulation of NRF2 in treating reperfusion injury harboring redox homeostasis *** of PKC and PKB phenocopied cardioprotection of DT in vitro and in vivo,further supporting the potential applicability of this rationale.

关键词： DihydrotanshinoneⅠ NRF2 Cytoplasmic/nuclear translocation PKC-δ PKB/GSK-3β/Fyn Phosphorylation Redox homeostasis Ischemia/reperfusion injury

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