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Machine learning for predicting fatigue properties of additively manufactured materials

Chinese Journal of Aeronautics 2024年第4期37卷 1-22页

作者： Min YI Ming XUE Peihong CONG Yang SONG Haiyang ZHANG lingfeng WANG liucheng ZHOU yinghong li Wanlin GUO State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenyang Engine Research Institute Shenyang 110015China liaoning Key Laboratory of Impact Dynamics on Aero Engine Shenyang 110015China Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an 710038China

Fatigue properties of materials by Additive Manufacturing(AM) depend on many factors such as AM processing parameter, microstructure, residual stress, surface roughness, porosities, post-treatments, etc. Their evaluation inevitably requires these factors combined as many as possible, thus resulting in low efficiency and high cost. In recent years, their assessment by leveraging the power of Machine Learning(ML) has gained increasing attentions. A comprehensive overview on the state-of-the-art progress of applying ML strategies to predict fatigue properties of AM materials, as well as their dependence on AM processing and post-processing parameters such as laser power, scanning speed, layer height, hatch distance, built direction, post-heat temperature,etc., were presented. A few attempts in employing Feedforward Neural Network(FNN), Convolutional Neural Network(CNN), Adaptive Network-Based Fuzzy Inference System(ANFIS), Support Vector Machine(SVM) and Random Forest(RF) to predict fatigue life and RF to predict fatigue crack growth rate are summarized. The ML models for predicting AM materials' fatigue properties are found intrinsically similar to the commonly used ones, but are modified to involve AM features. Finally, an outlook for challenges(i.e., small dataset, multifarious features,overfitting, low interpretability, and unable extension from AM material data to structure life) and potential solutions for the ML prediction of AM materials' fatigue properties is provided.

关键词： Additive manufacturing Machine learning Fatigue life Fatigue crack growth rate Prediction

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Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2567-2580页

作者： Hongying li Jianrui li Jiayu li Hu li Xuekai Wang Jing Jiang Lei Lei Han Sun Mei Tang Biao Dong Weiqing He Shuyi Si Bin Hong yinghong li Danqing Song Zonggen Peng Yongsheng Che Jian-Dong Jiang CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Key Laboratory of Biotechnology of Antibiotics the National Health and Family Planning Commission(NHFPC)Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs with broad-spectrum antiviral ***,we show that carrimycin,a new macrolide antibiotic in the clinic and an antiviral candidate for SARS-CoV-2 in phase III trials,decreases the efficiency of programmed–1 ribosomal frameshifting of coronaviruses and thus impedes viral replication in a broad-spectrum *** binds directly to the coronaviral frameshift-stimulatory element(FSE)RNA pseudoknot,interrupting the viral protein translation switch from ORF1a to ORF1b and thereby reducing the level of the core components of the viral replication and transcription *** carrimycin with known viral replicase inhibitors yielded a synergistic inhibitory effect on *** the FSE mechanism is essential in all coronaviruses,carrimycin could be a new broad-spectrum antiviral drug for human coronaviruses by directly targeting the conserved coronaviral FSE *** finding may open a new direction in antiviral drug discovery for coronavirus variants.

关键词： Carrimycin Coronavirus Broad-spectrum antiviral activity Programmed-1 ribosomal frameshifting RNA pseudoknot Antiviral agent RNA target Synergistic inhibitory effect

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Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1

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Chinese Chemical Letters 2024年第5期35卷 201-206页

作者： Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan yinghong li Rongmei Gao Yuhuan li Hongbin Deng Jiandong Jiang Yanxiang Wang Danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272000China

Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and *** them,compound 6b displayed a moderate anti-human coronavirus OC43(HCoV-OC43)potency and blocked the viral entry stage through a host mechanism of *** chemoproteomic techniques,both transmembrane serine protease 2(TMPRSS2)and scavenger receptor class B type 1(SR-B1)proteins,which act as host cofactors of viral entry,were identified to be the direct targets of 6b against ***,6b may deactivate the TMPRSS2 by inducing a change in protein conformation,rather than binding to its catalytic center,thus suppressing the viral membrane ***,our study provided key scientific data for the development of aloperine derivatives into a new class of antiviral candidates against humanβ-coronavirus,including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： Aloperine SARS-CoV-2 TMPRSS2 SR-B1 Synthesis

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单细胞转录组学细胞动态分化数据模拟算法的比较与评估

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重庆师范大学学报（自然科学版） 2024年第1期41卷 125-132页

作者：朵泓睿李映红李勃重庆师范大学生命科学学院重庆401331 重庆邮电大学生物信息学院重庆400065

对9种单细胞转录组学(single cell RNA sequencing,scRNA-seq)细胞动态分化数据模拟算法进行系统性地比较和评估,为算法的开发者和用户提供可靠的参考和帮助。利用多种评价指标对上述算法在准确性、可拓展性、适用性等3个方面进行全面评... 详细信息

对9种单细胞转录组学(single cell RNA sequencing,scRNA-seq)细胞动态分化数据模拟算法进行系统性地比较和评估,为算法的开发者和用户提供可靠的参考和帮助。利用多种评价指标对上述算法在准确性、可拓展性、适用性等3个方面进行全面评估,并对运行时间和内存消耗情况进行建模预测。结果显示:9种被评估的算法均不能在数据特征与拓扑结构这2个方面同时有完美的表现;算法Dyngen虽然能模拟与参考数据拓扑结构和细胞分化轨迹相似度较高的数据,但是它的运行时间较长且内存消耗过大;将近一半的算法还需要及时更新版本信息并维护相关功能。用户在使用scRNA-seq细胞动态分化数据模拟算法时应综合考虑不同的使用场景和特点来选择最适合的模拟算法。

关键词：单细胞转录组学动态分化数据模拟算法评估

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水电站运行标准化与智能化监测技术的创新与实践

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中国高新科技 2024年第9期 58-60页

作者：李英鸿国能长源恩施水电开发有限公司湖北恩施445000

研究水电站运行标准化与智能化监测技术,旨在提高水电站的运行效率、降低事故风险、实现经济效益最大化。通过本研究,可高效规范水电站运行管理流程,提高管理水平和运维效率。最终目的为实现水电站的智能化监测和管理,实时掌握水电站的... 详细信息

研究水电站运行标准化与智能化监测技术,旨在提高水电站的运行效率、降低事故风险、实现经济效益最大化。通过本研究,可高效规范水电站运行管理流程,提高管理水平和运维效率。最终目的为实现水电站的智能化监测和管理,实时掌握水电站的运行状态,及时发现问题并采取措施加以解决。

关键词：水电站运行标准化

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Improving aircraft aerodynamic performance with bionic wing obtained by ice shape modulation

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Chinese Journal of Aeronautics 2023年第2期36卷 76-86页

作者： like XIE Hua liANG Haohua ZONG Yun WU yinghong li Zhi SU Xuecheng liU Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi'an 710038China School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049China

For Unmanned Aerial Vehicles(UAVs)with limited electrical power to achieve effectively anti-/de-icing at the leading edge of the wing,a strategy of ice shape modulation was *** simulated ice shape pieces printed by 3D printing technology are mounted on a NACA0012 finite wing model,and its lift/drag coefficients and suction-side velocity fields are measured by the six-component force balance and the Particle Imaging Velocimetry(PIV),*** ratio of the spanwise length of a single ice shape piece to chord length and the spanwise length of the non-icing area between the two adjacent single ice shape pieces are defined as dimensionless ice shape length(w/c)and dimensionless modulation ratio(w/λ),*** results indicate that for a fixed w/λ,the wing lift coefficient first increases and then drops with increasing w/c,and a peak value exists when w/c is between 0.1 and *** lower the w/λis,the higher the wing lift coefficient will *** periodical variation of the flow separation area along the spanwise direction is attributed on the one hand to the acceleration effect of the flow field in the non-icing area which reduces the separation area,and on the other hand to the cross-flow caused by the streamwise vortices from the non-icing area to the icing area which promotes the mixing of the flow field(similar to vortex generators).The obtained modulation law is verified through flight tests and provides guidance for the use of ice shape modulation scheme for UAVs that cannot be completely anti-/deicing under severe weather conditions.

关键词： Dimensionless ice shape length Dimensionless modulation ratio Ice shape modulation NACA0012 finite wing Particle imaging velocimetry(PIV) Unmanned aerial vehicles(UAVs)

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制药用水系统中主要微生物类型及控制措施

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中国现代应用药学 2024年第3期41卷 415-419页

作者：李樱红张林爽李珏郑小玲王征南王银环陈君豪洪亮陶巧凤陈欢浙江省食品药品检验研究院 NMPA微生物检测与预警重点实验室浙江省药品接触材料质量控制研究重点实验室杭州310052 台州市药品检验研究院浙江台州318000 杭州微数生物科技有限公司杭州311231

目的对制药用水中主要微生物类型及控制措施进行分析,为制药用水系统的有效控制提供指导。方法分析饮用水、纯化水、注射用水中主要微生物种类、丰度及其危害性,并探讨制药用水中微生物的控制措施。结果制药用水中主要微生物类型存在差... 详细信息

目的对制药用水中主要微生物类型及控制措施进行分析,为制药用水系统的有效控制提供指导。方法分析饮用水、纯化水、注射用水中主要微生物种类、丰度及其危害性,并探讨制药用水中微生物的控制措施。结果制药用水中主要微生物类型存在差异,洋葱伯克霍尔德菌复合体和皮氏罗尔斯顿菌是潜在的条件致病菌,可造成生物安全隐患。结论制药企业可通过建立各级水系统微生物数据库及常见微生物菌种库,应基于警戒限和行动限进行趋势分析,从而加强对水系统中微生物的控制。

关键词：制药用水微生物洋葱伯克霍尔德菌复合体皮氏罗尔斯顿菌控制措施

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OIP5 Interacts with NCK2 to Mediate Human Spermatogonial Stem Cell Self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： yinghong Cui Wei Chen li Du Zuping He The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

Spermatogonial stem cells(SSCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human SSCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human SSCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-MS(mass spectrometry),and GST pulldown ***2 silencing decreased human SSC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human SSCs at S and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human SSC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human SSCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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Author correction to‘Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects’[Acta Pharmaceutica Sinica B 13(2023)2138-2151]

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1477-1477页

作者： Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan yinghong li Hongbin Deng liping Zhao Xintong Zhang Yonghua liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

The authors regret that there are some misplaced figure numbers in the body of this article due to negligence in the layout and proofreading of the *** it does not affect the conclusion,it is an obvious *** authors ha... 详细信息

关键词： journal correction conclusion

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固本培元方治疗脾肾阳虚型癌因性疲乏临床观察

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中国中医药现代远程教育 2024年第7期22卷 103-106页

作者：李应宏郝文婕张宇杰王沛李振清李霞甘肃省武威肿瘤医院中西医结合科甘肃武威733000

目的探讨固本培元方治疗脾肾阳虚型癌因性疲乏的临床效果。方法选择脾肾阳虚型癌因性疲乏患者120例,按随机数字表法分为对照组和观察组,各60例。对照组采用西医治疗,观察组在对照组基础上加用固本培元方,观察周期为4周。比较两组患者治... 详细信息

目的探讨固本培元方治疗脾肾阳虚型癌因性疲乏的临床效果。方法选择脾肾阳虚型癌因性疲乏患者120例,按随机数字表法分为对照组和观察组,各60例。对照组采用西医治疗,观察组在对照组基础上加用固本培元方,观察周期为4周。比较两组患者治疗后Piper疲乏量表(PFS)评分、中医证候评分、生命质量评分、机体功能状态评分,以及治疗期间不良反应情况。结果治疗后,观察组PFS评分和中医证候评分均低于对照组,卡氏(KPS)评分和生命质量评分均高于对照组(P<0.05);且观察组血常规、肝功能、肾功能、尿常规、粪便常规相关指标恢复正常比例均明显高于对照组(P<0.05)。结论固本培元方能够显著改善脾肾阳虚型癌因性疲乏患者的疲乏状态,提升其生命质量和机体功能状态,改善中医证候,安全性更高。

关键词：虚劳癌因性疲乏脾肾阳虚证固本培元方中医药疗法

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