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Damage Diagnosis of Bleacher Based on an Enhanced Convolutional Neural Network with Training Interference

Structural Durability & Health Monitoring 2024年第3期18卷 321-339页

作者： Chaozhi Cai Xiaoyu Guo yingfang xue Jianhua Ren School of Mechanical and Equipment Engineering Hebei University of EngineeringHandan056038China

Bleachers play a crucial role in practical engineering applications, and any damage incurred during their operationposes a significant threat to the safety of both life and property. Consequently, it becomes imperative to conductdamage diagnosis and health monitoring of bleachers. The intricate structure of bleachers, the varied types ofpotential damage, and the presence of similar vibration data in adjacent locations make it challenging to achievesatisfactory diagnosis accuracy through traditional time-frequency analysis methods. Furthermore, field environmentalnoise can adversely impact the accuracy of bleacher damage diagnosis. To enhance the accuracy and antinoisecapabilities of bleacher damage diagnosis, this paper proposes improvements to the existing ConvolutionalNeural Network with Training Interference (TICNN). The result is an advanced Convolutional Neural Networkmodel with superior accuracy and robust anti-noise capabilities, referred to as Enhanced TICNN (ETICNN).ETICNN autonomously extracts optimal damage-sensitive features from the original vibration data. To validatethe superiority of the proposed ETICNN, experiments are conducted using the bleacher model from Qatar Universityas the subject. Comparative studies under identical experimental conditions involve TICNN, Deep ConvolutionalNeural Networks with wide first-layer kernels (WDCNN), and One-Dimensional ConvolutionalNeural Network (1DCNN). The experimental findings demonstrate that the ETICNN model achieves the highestaccuracy, approximately 99%, and exhibits robust classification abilities in both Phases I and II of the damagediagnosis experiments. Simultaneously, the ETICNN model demonstrates strong anti-noise capabilities, outperformingTICNN by 3% to 4% and surpassing other models in performance.

关键词： Bleacher vibration signal damage diagnosis convolutional neural network anti-noise ability

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ERβ-activated LINC01018 promotes endometriosis development by regulating the CDC25C/CDK1/CyclinB1 pathway

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Journal of Genetics and Genomics 2024年第6期51卷 617-629页

作者： Ruihui Lu Jingwen Zhu Xin Li Cheng Zeng Yan Huang Chao Peng yingfang Zhou Qing xue Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Endometriosis refers to as an estrogen-dependent *** receptorβ(ERB),the main estrogen receptor subtype which is encoded by the estrogen receptor 2(ESR2)gene,can mediate the action of estrogen in *** selective estrogen receptor modulators can target the ERβ,they are not specific due to the wide distribution of ERβ.Recently,long noncoding RNAs have been implicated in ***,we aim to explore and validate the downstream regulatory mechanism of ERβ,and to investigate the potential role of long intergenic noncoding RNA 1018(LINC01018)as a nonhormonal treatment for *** study demonstrates that the expression levels of ESR2 and LINCo1018 are increased in ectopic endometrial tissues and reveals a significant positive correlation between the ESR2 and LINCo1018 ***,ERβdirectly binds to an estrogen response element located in the LINCO1018 promoter region and activates LINC01018 ***,ERβcan regulate the CDC25C/CDK1/CyclinB1 pathway and promote ectopic endometrial stromal cell proliferation via LINC01018 in *** with these findings,the knockdown of LINC01018 inhibits endometriotic lesion proliferation in *** summary,our study demonstrates that the ERβ/LINC01018/CDC25C/CDK1/CyclinB1 signaling axis regulates endometriosis progression.

关键词： Estrogen receptorβ Long intergenic noncoding RNA 1018 (LINC01018) Endometriosis Cell cycle Proliferation

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Chemotactic nanomotor for multimodal combined therapy of glioblastoma

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Science China Chemistry 2024年第4期67卷 1277-1288页

作者： Ting Li Lin Chen Yunxin xue Xiangyu Xiao Wenjun Dai Kaiyuan Tan Tiantian Chen yingfang Tao Chun Mao Jian Shen Mimi Wan National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.

关键词： chemotaxis combined therapy glioblastoma nanomotors

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固溶温度对冷轧双相不锈钢管组织和力学性能的影响

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金属热处理 2015年第9期40卷 167-170页

作者：曹晶晶赵文武薛应芳靳利翠河北工程大学机电学院河北邯郸056038

以S31803冷轧双相不锈钢管为研究对象,采用扫描电镜观察、α相面积分析、硬度和拉伸测试等手段研究了不同固溶处理温度对其显微组织和力学性能的影响。结果表明,热处理前,双相钢的α/γ两相组织在冷轧变形过程中沿平行轧向明显被拉长,... 详细信息

以S31803冷轧双相不锈钢管为研究对象,采用扫描电镜观察、α相面积分析、硬度和拉伸测试等手段研究了不同固溶处理温度对其显微组织和力学性能的影响。结果表明,热处理前,双相钢的α/γ两相组织在冷轧变形过程中沿平行轧向明显被拉长,且奥氏体均匀分布在铁素体基体上,由于加工硬化使其硬度增大远超过产品标准范围(≤290 HBW);经不同温度固溶处理后,显微组织中均未发现析出物,且组织均匀细小,硬度下降到产品标准范围内,塑性提高,铁素体相比例和抗拉强度、屈服强度等力学性能均符合要求;但在较高温度固溶处理后,由于发生再结晶晶粒长大,强度和硬度下降,且铁素体相比例(56.77%)偏高。综合考虑,确定固溶处理温度为1050℃。

关键词：双相钢冷轧固溶温度力学性能 α相

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初发点滴型银屑病患者皮损表面的微生物菌群结构发生变化

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皮肤性病诊疗学杂志 2022年第5期29卷 391-398页

作者：张嘉张凯云陈涛赵娟王红梅薛迎芳张国惠包头市中心医院内蒙古包头014040 内蒙古科技大学包头医学院内蒙古包头014040

目的探究初发点滴型银屑病患者与正常人群皮肤表面微生物菌群结构的差异。方法纳入18例初发点滴型银屑病患者,其中9例具有上呼吸道感染症状(银屑病上感组),9例不具有上呼吸道感染症状(银屑病非上感组),以9例同年龄段正常人作为对照组。... 详细信息

目的探究初发点滴型银屑病患者与正常人群皮肤表面微生物菌群结构的差异。方法纳入18例初发点滴型银屑病患者,其中9例具有上呼吸道感染症状(银屑病上感组),9例不具有上呼吸道感染症状(银屑病非上感组),以9例同年龄段正常人作为对照组。收集上述人群皮损和皮肤表面样本,采用16S rDNA测序技术对扩增后样本DNA测序,对测序结果进行注释,将实验数据进行生物信息学、医学统计学分析,分析三组间差异性微生物物种。结果在门水平,三组间优势物种均为厚壁菌门、变形菌门、放线菌门。三组间α多样性分析差异无统计学意义(均P>0.05)。β多样性分析,对照组与银屑病上感组、非上感组组间生物群落构成差异均有统计学意义(均P<0.05)。银屑病非上感组γ-变形菌纲、丙酸杆菌属低于正常组(均P<0.05);银屑病上感组劳森菌属、放线菌属低于正常组(均P<0.05),而未明确定义周蝶菌科丰度较高(P=0.011);银屑病上感组γ-变形菌纲、栖水菌属、假单胞菌属丰度高于银屑病非上感组(均P<0.05)。结论初发点滴型银屑病有上感者、无上感者及正常人群三者间皮肤表面微生物组成结构在属水平均存在差异。

关键词：初发点滴型银屑病微生物群落 16S rDNA 上呼吸道感染

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Bipolarized intrinsic faradaic layer on a semiconductor surface under illumination

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National Science Review 2023年第4期10卷 114-122页

作者： Mengfan xue Zhiqiang Chu Dongjian Jiang Hongzheng Dong Pin Wang Gengzhi Sun yingfang Yao Wenjun Luo Zhigang Zou Eco-Materials and Renewable Energy Research Center (ERERC) Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State Microstructures and Department of Physics Nanjing University National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University

Interface charge transfer plays a key role in the performance of semiconductors for different kinds of solar energy utilization, such as photocatalysis, photoelectrocatalysis, photochromism and photo-induced superhydrophilicity. In previous studies, different mechanisms have been used to understand interface charge transfer processes. However, the charge transfer mechanism at the solid/liquid interface remains a controversial topic. Here, taking TiO2as a model, we find and prove, via experiments, the new characteristic of photo-induced bipolarity of the surface layer(reduction faradaic layer and oxidation faradaic layer) on a semiconductor for the first time. Different from energy level positions in the classic surface states transfer mechanism, the potential window of a surface faradaic layer is located out of the forbidden band. Moreover,we find that the reduction faradaic layer and oxidation faradaic layer serve as electron and hole transfer mediators in photocatalysis, while the bipolarity or mono-polarity of the surface layer on a semiconductor depends on the applied potential in photoelectrocatalysis. The new characteristic of bipolarity can also offer new insights into the charge transfer process at the semiconductor/liquid interface for solar energy utilization.

关键词： semiconductor surface interface charge transfer reduction faradaic layer oxidation faradaic layer faradaic layer descriptor

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冷拔变形量对Ni80Cr20无缝管显微组织的影响

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热加工工艺 2017年第3期46卷 160-162页

作者：赵文武曹晶晶李河宗薛应芳河北工程大学机电学院河北邯郸056038

通过对Ni80Cr20锻造坯料进行挤压-冷拔-扩孔变形而获得无缝管,而后对Ni80Cr20无缝管进行不同变形量的冷轧变形,研究了不同轧制变形量对Ni80Cr20无缝管显微组织的影响。结果表明:挤压后的Ni80Cr20荒管具有单相奥氏体组织,且存在少量碳化... 详细信息

通过对Ni80Cr20锻造坯料进行挤压-冷拔-扩孔变形而获得无缝管,而后对Ni80Cr20无缝管进行不同变形量的冷轧变形,研究了不同轧制变形量对Ni80Cr20无缝管显微组织的影响。结果表明:挤压后的Ni80Cr20荒管具有单相奥氏体组织,且存在少量碳化物;荒管经冷拔-扩孔-固溶处理后获得Ni80Cr20无缝管,其奥氏体晶粒明显长大,碳化物基本溶解于基体中;Ni80Cr20无缝管在不同的冷轧变形后,随冷轧变形量的增加,显微组织呈明显的纤维化特征,经固溶处理后,其再结晶晶粒变小,获得了细小均匀的奥氏体组织。

关键词： Ni80Cr20合金轧制变形量显微组织

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基于ANSYS的锻造液压机工作缸缸体可靠性分析

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河北工程大学学报（自然科学版） 2018年第3期35卷 101-105页

作者：王晓敏王雅峰张立香薛应芳河北工程大学机械与装备工程学院河北邯郸056038 上海大学材料科学与工程学院上海200444

考虑随机不确定性因素的影响,对50 MN三梁四柱式锻造液压机工作缸缸体进行可靠性分析。通过ANSYS/APDL参数化设计语言,建立缸体三维参数化模型;根据应力-强度干涉原理,建立缸体可靠性模型;将缸体的几何参数、载荷及屈服强度等参数设为... 详细信息

考虑随机不确定性因素的影响,对50 MN三梁四柱式锻造液压机工作缸缸体进行可靠性分析。通过ANSYS/APDL参数化设计语言,建立缸体三维参数化模型;根据应力-强度干涉原理,建立缸体可靠性模型;将缸体的几何参数、载荷及屈服强度等参数设为服从一定分布规律的随机变量,运用ANSYS/PDS模块,采用Monte-Carlo模拟技术,对其进行可靠性仿真,给出了缸体的可靠度数值;通过灵敏度分析,探讨了各不确定性变量对缸体可靠度的影响规律。

关键词：锻造液压机缸体可靠性分析灵敏度 ANSYS

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Surpassing electrocatalytic limit of earth-abundant Fe^(4+)embedded in N-doped graphene for(photo)electrocatalytic water oxidation

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Journal of Energy Chemistry 2021年第3期30卷 274-281页

作者： Wenjia xue Feng Cheng Menglu Li Wenjian Hu Congping Wu Bing Wang Kuowei Liao ZhenTao Yu yingfang Yao Wenjun Luo Zhigang Zou Eco-materials and Renewable Energy Research Center(ERERC) College of Engineering and Applied SciencesNanjing UniversityNanjing 210093JiangsuChina Key Laboratory for Advanced Technology in Environment Protection of Jiangsu Province Vancheng Institute of TechnologyYancheng 224051JiangsuChina Jiangsu Key Laboratory for Nano Technology National Laboratory of Solid State MicrostructvresDepartment of PhysicsNanjing UniversityNanjing 210093JiangsuChina Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093JiangsuChina Kunshan Innovation Institute of Nanjing University Suzhou 215347JiangsuChina School of Science and Engineering The Chinese University of Hong KongShenzhen2001 Longxiang BlvdLonggang DistrictShenzhen 518172GuangdongChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao 999078China Huazhong University of Science and Technology Wuhan National Laboratory for OptoelectronicsWuhan 430074HubeiChina

Developing highly active,cost-effective,and environmental friendly oxygen evolution reaction(OER)electrocatalysts facilitates various(photo)electrochemical *** this work,Fe3N nanoparticles encapsulated into N-doped graphene nanoshells(Fe_(3)N@NG)as OER electrocatalysts in alkaline media were *** the experimental and theoretical comparison between Fe_(3) N@NG and Fe_(3)N/NG,specifically including in situ Mossbauer analyses,demonstrated that the NG nanoshells improved interfacial electron transfer process from Fe_(3)N to NG to form high-valence Fe^(4+)ions(Fe^(4+)@NG),thus modifying electronic properties of the outer NG shells and subsequently electron transfer from oxygen intermediate to NG nanoshells for OER catalytic ***,the NG nanoshells also protected Fe-based cores from forming OER inactive and insulated Fe_(2)O_(3),leading to high OER *** a result,the as-formed Fe^(4+)@NG shows one of the highest electrocatalytic efficiency among reported Fe-based OER electrocatalysts,which can as well highly improve the photoelectrochemical water oxidation when used as the cocatalysts for the Fe_(2)O_(3) nanoarray photoanode.

关键词： Fe(Ⅳ) Photoelectrochemistry Water oxidation Oxygen evolution reaction

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SEMG-based fighter pilot muscle fatigue analysis and operation performance research

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Medicine in Novel Technology and Devices 2022年第4期16卷 345-349页

作者： Biyun Zhou Bo Chen Huijuan Shi Lihao xue yingfang Ao Li Ding Beijing Advanced Innovation Center for Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityNo.37 XueYuan RoadHaiDian DistrictBeijing100191China Institute of Sports Medicine Peking University Third HospitalBeijing Key Laboratory of Sports InjuriesBeijing100191China Biomechanics Laboratory College of Human Movement Science Beijing Sport University Beijing100084China

Fatigue has a tremendously adverse impact on pilot *** study aims to explore the Biceps Brachii(BB),Rectus Femoris(RF),Flexor Carpi Radialis(FCR),and Tibialis Anterior(TA)activities of fighter pilots in the early and late combat stages,and the target hitting time.A total of 13 volunteers were recruited to conduct simulated combats inside a real fighter *** surface Electromyography(sEMG)was collected from all volunteers in the initial and final 20s of flight,and the target hitting time during three simulated combats was *** root mean square(RMS)values of right BB and TA were significantly higher than the left side values(p<0.001),while insignificant differences were found in the RMS values between the bilateral RF and *** to the early flight period,the median frequency(MF)values of BB and TA were significantly lower during the late flight period,and the RMS values were significantly higher(p<0.047).Contrastively,the RMS values of FCR and RF differed insignificantly during the late flight *** the target hitting time,a significant difference was noted between task 1 and *** exhibit varying levels of muscle fatigue for different muscle groups before and after the *** muscle fatigue levels are asymmetrical on the left and right *** fatigue might reduce the pilots'operational *** study provides a reference for fighter pilot fatigue protection and treatment.

关键词： Surface electromyography Flight fatigue Operation performance Daubechies wavelet

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