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Green Synthesis and Catalysis 2024年第1期5卷 31-34页

作者： Zhen Tang Chao pi Yangjie Wu Xiuling Cui Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan UniversitiesGreen Catalysis CenterCollege of ChemistryZhengzhou UniversityZhengzhou450052China

A visible-light-promoted formal[2+2+1]cyclization of N-aryl glycines with quinoxalin-2(1H)-ones to synthesize tetrahydroimidazo[1,5-a]quinoxalin-4(5H)-ones have been *** protocol features operational simplicity,mild reaction conditions with blue LED light employing Ru(bpy)3Cl2.6H2O as a photoredox catalyst,a combination of O2 from air and Cu(OAc)2 as the oxidant and broad substrate applicability.

关键词： Cyclization Decarboxylation Visible-light-promoted Quinoxalin-2(1H)-ones Mild conditions

Improving Thermal-oxidative Aging Resistance of Styrene-butadiene Rubber by Antioxidant Loaded Silica Aerogel

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Chinese Journal of Polymer Science 2024年第8期42卷 1198-1209页

作者： Xue-Fei ping Yu Wang Lu Liu Fu-Yong Liu Hong-Wei He pi Wang Wen-Wen Yu Qiang Zheng College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

The antioxidant N-isopropyl-N'-phenyl-p-phenylenediamine(4010NA)was dissolved in ethanol and impregnated into silica aerogel(SAG)via vacuum-pressure cycles,yielding composite particles(A-N)with enhanced sustained-release and reinforcing *** effect of A-N on the mechanical properties and thermal-oxidative aging resistance of styrene-butadiene rubber(SBR)vulcanizates was *** and BET assessments indicated that the loading efficiency of 4010NA in SAG reached 14.26%within ethanol's solu bility *** A-N into SBR vulcanizates significantly elevated tensile strength by 17.5%and elongation at break by 41.9%over those with fumed silica and ***,A-N notably enhanced the thermal-oxidative aging resistance of *** aging for 96 h at 100℃,the tensile strength and elongation at break of SBR with A-N sustained 70.09%and 58.61%of their initial values,respectively,with the retention rate of elongation at break being 62.8%higher than that of SBR with fumed silica and free *** study revealed that A-N composite particles significantly inhibited the crosslinking in SBR's molecular chains,reducing hardening and embrittlement during later thermal-oxidative aging stages.

关键词： Styrene-butadiene rubber Silica aerogel Loading modification Thermal-oxidative aging

Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

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Current Medical Science 2024年第1期44卷 156-167页

作者： Zi-guo YANG Le-hao REN Feng WANG pi-lin WANG Wen-yan WANG Shu-ye LIN Department of General Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Cancer Research Center Beijing Chest HospitalCapital Medical University/Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy(NAC)for breast cancer(BC)at ***,30% of early breast cancer(EBC)patients are resistant to anthracycline-containing chemotherapy,leading to poor prognosis and higher ***-67 is associated with the prognosis and response to therapy,and it changes after *** A total of 105 BC patients who received anthracycline-containing NAC were ***,the optimal model of Ki-67 was selected,and its predictive efficacy was ***(IHC)was used to determine the estrogen receptor(ER),progesterone receptor(PR),and human epidermal growth factor receptor 2(HER-2)status and Ki-67 *** in situ hybridization(FISH)was used to verify the HER-2 when the IHC score was 2+.Results The post-NAC Ki67 level after treatment with anthracycline drugs was lower than pre-NAC Ki-67(19.6%±23.3%vs.45.6%±23.1%,P<0.001).Furthermore,patients with the Ki-67 decrease had a border line higher pathological complete response(pCR)rate(17.2%vs.0.0%,P=0.068),and a higher overall response rate(ORR)(73.6%vs.27.8%,P<0.001),when compared to patients without the Ki-67 *** ΔKi-67 and ΔKi-67%were valuable markers for the prediction of both the pCR rate and *** area under the curve(AUC)for ΔKi-67 on pCR and ORR was 0.809(0.698-0.921)and 0.755(0.655-0.855),respectively,while the AUC for ΔKi-67% on pCR and ORR was 0.857(0.742-0.972)and 0.720(0.618-0.822),*** logistic regression model 1 revealed thatΔKi-67 was an independent predictor for both pCR[odds ratio(OR)=61.030,95% confidence interval(CI)=4.709-790.965;P=0.002]and ORR(OR=10.001,95%CI:3.044-32.858;P<0.001).Multivariate logistic regression model 2 revealed thatΔKi-67%was also an independent predictor for both pCR(OR=408.922,95%CI=8.908-18771.224;P=0.002)and ORR(OR=5.419,95%CI=1.842-15.943;P=0.002).Conclusions The present study results suggest thatΔKi67 andΔKi67%are candidate predictor

关键词： breast cancer change in Ki-67 neoadjuvant chemotherapy anthracycline,response

Suppression of Cs FAD3 in a JA-dependent manner, but not through the SA pathway, impairs drought stress tolerance in tea

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Journal of Integrative Agriculture 2024年第11期23卷 3737-3750页

作者： Na Chang Xiaotian pi Ziwen Zhou Yeyun Li Xianchen Zhang State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University

The growth and yield of tea plants are seriously limited by drought stress. Fatty acid desaturases（FADs） contribute to the mediation of membrane fluidity in response to different stresses, although the role of ω-3 FAD（Omega-3fatty acid desaturase）-mediated damage induced by drought stress in tea plants is poorly understood. In this study,drought stress significantly promoted the synthesis of C18:3（linolenic acid） and the expression level of *** experiments further demonstrated that CsFAD3 can convert C18:2 to C18:3, and that the 35S:GFP-CsFAD3fusion protein was localized in the endoplasmic reticulum of Nicotiana benthamiana cells. CsFAD3-silenced tea leaves exhibited poor drought tolerance, with a lower Fv/Fmand a higher malondialdehyde（MDA） content than the control plants. However, transgenic 35S:CsFAD3 Arabidopsis plants showed the opposite phenotypes. In addition,the jasmonic acid（JA） content and the expression levels of CsLOX2, CsLOX4, CsAOS, CsAOC3 and CsOPR2 were significantly reduced in CsFAD3-silenced leaves under drought stress. However, no substantial difference in the salicylic acid（SA） content was detected under normal or drought conditions. An analysis of Atcoi1（JA receptor） or Atnpr1（SA receptor） mutant Arabidopsis plants in 35S:CsFAD3 backgrounds further revealed that knockout of Atcoi1impaired the drought-tolerant phenotypes of CsFAD3 overexpression lines. Therefore, this study demonstrated that CsFAD3 plays a crucial role in drought tolerance by mediating JA pathways.

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利用稀少控制点的线阵推扫式光学卫星在轨几何定标方法

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测绘学报 2019年第2期48卷 216-225页

作者：皮英冬谢宝蓉杨博张昳玲李欣王密武汉大学遥感信息工程学院湖北武汉430079 上海航天电子技术研究所上海201109 武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079 地球空间信息协同创新中心湖北武汉430079

针对线阵推扫式光学遥感卫星,提出了一种基于稀少控制点的在轨几何定标方法。本文方法利用沿CCD方向的两景重叠影像对及影像覆盖区域的稀少控制点数据即可实现内外系统误差参数的高精度解算,进而有效恢复视场内每个CCD探元的光线指向,... 详细信息

针对线阵推扫式光学遥感卫星,提出了一种基于稀少控制点的在轨几何定标方法。本文方法利用沿CCD方向的两景重叠影像对及影像覆盖区域的稀少控制点数据即可实现内外系统误差参数的高精度解算,进而有效恢复视场内每个CCD探元的光线指向,摆脱了传统方法对昂贵的高精度地面定标场数据的依赖。本文首先在推扫式光学遥感卫星成像机理的基础上建立相应的严格几何成像模型,并对影响卫星影像几何精度的系统误差进行了分析,在此基础上采用一种基于指向角的内参数优化模型构建了适用于本方法的几何定标模型。然后,结合本方法的特点,采用一种分步解算的方法分别对外参数和内参数分别进行了标定。最后,通过一组ZY-3卫星下视相机的真实数据试验对本文方法的有效性及精度进行了对比验证。

关键词：光学卫星在轨几何定标重叠影像对稀少控制点指向角

Insights into ionic association boosting water oxidation activity and dynamic stability

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Journal of Energy Chemistry 2024年第2期89卷 99-109,I0004页

作者： Zanling Huang Shuqi Zhu Yuan Duan Chaoran pi Xuming Zhang Abebe Reda Woldu Jing-Xin Jian Paul K.Chu Qing-Xiao Tong Liangsheng Hu Xiangdong Yao Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063GuangdongChina Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063GuangdongChina State Key Laboratory of Refractories and Metallurgy and Institute of Advanced Materials and Nanotechnology Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongTat Chee AvenueKowloonHong KongChina School of Advanced Energy Sun Yat-sen University(Shenzhen)Shenzhen 518107GuangdongChina

There have been reports about Fe ions boosting oxygen evolution reaction(OER)activity of Ni-based catalysts in alkaline conditions,while the origin and reason for the enhancement remains ***,we attempt to identify the activity improvement and discover that Ni sites act as a host to attract Fe(Ⅲ)to form Fe(Ni)(Ⅲ)binary centres,which serve as the dynamic sites to promote OER activity and stability by cyclical formation of intermediates(Fe(Ⅲ)→Fe(Ni)(Ⅲ)→Fe(Ni)-OH→Fe(Ni)-O→Fe(Ni)OOH→Fe(Ⅲ))at the electrode/electrolyte interface to emit O_(2).Additionally,some ions(Co(Ⅱ),Ni(Ⅱ),and Cr(Ⅲ))can also be the active sites to catalyze the OER process on a variety of *** Fe(Ⅲ)-catalyzed overall water-splitting electrolyzer comprising bare Ni foam as the anode and Pt/Ni-Mo as the cathode demonstrates robust stability for 1600 h at 1000 mA cm^(-2)@~1.75 *** results provide insights into the ioncatalyzed effects boosting OER performance.

关键词： Oxygen evolution reaction Fe(Ⅲ)-catalysis Ni-Fe binary active centers Ion-catalyzed effects Robust stability

Artificial afferent neurons based on the metal-insulator transition of VO2

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Science China(Information Sciences) 2024年第11期 347-353页

作者： Jiayao CHEN Lei YIN Yue WANG Haolin WANG Dongke LI Deren YANG Xiaodong pi State Key Laboratory of Silicon and Advanced Semiconductor Materials & School of Materials Science and Engineering Zhejiang University Institute of Advanced Semiconductors & Zhejiang Provincial Key Laboratory of Power Semiconductor Materials and Devices ZJU-Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University

Neuromorphic computing offers significant advantages in addressing data redundancy and enhancing system energy efficiency. Although extensive research has been conducted on pulsed neural networks and bionic sensors, the development of artificial electronic afferent neurons for low-energy information transfer remains limited. This study introduces an artificial afferent neuron comprising a vanadium dioxide（VO2）device, capacitor and resistor. The VO2devices exhibit stable electrically induced metal-insulator transition（MIT）. Leveraging the MIT of this device, we develop an artificial afferent neuron to transform constant or sinusoidal analog signals into pulsed voltage signals. The output frequency increases with the increase of the input voltage, mimicking the faster pulse outputs of biological afferent neurons in response to stronger stimuli.

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Artificial afferent neurons based on the metal-insulator transition of VO

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Science China(Information Sciences) 2024年

Neuromorphic computing offers significant advantages in addressing data redundancy and enhancing system energy efficiency. Although extensive research has been conducted on pulsed neural networks and bionic sensors, the development of artificial electronic afferent neurons for low-energy information transfer remains limited. This study introduces an artificial afferent neuron comprising a vanadium dioxide （VO2）device, capacitor and resistor. The VO2devices exhibit stable electrically induced metal-insulator transition（MIT）. Leveraging the MIT of this device, we develop an artificial afferent neuron to transform constant or sinusoidal analog signals into pulsed voltage signals. The output frequency increases with the increase of the input voltage, mimicking the faster pulse outputs of biological afferent neurons in response to stronger stimuli.

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欧盟《人工智能法》中的风险防控机制及对我国的镜鉴

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比较法研究 2024年第4期 67-85页

作者：皮勇同济大学上海国际知识产权学院

欧盟《人工智能法》是世界上第一部促进人工智能安全发展的区域性国际法律文件,将人工智能系统定性为自主性工具,立足于人工智能安全风险全球化视角,以保障本土安全与发展利益为导向,规定了针对不同类型人工智能安全风险的、全过程多方... 详细信息

欧盟《人工智能法》是世界上第一部促进人工智能安全发展的区域性国际法律文件,将人工智能系统定性为自主性工具,立足于人工智能安全风险全球化视角,以保障本土安全与发展利益为导向,规定了针对不同类型人工智能安全风险的、全过程多方协同防控机制。该法根据风险的类别和大小程度,将防控对象分为禁止的人工智能活动、人工智能系统和通用人工智能模型三大类六小类,分别采取禁止和不同程度的管控措施,重点防控高风险人工智能系统和通用人工智能模型的安全风险。以上防控机制主要通过规定人工智能安全管理义务及其处罚规定来实现,重点规定了高风险人工智能系统和通用人工智能模型的要求及相关方的安全管理义务,并对违反不同义务的自然人、公司以及欧盟机构、部门或实体设置了与行为人类型及义务相称的罚款。我国制定人工智能安全立法应考虑借鉴该法的成功经验,同时避免其出现的防控不全面不充分、法律责任制度存在缺漏、风险防控责任分配不合理等缺点。

关键词：欧盟《人工智能法》风险类型化全程协同防控安全管理义务

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Geological reservoir and resource potential(10^(13)m^(3))of gas hydrates in the South China Sea

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China Geology 2024年第3期7卷 422-444页

作者： pi-bo Su Wei Wei Yun-bao Sun Yao-yao Lü Huai Cheng Wei-feng Han Wei Zhang Jin-qiang Liang National Engineering Research Center for Gas Hydrate Exploration and Development Guangzhou 511458China Sanya Institute of South China Sea Geology Guangzhou Marine Geological SurveySanya 572025China Central Laboratory of Geological Sciences Research Institute of Petroleum Exploration and DevelopmentLangfang 065007China Qingdao Institute of Marine Geology Qingdao 266237China Laboratory for Marine Mineral Resources Qingdao Marine Science and Technology CenterQingdao 266237China

A detailed understanding of the distribution and potential of natural gas hydrate(NGHs)resources is crucial to fostering the industrialization of those resources in the South China Sea,where NGHs are *** this study,this study analyzed the applicability of resource evaluation methods,including the volumetric,genesis,and analogy methods,and estimated NGHs resource potential in the South China Sea by using scientific resource evaluation methods based on the factors controlling the geological accumulation and the reservoir characteristics of ***,this study compared the evaluation results of NGHs resource evaluations in representative worldwise sea areas via rational *** results of this study are as follows:(1)The gas hydrate accumulation in the South China Sea is characterized by multiple sources of gas supply,multi-channel migration,and extensive accumulation,which are significantly different from those of oil and gas and other unconventional resources.(2)The evaluation of gas hydrate resources in the South China Sea is a highly targeted,stratified,and multidisciplinary evaluation of geological resources under the framework of a multi-type gas hydrate resource evaluation system and focuses on the comprehensive utilization of multi-source heterogeneous data.(3)Global NGHs resources is n×10^(15)m^(3),while the NGHs resources in the South China Sea are estimated to be 10^(13)m^(3),which is comparable to the abundance of typical marine NGHs deposits in other parts of the *** the South China Sea,the NGHs resources have a broad prospect and provide a substantial resource base for production tests and industrialization of NGHs.

关键词： Reservoir characteristics Natural gas hydrates Gas migration Resource potential Resource evaluation methods Hierarchical evaluation system Volumetric method South China Sea Clean energy exploration engineering