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Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2074-2078页

作者： Wan-Ling Xu Wen-Jing tang Wei-ying Yang Li-Chao Sun Ze-Qun Zhang Wei Li Xiu-Xian Zang Department of Emergency Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Chinese Traditional Medicine First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the comprehensive elucidation of the clinical manifestations of high-dose cantharidin poisoning,the intricate path to diagnosis,and the exploration of potential underlying *** SUMMARY A patient taking 10 g of cantharidin powder orally subsequently developed *** patient was treated with supportive care,fluid hydration and antibiotics,and hemoperfusion and hemofiltration therapy for 24 h and successfully recovered 8 d after hospital *** poisoning can cause lifethreatening MODS and is rare *** case underscores the challenge in diagnosis and highlights the need for early clinical differentiation to facilitate accurate assessment and prompt *** This article has reported and analyzed the clinical data,diagnosis,treatment,and prognosis of a case of high-dose cantharidin poisoning resulting in MODS and reviewed the relevant literature to improve the clinical understanding of this rare condition.

关键词： Cantharidin Poisoning Multiorgan dysfunction syndrome Clinical treatment and management Case report

An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie tang Shengjun Sun Xun He Hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng Wang Yuntong Sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping Sun Huiqing Wang Binwu ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

***2 regulates plant height by affecting the main inflorescence length and first effective branch height in Brassica napus L.

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The Crop Journal 2024年第4期12卷 1102-1111页

作者： Chengke Pang Jun Yu Liang Zhang Min tang Hongfang Liu ying Cai Feng Chen Jiefu Zhang Wei Hua Xiaodong Wang Ming Zheng Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Oil CropsMinistry of Agriculture and Rural AffairsWuhan 430062HubeiChina Key Laboratory of Cotton and Rapeseed Ministry of Agriculture and Rural AffairsKey Laboratory of Jiangsu Province for AgrobiologyInstitute of Industrial CropsJiangsu Academy of Agricultural SciencesNanjing 210014JiangsuChina National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina

Rapeseed(Brassica napus L.)is one of the main oil crops in the world,and increasing its yield is of great significance for ensuring the safety of edible ***,improving rapeseed plant architecture is an effective way to increase rapeseed yield with higher planting ***,the regulatory mechanism of rapeseed plant architecture is poorly *** this study,a dwarf rapeseed mutant dwarf08(df08)is obtained by ethyl methane sulfonate(EMS)-*** decrease in plant height of df08 is mainly caused by the reduction in main inflorescence length and first effective branch height and controlled by a single semi-dominant *** hybrid plants(F1)show a semi-dwarf *** map-based cloning and transgenic assay,we confirm that the nonsynonymous single nucleotide variant(SNV)(C to T)in ***2,which is homologous with Arabidopsis(Arabidopsis thaliana)BIN2,is responsible for the dwarfism of ***2 interacts with BnaBZR1/BES1 and involves in brassinosteroids(BRs)signal *** to Leucine substitution in 284(P284L)enhances the protein stability of ***2-D,disrupts BRs signal transduction and affects the expression of genes regulating cell division,leading to dwarfism of *** study provides a new insight for the mechanism of rapeseed plant height regulation and creates an elite germplasm that can be used for genetic improvement of rapeseed architecture.

关键词： Brassica napus Plant height Brassinosteroids BIN2

Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines

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Chinese Herbal Medicines 2024年第2期16卷 190-203页

作者： Yue Ouyang Qiqing Cheng Chunsong Cheng Ziyu tang Yufeng Huang Eyu Tan Shaofeng Ma Xinheng Lin ying Xie Hua Zhou Guangdong Provincial Hospital of Chinese Medicine Guangdong Provincial Academy of Chinese Medical SciencesState Key Laboratory of Dampness Syndrome of Chinese MedicineSecond Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease ResearchGuangzhou 510006China Faculty of Chinese Medicine Macao University of Science and TechnologyMacao 999078China School of Pharmacy Hubei University of Science and TechnologyXianning 437100China Key Laboratory of Plant Ex-situ Conservation and Research Center of Resource Plant Lushan Botanical GardenChinese Academy of SciencesJiujiang 332900China Jiangmen Wuyi Hospital of Traditional Chinese Medicine Jiangmen 529020China Joint Laboratory for Translational Cancer Research of Chinese Medicine Ministry of EducationGuangzhou University of Chinese MedicineGuangzhou 510006China

Microbial resource influences the life activities of medicinal plants from several ***,rhizosphere microorganisms,and other environmental microorganisms play essential roles in medicinal plant growth and development,plant yield,and clinical *** microbiota can influence the biosynthesis of active compounds in medicinal plants by stimulating specific metabolic *** induce host plants to improve their resistance to environmental stresses by accumulating secondary *** can interact with their host plants to produce long-term,targeted selection results and improve their ability to adapt to the *** to the interdependence and interaction between microorganisms and medicinal plants,Chinese herbal medicines(CHMs)quality is closely related to the associated *** review summarizes the relationship between medicinal plants and their associated microorganisms,including their species,distribution,life activities,and *** can aid in quality control,improve the efficacy of medicinal plants,and provide markers for identifying the origin and storage time of ***,a comprehensive understanding of the relationship between microorganisms and medicinal plants will help to control the quality of CHMs from different perspectives.

关键词： Chinese herbal medicines endophytes environmental microorganisms microbiota rhizosphere microorganisms

Comparative Evaluation of Antitumor Chinese Patent Medicine Injections Based on Evidence-Based Medicine and Markov Model

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 220-229页

作者： Jing Yang Yan-Peng Wang Wen-Gong Yu Yu-Yao Guan Prince Emmanuel Opoku Amponsah Xian-Shuai tang ying-Zi Sun Lei Zheng School of Medicine and Pharmacy Ocean University of ChinaQingdaoChina Department of Pharmacy Shandong Medical CollegeJinanChina Department of Pharmacy Cheeloo College of MedicineShandong Provincial Third HospitalShandong UniversityJinanChina Biomedical Engineering Graduate School University of ArizonaTucsonAZUSA

Objective: The objective of this study was to explore the safety, efficacy, economy, and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection, rational drug use, public awareness of safe drug use, and medical insurance. Materials and Methods: The names of five frequently used antitumor Chinese patent medicine injections were used as search terms, including the compound Sophora flavescens injection, Kangai injection, Aidi injection, Kanglaite injection, and Brucea javanica oil emulsion injection. Relevant evidence-based medical research was extracted from the databases. A descriptive evaluation was conducted, and the Markov model was used for the cost-benefit analysis. Finally, the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method. Results: The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments, improving the quality of life for cancer patients, and reducing the incidence of adverse reactions. From the perspective of economy and other attributes, compound S. flavescens was superior to B. javanica oil, Aidi, Kangai, and Kanglaite. After a comprehensive evaluation of the above five injections, the compound S. flavescens injection received the highest score. Conclusions: Compound S. flavescens, Kangai, Aidi, B. javanica oil, and Kanglaite have their own advantages in effectiveness and no significant difference in safety. Compound S. flavescens injection has the highest comprehensive score. Clinical attention should be paid to monitoring the initial stage of medication and special groups.

关键词： Anti-tumor Chinese patent medicine comprehensive evaluation medication safety pharmacoeconomics rational drug use

Low-intensity pulsed ultrasound reduces alveolar bone resorption during orthodontic treatment via Lamin A/C-Yes-associated protein axis in stem cells

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World Journal of Stem Cells 2024年第3期16卷 267-286页

作者： Tong Wu Fu Zheng Hong-Yi tang Hua-Zhi Li Xin-Yu Cui Shuai Ding Duo Liu Cui-ying Li Jiu-Hui Jiang Rui-Li Yang Department of Orthodontics Peking University School and Hospital of StomatologyNational Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China Department of Central Laboratory Peking University School and Hospital of StomatologyNational Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of StomatologyBeijing Key Laboratory of Digital StomatologyBeijing 100081China

BACKGROUND The bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years,which also may lead to some complications such as alveolar bone resorption or tooth root ***-intensity pulsed ultrasound(LIPUS),a noninvasive physical therapy,has been shown to promote bone fracture *** is also reported that LIPUS could reduce the duration of orthodontic treatment;however,how LIPUS regulates the bone metabolism during the orthodontic treatment process is still *** To investigate the effects of LIPUS on bone remodeling in an orthodontic tooth movement(OTM)model and explore the underlying *** A rat model of OTM was established,and alveolar bone remodeling and tooth movement rate were evaluated via micro-computed tomography and staining of tissue *** vitro,human bone marrow mesenchymal stem cells(hBMSCs)were isolated to detect their osteogenic differentiation potential under compression and LIPUS stimulation by quantitative reverse transcription-polymerase chain reaction,Western blot,alkaline phosphatase(ALP)staining,and Alizarin red *** expression of Yes-associated protein(YAP1),the actin cytoskeleton,and the Lamin A/C nucleoskeleton were detected with or without YAP1 small interfering RNA(siRNA)application via *** The force treatment inhibited the osteogenic differentiation potential of hBMSCs;moreover,the expression of osteogenesis markers,such as type 1 collagen(COL1),runt-related transcription factor 2,ALP,and osteocalcin(OCN),*** could rescue the osteogenic differentiation of hBMSCs with increased expression of osteogenic marker inhibited by ***,the expression of LaminA/C,F-actin,and YAP1 was downregulated after force treatment,which could be rescued by ***,the osteogenic differentiation of hBMSCs increased by LIPUS could be attenuated by YAP siRNA ***,LIPUS increased alveolar

关键词： Low-intensity pulsed ultrasound Bone resorption Osteogenesis Cytoskeleton-Lamin A/C-Yes-associated protein axis Bone marrow mesenchymal stem cells Orthodontic tooth movement

Therapeutic effect of San Bi tang combined with glucosamine sulfate capsules in cold-dampness-type knee osteoarthritis

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World Journal of Clinical Cases 2024年第19期12卷 3854-3865页

作者： Hui-ying Ni Yao-Ping Zhang Xiao-Feng Zhang Department of Orthopedics and Traumatology Hangzhou Fuyang Hospital of TCM Orthopedics and TraumatologyHangzhou 311400Zhejiang ProvinceChina

BACKGROUND Cold-dampness-type knee osteoarthritis is a common middle-aged and elderly disease,but its pathogenesis is not fully understood,and its clinical treatment has *** sulfate capsules are commonly used for treating arthritis,and San Bi tang is a classic formula of traditional Chinese medicine(TCM)that has the effects of warming yang,dispelling dampness,relaxing muscles,and activating *** research hypothesized that the combination of modified San Bi tang and glucosamine sulfate capsules could enhance the clinical efficacy of treating cold-dampness-type knee osteoarthritis through complementary *** To analyze the clinical efficacy of San Bi tang combined with glucosamine sulfate capsules when treating cold-dampness-type knee *** A total of 110 patients with cold-dampness-type knee osteoarthritis were selected as research subjects and randomly divided into a control group and an experimental group of 55 cases *** control group received only treatment with glucosamine sulfate capsules,while the experimental group received additional treatment with modified San Bi tang for a duration of 5 *** patients’knee joint functions,liver and kidney function indicators,adverse reactions,and vital signs were evaluated and analyzed using SPSS 26.0 *** Before treatment,the two groups’genders,ages,and scores were not significantly different,indicating *** groups’scores improved after treatment,which could indicate pain and knee joint function improvement,but the test group had better *** TCM-specific symptoms and the clinical efficacy of the treatment in the test group were *** and after treatment,there were no abnormalities in the patients’liver and kidney function *** The combination of modified San Bi tang and glucosamine sulfate capsules is superior to treatment with sulfated glucosamine alone and has high safety.

关键词： San Bi tang Combination therapy Knee osteoarthritis Aggravated by cold Glucosamine sulfate capsules

Cardiotoxicity induced by fluoropyrimidine drugs in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 251-254页

作者： Mo-Wei Kong Feng-Di Sun Zhen-ying Pei Li Xu Ze-Bi Wang Yan Chen Shu-Qing tang Ting-Fang Yang Guo-Xiang He Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the article published in World J Gastrointest Oncol 2019,11:*** specifically focus on the occurrence,clinical characteristics,and risk factors of fluoropyrimidine drug-related cardiotoxicity in patients with gastrointestinal *** significant advancements in diagnostic and therapeutic techniques that have reduced mortality rates associated with digestive system tumors,the incidence and mortality rates of treatment-related car-diotoxicity have been increasing,severely impacting the survival and prognosis of cancer *** drugs are widely used as antimetabolites in the treatment of malignant tumors,including gastrointestinal tumors,and they represent the second largest class of drugs associated with ***,there is often a lack of awareness or understanding regarding their cardiotoxic effects and associated risks.

关键词： Cardiotoxicity Gastrointestinal tumors Risk factors Fluoropyrimidine Chest pain

Optical trapping capability of tornado circular Pearcey beams

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Chinese Physics B 2024年第5期33卷 401-407页

作者：刘娜娜唐晓莹刘舜禹梁毅 Guangxi Key Laboratory for Relativistic Astrophysics Center on Nanoenergy ResearchGuangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory of Featured Metal Materials and Lifecycle Safety for Composite Structures Nanning 530004China

We systemically investigate optical trapping capability of a kind of tornado waves on Rayleigh *** tornado waves are named as tornado circular Pearcey beams(TCPBs)and produced by combining two circular Pearcey beams with different *** theoretical exploration delves into various aspects,including the propagation dynamics,energy flux,orbital angular momentum,trapping force,and torque characteristics of *** results reveal that the orbital angular momentum,trapping force,and torque of these beams can be finely tuned through the judicious manipulation of their topological charges(l_(1)and l_(2)).Notably,we observe a precise control mechanism wherein the force diminishes with|l_(1)+l_(2)|and|l_(1)-l_(2)|,while the torque exhibits enhancement by decreasing solely with|l_(1)+l_(2)|or increasing with|l_(1)-l_(2)|.These results not only provide quantitative insights into the optical trapping performance of TCPBs but also serve as a valuable reference for the ongoing development of innovative photonic tools.

关键词： trapping capability tornado beams autofocusing