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World Journal of Gastroenterology 2014年第1期20卷 264-273页

作者： Ming-Ming He Dong-Sheng Zhang Feng Wang Zhi-Qiang Wang Hui-Yan Luo Chao Ren ying jin Dong-Liang Chen Rui-Hua Xu State Key Laboratory of Oncology in South China Department of Medical OncologySun Yat-sen University Cancer Center

AIM: To investigate adjuvant chemotherapy, p53 and carcinoembryonic antigen (CEA) expression and prognosis after D2 gastrectomy for stage II/III gastric adenocarcinoma.

关键词： Gastric adenocarcinoma Adjuvant chemotherapy p53 Carcinoembryonic antigen Immunohistochemistry

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共振型地震表面波屏障设计与性能分析

同济大学学报（自然科学版） 2024年第7期52卷 1009-1017页

作者：宁少武金园园施汇斌柳占立西安建筑科技大学土木工程学院陕西西安710055 清华大学航空航天学院北京100081

周期结构的带隙特性使得位于带隙频率范围内的振动或波动无法在结构中传播。基于该思想,设计了一种埋入式的地震表面波屏障以调控Rayleigh表面波的传播,并研究了该表面波屏障的主要设计参数及共振单元与支撑基础之间的连接约束关系等对... 详细信息

周期结构的带隙特性使得位于带隙频率范围内的振动或波动无法在结构中传播。基于该思想,设计了一种埋入式的地震表面波屏障以调控Rayleigh表面波的传播,并研究了该表面波屏障的主要设计参数及共振单元与支撑基础之间的连接约束关系等对弹性波频散曲线和表面波带隙形成的影响。结果表明:该埋入式的地震表面波屏障能够形成低频的表面波带隙,实现有效的衰减域;共振单元与支撑基础之间的约束关系会显著改变地震表面波屏障的频散曲线,不同的约束条件会影响表面波带隙的形成,甚至造成带隙的消失,在屏障设计与实现过程中应对影响两者发生相对运动的因素如摩擦力等进行考虑,进行合理设计。

关键词：地震超材料波屏障表面波带隙地震

General Properties of Low-frequency Power Losses in Fe-based Nanocrystalline Soft Magnetic Alloys

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Journal of Materials Science & Technology 2000年第1期16卷 37-44页

作者： Yanzhong ZHANG, Huijuan jin and ying SHI (Shanghai Key Laboratory for Research and Developing and Applications of Metallic Function Materials, Research Center, Shanghai Iron and Steel Research institute,Shanghai 200940, China) Shanghai Key Lab. for Research and Developing and Applications of Metallic Function Materials Research Center Shanghai Iron and Steel Research Institute Shanghai 200940 China

The dependences of the power loss per cycle on frequency f and amplitude flux density Bm have been investigated for the three main original magnetic states in five sorts of Fe-based nanocrystalline soft magnetic alloys in the ranges of 10 Hz<=f<=1000 Hz and 0.4 T<= Bm <=1.0 T. The total loss P is decomposed into the sum of the hysteresis loss Physt, the classical eddy current loss Pel and the excess loss Pexc. Physt has been found to be proportional to Bm^2 and f. The behavior of Pexc/f vs f being equivalent to P/f vs f clearly exhibits nonlinearity in the range not more than about 120 Hz, whereas the behavior of P/f vs f roughly shows linearity in the range far above 100 Hz and not more than 1000 Hz. In the range up to 1000 Hz, Physt is dominant in the original high permeability state and the state of low residual flux density, whereas Pexc in the state of high residual flux density is dominant in the wider range above about 100 Hz. The framework of the statistical theory of power loss has been used for representing the behavior of Pexc/f vs f. It has been found that the number n of the simultaneously active 'Magnetic Objects' linearly varies as n = n0 + Hexc/H0 as a function of the dynamic field Hexc in the range below about 120 Hz, whereas n approximately follows a law of the form n = n0 + (Hexc/H0)^m with 1 < m < 2 in the range far above 100 Hz and not more than 1000 Hz. The values of the field HO in principle related to the microstructure and the domain structure have been calculated for the three states.

关键词： General Properties of Low-frequency Power Losses in Fe-based Nanocrystalline Soft Magnetic Alloys Fe

Accuracy of segmented measurement of axial length in ultra-high myopia filled with silicone oil using immersion B-scan ultrasonography

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 793-799页

作者： Qing-Hua Yang Hong-Tao Zhang Xiao-Qi Li Bing Chen Zhao-Hui Li Yi-Fei Huang Xin jin ying Zhang Li-Qiang Wang Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijingChina

AIM:To evaluate the accuracy of segmented measurement of axial length(AL)in high myopia filled with silicone oil by immersion B-scan ultrasonography(immersion B-scan).METHODS:From June 2016 to June 2020,a total of 67 ultra-high myopia inpatients(67 eyes)who underwent silicone oil removal combined with cataract extraction and intraocular lens(IOL)implantation were retrospectively *** preoperative axial length(AL)of 31 patients with severe cataract were segmented measured using immersion B-scan(B-scan group)and another 36 patients with mild or moderate cataract were measured using IOLMaster 500(IOLMaster group).The post-operative ALs in two groups were both measured using IOLMaster *** IOL power was calculated with Haigis *** differences in ALs between pre-and post-surgery,as well as the postoperative refractive spherical equivalent,absolute refractive error,the prediction deviation of postoperative refraction and best corrected visual acuity(BCVA)were ***:The pre-and post-operative ALs were 30.46±1.63 mm(range 28.09-33.51 mm)and 30.42±1.70 mm(range 28.03-33.90 mm)in B-scan group(t=0.644,P=0.542)and 30.51±1.21 mm(range 28.03-33.90 mm)and 30.43±1.27 mm(range 28.54-33.50 mm)in IOLMaster group(t=1.843,P=0.074),*** months after surgery,BCVA were 0.45±0.13(range 0.3-0.9)and 0.44±0.20(range 0.2-1.0)in B-scan and IOLMaster group respectively(t=0.086,P=0.932).There was no significant difference of the postoperative spherical equivalent(-3.11±0.65 D vs-3.21±0.51 D,t=0.671,P=0.505)and the absolute refractive error(0.589±0.340 vs 0.470±0.245 D,t=1.615,P=0.112)between two *** B-scan group,absolute refractive error within±0.50 D was found in 18 eyes(58.1%),within±1.00 D in 26 eyes(83.9%),and within±1.50 D in 31 eyes(100%).In IOLMaster group,absolute refractive error within±0.50 D was found in 23 eyes(63.9%),within±1.00 D in 34 eyes(94.4%),and within±1.50 D in 36 eyes(Z=0.757,P=0.449).CONCLUSION:The segmented measurement of ALs

关键词： high myopia axial length immersion B-ultrasound IOLMaster silicone oil cataract

YTHDF1对缺氧复氧损伤后H9c2心肌细胞凋亡及氧化应激的影响

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国际老年医学杂志 2024年第1期45卷 46-52页

作者：涅鲁排尔·热依木江金颖罗荔张雅玲刘刚李雪罗梅新疆医科大学第五附属医院乌鲁木齐830000

目的探讨含YTH域家族蛋白1(YTHDF1)对缺氧复氧(H/R)条件下H9c2细胞凋亡和氧化应激的影响。方法用H9c2细胞构建H/R模型,并用YTHDF1小干扰RNA(siRNA)和过表达质粒转染细胞,采用MTT比色法测定细胞活力,并用赫斯特染色及流式细胞术测定细胞... 详细信息

目的探讨含YTH域家族蛋白1(YTHDF1)对缺氧复氧(H/R)条件下H9c2细胞凋亡和氧化应激的影响。方法用H9c2细胞构建H/R模型,并用YTHDF1小干扰RNA(siRNA)和过表达质粒转染细胞,采用MTT比色法测定细胞活力,并用赫斯特染色及流式细胞术测定细胞凋亡及细胞中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量和细胞培养基上清中乳酸脱氢酶(LDH)活性,Western blot法测定细胞中YTHDF1、cleaved caspase-3、Bax和FasL的蛋白水平,比较对照组(control组)、H/R组、YTHDF1基因干扰和过表达组H9c2细胞凋亡和氧化损伤情况。结果H/R损伤后LDH活性和MDA含量明显升高(P<0.05),SOD活性和细胞活力显著降低(P<0.05),H/R处理后H9c2细胞中YTHDF1的蛋白水平均显著升高(P<0.05);YTHDF1干扰减轻了H/R损伤引起的形态学变化,YTHDF1过表达增加了H/R损伤引起的细胞形态变化;H/R损伤处理后cleaved caspase-3、Bax和FasL蛋白表达显著高于control组(P<0.05);H/R+YTHDF1-siRNA组cleaved caspase-3、Bax和FasL的蛋白水平显著低于H/R组(P<0.05),H/R+pcDNA3.1-YTHDF1组cleaved caspase-3、Bax和FasL蛋白水平显著高于H/R组(P<0.05)。结论下调YTHDF1可以抑制H/R处理的H9c2细胞cleaved caspase-3、Bax和FasL蛋白水平的上调并降低H/R处理的心肌细胞氧化损伤。

关键词： YTH域家族蛋白1 缺氧复氧 H9c2细胞凋亡氧化应激

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油气工业中氢对双相不锈钢腐蚀行为的影响

工程科学学报 2024年第4期46卷 684-694页

作者：刘子轩王竹唐德志金杰张雷北京科技大学新材料技术研究院北京100083 中国石油规划总院北京100083

随着双相不锈钢在海洋油气田和酸性服役工况下的应用越来越多,临氢环境下双相不锈钢的失效风险逐步提高.目前海洋油气田双相不锈钢管道面临的氢损伤失效主要出现在海水过阴极保护环境和含H2S的酸性服役环境.氢的引入除了引起双相不锈钢... 详细信息

随着双相不锈钢在海洋油气田和酸性服役工况下的应用越来越多,临氢环境下双相不锈钢的失效风险逐步提高.目前海洋油气田双相不锈钢管道面临的氢损伤失效主要出现在海水过阴极保护环境和含H2S的酸性服役环境.氢的引入除了引起双相不锈钢腐蚀性能和组织的改变外,还不可避免遭受氢损伤,包括氢脆、氢致开裂等.本文综述了氢进入双相不锈钢后引起的氢损伤问题、腐蚀性能的改变和组织的改变,旨在为双相不锈钢油气工业临氢环境下的应用提供指导;总结了氢在双相不锈钢中扩散和分布的研究现状:氢在双相不锈钢中的扩散路径是曲折的,倾向于在晶界处聚集,随后向铁素体扩散;介绍了与氢相关的现代分析技术与方法,同时展望了临氢环境双相不锈钢研究的发展趋势:氢损伤理论机制仍不完善,需要将现代分析技术和理论计算模拟相结合完善和发展新的氢损伤理论模型.

关键词：油气工业双相不锈钢临氢环境氢损伤腐蚀行为

融合学术文本词汇功能属性的交叉领域新兴社群预测

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数据分析与知识发现 2024年第4期8卷 99-111页

作者：操玉杰向荣荣毛进袁丹妮华中师范大学信息管理学院武汉430079 武汉大学信息管理学院武汉430072

【目的】充分挖掘科学知识网络社群多元特征,提升领域新兴趋势预测效果。【方法】基于e-Health领域新兴社群到热点社群的成长路径回溯,本文提出一种融合词汇功能属性的新兴趋势多元特征预测模型。【结果】在e-Health领域,所融合的主题... 详细信息

【目的】充分挖掘科学知识网络社群多元特征,提升领域新兴趋势预测效果。【方法】基于e-Health领域新兴社群到热点社群的成长路径回溯,本文提出一种融合词汇功能属性的新兴趋势多元特征预测模型。【结果】在e-Health领域,所融合的主题、技术等词汇功能属性特征能够提升新兴趋势预测性能,综合结构、影响、序列和属性4组特征的RF算法模型效果最佳。词汇功能属性规模大、密度低、中介中心性高、波动率大的社群更有可能成为新兴社群。序列特征对新兴社群预测效果欠佳,可能受到新兴社群的前瞻性影响。【局限】词汇功能识别结果存在一定领域依赖,结论扩展到其他领域的有效性需进一步验证。【结论】充分挖掘科学文本词汇细粒度语义特征,能够有效提升新兴趋势预测性能,对科学内容评价和科技决策支持具有一定参考意义。

关键词：新兴趋势词汇功能社群预测机器学习

Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress

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Neural Regeneration Research 2016年第9期11卷 1471-1479页

作者： De-guo Jiang Shi-li jin Gong-ying Li Qing-qing Li Zhi-ruo Li Hong-xia Ma Chuan-jun Zhuo Rong-huan Jiang Min-jie Ye Department of Psychiatry Wenzhou 7th People's Hospital Wenzhou Zhejiang Province China Department of Psychiatry Second Affiliated Hospital of Jining Medical University Jining Shandong Province China Department of Psychiatry Jining Medical University Jining Shandong Province China Department of Psychiatry Tianjin Anding Hospital Tianjin China Department of Psychological Medicine Chinese PLA General Hospital Department of Psychological Medicine Chinese PLA Medical School Beijing China The Affiliated Kangning Hospital of Wenzhou Medical University Wenzhou Zhejiang Province China

Previous studies suggest that serotonin （5-HT） might interact with brain-derived neurotrophic factor （BDNF） during the stress response. However, the relationship between 5-HT and BDNF expression under purely psychological stress is unclear. In this study, one hour before psychological stress exposure, the 5-HT1A receptor agonist 8-OH-DPAT or antagonist MDL73005, or the 5-HT2A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress. Immunohistochemistry and in situ hybridization revealed that after psychological stress, with the exception of the ventral tegmental area, BDNF protein and mRNA expression levels were higher in the 5-HT1A and the 5-HT2A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus, prefrontal cortex, central amygdaloid nucleus, dorsomedial hypothalamic nucleus, dentate gyrus, shell of the nucleus accumbens and the midbrain periaqueductal gray. There was no significant difference between the two agonist groups. In contrast, after stress exposure, BDNF protein and mRNA expression levels were lower in the 5-HT1A and 5-HT2A receptor antagonist groups than in the solvent control non-stress group, with the exception of the ventral tegmental area. Our findings suggest that 5-HT regulates BDNF expression in a rat model of acute psychological stress.

关键词： nerve regeneration psychological stress serotonin 5-HT1A 5-HT2A brain-derived neurotrophic factor neural regeneration

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双酶协同增加青稞慢消化淀粉含量的工艺优化

食品研究与开发 2024年第2期45卷 125-131页

作者：李岩孙康娜宋晓凡陈富章金苏宇韩丽娟叶英院珍珍青海大学农牧学院青海西宁810016 青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016

以萌芽黑青稞粉为原料,研究β-淀粉酶协同α-葡萄糖苷酶增加青稞慢消化淀粉含量及其体外降糖活性。通过单因素试验、体外模拟消化法和Box-Behnken响应面试验,确定最优工艺条件,并通过α-淀粉酶和α-葡糖苷酶抑制率的测定,评价其体外降... 详细信息

以萌芽黑青稞粉为原料,研究β-淀粉酶协同α-葡萄糖苷酶增加青稞慢消化淀粉含量及其体外降糖活性。通过单因素试验、体外模拟消化法和Box-Behnken响应面试验,确定最优工艺条件,并通过α-淀粉酶和α-葡糖苷酶抑制率的测定,评价其体外降糖活性。结果表明,双酶协同增加青稞慢消化淀粉含量的酶解最优条件为β-淀粉酶、α-葡萄糖苷酶添加量150 U/g青稞粉、酶解时间8 h、酶解温度50℃、青稞粉浓度10%。此条件下青稞慢消化淀粉含量达到最高,为33.62%。体外降糖活性测定结果显示,与原粉相比酶改性青稞粉的α-淀粉酶抑制率增加了62.97%,α-葡萄糖苷酶的抑制率增加了52.46%,表明酶解粉的体外降糖活性明显提高。

关键词：青稞慢消化淀粉 β-淀粉酶 α-葡萄糖苷酶工艺优化