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Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair

Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei Gu Anmao Li Chunyan He Rui Xiao Jiaxin Liao Li Xu Junhao Mu Xiaohui Wang Mingjin Yang jinyue Jiang Yang Bai Xingxing jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao jing Lin Yishi Li Shuliang Guo Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(ECM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and ECM ***,the mechanism of how SOX9 regulates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and ECM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regulated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted ECM *** SOX9 inhibited cell proliferation,migration,and ECM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in ECM deposition,as a direct target of SOX9,which promotes ECM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eECM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： Extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis

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积温驱动的稻谷热风干燥工艺优化与营养品质模型研究

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粮油食品科技 2024年第5期32卷 1-10页

作者：李进泉尹君金毅弋晓康张忠杰塔里木大学机械电气化工程学院新疆维吾尔自治区教育厅普通高等学校现代农业工程重点实验室南疆特色农林产物利用与装备兵团重点实验室新疆阿拉尔843300 国家粮食和物资储备局科学研究院粮食储运研究所北京100037 粮食储运国家工程研究中心北京100037

本研究开展了水稻薄层热风干燥实验,采用正交实验方法研究稻谷在不同热风温度、热风湿度、初始含水率、热风风速、缓苏比条件下的热风干燥特性,比较9种干燥积温-营养指标(蛋白质、脂肪、淀粉)数学模型在稻谷热风干燥中的适用性。结果表... 详细信息

本研究开展了水稻薄层热风干燥实验,采用正交实验方法研究稻谷在不同热风温度、热风湿度、初始含水率、热风风速、缓苏比条件下的热风干燥特性,比较9种干燥积温-营养指标(蛋白质、脂肪、淀粉)数学模型在稻谷热风干燥中的适用性。结果表明:利用Central-Composite设计了实验方案,通过回归模型优化参数组合为热风温度T=38.5℃、热风湿度RH=48.086%、初始含水率MC=19.82%、热风风速V=0.70m/s、缓苏比TR=1.45验证实验结果与优化结果的相对误差为3.65%,积温-营养品质模型的相对误差为5.92%。通过数学模型拟合发现,积温-蛋白质含量采用仿修正PageⅡ模型拟合效果最佳;积温-脂肪含量拟合效果最佳为仿Thompson方程;直链淀粉含量拟合效果最佳为仿Midilli方程;积温-支链淀粉含量拟合效果最佳为仿WeibullⅡ方程,模型都极其显著。优化后的干燥工艺保持了营养品质,提高了干燥效率,为深入探究稻谷品质变化机理提供新途径,为后续智能控制系统的开发奠定基础。

关键词：积温营养品质工艺优化干燥模型

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复杂裂纹涡流检测与评估方法研究

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仪器仪表学报 2024年第2期45卷 280-288页

作者：靳建辉张卿韩博杨世品任毅南京工业大学电气工程与控制科学学院南京211816 江苏省特种设备安全监督检验研究院南京210009

钢轨表面及上表面产生的滚动接触疲劳裂纹通常以斜裂纹或多角度复杂裂纹的形态存在,对其检测和评估是个难题。基于此,采用基于无线能量传输的涡流检测方法(WPT-ECT),设计新的探头结构并结合神经网络算法对裂纹进行检测和评估。首先,有... 详细信息

钢轨表面及上表面产生的滚动接触疲劳裂纹通常以斜裂纹或多角度复杂裂纹的形态存在,对其检测和评估是个难题。基于此,采用基于无线能量传输的涡流检测方法(WPT-ECT),设计新的探头结构并结合神经网络算法对裂纹进行检测和评估。首先,有别于现有WPT-ECT方法,采用增大激励频率,而非串并联电容的方式,构造谐振电路;其次,根据复杂裂纹的特点,设计由两个八字形激励线圈和两个矩形接收线圈组成的方向性探头结构;最后,充分提取检测信号的特征,并运用径向基神经网络算法对裂纹进行识别。仿真和实验结果表明,所提出的探头结构对任何角度的缺陷均敏感。同时,RBF算法对斜裂纹、T裂纹、Y裂纹和1.2 mm提离下的T裂纹的识别准确率分别为92.00%、95.27%、96.64%和89.50%。

关键词：滚动接触疲劳裂纹无线能量传输涡流检测特征量提取径向基神经网络

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Serum amyloid A levels in patients with liver diseases

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World Journal of Gastroenterology 2019年第43期25卷 6440-6450页

作者： Zi-ying Yuan Xing-Xin Zhang Yu-jing Wu Zhi-Ping Zeng Wei-Min She Shi-Yao Chen Yuan-Qing Zhang jin-Sheng Guo Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Shanghai Institute of Liver Diseases Shanghai 200032China Department of Gastroenterology Peking University Third HospitalBeijing 100191China The First Affiliated Hospital Yunnan Institute of Digestive DiseaseKunming Medical UniversityKunming 650000Yunnan ProvinceChina

BACKGROUND Serum amyloid A(SAA)is an acute phase protein mainly synthesized by the *** induces inflammatory phenotype and promotes cell proliferation in activated hepatic stellate cells,the major scar forming cells in the ***,few studies have reported on the serum levels of SAA in human liver disease and its clinical significance in various liver *** To investigate the serum levels of SAA in patients with different liver diseases and analyze the factors associated with the alteration of SAA levels in chronic hepatitis B(CHB)*** Two hundred and seventy-eight patients with different liver diseases and 117 healthy controls were included in this *** patients included 205 with CHB,22 with active autoimmune liver disease(AILD),21 with nonalcoholic steatohepatitis(NASH),14 with drug-induced liver injury(DILI),and 16 with pyogenic liver *** levels of SAA and other clinical parameters were collected for the analysis of the factors associated with SAA ***-Whitney U test was used to compare the serum SAA levels of patients with various liver diseases with those of healthy *** test was applied for post hoc comparisons to control the probability of type 1 error(alpha=0.05/6=0.008).For statistical tests of other variables,P<0.05 was considered statistically *** significant factors determined by single factor analysis were further analyzed by binary multivariate logistic regression *** All patients with active liver diseases had higher serum SAA levels than healthy controls and the inactive CHB patients,with the highest SAA level found in patients with pyogenic liver abscess(398.4±246.8 mg/L).Patients with active AILD(19.73±24.81 mg/L)or DILI(8.036±5.685 mg/L)showed higher SAA levels than those with active CHB(6.621±6.776 mg/L)and NASH(6.624±4.891 mg/L).Single(P<0.001)and multivariate logistic regression analyses(P=0.039)for the CHB patients suggested that patients with

关键词： Serum amyloid A Liver diseases Pyogenic liver abscess Chronic hepatitis B Inflammation

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软件定义云边协同架构下的水下监测新机制

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系统工程与电子技术 2024年第3期46卷 1101-1108页

作者：金志刚洪叶苏毅珊羊秋玲天津大学电气自动化与信息工程学院天津300072 海南大学计算机科学与技术学院海南海口570228

传统基于硬件的水声传感器网络(underwater acoustic sensor networks,UASNs)架构灵活性及可控性较差,难以满足水下多样化监测任务的需求。针对此问题,提出基于边缘计算的水下软件定义监测网络架构,并提出一种多级协同水下监测机制。该... 详细信息

传统基于硬件的水声传感器网络(underwater acoustic sensor networks,UASNs)架构灵活性及可控性较差,难以满足水下多样化监测任务的需求。针对此问题,提出基于边缘计算的水下软件定义监测网络架构,并提出一种多级协同水下监测机制。该架构通过主从控制器将集中式云处理任务部署至边缘端,并对网络进行分级控制。该机制首先通过低轨遥感卫星进行大范围海洋监测,其次进行小范围监测,数据经原位处理及边缘处理后上传至水面进行分析,最后进行水下联合监测。仿真结果表明,所提出的监测架构和监测机制可降低异常数据处理时间成本和网络开销,在不同场景下的端到端延迟、网络能耗和包投递率方面都有良好的表现,提高了监测架构的灵活性。

关键词：水声传感器网络监测架构软件定义水下监测机制

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Clinical features of multiple gastrointestinal stromal tumors:A pooling analysis combined with evidence and gap map

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World Journal of Gastroenterology 2020年第47期26卷 7550-7567页

作者： Chen Li Ke-Lu Yang Quan Wang jin-Hui Tian Yang Li Zhi-Dong Gao Xiao-Dong Yang ying-Jiang Ye Ke-Wei Jiang Department of Gastroenterological Surgery Peking University People's HospitalBeijing 100044China Evidence-Based Nursing Center School of NursingLanzhou UniversityLanzhou 730000Gansu ProvinceChina Evidence Based Medicine Center School of Basic Medical Science of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are a very rare type of gastrointestinal stromal tumor(GIST)and are usually observed in *** The paper aimed to describe the clinical and oncological features of MGISTs and to offer evidence for the diagnosis and *** Data of consecutive patients with MGISTs who were diagnosed at Peking University People’s Hospital(PKUPH)from 2008 to 2019 were retrospectively ***,a literature search was conducted by retrieving data from PubMed,EMBASE,and the Cochrane library databases from inception up to November 30,*** In all,12 patients were diagnosed with MGISTs at PKUPH,and 43 published records were ultimately included following the literature *** analysis of the whole individual patient data showed that female(59.30%),young(14.45%),and syndromic GIST(63.95%)patients comprised a large proportion of the total patient *** were mainly located in the small intestine(58.92%),and both CD117 and CD34 were generally *** a mean 78.32-mo follow-up,the estimated median overall survival duration(11.5 years)was similar to single GISTs,but recurrence-free survival was relatively *** The clinical and oncological features are potentially different between MGISTs and single *** studies are needed to explore appropriate surgical approach and adjuvant therapy.

关键词： Gastrointestinal stromal tumor Multiple Pooling analysis Cross sectional study Evidence and gap map

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A Mendelian randomisation,propensity score matching study to investigate causal association between serum homocysteine and intracranial aneurysm

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Stroke & Vascular Neurology 2024年第3期9卷 202-211,I0104-I0109页

作者： Zhuohua Wen Xin Feng Xin Tong Chao Peng Anqi Xu Haiyan Fan Yiming Bi Wenchao Liu Zhenjun Li Shenquan Guo Fa jin Ran Li Yanchao Liu Shixing Su Xin Zhang Xifeng Li Xuying He Aihua Liu Chuanzhi Duan Neurosurgery Center Department of Cerebrovascular SurgeryEngineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular DiseaseZhujiang HospitalSouthern Medical UniversityGuangzhouChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina

Background and purpose Recent observational studies have reported that serum total homocysteine(tHcy)is associated with intracranial aneurysms(IAs).However,the causal effect of tHcy on IAs is *** leveraged large-scale genetic association and real-world data to investigate the causal effect of tHcy on IA *** We performed a two-sample Mendelian randomisation(MR)using publicly available genome-wide association studies summary statistics to investigate the causal relationship between tHcy and IAs,following the recommendations of the Strengthening the Reporting of Observational Studies in Epidemiology-MR ***,a propensity score matching(PSM)analysis was conducted to evaluate the detailed effects of tHcy on risk of IA formation by utilizing real-world multicentre data,including 9902 patients with and without IAs(1:1 matched).Further interaction and subgroup analyses were performed to elucidate how tHcy affects risk of IA *** MR analyses indicated that genetically determined tHcy was causally associated with IA risk(OR,1.38,95%CI 1.07 to 1.79;p=0.018).This is consistent with the more conservative weighted median analysis(OR,1.41,95%CI 1.03 to 1.93;p=0.039).Further sensitivity analyses showed no evidence of horizontal pleiotropy or heterogeneity of single nucleotide polymorphisms in causal *** to the PSM study,we found that,compared with low tHcy(≤15μmol/L),moderate tHcy(>15-30μmol/L)(OR 2.13,95%CI 1.93 to 2.36)and high tHcy(>30μmol/L)(OR 3.66,95%CI 2.71 to 4.95)were associated with a higher IA risk(p trend<0.001).Subgroup analyses demonstrated significant ORs of tHcy in each subgroup when stratified by traditional cardiovascular risk ***,there was also a synergistic effect of tHcy and hypertension on IA risk(p interaction<0.001;the relative excess risk due to interaction=1.65,95%CI 1.29 to 2.01).Conclusion Both large-scale genetic evidence and multicentre real-world data support a causal as

关键词： matching random centre

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Generation of polarization-multiplexed terahertz orbital angular momentum combs via all-silicon metasurfaces

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Light(Advanced Manufacturing) 2024年第3期5卷 120-129页

作者： Ming-Zhe Chong Yiwen Zhou Zong-Kun Zhang jin Zhao Yue-Yi Zhang Chong-Qi Zhang Xiaofei Zang Chao-Hai Du Pu-Kun Liu Ming-Yao Xia School of Electronics Peking UniversityBeijing 100871China Terahertz Technology Innovation Research Institute and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyNo.516 Jun Gong RoadShanghai 200093China State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China

Electromagnetic waves carrying orbital angular momentum(OAM),namely OAM beams,are important in various fields including optics,communications,and quantum ***,most current schemes can only generate single or several simple OAM ***-mode OAM beams are rarely *** paper proposes a scheme to design metasurfaces that can generate multiple polarization-multiplexed OAM modes with equal intervals and intensities(i.e.,OAM combs)working in the terahertz(THz)*** a proof of concept,we first design a metasurface to generate a pair of polarization-multiplexed OAM combs with arbitrary mode ***,another metasurface is proposed to realize a pair of polarization-multiplexed OAM combs with arbitrary locations and intervals in the OAM *** results agree well with full-wave simulations,verifying a great performance of OAM combs *** method may provide a new solution to designing high-capacity THz devices used in multi-mode communication systems.

关键词： Metasurfaces Terahertz Orbital angular momentum comb Polarization multiplexing

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Cytotoxicity and DNA Damage Effect of TGA-capped CdTe Quantum Dots

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Chemical Research in Chinese Universities 2012年第2期28卷 276-281页

作者： LI Yan-bo ZHANG Hai-xia GUO Cai-xia HU Gui-qin DU Hai-ying jin Ming-hua HUANG Pei-li SUN Zhi-wei YANG Wen-sheng School of Public Health and Family Medicine Capital Medical UniversityBeijing 100069P.R.China Public Health Institute Beijing Chaoyang District Centre for Disease Control and PreventionBeijing 100021P R.China School of Public Health Jilin UniversityChangchun 130021P.R.China Key Laboratory of Surface and Interface Chemistry of Jilin Province College of ChemistryJilin UniversityChangchun 130012P.R.China

The cytotoxicity and DNA damage caused by thioglycolic acid（TGA）-capped cadmium telluride（CdTe） quantum dots（QDs） to hepatocyte line HL-7702 were *** viability was measured by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT） assay;DNA damage was detected by single cell gel electrophoresis（SCGE）;the change of cell cycle progression was examined by propidium iodide（PI）-flow cytometry（FCM）;apoptosis was measured by acridine orange/ethidium bromide（AO/EB） assay and Annexin V-FITC/PI-FCM（FITC：fluorescein isothiocyanate）.The results show that the cytotoxicity induced by CdTe QDs was increased in a dose-dependent and time-dependent manner;after exposure to QDs for 24 h,as the exposure dose increased,the rate of DNA damage was significantly increased（P0.05）,and the degree of DNA damage was *** the dose of CdTe QDs increased,the percentage of G 0 /G 1 phase cells was significantly decreased（P0.001）,while the percenttages of S and G 2 /M phases cells were significantly increased（P0.001）.In AO/EB assay,apoptotic cells could be observed under a fluorescence microscope,and apoptotic rate was increased as exposure dose *** Annexin V-FITC/PI-FCM assay,the apoptotic rates of CdTe QDs treated groups were significantly increased compared with that of control group（P0.05）.Our studies indicate that CdTe QDs could influence cell viability,and induce DNA damage,the S and G2 /M phases arrest and apoptosis of HL-7702.

关键词： Apoptosis CdTe quantum dot(QD) Cell cycle Cell viability DNA damage

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Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants

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Science China(Life Sciences) 2024年第1期67卷 83-95页

作者： Guangshan Xie Lin Zhu Siwen Liu Cun Li Xin Diao Yanhao Zhang Xiuli Su Yuanyuan Song Guodong Cao Li Zhong Pui Wang Xiaojuan Liu Bobo Wing-Yee Mok Shusheng Zhang Dong-Yan jin Jie Zhou Honglin Chen Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Hong Kong Baptist UniversityHong Kong SARChina State Key Laboratory for Emerging Infectious Diseases and Department of MicrobiologyLi Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Biomedical Sciences The University of Hong KongHong Kong SARChina HKBU Shenzhen Institute of Research and Continuing Education Shenzhen 518000China

SARS-CoV-2 continues to threaten human society by generating novel variants via mutation and *** high number of mutations that appeared in emerging variants not only enhanced their immune-escaping ability but also made it difficult to predict the pathogenicity and virulence based on viral nucleotide *** markers for evaluating the pathogenicity of new variants are therefore *** comparing host responses to wild-type and variants with attenuated pathogenicity at proteome and metabolome levels,six key molecules on the polyamine biosynthesis pathway including putrescine,SAM,dc-SAM,ODC1,SAMS,and SAMDC were found to be differentially upregulated and associated with pathogenicity of *** validate our discovery,human airway organoids were subsequently used which recapitulates SARS-CoV-2 replication in the airway epithelial cells of COVID-19 *** ODC1 as a proof-ofconcept,differential activation of polyamine biosynthesis was found to be modulated by the renin-angiotensin system(RAS)and positively associated with ACE2 *** experiments demonstrated that ODC1 expression could be differentially activated upon a panel of SARS-CoV-2 variants of concern(VOCs)and was found to be correlated with each VOCs’pathogenic ***,the presented study revealed the discriminative ability of key molecules on polyamine biosynthesis as a predictive marker for virulence evaluation and assessment of SARS-CoV-2 variants in cell or organoid *** work,therefore,presented a practical strategy that could be potentially applied as an evaluation tool for the pathogenicity of current and emerging SARS-CoV-2 variants.

关键词： SARS-CoV-2 multi-omics attenuated variant predictive pathogenic marker polyamine biosynthesis

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