检索结果-南通市图书馆

视网膜神经节细胞对自然刺激的时空反应模式(英文)

在线全文

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2010年第4期37卷 389-396页

作者：张莹莹金鑫龚海庆梁培基上海交通大学生命科学技术学院上海200240

神经系统信息处理的理论研究和计算结果表明,视皮层可以通过稀疏编码 (sparse coding) 模式来处理自然刺激信息.神经元群体中,单个神经元在大多数时间里没有强的脉冲发放 (时间维稀疏性,lifetime sparseness),而针对某一刺激,只有少数... 详细信息

神经系统信息处理的理论研究和计算结果表明,视皮层可以通过稀疏编码 (sparse coding) 模式来处理自然刺激信息.神经元群体中,单个神经元在大多数时间里没有强的脉冲发放 (时间维稀疏性,lifetime sparseness),而针对某一刺激,只有少数神经元在特定的时间内发放 (空间维稀疏性,population sparseness).从神经元放电的时间和空间模式两个方面考察了视网膜神经节细胞群体对自然刺激(电影)的编码方式,并同实验室常用的伪随机棋盘格刺激下视网膜的反应模式进行比较,分析了视网膜神经节细胞反应的稀疏性指标,并深入探讨了其内在的时间和空间特点.结果提示,视觉系统在其最初阶段——视网膜——即开始采用一种高效节能的稀疏编码方式来处理自然视觉信息,单个神经元的时间维稀疏性节省了代谢能量消耗,而群体神经元中邻近神经元的动态成组协同发放,提高了信息向突触后神经元传递的有效性.

关键词：时间维稀疏性空间维稀疏性峰度同步脉冲串

Exploration of the Collaborative Development of Disciplines and Majors with DNA Double Helix Mechanism

在线全文

学校读者我要写书评

暂无评论

Exploration of the Collaborative Development of Disciplines ...

Weatherability and heat resistance enhanced by interaction between AG25 and Mg/AI-LDH

2024社会发展与科技创新交流会

作者： Yi jin ying Li jing Wang School of Physics and Technology University of Jinan School of Physics and Electronic Information Yantai University

The construction of disciplines and majors is an important component of the basic construction of higher education institutions. It is the carrier of talent cultivation, scientific research, and social services, and also the main support for higher education institutions. The construction of disciplines and majors is related to the development planning, resource allocation, integration, and coordination of schools, as well as to the sustainable development of higher education. The construction of disciplines and majors in higher education institutions is closely linked, but after all, there are different emphases. On the basis of analyzing the connotations of disciplines and majors, taking the national first-class undergraduate physics major site in University of jinan as an example, this article proposes a development mechanism of DNA double helix style for the collaborative construction, in order to truly implement the collaborative system of first-class disciplines and majors, and thus assist in the cultivation of innovative talents in higher education.

关键词： collaborative development discipline and major Double Helix mechanism first-class major undergraduate physics major

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2758-2768页

作者： Pei-Yao Yang Xiang-Cui Liu Yu-Chao Wang Huan-Ran Zheng jin-Xian Wang Jia-Yi Zheng Meng-Jie Liu Dan-Ni Deng Yu Bai ying-Bi Chen Tong Zhang Zhi-Ming Liu Yong-Peng Lei State Key Laboratory of Powder Metallurgy Powder Metallurgy Research InstituteCentral South UniversityChangsha 410083China Research Institute of Chemical Defense Beijing 102205China

Although inorganic pigments in common spectral tuning materials show good weatherability and heat resistance,the limited color choices,weak coloring power,poor dispersibility,and a possibility of toxicity limit their *** the basis of organic pigments which possess a wide range of colors,high coloring power,good transparency,and high safety,herein,the modified pigment and biomimetic coating with improved weatherability,especially ultraviolet(UV)resistance(from 2 to 6 days),was achieved by intercalating acid green 25(AG25)pigment into Mg/Al-layered double hydroxides(Mg/Al-LDH).Furthermore,the heat resistance of AG25 was also significantly ***,the spectral stability of pigments after heat treatment is superior with almost unchanged spectral profile and green reflection *** formation of strong N-H bonds and the S-M(Mg,Al)bonds between Mg/Al-LDH laminates and AG25 molecules contributes to the *** work shows potential for biomimetic leaf materials in respect of reflective spectra stability.

关键词： Layered double hydroxide Biomimetic Acid green 25 Interaction Weatherability Heat resistance

Purple acid phosphatase promoted hydrolysis of organophosphate pesticides in microalgae

在线全文

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第2期18卷 137-149页

作者： Xiang Wang Guo-Hui He Zhen-Yao Wang Hui-ying Xu jin-Hua Mou Zi-Hao Qin Carol Sze Ki Lin Wei-Dong Yang Yalei Zhang Hong-Ye Li Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes College of Life Science and TechnologyJinan UniversityGuangzhou510632China School of Energy and Environment City University of Hong KongTat Chee AvenueKowloonHong Kong Centre for Technology in Water and Wastewater School of Civil and Environmental EngineeringUniversity of Technology SydneyUltimoNSW2007Australia Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou510000China State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai200092China

When organophosphate pesticides(OPs)are not used and handled in accordance with the current rules and standards,it results in serious threats to the aquatic environment and human *** tricornutum is a prospective microalgae-based system for pollutant removal and carbon *** engineered ***,designated as the OE line(endogenously expressing purple acid phosphatase 1[PAP1]),can utilize organic phosphorus for cellular ***,the competencies and mechanisms of the microalgae-based system(namely the OE line of ***)for metabolizing OPs remain to be *** this study,the OE line exhibited the effective biodegradation competencies of 72.12%and 68.2%for 30 mg L^(-1)of dichlorvos and 50 mg L^(-1)of glyphosate,accompanied by synergistic accumulations of biomass(0.91 and 0.95 g L^(-1))and lipids(32.71%and 32.08%),***,the biodiesel properties of the lipids from the OE line manifested a high potential as an alternative feedstock for microalgae-based biofuel production.A plausible mechanism of OPs biodegraded by overexpressed PAP1 is that sufficient inorganic P for adenosine triphosphate and concurrent carbon flux for the reduced form of nicotinamide adenine dinucleotide phosphate biosynthesis,which improved the OP tolerance and biodegradation competencies by regulating the antioxidant system,delaying programmed cell death and accumulating lipids via the upregulation of related *** sum up,this study demonstrates a potential strategy using a genetically engineered strain of *** to remove high concentrations of OPs with the simultaneous production of biomass and biofuels,which might provide novel insights for microalgae-based pollutant biodegradation.

关键词： Biodegradation Lipid accumulation Organophosphate pesticide Phaeodactylum tricornutum Purple acid phosphatase

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高流量呼吸湿化治疗仪在程序化撤机中的应用

中国现代医学杂志 2021年第3期31卷 76-79页

作者：张赞华金盈盈黄晨梦温州医科大学附属第二医院浙江温州325000

目的探讨高流量呼吸湿化治疗仪在程序化撤机中的应用。方法选取2017年6月—2017年12月温州医科大学附属第二医院重症监护治疗病房(ICU)行程序化撤机的患者80例,按照其给氧方式意愿分为观察组43例和对照组37例。观察组给予高流量呼吸湿... 详细信息

目的探讨高流量呼吸湿化治疗仪在程序化撤机中的应用。方法选取2017年6月—2017年12月温州医科大学附属第二医院重症监护治疗病房(ICU)行程序化撤机的患者80例,按照其给氧方式意愿分为观察组43例和对照组37例。观察组给予高流量呼吸湿化治疗仪给氧,对照组给予传统面罩给氧。记录两组患者在使用不同给氧方式后30 min、2 h和24 h的动脉血氧分压(PaO2)、血氧饱和度(SpO2)、改良英国医学研究会呼吸困难指数(mMRC)、痰液黏稠度、重新置管率和住院时间。结果不同时间点的PaO2、SpO2、mMRC均有差异(P0.05);给氧后24 h,观察组PaO2、SpO2均高于对照组(P<0.05),mMRC低于对照组(P<0.05),痰液黏稠度分级优于对照组(P<0.05)。观察组重新置管率低于对照组(P<0.05),住院时间短于对照组(P<0.05)。结论高流量呼吸湿化治疗仪在程序化撤机中的应用效果较好,值得临床推广使用。

关键词：机械通气高流量呼吸湿化治疗仪程序化撤机效果

Genetic and pathogenic characterization of new infectious bronchitis virus strains in the GVI-1 and GI-19 lineages isolated in central China

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第7期23卷 2407-2420页

作者： Yuhan Yang Dou Wang Yaning Bai Wenyan Huang Shimin Gao Xingchen Wu ying Wang Jianle Ren jinxin He Lin jin Mingming Hu Zhiwei Wang Zhongbing Wang Haili Ma Junping Li Libin Liang College of Veterinary Medicine Shanxi Agricultural UniversityJinzhong 030801China Shanxi Provincial Animal Disease Prevention and Control Center Taiyuan 030000China

Avian infectious bronchitis(IB)is a highly contagious infectious disease caused by infectious bronchitis virus(IBV),which is prevalent in many countries worldwide and causes serious harm to the poultry *** present,many commercial IBV vaccines have been used for the prevention and control of IB;however,IB outbreaks occur *** this study,two new strains of IBV,SX/2106 and SX/2204,were isolated from two flocks which were immunized with IBV H120 vaccine in central *** and recombination analysis indicated that SX/2106,which was clustered into the GI-19 lineage,may be derived from recombination events of the GI-19 and GI-7 strains and the LDT3-A *** analysis showed that SX/2204 belongs to the GVI-1 lineage,which may have originated from the recombination of the GI-13 and GVI-1 strains and the H120 *** virus cross-neutralization test showed that the antigenicity of SX/2106 and SX/2204 was different from *** experiments found that both SX/2106 and SX/2204 could replicate effectively in the lungs and kidneys of chickens and cause disease and death,and H120 immunization could not provide effective protection against the two IBV *** is noteworthy that the pathogenicity of SX/2204 has significantly increased compared to the GVI-1 strains isolated previously,with a mortality rate up to 60%.Considering the continuous mutation and recombination of the IBV genome to produce new variant strains,it is important to continuously monitor epidemic strains and develop new vaccines for the prevention and control of IBV epidemics.

关键词： infectious bronchitis virus GI-19 lineage GVI-1 lineage complete genome recombination pathogenicity

Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU jing-Sheng LAN Shuo CHEN You-Yi HUANG Lan-jin WU Zhi-Qing QIN ying HUANG Wan-Zhong HUANG Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of Cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of Cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BACKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(P<0.05),among which 8 plasma metabolites[propionylglycine levels(OR=0.922,95%CI:0.881–0.965,P<0.001),gamma-glutamylglycine levels(OR=0.903,95%CI:0.861–0.948,P<0.001),hexadecanedioate(C16-DC)levels(OR=0.941,95%CI:0.911–0.973,P<0.001),pentose acid levels(OR=0.923,95%CI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%CI:0.902–0.971,P<0.001),glycine levels(OR=0.936,95%CI:0.909–0.964,P<0.001),glycine to serine ratio(OR=0.930,95%CI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%CI:0.869–0.958,P<0.001)]were correlated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%CI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%CI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%CI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin YANG Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU Man-qi YAN Ge ZHOU Ya-qiong MIAO Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

Dendrite-free Zn deposition initiated by nanoscale inorganic-organic coating-modified 3D host for stable Zn-ion battery

在线全文

学校读者我要写书评

暂无评论

SusMat 2024年第2期4卷 13-27页

作者： Jiaming Dong Junwen Duan Ruirui Cao Wang Zhang Kangkang Fang Hao Yang ying Liu Zhitao Shen Fumin Li Rong Liu Mengqi jin Longhui Lei Huilin Li Chong Chen Henan Key Laboratory of Photovoltaic Materials College of Future TechnologyHenan UniversityKaifengChina College of Optoelectronic Engineering Shenzhen UniversityShenzhenChina Institute of Solid-State Physics Chinese Academy of SciencesHefeiChina

A 3D nanostructured scaffold as the host for zinc enables effective inhibition of anodic dendrite ***,the increased electrode/electrolyte interface area provided by using 3D matrices exacerbates the passivation and localized corrosion of the Zn anode,ultimately bringing about the degradation of the electrochemical ***,a nanoscale coating of inorganic-organic hybrid(α-In_(2)Se_(3)-Nafion)onto a flexible carbon nanotubes(CNTs)framework(ISNF@CNTs)is designed as a Zn plating/stripping scaffold to ensure uniform Zn nucleation,thus achieving a dendrite-free and durable Zn *** intro-duced inorganic-organic interfacial layer is dense and sturdy,which hinders the direct exposure of deposited Zn to electrolytes and mitigates the side ***,the zincophilic nature of ISNF can largely reduce the nucleation energy barrier and promote the ion-diffusion ***,the ISNF@CNTs@Zn electrode exhibits a low-voltage hysteresis and a superior cycling life(over 1500 h),with dendrite-free Zn-plating behaviors in a typical symmetrical cell ***,the superior feature of ISNF@CNTs@Zn anode is further demonstrated by Zn-MnO_(2)cells in both coin and flexible quasi-solid-state *** work puts forward an inspired remedy for advanced Zn-ion batteries.

关键词： 2D/3D configuration dendrite-free inorganic-organic layer interfacial protection Zn-ion batteries