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Highly variable γ-ray emission of CTD 135 and implications for its compact symmetric structure

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Research in Astronomy and Astrophysics 2021年第8期21卷 173-180页

作者： ying-ying gan Hai-Ming Zhang Jin Zhang Xing Yang Ting-Feng Yi Yun-Feng Liang En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China School of Physics Beijing Institute of TechnologyBeijing 100081China Department of Physics Yunnan Normal UniversityKunming 650500China

Theγ-ray emission properties of CTD 135,a typical compact symmetric object(CSO),are investigated with-11-year Fermi/LAT *** show that it has bright and significantly variable GeV emission,with theγ-ray luminosity of L_(γ)-10^(47) erg s^(-1) and a variation index of TS_(var)=1002.A quasi-periodic oscillation(QPO)with a periodicity of-460 days is detected in the global 95%false-alarm ***γ-ray emission features are similar to that of *** broadband spectral energy distribution(SED)can be attributed to the radiations of the relativistic electrons accelerated in the core region and the extended *** SED modeling shows that theγ-rays are from the core region,which has a Doppler boosting factor ofδ-10.8 and relativistically moves with a small viewing angle,being similar to blazar *** the base of the analysis results,we propose that the episodic activity of the central engine in CTD135 results in a blazar-like jet and the bubble-like lobes as the Fermi bubbles in the *** strong 7-ray emission with obvious variability is from the jet radiations and the symmetric radio structure is attributed to the *** jet radiation power and disk luminosity in units of Eddington luminosity of CTD 135 follow the same relation as other young radio sources,indicating that its jet radiation may also be driven by the Eddington ratio.

关键词： galaxies:active galaxies:jets radio continuum:galaxies gamma rays:galaxies

Low limit of detection of the Algan/gan-based sensor by the Kelvin connection detection technique

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Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang ying gan Shu Yang Kuang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomarker for the early diagnosis of HF(heart failure).In this work,a novel Algan/gan device with the Kelvin connection structure and the corresponding detection technique was *** technique can effectively suppress the background noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor package on background noise was investigated with the mechanism of the noise source ***,based on the optimized package,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

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羊栖菜和裙带菜中抗凝血活性物质的初步筛选

水产学报 2004年第4期28卷 473-476页

作者：刘承初周颖邬英睿甘建红周培根上海水产大学食品学院上海水产大学食品学院上海 200090

广阔的海洋占地球总面积的71％,其中蕴涵着丰富的生物资源。海藻系生长于海洋中的低等隐花植物,曾被大量用作工业原料、肥料和饲料。而近年来,其保健作用和药用价值越来越受到人们的关注。中国古代《神农本草经》和《本草纲目》等书中... 详细信息

广阔的海洋占地球总面积的71％,其中蕴涵着丰富的生物资源。海藻系生长于海洋中的低等隐花植物,曾被大量用作工业原料、肥料和饲料。而近年来,其保健作用和药用价值越来越受到人们的关注。中国古代《神农本草经》和《本草纲目》等书中曾记载,海藻具有软坚散结、清热解毒、利水消肿、补肾养心、破血祛瘀和消食驱虫等功效。近代研究表明,海藻中含有多种药理活性很强

关键词：羊栖菜裙带菜抗凝血活性硫酸多糖岩藻糖

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

重症急性胰腺炎并发ARDS强化胰岛素治疗的临床干预效果观察

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四川医学 2009年第11期30卷 1711-1712页

作者：雷贤英刘英甘辞海唐显玲泸州医学院附属医院ICU急诊科麻醉科四川泸州646000

目的观察重症急性胰腺炎并发ARDS强化胰岛素治疗的临床干预效果。方法将66例重症急性胰腺炎合并ARDS患者随机分为两组,传统组（TT组）与强化组（IT组）,两组均采用微量注射泵输入胰岛素,TT组将血糖控制在10.0～11.1mmol/L,IT组将血糖控... 详细信息

目的观察重症急性胰腺炎并发ARDS强化胰岛素治疗的临床干预效果。方法将66例重症急性胰腺炎合并ARDS患者随机分为两组,传统组（TT组）与强化组（IT组）,两组均采用微量注射泵输入胰岛素,TT组将血糖控制在10.0～11.1mmol/L,IT组将血糖控制在4.4～6.1mmol/L。观察两组使用呼吸机时间、ICU住院时间及低血糖例数等情况。结果两组存活患者比较,IT组使用呼吸机时间、ICU住院时间均明显缩短（P〈0.05）。结论强化胰岛素治疗对重症急性胰腺炎并发ARDS的治疗过程起着一定的干预因素,加快了脱机时间,缩短ICU住院时间。

关键词：重症急性胰腺炎 ARDS 强化治疗胰岛素

Twisted Helical Microfibers by Hierarchical Self-Assembly of an Aromatic Oligoamide Foldamer

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Chinese Journal of Chemistry 2013年第5期31卷 651-656页

作者： Quan gan ying Wang Hua Jiang College of Chemistry Beijing Normal University Beijing 100875 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China

A series of aromatic oligoamide foldamers based on 8-fluoro amino-quinoline carboxyl acid have been synthe- sized and characterized. Studies show that these foldamers self-assemble to form well-defined twisted helical mi- crofibers in chloroform-methanol （1 ： 1, V/V） binary solvent due to the intermolecular π-π stacking and van der Waals forces of aliphatic chains, which are supported by SEM, TEM and XRD. It is also revealed that the assembly morphologies show strong dependence on the length of alkyl chains.

关键词： foldamer self-assembly microfiber hydrogen bonding aromatic stacking

Formation of Functional Cyclooctadiene Derivatives by Supramolecularly- Controlled Topochemical Reactions and Their Use as Highly Selective Fluorescent Biomolecule Probes

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Chinese Journal of Chemistry 2020年第10期38卷 1040-1044页

作者： Ming-Ming gan ying-Feng Han Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi 710127China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002Chino

Summary of main observation and conclusion Controlling the regio-and stereochemistry of the photoproducts in solution is far more challenging for polvenes than for ***,a supramolecularly-controlled topochemical reaction of conjugated dienes in homogeneous system is developed,ultimately providing two cyclooctadiene-cored tetraimidazolium molecular receptors *** cyclooctadiene derivatives exhibited highly sensi-tive and selective fluorescence sensing for thymine relative to other biologically relevant species in aqueous solution at physiological *** the cycloo-ctadiene moieties and imidazolium units play important roles in the selective recognition *** presented supramolecularly-controlled method allows the simple yet rare selective photoconversion of flexible cyclooctadiene derivatives in *** study offers a new synthetic strategy for the preparation of functional molecules with potential for use in biological applic ations.

关键词： solution. diene chemical

An attention-embedded gan for SVBRDF recovery from a single image

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Computational Visual Media 2023年第3期9卷 551-561页

作者： Zeqi Shi Xiangyu Lin ying Song Zhejiang Sci-Tech University 2011 Collaborative Innovation Center for Garment Personal Customization of Zhejiang ProvinceHangzhou 310018China.

Learning-based approaches have made substantial progress in capturing spatially-varying bidirectional reflectance distribution functions(SVBRDFs)from a single image with unknown lighting and ***,most existing networks only consider per-pixel losses which limit their capability to recover local features such as smooth glossy regions.A few generative adversarial networks use multiple discriminators for different parameter maps,increasing network *** present a novel end-to-end generative adversarial network(gan)to recover appearance from a single picture of a nearly-flat surface lit by *** use a single unified adversarial framework for each parameter *** attention module guides the network to focus on details of the ***,the SVBRDF map loss is combined to prevent paying excess attention to specular *** demonstrate and evaluate our method on both public datasets and real *** analysis and visual comparisons indicate that our method achieves better results than the state-of-the-art in most cases.

关键词： spatially-varying bidirectional reflectance distribution function(SVBRDF) appearance capture generative adversarial network(gan) attention mechanism

Digital twin-enabled adaptive scheduling strategy based on deep reinforcement learning

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Science China(Technological Sciences) 2023年第7期66卷 1937-1951页

作者： gan XueMei ZUO ying ZHANG AnSi LI ShaoBo TAO Fei School of Mechanical Engineering Guizhou UniversityGuiyang 550025China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang 550025China

The modern complicated manufacturing industry and smart manufacturing tendency have imposed new requirements on the scheduling method,such as self-regulation and self-learning *** traditional scheduling methods cannot meet these needs due to their ***-learning is an inherent ability of reinforcement learning(RL) algorithm inhered from its continuous learning and trial-and-error ***-regulation of scheduling could be enabled by the emerging digital twin(DT) technology because of its virtual-real mapping and mutual control *** paper proposed a DT-enabled adaptive scheduling based on the improved proximal policy optimization RL algorithm,which was called explicit exploration and asynchronous update proximal policy optimization algorithm(E2APPO).Firstly,the DT-enabled scheduling system framework was designed to enhance the interaction between the virtual and the physical job shops,strengthening the self-regulation of the scheduling ***,an innovative action selection strategy and an asynchronous update mechanism were proposed to improve the optimization algorithm to strengthen the self-learning ability of the scheduling ***,the proposed scheduling model was extensively tested in comparison with heuristic and meta-heuristic algorithms,such as wellknown scheduling rules and genetic algorithms,as well as other existing scheduling methods based on reinforcement *** comparisons have proved both the effectiveness and advancement of the proposed DT-enabled adaptive scheduling strategy.

关键词： agent reinforcement learning digital twin adaptive scheduling generalization